LOCUS       NM_010751               4620 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus MAX dimerization protein 1 (Mxd1), transcript variant
            1, mRNA.
ACCESSION   NM_010751
VERSION     NM_010751.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4620)
  AUTHORS   Xiong,F., Liu,W., Wang,X., Wu,G., Wang,Q., Guo,T., Huang,W.,
            Wang,B. and Chen,Y.
  TITLE     HOXA5 inhibits the proliferation of extrahepatic cholangiocarcinoma
            cells by enhancing MXD1 expression and activating the p53 pathway
  JOURNAL   Cell Death Dis 13 (9), 829 (2022)
   PUBMED   36167790
  REMARK    GeneRIF: HOXA5 inhibits the proliferation of extrahepatic
            cholangiocarcinoma cells by enhancing MXD1 expression and
            activating the p53 pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4620)
  AUTHORS   Anderson,D.A. 3rd, Murphy,T.L., Eisenman,R.N. and Murphy,K.M.
  TITLE     The MYCL and MXD1 transcription factors regulate the fitness of
            murine dendritic cells
  JOURNAL   Proc Natl Acad Sci U S A 117 (9), 4885-4893 (2020)
   PUBMED   32071205
  REMARK    GeneRIF: The MYCL and MXD1 transcription factors regulate the
            fitness of murine dendritic cells.
REFERENCE   3  (bases 1 to 4620)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4620)
  AUTHORS   Dainichi,T., Hayden,M.S., Park,S.G., Oh,H., Seeley,J.J.,
            Grinberg-Bleyer,Y., Beck,K.M., Miyachi,Y., Kabashima,K.,
            Hashimoto,T. and Ghosh,S.
  TITLE     PDK1 Is a Regulator of Epidermal Differentiation that Activates and
            Organizes Asymmetric Cell Division
  JOURNAL   Cell Rep 15 (8), 1615-1623 (2016)
   PUBMED   27184845
REFERENCE   5  (bases 1 to 4620)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 4620)
  AUTHORS   Chin,L., Schreiber-Agus,N., Pellicer,I., Chen,K., Lee,H.W.,
            Dudast,M., Cordon-Cardo,C. and DePinho,R.A.
  TITLE     Contrasting roles for Myc and Mad proteins in cellular growth and
            differentiation
  JOURNAL   Proc Natl Acad Sci U S A 92 (18), 8488-8492 (1995)
   PUBMED   7667316
REFERENCE   7  (bases 1 to 4620)
  AUTHORS   Ayer,D.E., Lawrence,Q.A. and Eisenman,R.N.
  TITLE     Mad-Max transcriptional repression is mediated by ternary complex
            formation with mammalian homologs of yeast repressor Sin3
  JOURNAL   Cell 80 (5), 767-776 (1995)
   PUBMED   7889570
REFERENCE   8  (bases 1 to 4620)
  AUTHORS   Vastrik,I., Kaipainen,A., Penttila,T.L., Lymboussakis,A.,
            Alitalo,R., Parvinen,M. and Alitalo,K.
  TITLE     Expression of the mad gene during cell differentiation in vivo and
            its inhibition of cell growth in vitro
  JOURNAL   J Cell Biol 128 (6), 1197-1208 (1995)
   PUBMED   7896882
REFERENCE   9  (bases 1 to 4620)
  AUTHORS   Uchida,N., Shimamura,K., Miyatani,S., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A. and Takeichi,M.
  TITLE     Mouse alpha N-catenin: two isoforms, specific expression in the
            nervous system, and chromosomal localization of the gene
  JOURNAL   Dev Biol 163 (1), 75-85 (1994)
   PUBMED   8174789
REFERENCE   10 (bases 1 to 4620)
  AUTHORS   Edelhoff,S., Ayer,D.E., Zervos,A.S., Steingrimsson,E.,
            Jenkins,N.A., Copeland,N.G., Eisenman,R.N., Brent,R. and
            Disteche,C.M.
  TITLE     Mapping of two genes encoding members of a distinct subfamily of
            MAX interacting proteins: MAD to human chromosome 2 and mouse
            chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome
            19
  JOURNAL   Oncogene 9 (2), 665-668 (1994)
   PUBMED   8290278
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158662.7.
