LOCUS       NM_001008542            2639 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus MAX interactor 1, dimerization protein (Mxi1),
            transcript variant 2, mRNA.
ACCESSION   NM_001008542
VERSION     NM_001008542.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2639)
  AUTHORS   Li,X., Xiao,S., Li,F., Fang,K., Wen,J. and Gong,H.
  TITLE     Max interacting protein 1 induces IL-17-producing T
            helper/regulatory T imbalance in osteoarthritis by upregulating
            tectonic family member 2
  JOURNAL   Tissue Cell 78, 101906 (2022)
   PUBMED   36049372
  REMARK    GeneRIF: Max interacting protein 1 induces IL-17-producing T
            helper/regulatory T imbalance in osteoarthritis by upregulating
            tectonic family member 2.
REFERENCE   2  (bases 1 to 2639)
  AUTHORS   Menendez-Montes,I., Escobar,B., Palacios,B., Gomez,M.J.,
            Izquierdo-Garcia,J.L., Flores,L., Jimenez-Borreguero,L.J.,
            Aragones,J., Ruiz-Cabello,J., Torres,M. and Martin-Puig,S.
  TITLE     Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch
            Essential for Cardiac Maturation
  JOURNAL   Dev Cell 39 (6), 724-739 (2016)
   PUBMED   27997827
REFERENCE   3  (bases 1 to 2639)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2639)
  AUTHORS   Childress,P., Stayrook,K.R., Alvarez,M.B., Wang,Z., Shao,Y.,
            Hernandez-Buquer,S., Mack,J.K., Grese,Z.R., He,Y., Horan,D.,
            Pavalko,F.M., Warden,S.J., Robling,A.G., Yang,F.C., Allen,M.R.,
            Krishnan,V., Liu,Y. and Bidwell,J.P.
  TITLE     Genome-Wide Mapping and Interrogation of the Nmp4 Antianabolic Bone
            Axis
  JOURNAL   Mol Endocrinol 29 (9), 1269-1285 (2015)
   PUBMED   26244796
REFERENCE   5  (bases 1 to 2639)
  AUTHORS   Dugast-Darzacq,C., Pirity,M., Blanck,J.K., Scherl,A. and
            Schreiber-Agus,N.
  TITLE     Mxi1-SRalpha: a novel Mxi1 isoform with enhanced transcriptional
            repression potential
  JOURNAL   Oncogene 23 (55), 8887-8899 (2004)
   PUBMED   15467743
  REMARK    GeneRIF: Mxi1-SRalpha is an isoform with enhanced transcriptional
            repression potential
REFERENCE   6  (bases 1 to 2639)
  AUTHORS   Hurlin,P.J., Queva,C., Koskinen,P.J., Steingrimsson,E., Ayer,D.E.,
            Copeland,N.G., Jenkins,N.A. and Eisenman,R.N.
  TITLE     Mad3 and Mad4: novel Max-interacting transcriptional repressors
            that suppress c-myc dependent transformation and are expressed
            during neural and epidermal differentiation
  JOURNAL   EMBO J 14 (22), 5646-5659 (1995)
   PUBMED   8521822
  REMARK    Erratum:[EMBO J. 1996 Apr 15;15(8):2030.. PMID: 8617250]
REFERENCE   7  (bases 1 to 2639)
  AUTHORS   Steingrimsson,E., Sawadogo,M., Gilbert,D.J., Zervos,A.S., Brent,R.,
            Blanar,M.A., Fisher,D.E., Copeland,N.G. and Jenkins,N.A.
  TITLE     Murine chromosomal location of five bHLH-Zip transcription factor
            genes
  JOURNAL   Genomics 28 (2), 179-183 (1995)
   PUBMED   8530024
REFERENCE   8  (bases 1 to 2639)
  AUTHORS   Schreiber-Agus,N., Chin,L., Chen,K., Torres,R., Rao,G., Guida,P.,
            Skoultchi,A.I. and DePinho,R.A.
  TITLE     An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic
            activity and interacts with a homolog of the yeast transcriptional
            repressor SIN3
  JOURNAL   Cell 80 (5), 777-786 (1995)
   PUBMED   7889571
REFERENCE   9  (bases 1 to 2639)
  AUTHORS   Shimizu,E., Shirasawa,H., Kodama,K., Koseki,K., Sato,T. and
            Simizu,B.
  TITLE     Cloning and sequencing of the murine Mxi1 cDNA
  JOURNAL   Gene 152 (2), 283-284 (1995)
   PUBMED   7835718
REFERENCE   10 (bases 1 to 2639)
  AUTHORS   Edelhoff,S., Ayer,D.E., Zervos,A.S., Steingrimsson,E.,
            Jenkins,N.A., Copeland,N.G., Eisenman,R.N., Brent,R. and
            Disteche,C.M.
