LOCUS       NM_133250               1643 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus mutY DNA glycosylase (Mutyh), transcript variant 2,
            mRNA.
ACCESSION   NM_133250
VERSION     NM_133250.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1643)
  AUTHORS   Mizuno,Y., Abolhassani,N., Mazzei,G., Sakumi,K., Saito,T.,
            Saido,T.C., Ninomiya,T., Iwaki,T., Yamasaki,R., Kira,J.I. and
            Nakabeppu,Y.
  TITLE     MUTYH Actively Contributes to Microglial Activation and Impaired
            Neurogenesis in the Pathogenesis of Alzheimer's Disease
  JOURNAL   Oxid Med Cell Longev 2021, 8635088 (2021)
   PUBMED   34970419
  REMARK    Erratum:[Oxid Med Cell Longev. 2023 Feb 6;2023:9794081. doi:
            10.1155/2023/9794081. PMID: 36793979]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1643)
  AUTHORS   Jang,S., Schaich,M.A., Khuu,C., Schnable,B.L., Majumdar,C.,
            Watkins,S.C., David,S.S. and Van Houten,B.
  TITLE     Single molecule analysis indicates stimulation of MUTYH by UV-DDB
            through enzyme turnover
  JOURNAL   Nucleic Acids Res 49 (14), 8177-8188 (2021)
   PUBMED   34232996
  REMARK    GeneRIF: Single molecule analysis indicates stimulation of MUTYH by
            UV-DDB through enzyme turnover.
REFERENCE   3  (bases 1 to 1643)
  AUTHORS   Nakamura,T., Okabe,K., Hirayama,S., Chirifu,M., Ikemizu,S.,
            Morioka,H., Nakabeppu,Y. and Yamagata,Y.
  TITLE     Structure of the mammalian adenine DNA glycosylase MUTYH: insights
            into the base excision repair pathway and cancer
  JOURNAL   Nucleic Acids Res 49 (12), 7154-7163 (2021)
   PUBMED   34142156
  REMARK    GeneRIF: Structure of the mammalian adenine DNA glycosylase MUTYH:
            insights into the base excision repair pathway and cancer.
REFERENCE   4  (bases 1 to 1643)
  AUTHORS   Sakamoto,H., Miyanishi,K., Tanaka,S., Ito,R., Hamaguchi,K.,
            Sakurada,A., Sato,M., Kubo,T., Osuga,T., Murase,K., Takada,K.,
            Nakabeppu,Y., Kobune,M. and Kato,J.
  TITLE     MUTYH is associated with hepatocarcinogenesis in a non-alcoholic
            steatohepatitis mouse model
  JOURNAL   Sci Rep 11 (1), 3599 (2021)
   PUBMED   33574380
  REMARK    GeneRIF: MUTYH is associated with hepatocarcinogenesis in a
            non-alcoholic steatohepatitis mouse model.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1643)
  AUTHORS   Sun,Q., Chen,J., Xu,L., Kang,J., Wu,X., Ren,Y., Nakabeppu,Y. and
            Wang,Y.
  TITLE     MUTYH Deficiency Is Associated with Attenuated Pulmonary Fibrosis
            in a Bleomycin-Induced Model
  JOURNAL   Oxid Med Cell Longev 2020, 4828256 (2020)
   PUBMED   33149810
  REMARK    GeneRIF: MUTYH Deficiency Is Associated with Attenuated Pulmonary
            Fibrosis in a Bleomycin-Induced Model.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1643)
  AUTHORS   Chang,D.Y. and Lu,A.L.
  TITLE     Functional interaction of MutY homolog with proliferating cell
            nuclear antigen in fission yeast, Schizosaccharomyces pombe
  JOURNAL   J Biol Chem 277 (14), 11853-11858 (2002)
   PUBMED   11805113
REFERENCE   7  (bases 1 to 1643)
  AUTHORS   Lee,H.M., Wang,C., Hu,Z., Greeley,G.H., Makalowski,W.,
            Hellmich,H.L. and Englander,E.W.
  TITLE     Hypoxia induces mitochondrial DNA damage and stimulates expression
            of a DNA repair enzyme, the Escherichia coli MutY DNA glycosylase
            homolog (MYH), in vivo, in the rat brain
  JOURNAL   J Neurochem 80 (5), 928-937 (2002)
   PUBMED   11948257
REFERENCE   8  (bases 1 to 1643)
  AUTHORS   Hayashi,H., Tominaga,Y., Hirano,S., McKenna,A.E., Nakabeppu,Y. and
            Matsumoto,Y.
