LOCUS       NM_138656               1761 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus mevalonate (diphospho) decarboxylase (Mvd), transcript
            variant 1, mRNA.
ACCESSION   NM_138656
VERSION     NM_138656.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1761)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1761)
  AUTHORS   Munkacsi,A.B., Hammond,N., Schneider,R.T., Senanayake,D.S.,
            Higaki,K., Lagutin,K., Bloor,S.J., Ory,D.S., Maue,R.A., Chen,F.W.,
            Hernandez-Ono,A., Dahlson,N., Repa,J.J., Ginsberg,H.N.,
            Ioannou,Y.A. and Sturley,S.L.
  TITLE     Normalization of Hepatic Homeostasis in the Npc1nmf164 Mouse Model
            of Niemann-Pick Type C Disease Treated with the Histone Deacetylase
            Inhibitor Vorinostat
  JOURNAL   J Biol Chem 292 (11), 4395-4410 (2017)
   PUBMED   28031458
REFERENCE   3  (bases 1 to 1761)
  AUTHORS   Sisecioglu,M., Budak,H., Geffers,L., Cankaya,M., Ciftci,M.,
            Thaller,C., Eichele,G., Kufrevioglu,O.I. and Ozdemir,H.
  TITLE     A compendium of expression patterns of cholesterol biosynthetic
            enzymes in the mouse embryo
  JOURNAL   J Lipid Res 56 (8), 1551-1559 (2015)
   PUBMED   26108225
REFERENCE   4  (bases 1 to 1761)
  AUTHORS   Michihara,A., Akasaki,K., Yamori,Y. and Tsuji,H.
  TITLE     Subcellular distribution of mouse mevalonate pyrophosphate
            decarboxylase
  JOURNAL   Biol Pharm Bull 26 (5), 579-584 (2003)
   PUBMED   12736493
REFERENCE   5  (bases 1 to 1761)
  AUTHORS   Wadhwa,R., Yaguchi,T., Hasan,M.K., Taira,K. and Kaul,S.C.
  TITLE     Mortalin-MPD (mevalonate pyrophosphate decarboxylase) interactions
            and their role in control of cellular proliferation
  JOURNAL   Biochem Biophys Res Commun 302 (4), 735-742 (2003)
   PUBMED   12646231
  REMARK    GeneRIF: Results identify mevalonate pyrophosphate decarboxylase
            (MPD) as a binding partner of mortalin-2.
REFERENCE   6  (bases 1 to 1761)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK089354.1, AK134803.1 and AL591003.16.
            
            On Sep 1, 2009 this sequence version replaced NM_138656.1.
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154883.1, AK089354.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AK089354.1         3-14
            13-1757             AK134803.1         2-1746
            1758-1761           AL591003.16        201453-201456       c
FEATURES             Location/Qualifiers
     source          1..1761
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 71.05 cM"
     gene            1..1761
                     /gene="Mvd"
                     /gene_synonym="Mpd"
                     /note="mevalonate (diphospho) decarboxylase"
                     /db_xref="GeneID:192156"
                     /db_xref="MGI:MGI:2179327"
     exon            1..129
                     /gene="Mvd"
                     /gene_synonym="Mpd"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1262
                     /gene="Mvd"
                     /gene_synonym="Mpd"
                     /EC_number="4.1.1.33"
                     /note="mevalonate pyrophosphate decarboxylase; MDDase"
                     /codon_start=1
                     /product="diphosphomevalonate decarboxylase"
                     /protein_id="NP_619597.2"
                     /db_xref="CCDS:CCDS22738.1"
                     /db_xref="GeneID:192156"
                     /db_xref="MGI:MGI:2179327"
                     /translation="MASEKPQDLMVTCTAPVNIAVIKYWGKRDEALILPINSSLSVTL
                     HQDQLKTTTTVAISKDFTEDRIWLNGREEDVGQPRLQACLREIRRLARKRRSTEDGDT
                     LPLSLSYKVHVASVNNFPTAAGLASSAAGYACLAYTLAQVYGVEGDLSEVARRGSGSA
                     CRSLYGGFVEWQMGEQADGKDSIARQIAPEWHWPQLRILILVVSADKKQTGSTVGMQT
                     SVETSTLLKFRAESVVPERMKEMTRCIQEQDFQGFAQLTMKDSNQFHATCLDTFPPIS
                     YLNDTSRRIIQLVHRFNTHQGQTKVAYTFDAGPNAVIFTLEDTVAEFVAAVRHSFPPA
