LOCUS       NM_001316747            1531 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus mutY DNA glycosylase (Mutyh), transcript variant 3,
            mRNA.
ACCESSION   NM_001316747 XM_006503393
VERSION     NM_001316747.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1531)
  AUTHORS   Mizuno,Y., Abolhassani,N., Mazzei,G., Sakumi,K., Saito,T.,
            Saido,T.C., Ninomiya,T., Iwaki,T., Yamasaki,R., Kira,J.I. and
            Nakabeppu,Y.
  TITLE     MUTYH Actively Contributes to Microglial Activation and Impaired
            Neurogenesis in the Pathogenesis of Alzheimer's Disease
  JOURNAL   Oxid Med Cell Longev 2021, 8635088 (2021)
   PUBMED   34970419
  REMARK    Erratum:[Oxid Med Cell Longev. 2023 Feb 6;2023:9794081. doi:
            10.1155/2023/9794081.. PMID: 36793979]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1531)
  AUTHORS   Jang,S., Schaich,M.A., Khuu,C., Schnable,B.L., Majumdar,C.,
            Watkins,S.C., David,S.S. and Van Houten,B.
  TITLE     Single molecule analysis indicates stimulation of MUTYH by UV-DDB
            through enzyme turnover
  JOURNAL   Nucleic Acids Res 49 (14), 8177-8188 (2021)
   PUBMED   34232996
  REMARK    GeneRIF: Single molecule analysis indicates stimulation of MUTYH by
            UV-DDB through enzyme turnover.
REFERENCE   3  (bases 1 to 1531)
  AUTHORS   Nakamura,T., Okabe,K., Hirayama,S., Chirifu,M., Ikemizu,S.,
            Morioka,H., Nakabeppu,Y. and Yamagata,Y.
  TITLE     Structure of the mammalian adenine DNA glycosylase MUTYH: insights
            into the base excision repair pathway and cancer
  JOURNAL   Nucleic Acids Res 49 (12), 7154-7163 (2021)
   PUBMED   34142156
  REMARK    GeneRIF: Structure of the mammalian adenine DNA glycosylase MUTYH:
            insights into the base excision repair pathway and cancer.
REFERENCE   4  (bases 1 to 1531)
  AUTHORS   Sakamoto,H., Miyanishi,K., Tanaka,S., Ito,R., Hamaguchi,K.,
            Sakurada,A., Sato,M., Kubo,T., Osuga,T., Murase,K., Takada,K.,
            Nakabeppu,Y., Kobune,M. and Kato,J.
  TITLE     MUTYH is associated with hepatocarcinogenesis in a non-alcoholic
            steatohepatitis mouse model
  JOURNAL   Sci Rep 11 (1), 3599 (2021)
   PUBMED   33574380
  REMARK    GeneRIF: MUTYH is associated with hepatocarcinogenesis in a
            non-alcoholic steatohepatitis mouse model.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1531)
  AUTHORS   Sun,Q., Chen,J., Xu,L., Kang,J., Wu,X., Ren,Y., Nakabeppu,Y. and
            Wang,Y.
  TITLE     MUTYH Deficiency Is Associated with Attenuated Pulmonary Fibrosis
            in a Bleomycin-Induced Model
  JOURNAL   Oxid Med Cell Longev 2020, 4828256 (2020)
   PUBMED   33149810
  REMARK    GeneRIF: MUTYH Deficiency Is Associated with Attenuated Pulmonary
            Fibrosis in a Bleomycin-Induced Model.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1531)
  AUTHORS   Chang,D.Y. and Lu,A.L.
  TITLE     Functional interaction of MutY homolog with proliferating cell
            nuclear antigen in fission yeast, Schizosaccharomyces pombe
  JOURNAL   J Biol Chem 277 (14), 11853-11858 (2002)
   PUBMED   11805113
REFERENCE   7  (bases 1 to 1531)
  AUTHORS   Lee,H.M., Wang,C., Hu,Z., Greeley,G.H., Makalowski,W.,
            Hellmich,H.L. and Englander,E.W.
  TITLE     Hypoxia induces mitochondrial DNA damage and stimulates expression
            of a DNA repair enzyme, the Escherichia coli MutY DNA glycosylase
            homolog (MYH), in vivo, in the rat brain
  JOURNAL   J Neurochem 80 (5), 928-937 (2002)
   PUBMED   11948257
REFERENCE   8  (bases 1 to 1531)
  AUTHORS   Hayashi,H., Tominaga,Y., Hirano,S., McKenna,A.E., Nakabeppu,Y. and
            Matsumoto,Y.
  TITLE     Replication-associated repair of adenine:8-oxoguanine mispairs by
            MYH
  JOURNAL   Curr Biol 12 (4), 335-339 (2002)
   PUBMED   11864576
  REMARK    GeneRIF: Replication-associated repair of adenine:8-oxoguanine
            mispairs by MYH
REFERENCE   9  (bases 1 to 1531)
  AUTHORS   Yang,H., Clendenin,W.M., Wong,D., Demple,B., Slupska,M.M.,
            Chiang,J.H. and Miller,J.H.
  TITLE     Enhanced activity of adenine-DNA glycosylase (Myh) by
            apurinic/apyrimidinic endonuclease (Ape1) in mammalian base
            excision repair of an A/GO mismatch
  JOURNAL   Nucleic Acids Res 29 (3), 743-752 (2001)
   PUBMED   11160897
REFERENCE   10 (bases 1 to 1531)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB117937.1 and BX639400.1.
            
            On Oct 24, 2015 this sequence version replaced XM_006503393.2.