  TITLE     Replication-associated repair of adenine:8-oxoguanine mispairs by
            MYH
  JOURNAL   Curr Biol 12 (4), 335-339 (2002)
   PUBMED   11864576
  REMARK    GeneRIF: Replication-associated repair of adenine:8-oxoguanine
            mispairs by MYH
REFERENCE   9  (bases 1 to 1643)
  AUTHORS   Yang,H., Clendenin,W.M., Wong,D., Demple,B., Slupska,M.M.,
            Chiang,J.H. and Miller,J.H.
  TITLE     Enhanced activity of adenine-DNA glycosylase (Myh) by
            apurinic/apyrimidinic endonuclease (Ape1) in mammalian base
            excision repair of an A/GO mismatch
  JOURNAL   Nucleic Acids Res 29 (3), 743-752 (2001)
   PUBMED   11160897
REFERENCE   10 (bases 1 to 1643)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX213088.1, AB117938.1 and BB090873.1.
            
            On Apr 22, 2009 this sequence version replaced NM_133250.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 both encode the same
            isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057942.1, SRR7345562.4623625.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-432               CX213088.1         36-467
            433-1595            AB117938.1         395-1557
            1596-1643           BB090873.1         237-284
FEATURES             Location/Qualifiers
     source          1..1643
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.34 cM"
     gene            1..1643
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /note="mutY DNA glycosylase"
                     /db_xref="GeneID:70603"
                     /db_xref="MGI:MGI:1917853"
     exon            1..38
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            39..156
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            157..305
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            306..345
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            346..419
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            420..461
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            462..533
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            534..647
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            648..745
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            746..890
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            891..945
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1137
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1274
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1424
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1466
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1643
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1623..1628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /note="hexamer: AATAAA"
     polyA_site      1643
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /note="major polyA site"
ORIGIN      
        1 ggtttcttgg gagcggccgg tcggagactg cgcaggagat tatcatgaag aaactccaag
       61 catctgtgag gagtcacaaa aagcaaccag ccaaccacaa gagaaggaga acacgtgccc
      121 ttagcagcag ccaggccaag ccttccagcc tggatggcct ggccaagcag aagagagagg
      181 agttactgca ggcctctgtc tccccatatc atctcttcag cgacgtggcc gatgtcacag
      241 ctttccgaag caacttgctc agctggtatg accaagagaa gcgtgacctc ccttggagaa
      301 acttggcaaa agaagaggcc aactcggaca ggagggccta tgctgtgtgg gtgtcagagg
      361 ttatgctgca gcagacccag gttgccacag tgatcgacta ttatactcga tggatgcaga
      421 agtggccaaa gcttcaagac ctggccagcg cttccctgga ggaggtgaac cagctctggt
      481 ctggcctggg ctactattct cgaggccgtc ggctacaaga aggagctagg aaggtggtag
      541 aggagctagg aggccatatg ccacgtacag cagagaccct acagcagctc ctgcctggtg
      601 tggggcggta cacggctgga gccattgctt ccatcgcctt tgaccaggta accggtgtgg
      661 tggatgggaa cgttttacgg gtgctgtgcc gtgtccgggc cattggtgcc gatcccacca
      721 gcacccttgt ctctcatcac ctctggaact tagcccagca gctcgtggac ccagcccggc
      781 ctggggactt caatcaagct gccatggagc tgggggctac agtgtgcacc ccacagcgcc
      841 ctctctgcag ccattgcccc gtgcagagtt tatgccgggc ataccagagg gtgcagcggg
      901 gtcagctctc agccttgcca ggccgtcctg acatagagga gtgtgctctc aacactagac
      961 agtgccagct ttgcctcact tcctcaagcc cctgggaccc cagcatggga gtggccaact
     1021 ttcctcgaaa ggccagccgc aggcctccca gggaggagta ctctgccacc tgtgttgtgg
     1081 agcagcccgg agccatcggg ggtcccctgg tcctcctggt gcaaaggcct gactcaggtc
     1141 tgctggcagg actgtgggag ttcccatctg tcaccttgga gccctcagaa cagcatcagc
     1201 acaaagccct tctgcaggaa ctgcagcgct ggtgtgggcc cctccctgcc attcgtctcc
     1261 agcaccttgg ggaggttatc cacatcttct ctcacatcaa actgacgtat caagtatata
     1321 gtctggctct agatcaagcc ccagcgagca ctgcacctcc tggcgctcga tggctgacct
     1381 gggaggaatt ctgcaatgca gctgtgtcta ctgccatgaa aaaggtgttc cgcatgtatg
     1441 aggaccatcg gcaagggacc cgcaagggtt caaaaaggtc ccaggtgtgt cctccatcaa
     1501 gcaggaaaaa acccagcctg ggacagcaag tcctggatac tttctttcag cgtcatatcc
     1561 ccacagacaa acccaacagt actacccagt gatactggga ttccctaccc aaaatccagt
     1621 ctaataaagt gcttattttt gta
//