            
            On Jul 27, 2022 this sequence version replaced NM_010751.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784646.436860.1, AK151114.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               AC158662.7         144466-144647       c
            183-279             AC158662.7         144068-144164       c
            280-309             AC158662.7         138601-138630       c
            310-424             AC158662.7         128615-128729       c
            425-584             AC158662.7         126972-127131       c
            585-4620            AC158662.7         122574-126609       c
FEATURES             Location/Qualifiers
     source          1..4620
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.75 cM"
     gene            1..4620
                     /gene="Mxd1"
                     /gene_synonym="Mad; Mad1"
                     /note="MAX dimerization protein 1"
                     /db_xref="GeneID:17119"
                     /db_xref="MGI:MGI:96908"
     exon            1..182
                     /gene="Mxd1"
                     /gene_synonym="Mad; Mad1"
                     /inference="alignment:Splign:2.1.0"
     exon            183..279
                     /gene="Mxd1"
                     /gene_synonym="Mad; Mad1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..309
                     /gene="Mxd1"
                     /gene_synonym="Mad; Mad1"
                     /inference="alignment:Splign:2.1.0"
     exon            310..424
                     /gene="Mxd1"
                     /gene_synonym="Mad; Mad1"
                     /inference="alignment:Splign:2.1.0"
     exon            425..584
                     /gene="Mxd1"
                     /gene_synonym="Mad; Mad1"
                     /inference="alignment:Splign:2.1.0"
     exon            585..4620
                     /gene="Mxd1"
                     /gene_synonym="Mad; Mad1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2657..2662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mxd1"
                     /gene_synonym="Mad; Mad1"
                     /note="hexamer: CATAAA"
     polyA_site      2683
                     /gene="Mxd1"
                     /gene_synonym="Mad; Mad1"
                     /note="major polyA site"
     regulatory      4599..4604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mxd1"
                     /gene_synonym="Mad; Mad1"
                     /note="hexamer: AATAAA"
     polyA_site      4620
                     /gene="Mxd1"
                     /gene_synonym="Mad; Mad1"
                     /note="major polyA site"
ORIGIN      
        1 gtctccgtgc tgtcccatcg ctgcccctcc tggctggcca gcgcggcggc tcctcggtgt
       61 tcccggccgg tggcccgcgg gcacggagag gcggcccgcc gggtgcagga tggcgacagc
      121 cgtcgggatg aacatccagc tgctgctgga ggcggccgac tacctggagc ggcgggagag
      181 agaagctgaa catgggtatg cctccatgct gccatacagc aaggacagag atgccttcaa
      241 acggaggaac aagcccaaga agaacagcac cagtagcaga tcaactcaca atgaaatgga
      301 aaagaacagg cgtgctcacc tccgcctgtg cctagagaag ctaaagggat tggtaccgct
      361 gggccctgag tcaagccgac acaccactct gagcttgctg acaaaagcca aattgcatat
      421 aaagaaactt gaagactgtg acagaaaagc tgtccaccaa atagaccagc ttcagcggga
      481 acagcggcac ctgaagcggc ggctggagaa gctgggtgcc gagaggactc ggatggacag
      541 cgtgggctct gtggtgtctt cggagcgctc tgactctgat agagaagaac tggacgtgga
      601 cgtagacgtg gacgtggacg tggatgtgga gggcacagac tacctcaatg gggacctggg
      661 ctggagcagc agcgtgagtg actcggacga gcgaggcagc atgcagagcc tgggcagtga
      721 cgagggctac tccagtgcca ctgtcaaaag agccaagctc caggacgggc acaaggcggg
      781 cctcagtcta taggagagtc ctctccacct caccgggtta ggtagtgtac cggacctgtc
      841 cagacgccct tgcacgcaaa cctcatgtac caccttgacc aatagcagct ctgtccactt
      901 tgcagaaagc acatagggtt gtggtcttga gtgcagtcag tcgcttctct gtccatacat
      961 gtcggcactg agagactgca cattccagtc agttcagagc acccaagaat ccttagccca
     1021 agcaagtgtc acctctcagc agccccctgt gcactgtcct gcagctgacg agatctttcc
     1081 tagttttctg gctcacgatg atactcgccc aggagagaag ttggagcttt gtctggcaca
     1141 taggaaacca cagcaagcaa acttctcaaa gggaactcaa tcgcagaaac cccaaaggaa
     1201 gctttgaaag caaaaccgaa gagcactgag aagccaggag cacctccagc aagccctgct