            
            Transcript Variant: This variant (3) lacks an alternate coding exon
            and initiates translation at an alternate start codon compared to
            variant 1. The resulting isoform (b) has a shorter and distinct
            N-terminus compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB117937.1, SRR7345562.4472998.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1483              AB117937.1         1-1483
            1484-1531           BX639400.1         4-51                c
FEATURES             Location/Qualifiers
     source          1..1531
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.34 cM"
     gene            1..1531
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /note="mutY DNA glycosylase"
                     /db_xref="GeneID:70603"
                     /db_xref="MGI:MGI:1917853"
     exon            1..118
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1480
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /EC_number="3.2.2.31"
                     /note="isoform b is encoded by transcript variant 3;
                     a/G-specific adenine DNA glycosylase; mutY homolog alpha;
                     mMYH"
                     /codon_start=1
                     /product="adenine DNA glycosylase isoform b"
                     /protein_id="NP_001303676.1"
                     /db_xref="GeneID:70603"
                     /db_xref="MGI:MGI:1917853"
                     /translation="MAWPSRRERSYCRPLSPHIISSATWPMSQLSEATCSAGMTKRSV
                     TSLGETWQKKRPTRTGGPMLKWPKLQDLASASLEEVNQLWSGLGYYSRGRRLQEGARK
                     VVEELGGHMPRTAETLQQLLPGVGRYTAGAIASIAFDQVTGVVDGNVLRVLCRVRAIG
                     ADPTSTLVSHHLWNLAQQLVDPARPGDFNQAAMELGATVCTPQRPLCSHCPVQSLCRA
                     YQRVQRGQLSALPGRPDIEECALNTRQCQLCLTSSSPWDPSMGVANFPRKASRRPPRE
                     EYSATCVVEQPGAIGGPLVLLVQRPDSGLLAGLWEFPSVTLEPSEQHQHKALLQELQR
                     WCGPLPAIRLQHLGEVIHIFSHIKLTYQVYSLALDQAPASTAPPGARWLTWEEFCNAA
                     VSTAMKKVFRMYEDHRQGTRKGSKRSQVCPPSSRKKPSLGQQVLDTFFQRHIPTDKPN
                     STTQ"
     exon            119..267
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            268..307
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            308..349
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            350..421
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            422..535
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            536..633
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            634..778
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            779..833
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1025
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1162
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1312
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1354
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1531
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1511..1516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /note="hexamer: AATAAA"
     polyA_site      1531
                     /gene="Mutyh"
                     /gene_synonym="5730495A01Rik; Mutyha; Mutyhalpha; Mutyhb;
                     Mutyhbeta; Mutyhc; Myh"
                     /note="major polyA site"
ORIGIN      
        1 attatcatga agaaactcca agcatctgtg aggagtcaca aaaagcaacc agccaaccac
       61 aagagaagga gaacacgtgc ccttagcagc agccaggcca agccttccag cctggatggc
      121 ctggccaagc agaagagaga ggagttactg caggcctctg tctccccata tcatctcttc
      181 agcgacgtgg ccgatgtcac agctttccga agcaacttgc tcagctggta tgaccaagag
      241 aagcgtgacc tcccttggag aaacttggca aaagaagagg ccaactcgga caggagggcc
      301 tatgctgaag tggccaaagc ttcaagacct ggccagcgct tccctggagg aggtgaacca
      361 gctctggtct ggcctgggct actattctcg aggccgtcgg ctacaagaag gagctaggaa
      421 ggtggtagag gagctaggag gccatatgcc acgtacagca gagaccctac agcagctcct
      481 gcctggtgtg gggcggtaca cggctggagc cattgcttcc atcgcctttg accaggtaac
      541 cggtgtggtg gatgggaacg ttttacgggt gctgtgccgt gtccgggcca ttggtgccga
      601 tcccaccagc acccttgtct ctcatcacct ctggaactta gcccagcagc tcgtggaccc
      661 agcccggcct ggggacttca atcaagctgc catggagctg ggggctacag tgtgcacccc
      721 acagcgccct ctctgcagcc attgccccgt gcagagttta tgccgggcat accagagggt
      781 gcagcggggt cagctctcag ccttgccagg ccgtcctgac atagaggagt gtgctctcaa
      841 cactagacag tgccagcttt gcctcacttc ctcaagcccc tgggacccca gcatgggagt
      901 ggccaacttt cctcgaaagg ccagccgcag gcctcccagg gaggagtact ctgccacctg
      961 tgttgtggag cagcccggag ccatcggggg tcccctggtc ctcctggtgc aaaggcctga
     1021 ctcaggtctg ctggcaggac tgtgggagtt cccatctgtc accttggagc cctcagaaca
     1081 gcatcagcac aaagcccttc tgcaggaact gcagcgctgg tgtgggcccc tccctgccat
     1141 tcgtctccag caccttgggg aggttatcca catcttctct cacatcaaac tgacgtatca
     1201 agtatatagt ctggctctag atcaagcccc agcgagcact gcacctcctg gcgctcgatg
     1261 gctgacctgg gaggaattct gcaatgcagc tgtgtctact gccatgaaaa aggtgttccg
     1321 catgtatgag gaccatcggc aagggacccg caagggttca aaaaggtccc aggtgtgtcc
     1381 tccatcaagc aggaaaaaac ccagcctggg acagcaagtc ctggatactt tctttcagcg
     1441 tcatatcccc acagacaaac ccaacagtac tacccagtga tactgggatt ccctacccaa
     1501 aatccagtct aataaagtgc ttatttttgt a
//
