LOCUS       NM_001037129            3360 bp    mRNA    linear   ROD 11-OCT-2024
DEFINITION  Mus musculus muscle, skeletal, receptor tyrosine kinase (Musk),
            transcript variant 3, mRNA.
ACCESSION   NM_001037129
VERSION     NM_001037129.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3360)
  AUTHORS   Ohkawara,B., Kurokawa,M., Kanai,A., Imamura,K., Chen,G., Zhang,R.,
            Masuda,A., Higashi,K., Mori,H., Suzuki,Y., Kurokawa,K. and Ohno,K.
  TITLE     Transcriptome profile of subsynaptic myonuclei at the neuromuscular
            junction in embryogenesis
  JOURNAL   J Neurochem 168 (4), 342-354 (2024)
   PUBMED   37994470
REFERENCE   2  (bases 1 to 3360)
  AUTHORS   Eguchi,T., Tezuka,T., Watanabe,Y., Inoue-Yamauchi,A., Sagara,H.,
            Ozawa,M. and Yamanashi,Y.
  TITLE     Calcium-binding protein 7 expressed in muscle negatively regulates
            age-related degeneration of neuromuscular junctions in mice
  JOURNAL   iScience 27 (2), 108997 (2024)
   PUBMED   38327785
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3360)
  AUTHORS   Jaime,D., Fish,L.A., Madigan,L.A., Xi,C., Piccoli,G., Ewing,M.D.,
            Blaauw,B. and Fallon,J.R.
  TITLE     The MuSK-BMP pathway maintains myofiber size in slow muscle through
            regulation of Akt-mTOR signaling
  JOURNAL   Skelet Muscle 14 (1), 1 (2024)
   PUBMED   38172960
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3360)
  AUTHORS   Mori,S., Suzuki,S., Konishi,T., Kawaguchi,N., Kishi,M.,
            Kuwabara,S., Ishizuchi,K., Zhou,H., Shibasaki,F., Tsumoto,H.,
            Omura,T., Miura,Y., Mori,S., Higashihara,M., Murayama,S. and
            Shigemoto,K.
  TITLE     Proteolytic ectodomain shedding of muscle-specific tyrosine kinase
            in myasthenia gravis
  JOURNAL   Exp Neurol 361, 114300 (2023)
   PUBMED   36525997
  REMARK    GeneRIF: Proteolytic ectodomain shedding of muscle-specific
            tyrosine kinase in myasthenia gravis.
REFERENCE   5  (bases 1 to 3360)
  AUTHORS   Kaplan,M.M. and Flucher,B.E.
  TITLE     Counteractive and cooperative actions of muscle beta-catenin and
            CaV1.1 during early neuromuscular synapse formation
  JOURNAL   iScience 25 (4), 104025 (2022)
   PUBMED   35340430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3360)
  AUTHORS   Kuehn,R., Eckler,S.A. and Gautam,M.
  TITLE     Multiple alternatively spliced transcripts of the receptor tyrosine
            kinase MuSK are expressed in muscle
  JOURNAL   Gene 360 (2), 83-91 (2005)
   PUBMED   16146674
REFERENCE   7  (bases 1 to 3360)
  AUTHORS   DeChiara,T.M., Bowen,D.C., Valenzuela,D.M., Simmons,M.V.,
            Poueymirou,W.T., Thomas,S., Kinetz,E., Compton,D.L., Rojas,E.,
            Park,J.S., Smith,C., DiStefano,P.S., Glass,D.J., Burden,S.J. and
            Yancopoulos,G.D.
  TITLE     The receptor tyrosine kinase MuSK is required for neuromuscular
            junction formation in vivo
  JOURNAL   Cell 85 (4), 501-512 (1996)
   PUBMED   8653786
REFERENCE   8  (bases 1 to 3360)
  AUTHORS   Reith,A.D.
  TITLE     Isolation and chromosomal location of Nsk1, a novel murine putative
            receptor tyrosine kinase
  JOURNAL   Mamm Genome 6 (9), 689 (1995)
   PUBMED   8535092
REFERENCE   9  (bases 1 to 3360)
  AUTHORS   Valenzuela,D.M., Stitt,T.N., DiStefano,P.S., Rojas,E., Mattsson,K.,
            Compton,D.L., Nunez,L., Park,J.S., Stark,J.L., Gies,D.R. et al.
