LOCUS       NM_027877               2315 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus MUS81 structure-specific endonuclease subunit (Mus81),
            transcript variant 1, mRNA.
ACCESSION   NM_027877
VERSION     NM_027877.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2315)
  AUTHORS   Wu,S., Tang,J. and Wang,L.
  TITLE     A study of protective effects of Mus81 in preeclampsia
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (10), 248-253 (2023)
   PUBMED   37953555
  REMARK    GeneRIF: A study of protective effects of Mus81 in preeclampsia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2315)
  AUTHORS   Fernandez,K.C., Feeney,L., Smolkin,R.M., Yen,W.F., Matthews,A.J.,
            Alread,W., Petrini,J.H.J. and Chaudhuri,J.
  TITLE     The structure-selective endonucleases GEN1 and MUS81 mediate
            complementary functions in safeguarding the genome of proliferating
            B lymphocytes
  JOURNAL   Elife 11, e77073 (2022)
   PUBMED   36190107
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2315)
  AUTHORS   Pfander,B. and Matos,J.
  TITLE     Control of Mus81 nuclease during the cell cycle
  JOURNAL   FEBS Lett 591 (14), 2048-2056 (2017)
   PUBMED   28640495
  REMARK    Review article
REFERENCE   4  (bases 1 to 2315)
  AUTHORS   Dehe,P.M. and Gaillard,P.H.L.
  TITLE     Control of structure-specific endonucleases to maintain genome
            stability
  JOURNAL   Nat Rev Mol Cell Biol 18 (5), 315-330 (2017)
   PUBMED   28327556
  REMARK    Review article
REFERENCE   5  (bases 1 to 2315)
  AUTHORS   Lilley,D.M.J.
  TITLE     Holliday junction-resolving enzymes-structures and mechanisms
  JOURNAL   FEBS Lett 591 (8), 1073-1082 (2017)
   PUBMED   27990631
  REMARK    Review article
REFERENCE   6  (bases 1 to 2315)
  AUTHORS   West,S.C., Blanco,M.G., Chan,Y.W., Matos,J., Sarbajna,S. and
            Wyatt,H.D.
  TITLE     Resolution of Recombination Intermediates: Mechanisms and
            Regulation
  JOURNAL   Cold Spring Harb Symp Quant Biol 80, 103-109 (2015)
   PUBMED   26370409
  REMARK    Review article
REFERENCE   7  (bases 1 to 2315)
  AUTHORS   Wyatt,H.D. and West,S.C.
  TITLE     Holliday junction resolvases
  JOURNAL   Cold Spring Harb Perspect Biol 6 (9), a023192 (2014)
   PUBMED   25183833
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2315)
  AUTHORS   Dendouga,N., Gao,H., Moechars,D., Janicot,M., Vialard,J. and
            McGowan,C.H.
  TITLE     Disruption of murine Mus81 increases genomic instability and DNA
            damage sensitivity but does not promote tumorigenesis
  JOURNAL   Mol Cell Biol 25 (17), 7569-7579 (2005)
   PUBMED   16107704
  REMARK    GeneRIF: Mus81 acts at a late step in the repair of
            cross-link-induced lesions
REFERENCE   9  (bases 1 to 2315)
  AUTHORS   Abraham,J., Lemmers,B., Hande,M.P., Moynahan,M.E., Chahwan,C.,
            Ciccia,A., Essers,J., Hanada,K., Chahwan,R., Khaw,A.K.,
            McPherson,P., Shehabeldin,A., Laister,R., Arrowsmith,C., Kanaar,R.,
            West,S.C., Jasin,M. and Hakem,R.
  TITLE     Eme1 is involved in DNA damage processing and maintenance of
            genomic stability in mammalian cells
  JOURNAL   EMBO J 22 (22), 6137-6147 (2003)
   PUBMED   14609959
REFERENCE   10 (bases 1 to 2315)
  AUTHORS   Chen,X.B., Melchionna,R., Denis,C.M., Gaillard,P.H.L., Blasina,A.,
            Van de Weyer,I., Boddy,M.N., Russell,P., Vialard,J. and
            McGowan,C.H.
  TITLE     Human Mus81-associated endonuclease cleaves Holliday junctions in
            vitro
  JOURNAL   Mol Cell 8 (5), 1117-1127 (2001)
   PUBMED   11741546
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126029.3, BY208661.1, AK145858.1, AK004647.1 and AA014278.1.
