LOCUS       NM_001039544             913 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus major urinary protein 3 (Mup3), transcript variant 1,
            mRNA.
ACCESSION   NM_001039544
VERSION     NM_001039544.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 913)
  AUTHORS   Rong,R., Wei,Y., Li,L., Wang,T., Zhu,H., Xiao,G. and Wang,Y.
  TITLE     Image-based quantification of histological features as a function
            of spatial location using the Tissue Positioning System
  JOURNAL   EBioMedicine 94, 104698 (2023)
   PUBMED   37453365
REFERENCE   2  (bases 1 to 913)
  AUTHORS   Wei,Y., Wang,Y.G., Jia,Y., Li,L., Yoon,J., Zhang,S., Wang,Z.,
            Zhang,Y., Zhu,M., Sharma,T., Lin,Y.H., Hsieh,M.H., Albrecht,J.H.,
            Le,P.T., Rosen,C.J., Wang,T. and Zhu,H.
  TITLE     Liver homeostasis is maintained by midlobular zone 2 hepatocytes
  JOURNAL   Science 371 (6532) (2021)
   PUBMED   33632817
  REMARK    Erratum:[Science. 2021 Sep 3;373(6559):eabl8195. doi:
            10.1126/science.abl8195.. PMID: 34516857]
REFERENCE   3  (bases 1 to 913)
  AUTHORS   Charkoftaki,G., Wang,Y., McAndrews,M., Bruford,E.A., Thompson,D.C.,
            Vasiliou,V. and Nebert,D.W.
  TITLE     Update on the human and mouse lipocalin (LCN) gene family,
            including evidence the mouse Mup cluster is result of an
            'evolutionary bloom'
  JOURNAL   Hum Genomics 13 (1), 11 (2019)
   PUBMED   30782214
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 913)
  AUTHORS   Jiang,J., Creasy,K.T., Purnell,J., Peterson,M.L. and Spear,B.T.
  TITLE     Zhx2 (zinc fingers and homeoboxes 2) regulates major urinary
            protein gene expression in the mouse liver
  JOURNAL   J Biol Chem 292 (16), 6765-6774 (2017)
   PUBMED   28258223
REFERENCE   5  (bases 1 to 913)
  AUTHORS   Karn,R.C. and Laukaitis,C.M.
  TITLE     The roles of gene duplication, gene conversion and positive
            selection in rodent Esp and Mup pheromone gene families with
            comparison to the Abp family
  JOURNAL   PLoS One 7 (10), e47697 (2012)
   PUBMED   23094077
REFERENCE   6  (bases 1 to 913)
  AUTHORS   Kawamoto,S., Matsumoto,Y., Mizuno,K., Okubo,K. and Matsubara,K.
  TITLE     Expression profiles of active genes in human and mouse livers
  JOURNAL   Gene 174 (1), 151-158 (1996)
   PUBMED   8863742
REFERENCE   7  (bases 1 to 913)
  AUTHORS   Held,W.A., Gallagher,J.F., Hohman,C.M., Kuhn,N.J., Sampsell,B.M.
            and Hughes,R.G. Jr.
  TITLE     Identification and characterization of functional genes encoding
            the mouse major urinary proteins
  JOURNAL   Mol Cell Biol 7 (10), 3705-3712 (1987)
   PUBMED   2824995
REFERENCE   8  (bases 1 to 913)
  AUTHORS   Shahan,K., Gilmartin,M. and Derman,E.
  TITLE     Nucleotide sequences of liver, lachrymal, and submaxillary gland
            mouse major urinary protein mRNAs: mosaic structure and
            construction of panels of gene-specific synthetic oligonucleotide
            probes
  JOURNAL   Mol Cell Biol 7 (5), 1938-1946 (1987)
   PUBMED   3600652
REFERENCE   9  (bases 1 to 913)
  AUTHORS   Clark,A.J., Chave-Cox,A., Ma,X. and Bishop,J.O.
  TITLE     Analysis of mouse major urinary protein genes: variation between
            the exonic sequences of group 1 genes and a comparison with an
            active gene out with group 1 both suggest that gene conversion has
            occurred between MUP genes
  JOURNAL   EMBO J 4 (12), 3167-3171 (1985)
   PUBMED   3004936
REFERENCE   10 (bases 1 to 913)
  AUTHORS   Kuhn,N.J., Woodworth-Gutai,M., Gross,K.W. and Held,W.A.
  TITLE     Subfamilies of the mouse major urinary protein (MUP) multi-gene
            family: sequence analysis of cDNA clones and differential
            regulation in the liver
  JOURNAL   Nucleic Acids Res 12 (15), 6073-6090 (1984)
   PUBMED   6548015
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX088584.14, CJ043431.1, EU882235.1, AW112847.1, AW110320.1 and
            D18031.1.
