LOCUS       NM_008647                905 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus major urinary protein 2 (Mup2), transcript variant 1,
            mRNA.
ACCESSION   NM_008647 XM_909870
VERSION     NM_008647.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 905)
  AUTHORS   Charkoftaki,G., Wang,Y., McAndrews,M., Bruford,E.A., Thompson,D.C.,
            Vasiliou,V. and Nebert,D.W.
  TITLE     Update on the human and mouse lipocalin (LCN) gene family,
            including evidence the mouse Mup cluster is result of an
            'evolutionary bloom'
  JOURNAL   Hum Genomics 13 (1), 11 (2019)
   PUBMED   30782214
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 905)
  AUTHORS   Cho,Y.H., Kim,D., Choi,I. and Bae,K.
  TITLE     Identification of transcriptional regulatory elements required for
            the Mup2 expression in circadian clock mutant mice
  JOURNAL   Biochem Biophys Res Commun 410 (4), 834-840 (2011)
   PUBMED   21703244
  REMARK    GeneRIF: these results indicate that Mup2 expression is regulated
            by both the circadian clock and glucocorticoid.
REFERENCE   3  (bases 1 to 905)
  AUTHORS   Logan,D.W., Marton,T.F. and Stowers,L.
  TITLE     Species specificity in major urinary proteins by parallel evolution
  JOURNAL   PLoS One 3 (9), e3280 (2008)
   PUBMED   18815613
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 905)
  AUTHORS   Chamero,P., Marton,T.F., Logan,D.W., Flanagan,K., Cruz,J.R.,
            Saghatelian,A., Cravatt,B.F. and Stowers,L.
  TITLE     Identification of protein pheromones that promote aggressive
            behaviour
  JOURNAL   Nature 450 (7171), 899-902 (2007)
   PUBMED   18064011
REFERENCE   5  (bases 1 to 905)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
REFERENCE   6  (bases 1 to 905)
  AUTHORS   Lucke,C., Franzoni,L., Abbate,F., Lohr,F., Ferrari,E., Sorbi,R.T.,
            Ruterjans,H. and Spisni,A.
  TITLE     Solution structure of a recombinant mouse major urinary protein
  JOURNAL   Eur J Biochem 266 (3), 1210-1218 (1999)
   PUBMED   10583419
REFERENCE   7  (bases 1 to 905)
  AUTHORS   Ferrari,E., Lodi,T., Sorbi,R.T., Tirindelli,R., Cavaggioni,A. and
            Spisni,A.
  TITLE     Expression of a lipocalin in Pichia pastoris: secretion,
            purification and binding activity of a recombinant mouse major
            urinary protein
  JOURNAL   FEBS Lett 401 (1), 73-77 (1997)
   PUBMED   9003809
REFERENCE   8  (bases 1 to 905)
  AUTHORS   Held,W.A., Gallagher,J.F., Hohman,C.M., Kuhn,N.J., Sampsell,B.M.
            and Hughes,R.G. Jr.
  TITLE     Identification and characterization of functional genes encoding
            the mouse major urinary proteins
  JOURNAL   Mol Cell Biol 7 (10), 3705-3712 (1987)
   PUBMED   2824995
REFERENCE   9  (bases 1 to 905)
  AUTHORS   Shahan,K., Gilmartin,M. and Derman,E.
  TITLE     Nucleotide sequences of liver, lachrymal, and submaxillary gland
            mouse major urinary protein mRNAs: mosaic structure and
            construction of panels of gene-specific synthetic oligonucleotide
            probes
  JOURNAL   Mol Cell Biol 7 (5), 1938-1946 (1987)
   PUBMED   3600652
REFERENCE   10 (bases 1 to 905)
  AUTHORS   Krauter,K., Leinwand,L., D'Eustachio,P., Ruddle,F. and Darnell,J.E.
            Jr.
  TITLE     Structural genes of the mouse major urinary protein are on
            chromosome 4
  JOURNAL   J Cell Biol 94 (2), 414-417 (1982)
   PUBMED   7107707
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772327.4.
