LOCUS       NM_008648                879 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus major urinary protein 4 (Mup4), mRNA.
ACCESSION   NM_008648
VERSION     NM_008648.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 879)
  AUTHORS   Charkoftaki,G., Wang,Y., McAndrews,M., Bruford,E.A., Thompson,D.C.,
            Vasiliou,V. and Nebert,D.W.
  TITLE     Update on the human and mouse lipocalin (LCN) gene family,
            including evidence the mouse Mup cluster is result of an
            'evolutionary bloom'
  JOURNAL   Hum Genomics 13 (1), 11 (2019)
   PUBMED   30782214
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 879)
  AUTHORS   Perez-Miller,S., Zou,Q., Novotny,M.V. and Hurley,T.D.
  TITLE     High resolution X-ray structures of mouse major urinary protein
            nasal isoform in complex with pheromones
  JOURNAL   Protein Sci 19 (8), 1469-1479 (2010)
   PUBMED   20509168
  REMARK    GeneRIF: Data determine the X-ray crystal structure of major
            urinary protein-IV bound to three mouse pheromones: SBT,
            2,5-dimethylpyrazine, and 2-heptanone, and report the structure of
            MUP-IV with 2-ethylhexanol bound in the cavity.
REFERENCE   3  (bases 1 to 879)
  AUTHORS   Logan,D.W., Marton,T.F. and Stowers,L.
  TITLE     Species specificity in major urinary proteins by parallel evolution
  JOURNAL   PLoS One 3 (9), e3280 (2008)
   PUBMED   18815613
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 879)
  AUTHORS   Ohashi,Y., Tsuzaka,K., Takeuchi,T., Sasaki,Y. and Tsubota,K.
  TITLE     Altered distribution of aquaporin 5 and its C-terminal binding
            protein in the lacrimal glands of a mouse model for Sjogren's
            syndrome
  JOURNAL   Curr Eye Res 33 (8), 621-629 (2008)
   PUBMED   18696337
REFERENCE   5  (bases 1 to 879)
  AUTHORS   Chamero,P., Marton,T.F., Logan,D.W., Flanagan,K., Cruz,J.R.,
            Saghatelian,A., Cravatt,B.F. and Stowers,L.
  TITLE     Identification of protein pheromones that promote aggressive
            behaviour
  JOURNAL   Nature 450 (7171), 899-902 (2007)
   PUBMED   18064011
REFERENCE   6  (bases 1 to 879)
  AUTHORS   Sharrow,S.D., Vaughn,J.L., Zidek,L., Novotny,M.V. and Stone,M.J.
  TITLE     Pheromone binding by polymorphic mouse major urinary proteins
  JOURNAL   Protein Sci 11 (9), 2247-2256 (2002)
   PUBMED   12192080
  REMARK    Erratum:[Protein Sci. 2004 Jan;13(1):306]
REFERENCE   7  (bases 1 to 879)
  AUTHORS   Held,W.A., Gallagher,J.F., Hohman,C.M., Kuhn,N.J., Sampsell,B.M.
            and Hughes,R.G. Jr.
  TITLE     Identification and characterization of functional genes encoding
            the mouse major urinary proteins
  JOURNAL   Mol Cell Biol 7 (10), 3705-3712 (1987)
   PUBMED   2824995
REFERENCE   8  (bases 1 to 879)
  AUTHORS   Shahan,K., Denaro,M., Gilmartin,M., Shi,Y. and Derman,E.
  TITLE     Expression of six mouse major urinary protein genes in the mammary,
            parotid, sublingual, submaxillary, and lachrymal glands and in the
            liver
  JOURNAL   Mol Cell Biol 7 (5), 1947-1954 (1987)
   PUBMED   3600653
REFERENCE   9  (bases 1 to 879)
  AUTHORS   Shahan,K., Gilmartin,M. and Derman,E.
  TITLE     Nucleotide sequences of liver, lachrymal, and submaxillary gland
            mouse major urinary protein mRNAs: mosaic structure and
            construction of panels of gene-specific synthetic oligonucleotide
            probes
  JOURNAL   Mol Cell Biol 7 (5), 1938-1946 (1987)
   PUBMED   3600652
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL831738.4.
