LOCUS       NM_010753               3894 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus Max dimerization protein 4 (Mxd4), mRNA.
ACCESSION   NM_010753
VERSION     NM_010753.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3894)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3894)
  AUTHORS   Gamart,J., Barozzi,I., Laurent,F., Reinhardt,R., Martins,L.R.,
            Oberholzer,T., Visel,A., Zeller,R. and Zuniga,A.
  TITLE     SMAD4 target genes are part of a transcriptional network that
            integrates the response to BMP and SHH signaling during early limb
            bud patterning
  JOURNAL   Development 148 (23) (2021)
   PUBMED   34822715
REFERENCE   3  (bases 1 to 3894)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3894)
  AUTHORS   Boros,K., Lacaud,G. and Kouskoff,V.
  TITLE     The transcription factor Mxd4 controls the proliferation of the
            first blood precursors at the onset of hematopoietic development in
            vitro
  JOURNAL   Exp Hematol 39 (11), 1090-1100 (2011)
   PUBMED   21782766
  REMARK    GeneRIF: during embryonic hematopoietic differentiation Mxd4 is an
            important player in the regulation of blood progenitor
            proliferation, and downregulation of its expression might be
            required for a proliferative burst preceding lineage specification.
REFERENCE   5  (bases 1 to 3894)
  AUTHORS   Vasilevsky,N.A., Ruby,C.E., Hurlin,P.J. and Weinberg,A.D.
  TITLE     OX40 engagement stabilizes Mxd4 and Mnt protein levels in
            antigen-stimulated T cells leading to an increase in cell survival
  JOURNAL   Eur J Immunol 41 (4), 1024-1034 (2011)
   PUBMED   21400495
  REMARK    GeneRIF: Mxd4 and Mnt upregulation following OX40 engagement most
            likely increases T-cell survival
REFERENCE   6  (bases 1 to 3894)
  AUTHORS   FitzGerald,M.J., Arsura,M., Bellas,R.E., Yang,W., Wu,M., Chin,L.,
            Mann,K.K., DePinho,R.A. and Sonenshein,G.E.
  TITLE     Differential effects of the widely expressed dMax splice variant of
            Max on E-box vs initiator element-mediated regulation by c-Myc
  JOURNAL   Oncogene 18 (15), 2489-2498 (1999)
   PUBMED   10229200
REFERENCE   7  (bases 1 to 3894)
  AUTHORS   Gupta,K., Anand,G., Yin,X., Grove,L. and Prochownik,E.V.
  TITLE     Mmip1: a novel leucine zipper protein that reverses the suppressive
            effects of Mad family members on c-myc
  JOURNAL   Oncogene 16 (9), 1149-1159 (1998)
   PUBMED   9528857
REFERENCE   8  (bases 1 to 3894)
  AUTHORS   Queva,C., Hurlin,P.J., Foley,K.P. and Eisenman,R.N.
  TITLE     Sequential expression of the MAD family of transcriptional
            repressors during differentiation and development
  JOURNAL   Oncogene 16 (8), 967-977 (1998)
   PUBMED   9519870
REFERENCE   9  (bases 1 to 3894)
  AUTHORS   Hurlin,P.J., Queva,C., Koskinen,P.J., Steingrimsson,E., Ayer,D.E.,
            Copeland,N.G., Jenkins,N.A. and Eisenman,R.N.
  TITLE     Mad3 and Mad4: novel Max-interacting transcriptional repressors
            that suppress c-myc dependent transformation and are expressed
            during neural and epidermal differentiation
  JOURNAL   EMBO J 15 (8), 2030 (1996)
   PUBMED   8617250
  REMARK    Correction to:[EMBO J. 1995 Nov 15;14(22):5646-59. doi:
            10.1002/j.1460-2075.1995.tb00252.x.. PMID: 8521822]
REFERENCE   10 (bases 1 to 3894)
  AUTHORS   Hurlin,P.J., Queva,C., Koskinen,P.J., Steingrimsson,E., Ayer,D.E.,
            Copeland,N.G., Jenkins,N.A. and Eisenman,R.N.
  TITLE     Mad3 and Mad4: novel Max-interacting transcriptional repressors
            that suppress c-myc dependent transformation and are expressed
            during neural and epidermal differentiation
  JOURNAL   EMBO J 14 (22), 5646-5659 (1995)
   PUBMED   8521822
  REMARK    Erratum:[EMBO J. 1996 Apr 15;15(8):2030.. PMID: 8617250]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157989.8.