  TITLE     Receptor tyrosine kinase specific for the skeletal muscle lineage:
            expression in embryonic muscle, at the neuromuscular junction, and
            after injury
  JOURNAL   Neuron 15 (3), 573-584 (1995)
   PUBMED   7546737
REFERENCE   10 (bases 1 to 3360)
  AUTHORS   Ganju,P., Walls,E., Brennan,J. and Reith,A.D.
  TITLE     Cloning and developmental expression of Nsk2, a novel receptor
            tyrosine kinase implicated in skeletal myogenesis
  JOURNAL   Oncogene 11 (2), 281-290 (1995)
   PUBMED   7624144
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U37709.1 and BC100342.1.
            
            Summary: This gene encodes a member of the protein tyrosine kinase
            family. The encoded protein is a type 1 receptor-like protein
            located in muscle membrane that is activated by the heparan sulfate
            proteoglycan agrin released by nerve cells. The encoded protein
            activates signaling cascades responsible for multiple aspects of
            motor neuron and muscle development, including organization of the
            postsynaptic membrane, synaptic gene transcription, patterning of
            skeletal muscle, anchoring of acetylcholinesterase, and guidance of
            motor axons. Alternatively spliced transcript variants encoding
            different isoforms have been described. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (3) lacks two alternate, in-frame
            segments in the coding region, compared to variant 1. The encoded
            isoform (3) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100342.1, SRR1660815.95090.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                U37709.1           3-83
            82-3351             BC100342.1         6-3275
            3352-3360           U37709.1           3344-3352
FEATURES             Location/Qualifiers
     source          1..3360
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 31.87 cM"
     gene            1..3360
                     /gene="Musk"
                     /gene_synonym="Mdk4; Mlk; Nsk1; Nsk2; Nsk3"
                     /note="muscle, skeletal, receptor tyrosine kinase"
                     /db_xref="GeneID:18198"
                     /db_xref="MGI:MGI:103581"
     exon            1..229
                     /gene="Musk"
                     /gene_synonym="Mdk4; Mlk; Nsk1; Nsk2; Nsk3"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..2763
                     /gene="Musk"
                     /gene_synonym="Mdk4; Mlk; Nsk1; Nsk2; Nsk3"
                     /EC_number="2.7.10.1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     muscle-specific kinase receptor; muscle, skeletal receptor
                     tyrosine-protein kinase; muscle-specific tyrosine-protein
                     kinase receptor; muscle localized kinase 2"
                     /codon_start=1
                     /product="muscle, skeletal receptor tyrosine-protein
                     kinase isoform 3"
                     /protein_id="NP_001032206.1"
                     /db_xref="CCDS:CCDS38770.1"
                     /db_xref="GeneID:18198"
                     /db_xref="MGI:MGI:103581"
                     /translation="MRELVNIPLLQMLTLVAFSGTEKLPKAPVITTPLETVDALVEEV
                     ATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCIAN
                     NGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDNA
                     LRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKLVKLEVEEDREPEQDA
                     KVFARILRAPESHNVTFGSFVTLRCTAIGIPVPTISWIENGNAVSSGSIQESVKDRVI
                     DSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATVSIAEWSKSQKDSQGYCAQYRGEV
                     CDAVLAKDALVFFNTSYRDPEDAQELLIHTAWNELKAVSPLCRPAAEALLCNHLFQEC