            
            On Feb 9, 2018 this sequence version replaced NM_027877.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026560.1, AF425647.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC126029.3         155597-155639
            44-94               BY208661.1         1-51
            95-540              AK145858.1         2-447
            541-862             AK004647.1         181-502
            863-1762            AK145858.1         770-1669
            1763-2018           AK145858.1         1700-1955
            2019-2119           AA014278.1         406-506
            2120-2315           AC126029.3         161220-161415
FEATURES             Location/Qualifiers
     source          1..2315
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.34 cM"
     gene            1..2315
                     /gene="Mus81"
                     /gene_synonym="1200008A18Rik"
                     /note="MUS81 structure-specific endonuclease subunit"
                     /db_xref="GeneID:71711"
                     /db_xref="MGI:MGI:1918961"
     exon            1..392
                     /gene="Mus81"
                     /gene_synonym="1200008A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            393..522
                     /gene="Mus81"
                     /gene_synonym="1200008A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            523..605
                     /gene="Mus81"
                     /gene_synonym="1200008A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            606..707
                     /gene="Mus81"
                     /gene_synonym="1200008A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            708..776
                     /gene="Mus81"
                     /gene_synonym="1200008A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            777..862
                     /gene="Mus81"
                     /gene_synonym="1200008A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1000
                     /gene="Mus81"
                     /gene_synonym="1200008A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1096
                     /gene="Mus81"
                     /gene_synonym="1200008A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1218
                     /gene="Mus81"
                     /gene_synonym="1200008A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1316
                     /gene="Mus81"
                     /gene_synonym="1200008A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1433
                     /gene="Mus81"
                     /gene_synonym="1200008A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1529
                     /gene="Mus81"
                     /gene_synonym="1200008A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1658
                     /gene="Mus81"
                     /gene_synonym="1200008A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1762
                     /gene="Mus81"
                     /gene_synonym="1200008A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1846
                     /gene="Mus81"
                     /gene_synonym="1200008A18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2315
                     /gene="Mus81"
                     /gene_synonym="1200008A18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2001..2006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mus81"
                     /gene_synonym="1200008A18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2040
                     /gene="Mus81"
                     /gene_synonym="1200008A18Rik"
                     /note="major polyA site"
ORIGIN      
        1 aagctccatg gcctgggtgg ggcctgtcca aaaggctggt gccggcgggc gaatgggggc
       61 ggttctaagg aaaggccgtg caaaccgagc tagcctctta ctgcatagta catggcgaaa
      121 ggaggtcatt ccatgagctg gtgccctgct aggttggaga gaccctaccc tcaaacaagt
      181 gttcttatac caactgaatt gtcgcgatcc tagtctcagg ggttttttga gactctgaag
      241 gagccagtct agttcttatg gcggagccgg tccgcctggg ccggaagcgt ccgctgcccg
      301 tttgccccaa cccgctcttc gttcgttggc tgaccgagtg gcgggacgag gcagccagca
      361 gggggcgcca cacgcgtttc gtgtttcaaa aggcattgcg ctccctccaa cggtacccgc
      421 taccattgcg cagcgggaag gaagccaaga tactccagca cttcggagac aggctctgcc
      481 gcatgctgga cgaaaagctg aagcagcacc tagcatcagg cggtgaccat gcccccagct
      541 caccatctgg aaagaaggga gccagcaaag ggccacctga gcaagtccag gactcttcca
      601 tgccagttcc cacccagcct caagcaggaa gcaccagtgt tggctattgg ccagctcaga
      661 actcaggtgc tcgagagatc ctgctgcaac tctacaggga gcacctgaat tctgatggcc
      721 acagcttcct aaccaaagag gagctgctgc agaagtgtgc ccagaagacc cccagggtag
      781 tgcctggaag ttcgaaaccc tggcctgccc tccggagcct cctccatagg aacctcatcc
      841 ttggaacgca tcggccagcc aggtatgcac tcacaccaga gggtctggag ctggctcaga
      901 agctggccga ggcggaaggc ctgagcactc ggcacgctgg ctttaggcca gaggaacatc
      961 acggagagga ctcagcagtt ccagaagcct tgtcagaacc tggcaccacc gagggggccg
     1021 tccagcagag accactggag ctaaggccta gcgagtacag agtgctgttg tgtgtggaca
     1081 ttggcgaaac cagaggggca ggacacaggc cagaaatgct ccgagagtta caaaggctgc
     1141 gtgtgcccca caccgtacgc aagctacacg ttggagactt tgtgtgggtg gcacaggaga
     1201 ccaggcccag agacccagaa agacctgggg agctggtcct ggaccacatt gtggaacgca
     1261 agcggctaga tgacctatgc agcagcatca ttgacggccg ctttcgggag cagaagttcc
     1321 gcctgaagcg ctgtggcctg gggcaccggg tatacttagt ggaagaacat gggtctgtcc
     1381 acaaccttag ccttcccgag agcaccttgc tgcaggctgt cacaaacacc caggtcattg
     1441 atggcttttt tgtgaagcga accatggata ttaaggagtc ggctggctac ctggcgcttt
     1501 tgacaaaggg cctggaaaga ctgtaccagg gccacaccct acgcagccgc ccttgggggg
     1561 ccccaggggc tgctgaatca gaagcaaagc cttccacaaa ccctctctgc tcactcctca
     1621 ccttcagtga cttcaatgca gaagctgtca agaacaaggc ccagtctgtg cgagaagtat
     1681 ttgcccggca gctgatgcag gtgcgtggac tgagtgggga gaaggcagca gccgtggtgg
     1741 atcgatacag cacccctgcc agtctcctgg ctgcttatga tgcctgtgcc accgcgaagg
     1801 agcaggagat gctcttgagc accatcaagt gtgggcgtct gcagaggaat ctgggacccg
     1861 ctctgagcag gaccctgtac cagttgtact gcagccacag ccctctgagc tgagctgtac
     1921 caggagacgc tcgctcccca gcacccatct tcatctctac caaggctggc tagcctttta
     1981 gctgagatcc cctgggcttt aataaaaatc tggatgtgtg tggtctcggc tgttaaggaa
     2041 gcaatgccaa ggtccttctg aaatctacag gggttggaag actacactgc tgagccaact
     2101 gttgtgtgtg gtggtgctag cagcggaacc cagagcctca cacctactag gcaattcctc
     2161 ttccaaaaag caatgatccg cagccctgta cagtgtcctt acccattcct aaaaccagct
     2221 tggcctaaaa cttgctctgt aacctagtct agcctagaac tcccagtttt tctgggtcta
     2281 ccttccaaga cctgaaatta aaggtgtggg gcacc
//
