LOCUS       NM_181390               1194 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus musculoskeletal, embryonic nuclear protein 1 (Mustn1),
            mRNA.
ACCESSION   NM_181390
VERSION     NM_181390.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1194)
  AUTHORS   Ducommun,S., Jannig,P.R., Cervenka,I., Murgia,M.,
            Mittenbuhler,M.J., Chernogubova,E., Dias,J.M., Jude,B.,
            Correia,J.C., Van Vranken,J.G., Ocana-Santero,G.,
            Porsmyr-Palmertz,M., McCann Haworth,S., Martinez-Redondo,V.,
            Liu,Z., Carlstrom,M., Mann,M., Lanner,J.T., Teixeira,A.I.,
            Maegdefessel,L., Spiegelman,B.M. and Ruas,J.L.
  TITLE     Mustn1 is a smooth muscle cell-secreted microprotein that modulates
            skeletal muscle extracellular matrix composition
  JOURNAL   Mol Metab 82, 101912 (2024)
   PUBMED   38458566
  REMARK    GeneRIF: Mustn1 is a smooth muscle cell-secreted microprotein that
            modulates skeletal muscle extracellular matrix composition.
REFERENCE   2  (bases 1 to 1194)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1194)
  AUTHORS   Kim,C.J., Singh,C., Lee,C., DiMagno,K., O'Donnell,M., Kaczmarek,M.,
            Ahmed,A., Salvo-Schaich,J., Perez,A., Letsou,W., Sepulveda,M.C.,
            Ramos,R.L. and Hadjiargyrou,M.
  TITLE     Mustn1 ablation in skeletal muscle results in increased glucose
            tolerance concomitant with upregulated GLUT expression in male mice
  JOURNAL   Physiol Rep 11 (9), e15674 (2023)
   PUBMED   37170065
  REMARK    GeneRIF: Mustn1 ablation in skeletal muscle results in increased
            glucose tolerance concomitant with upregulated GLUT expression in
            male mice.
REFERENCE   4  (bases 1 to 1194)
  AUTHORS   Kurz,J., Weiss,A.C., Thiesler,H., Qasrawi,F., Deuper,L., Kaur,J.,
            Rudat,C., Ludtke,T.H., Wojahn,I., Hildebrandt,H., Trowe,M.O. and
            Kispert,A.
  TITLE     Notch signaling is a novel regulator of visceral smooth muscle cell
            differentiation in the murine ureter
  JOURNAL   Development 149 (4) (2022)
   PUBMED   35103284
REFERENCE   5  (bases 1 to 1194)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1194)
  AUTHORS   Risley,M.D., Clowes,C., Yu,M., Mitchell,K. and Hentges,K.E.
  TITLE     The Mediator complex protein Med31 is required for embryonic growth
            and cell proliferation during mammalian development
  JOURNAL   Dev Biol 342 (2), 146-156 (2010)
   PUBMED   20347762
REFERENCE   7  (bases 1 to 1194)
  AUTHORS   Liu,C., Gersch,R.P., Hawke,T.J. and Hadjiargyrou,M.
  TITLE     Silencing of Mustn1 inhibits myogenic fusion and differentiation
  JOURNAL   Am J Physiol Cell Physiol 298 (5), C1100-C1108 (2010)
   PUBMED   20130207
  REMARK    GeneRIF: This study demonstrates that Mustn1 is an essential
            regulator of myogenic differentiation and myofusion, and implicates
            Myod and Myog as its downstream targets.
REFERENCE   8  (bases 1 to 1194)
  AUTHORS   Gersch,R.P. and Hadjiargyrou,M.
  TITLE     Mustn1 is expressed during chondrogenesis and is necessary for
            chondrocyte proliferation and differentiation in vitro
  JOURNAL   Bone 45 (2), 330-338 (2009)
   PUBMED   19410023
  REMARK    GeneRIF: Mustn1 is a necessary regulator of chondrocyte function.
REFERENCE   9  (bases 1 to 1194)
  AUTHORS   Liu,C. and Hadjiargyrou,M.
  TITLE     Identification and characterization of the Mustang promoter:
            regulation by AP-1 during myogenic differentiation
  JOURNAL   Bone 39 (4), 815-824 (2006)
   PUBMED   16731063
REFERENCE   10 (bases 1 to 1194)
  AUTHORS   Lombardo,F., Komatsu,D. and Hadjiargyrou,M.
  TITLE     Molecular cloning and characterization of Mustang, a novel nuclear
            protein expressed during skeletal development and regeneration
  JOURNAL   FASEB J 18 (1), 52-61 (2004)
   PUBMED   14718386
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025528.10, AK003945.1 and AW493989.1.