            
            On Jan 31, 2019 this sequence version replaced NM_008648.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012227.1, BF535758.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849381,
                                           SAMN00849386 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AL831738.4         157640-157797       c
            159-292             AL831738.4         157169-157302       c
            293-366             AL831738.4         156326-156399       c
            367-477             AL831738.4         155620-155730       c
            478-579             AL831738.4         155186-155287       c
            580-625             AL831738.4         154975-155020       c
            626-879             AL831738.4         153934-154187       c
FEATURES             Location/Qualifiers
     source          1..879
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 32.82 cM"
     gene            1..879
                     /gene="Mup4"
                     /gene_synonym="Mup-4; Mup1"
                     /note="major urinary protein 4"
                     /db_xref="GeneID:17843"
                     /db_xref="MGI:MGI:97236"
     exon            1..158
                     /gene="Mup4"
                     /gene_synonym="Mup-4; Mup1"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..605
                     /gene="Mup4"
                     /gene_synonym="Mup-4; Mup1"
                     /note="major urinary protein 1; MUP 4"
                     /codon_start=1
                     /product="major urinary protein 4 precursor"
                     /protein_id="NP_032674.1"
                     /db_xref="CCDS:CCDS18228.1"
                     /db_xref="GeneID:17843"
                     /db_xref="MGI:MGI:97236"
                     /translation="MKLLLCLGLTLVCIHAEEATSKGQNLNVEKINGEWFSILLASDK
                     REKIEEHGSMRVFVEHIHVLENSLAFKFHTVIDGECSEIFLVADKTEKAGEYSVMYDG
                     FNTFTILKTDYDNYIMFHLINEKDGKTFQLMELYGRKADLNSDIKEKFVKLCEEHGII
                     KENIIDLTKTNRCLKARE"
     exon            159..292
                     /gene="Mup4"
                     /gene_synonym="Mup-4; Mup1"
                     /inference="alignment:Splign:2.1.0"
     exon            293..366
                     /gene="Mup4"
                     /gene_synonym="Mup-4; Mup1"
                     /inference="alignment:Splign:2.1.0"
     exon            367..477
                     /gene="Mup4"
                     /gene_synonym="Mup-4; Mup1"
                     /inference="alignment:Splign:2.1.0"
     exon            478..579
                     /gene="Mup4"
                     /gene_synonym="Mup-4; Mup1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..625
                     /gene="Mup4"
                     /gene_synonym="Mup-4; Mup1"
                     /inference="alignment:Splign:2.1.0"
     exon            626..879
                     /gene="Mup4"
                     /gene_synonym="Mup-4; Mup1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggagtgta ggcaccatca ccagaaggac gtggtcctga cagacagaca attctactcc
       61 ctaccaaaat gaagctgctg ctgtgtttgg gactgaccct agtctgtatt catgcagaag
      121 aagctacttc caagggacag aacttaaatg tagaaaagat taatggggaa tggttttcta
      181 ttctcctggc ctctgacaaa agagaaaaga tagaagaaca tggcagcatg agagtttttg
      241 tggagcacat ccatgtcttg gagaattcct tagcttttaa attccatact gttatagatg
      301 gagagtgctc tgaaatattt ttggttgctg acaaaacaga gaaggctggt gaatattctg
      361 tgatgtatga tggattcaat acatttacta tacttaagac agactatgat aattatatta
      421 tgtttcatct cattaacgaa aaggatggga aaaccttcca gctgatggag ctctatggcc
      481 gaaaagcaga tttgaattca gacatcaagg aaaagtttgt aaaactttgt gaggagcatg
      541 gaatcattaa agaaaatatc attgacttaa ccaaaaccaa tcgctgcctc aaggcccgag
      601 aatgaagaat ggcctgagcc tccagtgttg agtggagact tctcaccagg actccagcat
      661 cctctcttcc gatcgataca gcattgggtg acaagttctg tgatctgctt tccatcctgt
      721 ctcacagaga agtgcaatcc tggtctctcc agcatgttac ctaggataac tcatcaagaa
      781 tcaaagactt tctttaaatt tctctttgac atacccatga caattctcca agaattgctt
      841 cctcttcctg ttcaataaat gattacactt gcacttaaa
//