            
            On Jan 28, 2022 this sequence version replaced NM_010753.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422591.323798.1, BC011303.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               AC157989.8         155764-155986       c
            224-323             AC157989.8         155583-155682       c
            324-353             AC157989.8         152568-152597       c
            354-468             AC157989.8         147064-147178       c
            469-631             AC157989.8         145852-146014       c
            632-3894            AC157989.8         142141-145403       c
FEATURES             Location/Qualifiers
     source          1..3894
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.84 cM"
     gene            1..3894
                     /gene="Mxd4"
                     /gene_synonym="2810410A03Rik; bHLHc12; Mad4"
                     /note="Max dimerization protein 4"
                     /db_xref="GeneID:17122"
                     /db_xref="MGI:MGI:104991"
     exon            1..223
                     /gene="Mxd4"
                     /gene_synonym="2810410A03Rik; bHLHc12; Mad4"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..789
                     /gene="Mxd4"
                     /gene_synonym="2810410A03Rik; bHLHc12; Mad4"
                     /note="max dimerizer 4; max-associated protein 4;
                     max-interacting transcriptional repressor MAD4"
                     /codon_start=1
                     /product="max dimerization protein 4"
                     /protein_id="NP_034883.2"
                     /db_xref="CCDS:CCDS19212.1"
                     /db_xref="GeneID:17122"
                     /db_xref="MGI:MGI:104991"
                     /translation="MELNSLLLLLEAAEYLERRDREAEHGYASVLPFDGDFARKKTKT
                     AGLVRKAPNNRSSHNELEKHRRAKLRLYLEQLKQLVPLGPDSTRHTTLSLLKRAKMHI
                     KKLEEQDRRALSIKEQLQREHRFLKRRLEQLSVQSVERVRTDSTGSAVSTDDSEQEVD
                     IEGMEFGPGELDSAGSSSDADDHYSLQSSGCSDSSYGHPCRRPGCPGLS"
     exon            224..323
                     /gene="Mxd4"
                     /gene_synonym="2810410A03Rik; bHLHc12; Mad4"
                     /inference="alignment:Splign:2.1.0"
     exon            324..353
                     /gene="Mxd4"
                     /gene_synonym="2810410A03Rik; bHLHc12; Mad4"
                     /inference="alignment:Splign:2.1.0"
     exon            354..468
                     /gene="Mxd4"
                     /gene_synonym="2810410A03Rik; bHLHc12; Mad4"
                     /inference="alignment:Splign:2.1.0"
     exon            469..631
                     /gene="Mxd4"
                     /gene_synonym="2810410A03Rik; bHLHc12; Mad4"
                     /inference="alignment:Splign:2.1.0"
     exon            632..3894
                     /gene="Mxd4"
                     /gene_synonym="2810410A03Rik; bHLHc12; Mad4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1092..1097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mxd4"
                     /gene_synonym="2810410A03Rik; bHLHc12; Mad4"
                     /note="hexamer: ATTAAA"
     polyA_site      1112
                     /gene="Mxd4"
                     /gene_synonym="2810410A03Rik; bHLHc12; Mad4"
     regulatory      3874..3879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mxd4"
                     /gene_synonym="2810410A03Rik; bHLHc12; Mad4"
                     /note="hexamer: AATACA"
     polyA_site      3894
                     /gene="Mxd4"
                     /gene_synonym="2810410A03Rik; bHLHc12; Mad4"
                     /note="major polyA site"
ORIGIN      
        1 atgtgtcaat ttgagggcct gaggcagagg gtggcggccc agcgctggag tccgcgagtc
       61 gggctggtgt gccgccaggc gcggggcgtg cggcgagcag agccggcagg agcgcgccgg
      121 gcagccgccg ccgccgccgt cccgtgcgcg ggcggcagga tggagctgaa ctctctgctg
      181 ctgctgttgg aggcggccga gtacctggag cgtagggacc gagaggccga gcacggctac
      241 gcctccgtgc tgcccttcga cggcgacttc gcaaggaaga aaacaaagac ggccggcctg
      301 gtgcgcaagg ccccgaacaa caggtcttca cacaacgaac tagaaaagca cagacgagct
      361 aaactcaggc tctacttgga gcagctcaag cagctggtac ccctgggccc tgacagcaca
      421 cgtcacacta ctctgagcct tctgaagcgt gctaagatgc acatcaagaa actggaggag
