LOCUS       NM_016662               1298 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus Max dimerization protein 3 (Mxd3), mRNA.
ACCESSION   NM_016662 NM_053213
VERSION     NM_016662.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1298)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1298)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1298)
  AUTHORS   Lowenstein,E.D., Rusanova,A., Stelzer,J., Hernaiz-Llorens,M.,
            Schroer,A.E., Epifanova,E., Bladt,F., Isik,E.G., Buchert,S.,
            Jia,S., Tarabykin,V. and Hernandez-Miranda,L.R.
  TITLE     Olig3 regulates early cerebellar development
  JOURNAL   Elife 10, e64684 (2021)
   PUBMED   33591268
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1298)
  AUTHORS   Nabeshima,R., Nishimura,O., Maeda,T., Shimizu,N., Ide,T.,
            Yashiro,K., Sakai,Y., Meno,C., Kadota,M., Shiratori,H., Kuraku,S.
            and Hamada,H.
  TITLE     Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and
            is associated with aberrant methylation at a subset of gene
            promoters
  JOURNAL   Elife 7, e36435 (2018)
   PUBMED   30070635
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1298)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 1298)
  AUTHORS   FitzGerald,M.J., Arsura,M., Bellas,R.E., Yang,W., Wu,M., Chin,L.,
            Mann,K.K., DePinho,R.A. and Sonenshein,G.E.
  TITLE     Differential effects of the widely expressed dMax splice variant of
            Max on E-box vs initiator element-mediated regulation by c-Myc
  JOURNAL   Oncogene 18 (15), 2489-2498 (1999)
   PUBMED   10229200
REFERENCE   7  (bases 1 to 1298)
  AUTHORS   Gupta,K., Anand,G., Yin,X., Grove,L. and Prochownik,E.V.
  TITLE     Mmip1: a novel leucine zipper protein that reverses the suppressive
            effects of Mad family members on c-myc
  JOURNAL   Oncogene 16 (9), 1149-1159 (1998)
   PUBMED   9528857
REFERENCE   8  (bases 1 to 1298)
  AUTHORS   Queva,C., Hurlin,P.J., Foley,K.P. and Eisenman,R.N.
  TITLE     Sequential expression of the MAD family of transcriptional
            repressors during differentiation and development
  JOURNAL   Oncogene 16 (8), 967-977 (1998)
   PUBMED   9519870
REFERENCE   9  (bases 1 to 1298)
  AUTHORS   Hurlin,P.J., Queva,C., Koskinen,P.J., Steingrimsson,E., Ayer,D.E.,
            Copeland,N.G., Jenkins,N.A. and Eisenman,R.N.
  TITLE     Mad3 and Mad4: novel Max-interacting transcriptional repressors
            that suppress c-myc dependent transformation and are expressed
            during neural and epidermal differentiation
  JOURNAL   EMBO J 15 (8), 2030 (1996)
   PUBMED   8617250
  REMARK    Correction to:[EMBO J. 1995 Nov 15;14(22):5646-59. doi:
            10.1002/j.1460-2075.1995.tb00252.x.. PMID: 8521822]
REFERENCE   10 (bases 1 to 1298)
  AUTHORS   Hurlin,P.J., Queva,C., Koskinen,P.J., Steingrimsson,E., Ayer,D.E.,
            Copeland,N.G., Jenkins,N.A. and Eisenman,R.N.
  TITLE     Mad3 and Mad4: novel Max-interacting transcriptional repressors
            that suppress c-myc dependent transformation and are expressed
            during neural and epidermal differentiation
  JOURNAL   EMBO J 14 (22), 5646-5659 (1995)
   PUBMED   8521822
  REMARK    Erratum:[EMBO J. 1996 Apr 15;15(8):2030.. PMID: 8617250]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC051970.1 and AK138742.1.