  TITLE     Mapping of two genes encoding members of a distinct subfamily of
            MAX interacting proteins: MAD to human chromosome 2 and mouse
            chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome
            19
  JOURNAL   Oncogene 9 (2), 665-668 (1994)
   PUBMED   8290278
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC133451.14 and BC064453.1.
            
            On Feb 1, 2018 this sequence version replaced NM_001008542.2.
            
            Summary: This gene encodes a protein containing a helix-loop-helix
            domain characteristic of transcription factors, which allows
            heterodimerization and sequence-specific DNA binding. The encoded
            protein is related to a family of Myc/Max/Mad proteins that are
            involved in the regulation of several cellular processes. The
            protein encoded by this gene is a transcriptional repressor thought
            to negatively regulate Myc function. Three alternatively spliced
            transcripts encoding different isoforms have been described.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2), also referred to as SRalpha,
            differs in the 5' UTR and 5' coding region, compared to variant 1.
            The resulting isoform (b) is longer and has a distinct N-terminus
            compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064453.1, AK154538.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC133451.14        65457-65471
            16-2074             BC064453.1         1-2059
            2075-2639           AC133451.14        127680-128244
FEATURES             Location/Qualifiers
     source          1..2639
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 47.53 cM"
     gene            1..2639
                     /gene="Mxi1"
                     /gene_synonym="bHLHc11; Gm10197; Mad2"
                     /note="MAX interactor 1, dimerization protein"
                     /db_xref="GeneID:17859"
                     /db_xref="MGI:MGI:97245"
     exon            1..468
                     /gene="Mxi1"
                     /gene_synonym="bHLHc11; Gm10197; Mad2"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1082
                     /gene="Mxi1"
                     /gene_synonym="bHLHc11; Gm10197; Mad2"
                     /note="isoform b is encoded by transcript variant 2;
                     max-interacting protein 1"
                     /codon_start=1
                     /product="max-interacting protein 1 isoform b"
                     /protein_id="NP_001008542.2"
                     /db_xref="CCDS:CCDS38022.1"
                     /db_xref="GeneID:17859"
                     /db_xref="MGI:MGI:97245"
                     /translation="MGKRGRPRKEARCEGAGLVPVAPPAMPPAAAAPQPPAQPEEPAG
                     AKPRCPFSDIFNTSENSMEKHINTFLQNVQILLEAASYLEQIEKENKKCEHGYASSFP
                     SMPSPRLQHSKPPRRLSRAQKHSSGSSNTSTANRSTHNELEKNRRAHLRLCLERLKVL
                     IPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQLENLEREQRFLKRRLEQLQGPQ
                     EMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEADSVSTTSISDLDDHSSLQ
                     SVGSDEGYSSASVKLSFAS"
     exon            469..601
                     /gene="Mxi1"
                     /gene_synonym="bHLHc11; Gm10197; Mad2"
                     /inference="alignment:Splign:2.1.0"
     exon            602..631
                     /gene="Mxi1"
                     /gene_synonym="bHLHc11; Gm10197; Mad2"
                     /inference="alignment:Splign:2.1.0"
     exon            632..746
                     /gene="Mxi1"
                     /gene_synonym="bHLHc11; Gm10197; Mad2"
                     /inference="alignment:Splign:2.1.0"
     exon            747..918
                     /gene="Mxi1"
                     /gene_synonym="bHLHc11; Gm10197; Mad2"