                     ANGDKFLKGLQVAPVLLSDELKAALAVEPSPGGVQYIIATQVGPGPQVLDDTHDHLLG
                     QDGLPQRDL"
     exon            130..200
                     /gene="Mvd"
                     /gene_synonym="Mpd"
                     /inference="alignment:Splign:2.1.0"
     exon            201..315
                     /gene="Mvd"
                     /gene_synonym="Mpd"
                     /inference="alignment:Splign:2.1.0"
     exon            316..462
                     /gene="Mvd"
                     /gene_synonym="Mpd"
                     /inference="alignment:Splign:2.1.0"
     exon            463..662
                     /gene="Mvd"
                     /gene_synonym="Mpd"
                     /inference="alignment:Splign:2.1.0"
     exon            663..737
                     /gene="Mvd"
                     /gene_synonym="Mpd"
                     /inference="alignment:Splign:2.1.0"
     exon            738..956
                     /gene="Mvd"
                     /gene_synonym="Mpd"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1072
                     /gene="Mvd"
                     /gene_synonym="Mpd"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1181
                     /gene="Mvd"
                     /gene_synonym="Mpd"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1761
                     /gene="Mvd"
                     /gene_synonym="Mpd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1735..1740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mvd"
                     /gene_synonym="Mpd"
                     /note="hexamer: AATAAA"
     polyA_site      1756
                     /gene="Mvd"
                     /gene_synonym="Mpd"
                     /note="major polyA site"
ORIGIN      
        1 tagacaccgg gtaatcggtg ctgggctctc tagctcggga ctccagcatc tcagttatgg
       61 cctcagaaaa gcctcaggac ctaatggtca cctgcacggc gccggtcaac atcgcagtta
      121 tcaagtactg ggggaagcga gatgaagcgc tgatcctgcc catcaactcc tccctgagcg
      181 tcacgctgca ccaggaccag ctaaaaacga ccacaaccgt tgccattagc aaggacttca
      241 cagaggaccg catctggctg aatggtcgcg aggaggacgt ggggcagcca cggctccagg
      301 cctgcctgag agagattcgc cgcctggctc ggaagcggag gagcacagag gacggggaca
      361 ctctacccct cagcctcagc tataaggtgc acgtggcgtc agtgaacaac ttccccactg
      421 ctgcaggcct ggcgtcctca gccgcaggct atgcctgcct agcctatacc ctggctcagg
      481 tctatggggt tgagggagac ctctccgaag tggctcggcg gggctcaggc agtgcgtgcc
      541 gcagtctcta tgggggcttt gtggagtggc agatggggga acaggccgat gggaaggaca
      601 gcatcgcccg gcagatagcc ccagagtggc actggcccca gctccgaatc cttatccttg
      661 tggtgagcgc cgacaagaag cagacgggca gtacagtggg catgcagacc agcgtggaga
      721 ccagcaccct gctcaagttc cgggctgagt ctgttgtgcc tgagcgcatg aaggagatga
      781 cccgctgcat ccaagagcag gactttcagg gctttgccca gctgaccatg aaggatagca
      841 accagtttca tgccacctgc ctggacacct tcccaccgat ctcctacctc aatgacacct
      901 ccaggcgcat catccagcta gtccaccgct tcaacaccca ccaggggcag acgaaggtgg
      961 catacacatt tgatgctggc cccaacgctg tgatcttcac tctggaggac actgtggctg
     1021 agtttgtggc agctgtaaga cacagctttc cccctgcagc caatggagac aagttcctaa
     1081 aggggctgca ggtggcacct gttcttctct ctgatgagct gaaggccgcg ctggcggtgg
     1141 agcccagccc tggtggggtc cagtacatca ttgccactca ggtcggacca ggacctcaag
     1201 tcctagacga cactcatgat catctgctag gccaggatgg actgccacaa cgggaccttt
     1261 gacctcttcc acgtccagtg ccatttggag aaaggggttg cccactggaa ctcgggagct
     1321 ggcctgctgg tcagcctctc ctgaagggct gcttgatgat cgattatact gggggatgtc
     1381 gagtgtgatg ggcagccatc taggcgatca cgggaacccc tctcaagtgc ctccggttcc
     1441 ccgctggttt ctgaagggct agctgaccca ctcgatggac cttccagcac tccagacagc
     1501 tgctcatcag ggatggggag tcggtgcctc ccccctcccc caagatgctc tgagggcctc
     1561 agtaaccatc taagcgtgat ggctcagaca gcggtgcctc tctgctgaga ctcaggccac
     1621 agtttcttta taaagcctcc tggtgagggt aggggctgtc gagcccacag gtagggtcca
     1681 ttgtgtgtgt gggtgcctca tgagggtgca gtcagtggac ctgaggacca caggaataaa
     1741 gtgtgctgtt cctgcctgcc c
//