     1261 gcggcccggt cgcagtgctg aggcggctct acttaagagc gggcactcgg cagctcagga
     1321 gaacagtgtg ccccctgcgt gctgttctgg gggcttggtg tgtgctgtgt ctcaaggccc
     1381 ccccatgccc cgagtttgtt gatgctcctt gtctctggaa cattgtccta cctcagagat
     1441 agatgagatc tccttgtcca catgacaaaa gtcactgctt ctttgtcccc atggtccctc
     1501 ccacctgcgc ccctgtcgga ttcccagcaa taactgagtt ttggcactgg ctgagctagt
     1561 agccactatc tgtgagagaa agaggccaca tttcttctct gtggcaagtg aacgggaggg
     1621 ttcctcatgt caccagaacc ctcctgctaa gttatttttg aacacatctg gaattctcct
     1681 tctggagacg tccaggtcta tggcttaaag gatgattttt ttccccttgt ggtattttta
     1741 tttaaggtaa accagagcac atgtgtatgt acataagaca cacaacacct ataaatacta
     1801 tttattcatt ttatataaac taatgtaatg caatataaat tcttatgact gcttttatag
     1861 atgttctaga aactttgtac gtagctgtct acaaaattaa ttcattcccc tgaatatttt
     1921 tgcattcata ctctgaagtc tggatgtttt cagcctctgg caagtctttt tcactgaatc
     1981 cgaaccacct gtaaagactg cgctctgcgg ccgaacctgt gtcaccaggt aatgggacag
     2041 tcctgagatc cacaggtgtc acctaagggc tccacagctg actcagcagc aggcagctac
     2101 acagtcacac accccctcct caagtccaaa cacaccctgg cagagagaat agtcccagcc
     2161 acacaaggtc actgtggacg gcatgtgttc cttgatggtc ccaaaatcct gttttggctt
     2221 tttttttttt ttttaacttg ttggagtgtt tttcaaatac cagctgaaat gtagcccaga
     2281 aacacagctt ggacaccatt tgtgtttgta aagccccttc cagagcctaa cagtgcaggt
     2341 gtccagggag ctggcaggcc tggctctaga tacagctgtg cctggagggc cactggatcc
     2401 ccacccgtta gatctcgagg gcatcaggtc tgttcactgc acccaaaggc aacggaaagt
     2461 caggaccaca ggaggacgct gtgggctgcc caggggaggg aacaaacctc tacacatctt
     2521 tattccactt agaaggtgtc tgagagacac cgccattctc tgtgctttca ttgttgcgcc
     2581 tttgcgttaa actgtttttt attttttatt ttttattttt tgtctttcag ttgaaatatg
     2641 aagtgtactg tcccaacata aaacagtgat tatttgacct tcaccctgtt tgtctggtcc
     2701 ttgcataggt gtgtggtaga tctctgtatt cttagagcac ttgacaggct aactgccaag
     2761 ggcaggcctg actctggaag ctggactgag tcactgtggt aggcaggctt ttctctgacc
     2821 aaaactgtag cttttgggga cctgcaggtg ttgcccaggg cagctaattc ccacccagtc
     2881 tctccttcac tcatcaccag catgtctgcc aagagctagg ctccagggtg gtttttgttt
     2941 gcttaagcaa aaggagaaac ctttctatta aagttgttgg ggtggggggt gaggaagacg
     3001 caggtatgaa ccccagcatt aagactttga cagtgtacaa gagcagaagt gtttcagtca
     3061 gtcaagcccc tggatattta tatgtgaaag ttccttctga aactaaaatc tcagctgtac
     3121 cctaacgaca ctgtcgcaat acaagtggga acacaggagc ttgctgtcaa cttcatccca
     3181 tgccacaagg aaattgtccg cgtcgtccgg aaaacacaga atggctttgg atgtctgccc
     3241 tgcagccaac aagtggtgat ccgggttttc tttggctagc caggtatctt gaaatcagta
     3301 gcaccgacca gtgcctctgc ccttgaagaa ctggtgctgg cttggtgagg ccattggggg
     3361 gtcgtgaaca ggacctgatt ttccctctgg acccaaggct agaatgtctc cagctgggat
     3421 ccctgagttg ggcaggccca accctccagt ggctcctgca atagttttac tgtttgtttt
     3481 taaagtagca ttttcaccta cccctgctgt gttcggcaga agcggggttt cctgtggccc
     3541 ttctccccgt gtctgatggg gccaagggtg tttggggtct aagaacacag gagatggcat
     3601 atgatactca aaaccttcta gcaatatctt ggggacttga cgatgagttc tgtggacttt
     3661 ctccctcttg ccttcttccc tgccccttca agagagaact tattttttga agagcatata
     3721 tagacacatt aaggttttat accacgctgt attggcagga ataccacttt tgttgtggtc
     3781 tgtaatttat cagccacatc ctgctttctg tttctttcct ggctacagtg ttttgtctcc
     3841 ctgcttgacc atccctctgt gtgtcctgct atttttctgt ctctttggta cttcaatggc
     3901 tgctactcct gacttagtgc tttctgggag aagccagcgc agcgcctttt gccgtgtgct
     3961 ggcctctctc atgctgtgtg cccagagcac tgtagtctgc agcatggttt gttttcagag
     4021 atcctgggtt gaggtggtgt gagatgtgat ccatcaatac ttctaatact tttctttaac
     4081 tgtgggcttc taaaagaaat agttgattgg caccattaga ttccactcgt ggatggccaa
     4141 agaaattgac tgtttagcat atctcaaaat caaacggtga gaatcaggaa ggcgctctgt
     4201 gctgggatat gcctggatgt cttcctttga gttcttactc tgcctaggag ggcagtgggt
     4261 tgaagagggc attcttcttt ttagctttga tctaaaaaac caagcttgcc tctaccgctg
     4321 tccctagaat tggtgctctg gtatgttgct gtgagtggct agtttggggg actatctttc
     4381 taaaggtgga cggcctccgc aggagagccg cgggtgaaga atgggaagcg cgtttccaga
     4441 tgtttctttc tgtaaatatg gtgccaatgt aaacctctgc tgagactgga gaatggtgct
     4501 ggggggggag gggctgcagt tagtacacgt gtttttagaa gccatcatga tttagagact
     4561 ccatgctgtg tgtaaagtta tgtgtccgtc cattaacaaa taaattattt cattattaaa
//