                     /inference="alignment:Splign:2.1.0"
     exon            919..2639
                     /gene="Mxi1"
                     /gene_synonym="bHLHc11; Gm10197; Mad2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2612..2617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mxi1"
                     /gene_synonym="bHLHc11; Gm10197; Mad2"
                     /note="hexamer: AATAAA"
     polyA_site      2639
                     /gene="Mxi1"
                     /gene_synonym="bHLHc11; Gm10197; Mad2"
                     /note="major polyA site"
ORIGIN      
        1 cacagaccca cacagcgaga gcgacacaca ctcacactca caaccgcacg cagcgaggct
       61 cgggaagtca gtcaggccgg ctccttgccc cggtgcctcg gtgactccag caggccgggt
      121 ctcccagagg ccctgcagct cggccggccg cgcagccccg gacaaggagc agctccgcgg
      181 acccccgtgc ctccatgggc aaacgcgggc ggccgcgcaa ggaggcgcgc tgcgagggcg
      241 cggggctggt ccccgtcgcg cccccggcca tgcccccggc cgcggccgcg ccccagcccc
      301 cggcgcagcc ggaggagccg gcgggggcca agccccggtg ccccttctcg gacattttca
      361 acaccagcga gaactcgatg gagaagcaca tcaacacttt tctgcagaac gtgcagattc
      421 tgctcgaggc agccagctac ctggagcaga tcgagaaaga aaacaaaaag tgtgaacatg
      481 gctacgcctc atcgttcccc tccatgccga gcccccggct acagcactcg aagcccccac
      541 ggaggttgag ccgggcacag aaacacagca gtggaagcag caacaccagc actgccaaca
      601 gatctacaca caatgagttg gaaaagaacc gacgagctca cctgcgcctg tgtttagaac
      661 gcttgaaagt tctgatcccg ctgggcccag actgcaccag gcacacaaca ctcggtttgc
      721 tcaacaaagc caaagcacac atcaagaaac ttgaagaagc ggagaggaag agccagcacc
      781 agctagagaa cttggaacga gaacagaggt ttttaaagcg gcgactggaa cagctgcagg
      841 ggcctcagga gatggagcgg atacgaatgg acagcattgg atcaaccatc tcttcagatc
      901 gctcggattc agagcgagag gagattgaag tggatgtgga aagcacagag ttctcccatg
      961 gagaagcaga cagtgtcagt accaccagca tcagtgacct tgacgaccac agcagcctgc
     1021 agagtgtcgg gagtgacgag ggttattcca gtgccagtgt caaactctcc ttcgcgtcct
     1081 aggacccagc atggcctaac agtgcagggc ggagcgctca ctgggccgag tcaacaccgg
     1141 ctctcaaatt gggttcatga tgcagtctcc tctttaaaac taaaaactat acttgaacaa
     1201 aacggtcaga agacctgtat ttaagcaaat acttaacgaa aagtggggta gagcctccct
     1261 ggtagaacaa atattcctat atttggaaag agtacagttt ctaacggcag cagaaaccat
     1321 gcgcgtgatt atcttgagtt gaccaggttg acttgagaga caatggagac ttcactctcc
     1381 tgttgcagtt tgctcactct gtggtggtga gcagacattt aaggataggg ttatgaaccc
     1441 ttcccgagct tcttggccct agaaacaaaa tcacacttag agtaaggaaa aggcaggata
     1501 atcaggcatt aatctcagat agctgaagag ctattaaaac tcagcctctg tttatcatga
     1561 agcctgtgga tgatcagttc ttttaaacaa aatgaatttt taaaaagctc atatcgtgct
     1621 ctacaaaagg agagactcca tgaagccttt tgaaagaggc cctgacgcag cccggctttc
     1681 tgttggattc catgctaagc cagctaacct tacctgcatt gttagctcta gagcagccga
     1741 ccacccgctc gccacccttc ggccacgtag gggcagccca tgcatgacgg cctgaatcac
     1801 aggaggaaaa gctctgtgtg cctcggtgtc tgcgcggagc tgaggaggtg cgcacgcagt
     1861 atagcagcca aggtctgagc caccgcagca tttttatttg agattttgat aactgtttgt
     1921 atgtgttgaa aaccaaaatg acatcttttt aaagcttgtc cataagtaaa aacatagatg
     1981 tcttttatag tggaataaac cacgtgggga aatcatctat tttgatgcag catttgataa
     2041 tgataaacac ctcacgcctc actcttcaca gtgcgcagga cagacagacg gacgaggtct
     2101 gggctgggta gacggaggtc aatgctgttt ttgttttctt taggaccact cccttttacc
     2161 agctttaacc atctgatatc catagtagac atactatcct agttaacata gttacgttca
     2221 gcacttgtct catttaatgt aaagattttc tacaggcagt ctcctccccc acaatcccac
     2281 tgtgcgggtg ctattgttgc tcttacaaat cccttcagaa atgttatctt ctaagtggaa
     2341 cttctagcct gcactctgat gtcatgtgtt ccctctgtct ttcaaactct caggtttccc
     2401 tctgggccac tgcttttccc tgggaagcct tgctggagac cttaccccaa gctgtttgga
     2461 ctttgtattc tttaaataat ttaactaccc ttaattactt aaaaaaaaaa gctttatgat
     2521 tttcataact tattgctgat tttaatgggt tgttaatttc agtcctgtag ttttatttta
     2581 tgtttagata gggctgggca aggaaaaaga aaataaaaac aaccatattt agcagtgca
//
