LOCUS       NM_001199333             888 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus major urinary protein 18 (Mup18), mRNA.
ACCESSION   NM_001199333 XM_003084579 XM_003084580 XM_003084581
VERSION     NM_001199333.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 888)
  AUTHORS   Charkoftaki,G., Wang,Y., McAndrews,M., Bruford,E.A., Thompson,D.C.,
            Vasiliou,V. and Nebert,D.W.
  TITLE     Update on the human and mouse lipocalin (LCN) gene family,
            including evidence the mouse Mup cluster is result of an
            'evolutionary bloom'
  JOURNAL   Hum Genomics 13 (1), 11 (2019)
   PUBMED   30782214
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 888)
  AUTHORS   Logan,D.W., Marton,T.F. and Stowers,L.
  TITLE     Species specificity in major urinary proteins by parallel evolution
  JOURNAL   PLoS One 3 (9), e3280 (2008)
   PUBMED   18815613
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 888)
  AUTHORS   Chamero,P., Marton,T.F., Logan,D.W., Flanagan,K., Cruz,J.R.,
            Saghatelian,A., Cravatt,B.F. and Stowers,L.
  TITLE     Identification of protein pheromones that promote aggressive
            behaviour
  JOURNAL   Nature 450 (7171), 899-902 (2007)
   PUBMED   18064011
REFERENCE   4  (bases 1 to 888)
  AUTHORS   Bingham,R.J., Findlay,J.B., Hsieh,S.Y., Kalverda,A.P.,
            Kjellberg,A., Perazzolo,C., Phillips,S.E., Seshadri,K., Trinh,C.H.,
            Turnbull,W.B., Bodenhausen,G. and Homans,S.W.
  TITLE     Thermodynamics of binding of 2-methoxy-3-isopropylpyrazine and
            2-methoxy-3-isobutylpyrazine to the major urinary protein
  JOURNAL   J Am Chem Soc 126 (6), 1675-1681 (2004)
   PUBMED   14871097
REFERENCE   5  (bases 1 to 888)
  AUTHORS   Timm,D.E., Baker,L.J., Mueller,H., Zidek,L. and Novotny,M.V.
  TITLE     Structural basis of pheromone binding to mouse major urinary
            protein (MUP-I)
  JOURNAL   Protein Sci 10 (5), 997-1004 (2001)
   PUBMED   11316880
REFERENCE   6  (bases 1 to 888)
  AUTHORS   Bocskei,Z., Groom,C.R., Flower,D.R., Wright,C.E., Phillips,S.E.,
            Cavaggioni,A., Findlay,J.B. and North,A.C.
  TITLE     Pheromone binding to two rodent urinary proteins revealed by X-ray
            crystallography
  JOURNAL   Nature 360 (6400), 186-188 (1992)
   PUBMED   1279439
REFERENCE   7  (bases 1 to 888)
  AUTHORS   Held,W.A., Gallagher,J.F., Hohman,C.M., Kuhn,N.J., Sampsell,B.M.
            and Hughes,R.G. Jr.
  TITLE     Identification and characterization of functional genes encoding
            the mouse major urinary proteins
  JOURNAL   Mol Cell Biol 7 (10), 3705-3712 (1987)
   PUBMED   2824995
REFERENCE   8  (bases 1 to 888)
  AUTHORS   Clark,A.J., Ghazal,P., Bingham,R.W., Barrett,D. and Bishop,J.O.
  TITLE     Sequence structures of a mouse major urinary protein gene and
            pseudogene compared
  JOURNAL   EMBO J 4 (12), 3159-3165 (1985)
   PUBMED   3004935
REFERENCE   9  (bases 1 to 888)
  AUTHORS   Ghazal,P., Clark,A.J. and Bishop,J.O.
  TITLE     Evolutionary amplification of a pseudogene
  JOURNAL   Proc Natl Acad Sci U S A 82 (12), 4182-4185 (1985)
   PUBMED   3858875
REFERENCE   10 (bases 1 to 888)
  AUTHORS   Clark,A.J., Clissold,P.M., Al Shawi,R., Beattie,P. and Bishop,J.
  TITLE     Structure of mouse major urinary protein genes: different splicing
            configurations in the 3'-non-coding region
  JOURNAL   EMBO J 3 (5), 1045-1052 (1984)
   PUBMED   6329733
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX470151.16.