            
            On Oct 30, 2013 this sequence version replaced NM_008647.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 2 encode the same isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI144701.1, BI145445.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               AL772327.4         110810-110975
            167-300             AL772327.4         111314-111447
            301-374             AL772327.4         112206-112279
            375-485             AL772327.4         112929-113039
            486-587             AL772327.4         113381-113482
            588-633             AL772327.4         113646-113691
            634-905             AL772327.4         114482-114753
FEATURES             Location/Qualifiers
     source          1..905
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 32.83 cM"
     gene            1..905
                     /gene="Mup2"
                     /gene_synonym="Mup-2; Mup18; Mup4"
                     /note="major urinary protein 2"
                     /db_xref="GeneID:17841"
                     /db_xref="MGI:MGI:97234"
     exon            1..166
                     /gene="Mup2"
                     /gene_synonym="Mup-2; Mup18; Mup4"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..613
                     /gene="Mup2"
                     /gene_synonym="Mup-2; Mup18; Mup4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; major urinary protein 4; 2610016E04Rik"
                     /codon_start=1
                     /product="major urinary protein 2 isoform 1 precursor"
                     /protein_id="NP_032673.3"
                     /db_xref="CCDS:CCDS18230.1"
                     /db_xref="GeneID:17841"
                     /db_xref="MGI:MGI:97234"
                     /translation="MKMLLLLCLGLTLVCVHAEEASSTGRNFNVQKINGEWHTIILAS
                     DKREKIEDNGNFRLFLEQIHVLENSLVLKFHTVRDEECSELSMVADKTEKAGEYSVTY
                     DGFNTFTIPKTDYDNFLMAHLINEKDGETFQLMGLYGREPDLSSDIKERFAQLCEEHG
                     ILRENIIDLSNANRCLQARE"
     exon            167..300
                     /gene="Mup2"
                     /gene_synonym="Mup-2; Mup18; Mup4"
                     /inference="alignment:Splign:2.1.0"
     exon            301..374
                     /gene="Mup2"
                     /gene_synonym="Mup-2; Mup18; Mup4"
                     /inference="alignment:Splign:2.1.0"
     exon            375..485
                     /gene="Mup2"
                     /gene_synonym="Mup-2; Mup18; Mup4"
                     /inference="alignment:Splign:2.1.0"
     exon            486..587
                     /gene="Mup2"
                     /gene_synonym="Mup-2; Mup18; Mup4"
                     /inference="alignment:Splign:2.1.0"
     exon            588..633
                     /gene="Mup2"
                     /gene_synonym="Mup-2; Mup18; Mup4"
                     /inference="alignment:Splign:2.1.0"
     exon            634..905
                     /gene="Mup2"
                     /gene_synonym="Mup-2; Mup18; Mup4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtggagtg tagccacgat cacaagaaag acgtggtcct gacagacaga caatcctatt
       61 ccctaccaaa atgaagatgc tgctgctgct gtgtttggga ctgaccctag tctgtgtcca
      121 tgcagaagaa gctagttcta cgggaaggaa ctttaatgta caaaagatta atggggaatg
      181 gcatactatt atcctggcct ctgacaaaag agaaaagata gaagataatg gcaactttag
      241 actttttctg gagcaaatcc atgtcttgga gaattcctta gttcttaaat tccatactgt
      301 aagagatgaa gagtgctcgg aattatctat ggttgctgac aaaacagaaa aggctggtga
      361 atattctgtg acgtatgatg gattcaatac atttactata cctaagacag actatgataa
      421 ctttcttatg gctcatctca ttaacgaaaa ggatggggaa accttccagc tgatggggct
      481 ctatggccga gaaccagatt tgagttcaga catcaaggaa aggtttgcac aactatgtga
      541 ggagcatgga atccttagag aaaatatcat tgacctatcc aatgccaatc gctgcctcca
      601 ggcccgagaa tgaagaatgg cctgagcctc cagtgttgag tggagacttc tcaccaggac
      661 tccaccatca tcccttccta tccatacagc atccccagta taaattctgt gatctgcatt
      721 ccatcctgtc tcactgagaa gtccaattcc agtctatcca catgttacct aggatacctc
      781 atcaagaatc aaagacttct ttaaatttct ctttgatata cccatgacaa tttttcatga
      841 atttcttcct cttcctgttc aataaatgat tacccttgca cttaaatata tgtctctatg
      901 tccag
//