                     SPGVVPTPMPICREYCLAVKELFCAKEWQAMEGKAHRGLYRSGMHLLPVPECSKLPSM
                     HRDPTACTRLPYLAFPSITSSRPSADIPNLPASTSSFAVSPAYSMTVIISIVSSFALF
                     ALLTIATLYCCRRRKEWKNKKRESTAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKL
                     LSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADF
                     QREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHS
                     DLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVV
                     KIADFGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFS
                     YGLQPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRI
                     LQRMCERAEGTVGV"
     exon            230..356
                     /gene="Musk"
                     /gene_synonym="Mdk4; Mlk; Nsk1; Nsk2; Nsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            357..508
                     /gene="Musk"
                     /gene_synonym="Mdk4; Mlk; Nsk1; Nsk2; Nsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            509..636
                     /gene="Musk"
                     /gene_synonym="Mdk4; Mlk; Nsk1; Nsk2; Nsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            637..778
                     /gene="Musk"
                     /gene_synonym="Mdk4; Mlk; Nsk1; Nsk2; Nsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            779..808
                     /gene="Musk"
                     /gene_synonym="Mdk4; Mlk; Nsk1; Nsk2; Nsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            809..933
                     /gene="Musk"
                     /gene_synonym="Mdk4; Mlk; Nsk1; Nsk2; Nsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1093
                     /gene="Musk"
                     /gene_synonym="Mdk4; Mlk; Nsk1; Nsk2; Nsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1100
                     /gene="Musk"
                     /gene_synonym="Mdk4; Mlk; Nsk1; Nsk2; Nsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1364
                     /gene="Musk"
                     /gene_synonym="Mdk4; Mlk; Nsk1; Nsk2; Nsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1540
                     /gene="Musk"
                     /gene_synonym="Mdk4; Mlk; Nsk1; Nsk2; Nsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1739
                     /gene="Musk"
                     /gene_synonym="Mdk4; Mlk; Nsk1; Nsk2; Nsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1931
                     /gene="Musk"
                     /gene_synonym="Mdk4; Mlk; Nsk1; Nsk2; Nsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2080
                     /gene="Musk"
                     /gene_synonym="Mdk4; Mlk; Nsk1; Nsk2; Nsk3"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..3353
                     /gene="Musk"
                     /gene_synonym="Mdk4; Mlk; Nsk1; Nsk2; Nsk3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3332..3337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Musk"
                     /gene_synonym="Mdk4; Mlk; Nsk1; Nsk2; Nsk3"
                     /note="hexamer: AATAAA"
     polyA_site      3353
                     /gene="Musk"
                     /gene_synonym="Mdk4; Mlk; Nsk1; Nsk2; Nsk3"
                     /note="major polyA site"
ORIGIN      
        1 gcagacacaa acagtcctta gcggacaact ctattgtaac aaaccatgct ttaaaatgta
       61 aacccgggag cgtgtttttt gttttttttt tttttttttt tttcctcacg ttgtccagaa
      121 gcaacctttc ttcctgagcc tggattaatc atgagagagc ttgtcaacat tccactgtta
      181 cagatgctca ccctggttgc cttcagcggg actgagaaac ttccaaaagc ccctgtcatc
      241 accacgcctc ttgaaactgt agatgccttg gttgaagaag tagcgacttt catgtgtgcc
      301 gtggaatcct accctcagcc cgagatttct tggaccagaa ataaaattct cattaagctg