            
            On Oct 5, 2007 this sequence version replaced NM_181390.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY704198.1, AK003945.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               CT025528.10        109835-110117       c
            284-1073            AK003945.1         2-791
            1074-1194           AW493989.1         1-121               c
FEATURES             Location/Qualifiers
     source          1..1194
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 19.09 cM"
     gene            1..1194
                     /gene="Mustn1"
                     /gene_synonym="1110028G01Rik; Mustang"
                     /note="musculoskeletal, embryonic nuclear protein 1"
                     /db_xref="GeneID:66175"
                     /db_xref="MGI:MGI:1913425"
     exon            1..359
                     /gene="Mustn1"
                     /gene_synonym="1110028G01Rik; Mustang"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..599
                     /gene="Mustn1"
                     /gene_synonym="1110028G01Rik; Mustang"
                     /codon_start=1
                     /product="musculoskeletal embryonic nuclear protein 1"
                     /protein_id="NP_852055.1"
                     /db_xref="CCDS:CCDS36849.1"
                     /db_xref="GeneID:66175"
                     /db_xref="MGI:MGI:1913425"
                     /translation="MSEAGTPEGPIKKKRPPVKEEDLKGARGTLAKNQDIKSKTYQVM
                     RDYEQAGSAAPSVFSRNRTGTETVFEKPKEGPAKSVFG"
     exon            360..492
                     /gene="Mustn1"
                     /gene_synonym="1110028G01Rik; Mustang"
                     /inference="alignment:Splign:2.1.0"
     exon            493..1179
                     /gene="Mustn1"
                     /gene_synonym="1110028G01Rik; Mustang"
                     /inference="alignment:Splign:2.1.0"
     regulatory      738..743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mustn1"
                     /gene_synonym="1110028G01Rik; Mustang"
                     /note="hexamer: AATAAA"
     polyA_site      764
                     /gene="Mustn1"
                     /gene_synonym="1110028G01Rik; Mustang"
                     /note="major polyA site"
     regulatory      1162..1167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mustn1"
                     /gene_synonym="1110028G01Rik; Mustang"
                     /note="hexamer: AATGAA"
     polyA_site      1168
                     /gene="Mustn1"
                     /gene_synonym="1110028G01Rik; Mustang"
     polyA_site      1179
                     /gene="Mustn1"
                     /gene_synonym="1110028G01Rik; Mustang"
ORIGIN      
        1 tcagcctggg caggctgtct cacacattcc agggttcaca ttcataaaca cagtctgtga
       61 acaacagtgc caacacctcc caccgtcgag taagcagctg tccccagaga tgcggggtcc
      121 ccgcggccat ctcctctcac cagggcagct gcccatcatc gccaagaata aactccagct
      181 agtcgctgcg tggatctgaa tcatctgaga gcttccaaag gaggggagtg actacccagg
      241 acgcacaagc agactatata agttcccaag ggttgggcct cacgcagatc ctttcctgtg
      301 gctactgcct gccagagagc taccaacagc gagcttgctt ggcatccaac atgtccgagg
      361 ctggcactcc tgaaggcccc atcaagaaga agcggccccc tgtgaaggaa gaagacctga
      421 agggggcccg agggaccctg gccaagaacc aggacatcaa gtctaagaca taccaggtca
      481 tgcgggacta cgagcaagcc ggctcagctg ccccatctgt attcagccgc aaccgcacag
      541 gcaccgagac agtctttgag aagcccaaag agggaccagc caagagcgtg tttggctgag
      601 acatgcacat tgcaccatcc acccggacac aggagcctcc ccacgaactt tttttttttt
      661 gtaatgctgg aagatgcctt tcctctgctg tctcttgaac catcatgact cccacaaccc
      721 tagcccttgg aaacaccaat aaagagtatg cccaatgtcc ccaaccttgg gacgttgcca
      781 tggccgctac ctgcagaaga gagggaagtg tggggacata gcatatctgg tgcccttcct
      841 ggactctgag gtgggacagg gaataatgtg tgtgctctca gaaccactga ggtgttccag
      901 gcagagcctt agccgtggag tcctggtgcg gactttctga tgcgtgtagg agacagttct
      961 tcctaaatct ctgttttagg ctgggaagat ggtgccatag ctaaaagtac ttgccatttc
     1021 tttagaggac tctggttcag ttcccaaata tcctcatggt agctcataac cattgaactc
     1081 tgccaccctc ttctggcccc tgcgggcatt gcattacgtg tggtatgcct gtagtcaaaa
     1141 tactcacgta cctaaaataa aaatgaaatg gaaaagtaaa aaaaaaaaaa aaaa
//