            
            On Feb 5, 2019 this sequence version replaced NM_016662.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK138742.1, BC051970.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-989               BC051970.1         3-991
            990-1298            AK138742.1         990-1298
FEATURES             Location/Qualifiers
     source          1..1298
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 29.8 cM"
     gene            1..1298
                     /gene="Mxd3"
                     /gene_synonym="4631412E13Rik; bHLHc13; Mad3"
                     /note="Max dimerization protein 3"
                     /db_xref="GeneID:17121"
                     /db_xref="MGI:MGI:104987"
     exon            1..134
                     /gene="Mxd3"
                     /gene_synonym="4631412E13Rik; bHLHc13; Mad3"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..685
                     /gene="Mxd3"
                     /gene_synonym="4631412E13Rik; bHLHc13; Mad3"
                     /note="max dimerizer 3; max-associated protein 3"
                     /codon_start=1
                     /product="max dimerization protein 3"
                     /protein_id="NP_057871.2"
                     /db_xref="CCDS:CCDS26543.1"
                     /db_xref="GeneID:17121"
                     /db_xref="MGI:MGI:104987"
                     /translation="MEPVASNIQVLLQAAEFLERREREAEHGYASLCPHHSPGTVCRR
                     RKPPLQAPGALNSGRSVHNELEKRRRAQLKRCLEQLRQQMPLGVDCTRYTTLSLLRRA
                     RVHIQKLEEQEQQARRLKEKLRSKQQSLQQQLEQLQGLPGARERERLRADSLDSSGLS
                     SERSDSDQEDLEVDVESLVFGTETELLQSFSAGREHSYSHSTCAWL"
     exon            135..240
                     /gene="Mxd3"
                     /gene_synonym="4631412E13Rik; bHLHc13; Mad3"
                     /inference="alignment:Splign:2.1.0"
     exon            241..270
                     /gene="Mxd3"
                     /gene_synonym="4631412E13Rik; bHLHc13; Mad3"
                     /inference="alignment:Splign:2.1.0"
     exon            271..385
                     /gene="Mxd3"
                     /gene_synonym="4631412E13Rik; bHLHc13; Mad3"
                     /inference="alignment:Splign:2.1.0"
     exon            386..569
                     /gene="Mxd3"
                     /gene_synonym="4631412E13Rik; bHLHc13; Mad3"
                     /inference="alignment:Splign:2.1.0"
     exon            570..1298
                     /gene="Mxd3"
                     /gene_synonym="4631412E13Rik; bHLHc13; Mad3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      970..975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mxd3"
                     /gene_synonym="4631412E13Rik; bHLHc13; Mad3"
                     /note="hexamer: ATTAAA"
     polyA_site      989
                     /gene="Mxd3"
                     /gene_synonym="4631412E13Rik; bHLHc13; Mad3"
                     /note="major polyA site"
     regulatory      1275..1280
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mxd3"
                     /gene_synonym="4631412E13Rik; bHLHc13; Mad3"
                     /note="hexamer: AATAAA"
     polyA_site      1295
                     /gene="Mxd3"
                     /gene_synonym="4631412E13Rik; bHLHc13; Mad3"
ORIGIN      
        1 aaaagtggta aggcggctga cagggctagc atccctagcc cgctggtcgt cggctgtcgc
       61 cgacatggaa cccgtggcta gcaacatcca ggtcctgctg caggcagcgg agttcctgga
      121 gaggcgcgag agagaggcag agcacggtta tgcgtccctg tgtccacacc acagccccgg
      181 gaccgtctgc aggaggagga agccacccct gcaagctcct ggcgcgctga acagtgggcg
      241 gtctgtgcac aacgagctgg agaagcgcag gagagcccag ctgaagcggt gcttagagca
      301 actgaggcag cagatgcccc tgggagttga ctgtacccga tacactacac taagcctcct
      361 gcgccgggcc agggtgcata tccagaagct ggaggagcag gagcagcaag cccggcggct
      421 caaggaaaag cttcgcagca aacagcagag cctgcagcag cagctggagc agctccaggg
      481 gctgccagga gctagggagc gagagcggct gagggcagac agcttggact cttcaggcct
      541 gtcctctgag cgctcagact cagaccaaga ggatctggag gtggatgtgg agagcctggt
      601 gtttgggact gaaacagagc tcctacagag cttcagcgct gggcgggagc acagctactc
      661 acacagcacc tgcgcctggc tatgatgccc actgcggcct gtactctcct tggactgagc
      721 ctgccagtca gtggccccca cacaagttgg cttagagcca catgttgaag agactaaagc
      781 caaggtgtgg gagcagactc cagactctgc tgcacagctt gagcttgggc caccctcccc
      841 atcccccagg gaatttcatg tagcacttgg ccctgctttg ctgctcccca cagggacagg
      901 aagcctcaaa acttcttgtt cctgggcaaa gccccaggcc tctgcccgta tatactgcac
      961 agtattttca ttaaaatcct cttttgtaag ttcctgtcca tggttttgcc ccgatgagat
     1021 gaagtccctg ccacaactgg aagagaggaa ataaggtcag tagctggcaa aaagggtctt
     1081 gtgaaggcag tgcacatctg acagcgtgga ggatgctctg tggtcctgat gctgaggcag
     1141 agtgtgtgac gtgcctgagc tcctgattca aaccaaagct atctgactcc agaactgggg
     1201 ctaatcaaat catgtgttta ttgagtgcct gttatgtgct aaatattgtt cagggtactt
     1261 gggacacagc agagaataaa acaaggagcc ctgccctc
//