      361 tttgacaccc gctacagcat ccgggagaat ggtcagctcc tcaccattct gagcgtggaa
      421 gacagtgatg atggcatcta ctgctgcata gccaacaatg gagtgggagg agccgtggag
      481 agttgtggtg ccctgcaagt gaagatgaaa cctaaaataa ctcgtcctcc cattaatgta
      541 aaaataatag agggattgaa ggcagttctg ccgtgcacta cgatgggtaa ccccaaacca
      601 tctgtgtcct ggatcaaggg ggacaatgct ctcagggaaa attccagaat cgcagttctt
      661 gaatctggga gcttaaggat ccataatgtg caaaaggaag atgcaggaca gtaccgctgt
      721 gtggccaaaa acagcctggg cacagcttac tccaaactgg tgaagctgga agtggaggaa
      781 gacagagaac ctgagcagga cgctaaagtt tttgcaagaa tcctgcgtgc tcctgaatcc
      841 cacaatgtca cctttggttc ctttgtaacc ctacgctgca cagcaatagg catccctgtc
      901 cccaccatca gctggattga aaacggaaat gctgtttctt caggttccat tcaagagagt
      961 gtgaaagacc gagtgattga ctcaagactc cagctcttca tcacaaagcc aggactctac
     1021 acatgcatag ctaccaataa gcacggagaa aagttcagta ccgcaaaggc tgcagccact
     1081 gtcagcatag cagaatggag taagtcacag aaagacagcc aaggctactg tgcccagtac
     1141 agaggggagg tgtgtgatgc agtcctggcg aaagatgctc ttgtcttctt caacacctcc
     1201 taccgggacc ccgaggacgc ccaggagctg ctgatccaca ctgcgtggaa tgagctgaag
     1261 gctgtgagtc cactgtgccg gccagctgct gaggctctgc tgtgtaacca cctcttccaa
     1321 gagtgcagcc ctggagtggt acctactccc atgcccattt gcagagagta ctgcctggcg
     1381 gtaaaggagc tcttctgtgc aaaggaatgg caggcaatgg aaggaaaggc ccaccggggc
     1441 ctctacagat ctgggatgca tctccttccg gtaccagagt gcagcaagct tcccagcatg
     1501 caccgggacc ccacagcctg cacaagactg ccatatttag cattcccgtc aataacgtcc
     1561 tccaggccga gcgcggacat tccaaacctg cctgcctcca cctcttcctt tgccgtctcg
     1621 cctgcgtact ccatgaccgt catcatctcc atcgtgtcca gctttgccct gtttgctctt
     1681 ctcaccatcg ctactctcta ttgctgccga aggaggaaag aatggaaaaa taagaaaaga
     1741 gagtcgaccg cggtgaccct caccacgttg ccttccgagc tcctgctgga taggctccat
     1801 cccaacccca tgtaccagag gatgccactc cttctgaatc ctaagttgct cagcctggag
     1861 tatccgagga ataacattga gtatgtccga gacatcggag agggggcgtt tggaagagtc
     1921 ttccaagcaa gggcccctgg cttgctgcct tatgaacctt tcactatggt ggccgtgaag
     1981 atgcttaagg aagaggcctc tgcagacatg caagcggact ttcagaggga ggcggccctc
     2041 atggcagagt ttgacaaccc caacattgtg aaactcttag gtgtgtgtgc cgttgggaag
     2101 ccgatgtgtc tgctctttga atatatggcc tatggtgacc tcaatgagtt cctccgaagt
     2161 atgtccccgc acactgtttg cagcctcagc cacagtgacc tgtccacgag ggctcgggtg
     2221 tctagccctg gtcctccacc actgtcctgt gcagaacagc tctgcattgc caggcaggtg
     2281 gcagctggca tggcctacct ttcagagcgc aagtttgtcc accgggactt agctaccagg
     2341 aactgcctgg ttggggagac catggtggtg aaaattgcag actttggcct ctccaggaac
     2401 atctattccg cagactacta caaagctgat ggaaatgacg ccatccctat ccgctggatg
     2461 ccgcccgagt ctatcttcta caaccgctac accactgagt cggatgtatg ggcctatggt
     2521 gtggtcctct gggagatctt ctcctatggg ctgcagccct actatggaat ggcccacgag
     2581 gaggtcattt actatgtgag agatggcaac atcctcgcct gccctgagaa ctgccccttg
     2641 gaactgtaca acctcatgcg cctgtgttgg agcaagctgc ctgctgatag acccagcttc
     2701 tgcagtatcc acaggatcct gcagcgcatg tgcgagagag cagagggaac ggtgggtgtc
     2761 taaagttgac cattctcaaa caacacccag gaggctcttt tcagactgtg agctggagga
     2821 accctaccgc agaggccgtg taagaccaga taggaggagt ttaactcaga catcacgtgc
     2881 cagttgattg tttgccagga gaaacagatg gtgaatatcc cacagggtta aagagtcaca
     2941 tcaaaatagg ttggagatac aggctaggaa agaggacagc aggtagctcc tctccctcac
     3001 agggaccgtt tctaatatat attgcataat aagaacatcc cggttacgtt cctacataat
     3061 ctctcagagc gagactgcag tgcttaggtt gaatccaaaa ctggatgggc aacttcattt
     3121 ttaacagaag acatcctgcc cattgcaaaa gcaatgtgtc tttgtgtata tttaggtaaa
     3181 ggactgaaaa ctaaagatag gaatcccttc ttccaccagt caagacacgt ggcagggtct
     3241 tgctgttgtt tagttcttcc ttgcacagaa tatgtaacgt tgtatttgca ttctggaatt
     3301 gagtatctat tttactgata gacttttgaa gaataaaaag tggaaagcct gcaaaaaaaa
//