            
            On or before Dec 4, 2010 this sequence version replaced
            XM_003084581.1, XM_003084579.1, XM_003084580.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA457641.1, CA478593.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               BX470151.16        11029-11196         c
            169-302             BX470151.16        10557-10690         c
            303-376             BX470151.16        9714-9787           c
            377-487             BX470151.16        8974-9084           c
            488-589             BX470151.16        8531-8632           c
            590-635             BX470151.16        8322-8367           c
            636-888             BX470151.16        7279-7531           c
FEATURES             Location/Qualifiers
     source          1..888
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 32.89 cM"
     gene            1..888
                     /gene="Mup18"
                     /gene_synonym="100039228; Gm12561; Mup16; Mup6; Mup9"
                     /note="major urinary protein 18"
                     /db_xref="GeneID:100048884"
                     /db_xref="MGI:MGI:3705220"
     exon            1..168
                     /gene="Mup18"
                     /gene_synonym="100039228; Gm12561; Mup16; Mup6; Mup9"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..615
                     /gene="Mup18"
                     /gene_synonym="100039228; Gm12561; Mup16; Mup6; Mup9"
                     /note="Major urinary protein 6; MUP 6; group 1, BS6;
                     alpha-2U-globulin; major urinary protein 9; major urinary
                     protein 16"
                     /codon_start=1
                     /product="major urinary protein 18 precursor"
                     /protein_id="NP_001186262.1"
                     /db_xref="CCDS:CCDS51199.1"
                     /db_xref="GeneID:100048884"
                     /db_xref="MGI:MGI:3705220"
                     /translation="MKMLLLLLCLGLTLVCVHAEEASSTGRNFNVEKINGEWHTIILA
                     SDKREKIEDNGNFRLFLEQIHVLENSLVLKFHTVRDEECSELSMVADKTEKAGEYSVT
                     YDGFNTFTIPKTDYDNFLMAHLINEKDGETFQLMGLYGREPDLSSDIKERFAQLCEEH
                     GILRENIIDLSNANRCLQARE"
     exon            169..302
                     /gene="Mup18"
                     /gene_synonym="100039228; Gm12561; Mup16; Mup6; Mup9"
                     /inference="alignment:Splign:2.1.0"
     exon            303..376
                     /gene="Mup18"
                     /gene_synonym="100039228; Gm12561; Mup16; Mup6; Mup9"
                     /inference="alignment:Splign:2.1.0"
     exon            377..487
                     /gene="Mup18"
                     /gene_synonym="100039228; Gm12561; Mup16; Mup6; Mup9"
                     /inference="alignment:Splign:2.1.0"
     exon            488..589
                     /gene="Mup18"
                     /gene_synonym="100039228; Gm12561; Mup16; Mup6; Mup9"
                     /inference="alignment:Splign:2.1.0"
     exon            590..635
                     /gene="Mup18"
                     /gene_synonym="100039228; Gm12561; Mup16; Mup6; Mup9"
                     /inference="alignment:Splign:2.1.0"
     exon            636..888
                     /gene="Mup18"
                     /gene_synonym="100039228; Gm12561; Mup16; Mup6; Mup9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      863..868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mup18"
                     /gene_synonym="100039228; Gm12561; Mup16; Mup6; Mup9"
                     /note="hexamer: AATAAA"
     polyA_site      888
                     /gene="Mup18"
                     /gene_synonym="100039228; Gm12561; Mup16; Mup6; Mup9"
                     /note="major polyA site"
ORIGIN      
        1 agtggagtgt agccacgatc acaagaaaga cgtggtcctg acagacagac aatcctattc
       61 cctaccaaaa tgaagatgct gctgctgctg ctgtgtttgg gactgaccct agtctgtgtc
      121 catgcagaag aagctagttc tacgggaagg aactttaatg tagaaaagat taatggggaa
      181 tggcatacta ttatcctggc ctctgacaaa agagaaaaga tagaagataa tggcaacttt
      241 agactttttc tggagcaaat ccatgtcttg gagaattcct tagttcttaa attccatact
      301 gtaagagatg aagagtgctc cgaattatct atggttgctg acaaaacaga aaaggctggt
      361 gaatattctg tgacgtatga tggattcaat acatttacta tacctaagac agactatgat
      421 aactttctta tggctcatct cattaacgaa aaggatgggg aaaccttcca gctgatgggg
      481 ctctatggcc gagaaccaga tttgagttca gacatcaagg aaaggtttgc acaactatgt
      541 gaggagcatg gaatccttag agaaaatatc attgacctat ccaatgccaa tcgctgcctc
      601 caggcccgag aatgaagaat ggcctgagcc tccagtgttg agtggagact tctcaccagg
      661 actccaccat catcccttcc tatccataca gcatccccag tataaattct gtgatctgca
      721 ttccatcctg tctcactgag aagtccaata ccagtatatc cacatgttac ctaggatacc
      781 tcatcaagaa tcaaagactt ctttaaattt ctctttgata cacacatgac aatttttcat
      841 gaatttcttc ctcttcctgt tcaataaatg attacccttg cacttaaa
//