      481 caggaccgca gggcactgag catcaaggaa cagcttcagc gggaacatcg cttcctaaag
      541 agacgtttgg agcagctatc agtgcagagt gtagagcgtg tgcgcacaga cagcactggc
      601 tctgctgtgt ccacagatga ctcagagcaa gaggtggata tagagggcat ggagtttggc
      661 cctggggagc tggacagtgc tggcagcagc agtgatgccg atgaccacta cagcctacag
      721 agcagtggct gcagcgacag cagctatggg cacccttgca ggcggcctgg ctgccctggc
      781 ctttcgtagg ctccatgtcc tttgcttctt ggcccacctg cctgctcacc tagccaagcg
      841 tctcagcctt ccaatcctcc cttgactgaa gccagcctcg tcatgggcct actgctgtgc
      901 cattctcgaa gctacagctg ctgtctggtc tgcctgcctc tgcctgccta cccttcggtc
      961 aggactcaag ttgcctgccc cttctccgca gggctagacc ccatgcaggg aagcagtgtc
     1021 aggctcttac atcctggagt ccagcgtagc cacccacaat ctgttctcag attcctaatc
     1081 attccagaag tattaaatat catttctaca aatctcggca ggatccgtgt aggggcctta
     1141 atgaccacca tagggagctt gaaccccaac atcggatccc aagagaaagg agtggactga
     1201 agaagaaagg aaggaaggaa agaagggagg gagggaggga agggaaggag ggagggaggg
     1261 agggagggag gaaggaagga aggaaggaag gaaggaagga aggaaggaag gaaggaagga
     1321 aagagctgct gtctgtctat ccatctatcc atctacttgt tggtccacat agtgtggaca
     1381 gagggatctg tgaggggcag gacttggatg agcatctagt gggtggcccc cttttccatg
     1441 gtgtcagcag ccatggggat gctcctgggg tctggctgga ccacctcaaa ccaagttggg
     1501 tggcttctgc tcttttagga ccatcagacg tatgcacaca cgcctaggct cacacccaca
     1561 agcacaaata cacatggaca tcagagaatg tatgtgttga gatagttggt ctgaggtcac
     1621 ttggaaatgg tggcccctaa cctgtgcctg actctcactc aggccctgga tcacctgggc
     1681 cagtccagac agctctgcct ggtctgcaca ggaaatagac agggcttttc ttcctggcag
     1741 aggactggaa taagctgggt ggcaagctga aaccactggg tcctccaagc tttctcaact
     1801 tcctttctta agaaaagaaa aaaaaaaaaa agaaaaaaaa aaagtgcgac agggagctcc
     1861 cagaaggggc ctcgcgaacc ctgcccaggg cagcctcagc tggcagaggc tttacccaaa
     1921 acacaaaaca gaaacatttt taaaaagaga gaaaagctct gaagactcgc caagggacat
     1981 gagtgtgtgc tgcctctatt tcctgtatga gaattttgta ctctattttc ctagccattg
     2041 ttgtgtcctt gtttgctgag gggtgggagc gacccagcgt ctcagggacc catcctctgt
     2101 cacatcgtca tagtgtgcct tgtgttcctt gtctcacccc acccactgcc accagcatgc
     2161 ccgtgtggct tatgggatgc accaggcctc ctggtaggtg cccccctcac tgctttccga
     2221 caggtagccc ctcccagcag ctgcagcctc ctgggaggga catatgcatg cctttgtggc
     2281 tcccgaggct gattcctgta tcctgcaggg ctataacctg gcctccagtg gtgcctccat
     2341 ggtaactggc agagtggctg tgcctgaaag ttccgggaca gcaggcctgc tagcatagag
     2401 cctggagtgt cagccatggg cagcttataa atacacagtt ctggaagtag tacaggcctg
     2461 tccaggaggc ttctgttggc ctttcaatac tagaagactt tgtttctagg ggcaccacac
     2521 agcaatattt gggtagtggc cacgggctgg cccacagcag cacctgccac ctcctctggt
     2581 gcattcgtaa acaatttcca aactgtgggg aaattcttgt ttatcttcag tcatgccaat
     2641 gagcatccta gggtgagagg cctactgata ggcagaatga ggttcccgga gacagctctg
     2701 gcatagaacc tgctctgtgg gcactcagaa tgacaggtgg acagcaggcc tgggtaggtg
     2761 tctccaggaa agatcgtcaa catcctagta agctggttct gtcaacattt tctgcccatc
     2821 tgggcacttc agtgtctgcc caagcacctc cccagcacac ctacccttag cacaggactt
     2881 tgtttaaagg acccacaact ccagggctcc tgatgtgccc tgaattctta gattatcaac
     2941 tccctgctcc atctccagca cctgagcttc tgcttccacc cctgacagca gagcccattc
     3001 ctggtgacca gattggcccc cttggctgaa ttttgtggca gctcagccct ttgccttttc
     3061 aggctatgga tcccatgtag cctgggagtt ggcctcctca gtcacccagg ggtgctagcc
     3121 agctgcccct tccgctagca ggcctgtgag gggtgatcta taggcatggg ggctggtgct
     3181 aagagttaca tatctattac tccttctcct gctctctacc atttgcacag tatggccatt
     3241 actggtagcc acagattcag ccaaggctat tgtgtgtctg tggaaagaaa gctggaccaa
     3301 aatagctgct gctatgtcct ccacctgcac ctgtccatgt gagccatgcg gtgtgccata
     3361 acagagtctg gaactccagg ctcaggcttg ggcctctcta ctaggaggtg gtccagatgt
     3421 accagaccca ccatcctgct gcaggcccag ctggtctagc aggagaggac acagaggttt
     3481 tgtctctaga cggcccctag gcctgcctct gtatttctca cctgcaggtg cttgagcttg
     3541 cctttctagg cagatggagt tgtgcaccaa actgtggctg gacagttcct acctttctgt
     3601 gtgccccaag ccttccctgc ctctggtggg tcagttagcc tctcacccct tgtgcctgca
     3661 cagagggtct tgatcccagg ctagcaagca agttctcagg cctctaaact agggcactag
     3721 ggcaggttcc gtgccagagt caggggctac acaaggggcc tggtgccagt gcggtgggcg
     3781 agttatgaga cctgagctgc agactggaat gggaccccat cccacctgtc aaacagatgg
     3841 ggctgtgctg tgtcattctg tcattgtaat ataaatacag atttttatac ctca
//