            
            On Sep 27, 2017 this sequence version replaced NM_001039544.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC106100.1, AI195987.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BX088584.14        145472-145491       c
            21-86               CJ043431.1         2-67
            87-641              EU882235.1         1-555
            642-835             AW112847.1         5-198               c
            836-906             AW110320.1         1-71                c
            907-913             D18031.1           170-176
FEATURES             Location/Qualifiers
     source          1..913
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 32.99 cM"
     gene            1..913
                     /gene="Mup3"
                     /gene_synonym="Mup-3; MUP15; Mup25; MUPIII"
                     /note="major urinary protein 3"
                     /db_xref="GeneID:17842"
                     /db_xref="MGI:MGI:97235"
     exon            1..194
                     /gene="Mup3"
                     /gene_synonym="Mup-3; MUP15; Mup25; MUPIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..641
                     /gene="Mup3"
                     /gene_synonym="Mup-3; MUP15; Mup25; MUPIII"
                     /note="major urinary protein 25; alpha-2u-globulin III;
                     MUP 3; non-group 1/group 2 MUP15"
                     /codon_start=1
                     /product="major urinary protein 3 precursor"
                     /protein_id="NP_001034633.1"
                     /db_xref="CCDS:CCDS18234.1"
                     /db_xref="GeneID:17842"
                     /db_xref="MGI:MGI:97235"
                     /translation="MKLLLPLLLLLCLELTLVCIHAEESSSMERNFNVEQISGYWFSI
                     AEASDEREKIEEHGSMRAFVENITVLENSLVFKFHLIVNEECTEMTAIGEQTEKAGIY
                     YMNYDGFNTFSILKTDYDNYIMIHLINKKDGKTFQLMELYGREPDLSLDIKEKFAKLC
                     EEHGIIRENIIDLTNVNRCLEARE"
     exon            195..328
                     /gene="Mup3"
                     /gene_synonym="Mup-3; MUP15; Mup25; MUPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            329..402
                     /gene="Mup3"
                     /gene_synonym="Mup-3; MUP15; Mup25; MUPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            403..513
                     /gene="Mup3"
                     /gene_synonym="Mup-3; MUP15; Mup25; MUPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            514..615
                     /gene="Mup3"
                     /gene_synonym="Mup-3; MUP15; Mup25; MUPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            616..661
                     /gene="Mup3"
                     /gene_synonym="Mup-3; MUP15; Mup25; MUPIII"
                     /inference="alignment:Splign:2.1.0"
     exon            662..913
                     /gene="Mup3"
                     /gene_synonym="Mup-3; MUP15; Mup25; MUPIII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      888..893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mup3"
                     /gene_synonym="Mup-3; MUP15; Mup25; MUPIII"
                     /note="hexamer: AATAAA"
     regulatory      896..901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mup3"
                     /gene_synonym="Mup-3; MUP15; Mup25; MUPIII"
                     /note="hexamer: ATTACA"
     polyA_site      907
                     /gene="Mup3"
                     /gene_synonym="Mup-3; MUP15; Mup25; MUPIII"
     polyA_site      913
                     /gene="Mup3"
                     /gene_synonym="Mup-3; MUP15; Mup25; MUPIII"
                     /note="major polyA site"
ORIGIN      
        1 aagcaaagga gctggggagt ggagtgtagg cactataacc tgaaagacgt ggtcctgaca
       61 ggaggacaat tctattccct accaaaatga agctgctgct gccgctgctt ctgctcctgt
      121 gtttggaact gactttagtc tgtatccatg cagaagaatc tagttctatg gaaaggaact
      181 ttaatgtaga acagattagt gggtattggt tttctattgc tgaagcctct gatgaaagag
      241 aaaagataga agaacatggc agcatgagag cttttgtgga aaacatcact gtcttggaga
      301 attccttagt ctttaaattc catttaattg taaatgaaga gtgcaccgaa atgactgcga
      361 ttggtgaaca aacagaaaag gctggcatat attatatgaa ctatgatgga ttcaatacat
      421 ttagtatact taagacagac tatgataatt atattatgat tcatctcatt aacaaaaagg
      481 atgggaaaac cttccagctg atggagctct atggccgaga accagatttg agtttagaca
      541 tcaaggaaaa gtttgcaaaa ctatgcgagg agcatggaat cattagagaa aatatcattg
      601 acctaaccaa tgtcaatcgc tgcctcgagg cccgagaatg aagaatggcc tgagcctcca
      661 gtgttgagtg gagacttttc accaggactc cagcatcatc ccttcctatc catacagact
      721 cccatgccaa ggtctgtgat ctgctctcca cctgtctcac agagaagtgc aatcccgttc
      781 tctccagcat gttacctagg ataactcatc aagaatcaaa gactttcttt aaatttctct
      841 ttgccaacac atggaaattc tccattgatt tctttcctgt cctgttcaat aaatgattac
      901 acttgcactt aaa
//
