LOCUS       NM_001199995             883 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus major urinary protein 12 (Mup12), mRNA.
ACCESSION   NM_001199995 XM_003084565
VERSION     NM_001199995.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 883)
  AUTHORS   Charkoftaki,G., Wang,Y., McAndrews,M., Bruford,E.A., Thompson,D.C.,
            Vasiliou,V. and Nebert,D.W.
  TITLE     Update on the human and mouse lipocalin (LCN) gene family,
            including evidence the mouse Mup cluster is result of an
            'evolutionary bloom'
  JOURNAL   Hum Genomics 13 (1), 11 (2019)
   PUBMED   30782214
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 883)
  AUTHORS   Hui,X., Zhu,W., Wang,Y., Lam,K.S., Zhang,J., Wu,D., Kraegen,E.W.,
            Li,Y. and Xu,A.
  TITLE     Major urinary protein-1 increases energy expenditure and improves
            glucose intolerance through enhancing mitochondrial function in
            skeletal muscle of diabetic mice
  JOURNAL   J Biol Chem 284 (21), 14050-14057 (2009)
   PUBMED   19336396
REFERENCE   3  (bases 1 to 883)
  AUTHORS   Zhou,Y., Jiang,L. and Rui,L.
  TITLE     Identification of MUP1 as a regulator for glucose and lipid
            metabolism in mice
  JOURNAL   J Biol Chem 284 (17), 11152-11159 (2009)
   PUBMED   19258313
REFERENCE   4  (bases 1 to 883)
  AUTHORS   Timm,D.E., Baker,L.J., Mueller,H., Zidek,L. and Novotny,M.V.
  TITLE     Structural basis of pheromone binding to mouse major urinary
            protein (MUP-I)
  JOURNAL   Protein Sci 10 (5), 997-1004 (2001)
   PUBMED   11316880
REFERENCE   5  (bases 1 to 883)
  AUTHORS   al-Shawi,R., Ghazal,P., Clark,A.J. and Bishop,J.O.
  TITLE     Intraspecific evolution of a gene family coding for urinary
            proteins
  JOURNAL   J Mol Evol 29 (4), 302-313 (1989)
   PUBMED   2514272
REFERENCE   6  (bases 1 to 883)
  AUTHORS   Bishop,J.O., Selman,G.G., Hickman,J., Black,L., Saunders,R.D. and
            Clark,A.J.
  TITLE     The 45-kb unit of major urinary protein gene organization is a
            gigantic imperfect palindrome
  JOURNAL   Mol Cell Biol 5 (7), 1591-1600 (1985)
   PUBMED   4022008
REFERENCE   7  (bases 1 to 883)
  AUTHORS   Sampsell,B.M. and Held,W.A.
  TITLE     Variation in the major urinary protein multigene family in
            wild-derived mice
  JOURNAL   Genetics 109 (3), 549-568 (1985)
   PUBMED   3979814
REFERENCE   8  (bases 1 to 883)
  AUTHORS   Hayakawa,J., Nikaido,H. and Koizumi,T.
  TITLE     Components of major urinary proteins (MUP's) in the mouse. Sex,
            strain, and subspecies differences
  JOURNAL   J Hered 74 (6), 453-456 (1983)
   PUBMED   6643987
REFERENCE   9  (bases 1 to 883)
  AUTHORS   Shaw,P.H., Held,W.A. and Hastie,N.D.
  TITLE     The gene family for major urinary proteins: expression in several
            secretory tissues of the mouse
  JOURNAL   Cell 32 (3), 755-761 (1983)
   PUBMED   6831559
REFERENCE   10 (bases 1 to 883)
  AUTHORS   Krauter,K., Leinwand,L., D'Eustachio,P., Ruddle,F. and Darnell,J.E.
            Jr.
  TITLE     Structural genes of the mouse major urinary protein are on
            chromosome 4
  JOURNAL   J Cell Biol 94 (2), 414-417 (1982)
   PUBMED   7107707
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CU062621.5.
            
            On Jan 6, 2011 this sequence version replaced XM_003084565.1.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI145254.1, CA478758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               CU062621.5         55995-56156         c
            163-296             CU062621.5         55523-55656         c
            297-370             CU062621.5         54680-54753         c
            371-481             CU062621.5         53955-54065         c
            482-583             CU062621.5         53510-53611         c
            584-629             CU062621.5         53300-53345         c
            630-883             CU062621.5         52256-52509         c
FEATURES             Location/Qualifiers
     source          1..883
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 32.86 cM"
     gene            1..883
                     /gene="Mup12"
                     /gene_synonym="100039054; Gm2024; Mup1"
                     /note="major urinary protein 12"
                     /db_xref="GeneID:100039054"
                     /db_xref="MGI:MGI:3780193"
     exon            1..162
                     /gene="Mup12"
                     /gene_synonym="100039054; Gm2024; Mup1"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..609
                     /gene="Mup12"
                     /gene_synonym="100039054; Gm2024; Mup1"
                     /note="Major urinary protein 1; MUP 1"
                     /codon_start=1
                     /product="major urinary protein 12 precursor"
                     /protein_id="NP_001186924.1"
                     /db_xref="CCDS:CCDS51192.1"
                     /db_xref="GeneID:100039054"
                     /db_xref="MGI:MGI:3780193"
                     /translation="MKMLLLLCLGLTLVCVHAEEASSTGRNFNVEKINGEWHTIILAS
                     DKREKIEDNGNFRLFLEQIHVLENSLVLKFHTVRDEECSELSMVADKTEKAGEYSVTY
                     DGFNTFTIPKTDYDNFLMAHLINEKDGETFQLMGLYGREPDLSSDIKERFAQLCEKHG
                     ILRENIIDLSNANRCLQARE"
     exon            163..296
                     /gene="Mup12"
                     /gene_synonym="100039054; Gm2024; Mup1"
                     /inference="alignment:Splign:2.1.0"
     exon            297..370
                     /gene="Mup12"
                     /gene_synonym="100039054; Gm2024; Mup1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..481
                     /gene="Mup12"
                     /gene_synonym="100039054; Gm2024; Mup1"
                     /inference="alignment:Splign:2.1.0"
     exon            482..583
                     /gene="Mup12"
                     /gene_synonym="100039054; Gm2024; Mup1"
                     /inference="alignment:Splign:2.1.0"
     exon            584..629
                     /gene="Mup12"
                     /gene_synonym="100039054; Gm2024; Mup1"
                     /inference="alignment:Splign:2.1.0"
     exon            630..883
                     /gene="Mup12"
                     /gene_synonym="100039054; Gm2024; Mup1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      858..863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mup12"
                     /gene_synonym="100039054; Gm2024; Mup1"
                     /note="hexamer: AATAAA"
     polyA_site      863
                     /gene="Mup12"
                     /gene_synonym="100039054; Gm2024; Mup1"
                     /note="major polyA site"
     polyA_site      883
                     /gene="Mup12"
                     /gene_synonym="100039054; Gm2024; Mup1"
ORIGIN      
        1 ggagtgtagc cacggtcaca agaaagacgt ggtcctgaca gacagacaat cctattccct
       61 accaaaatga agatgctgct gctgctgtgt ttgggactga ccctagtgtg tgtccatgca
      121 gaagaagcta gttctacggg aaggaacttt aatgtagaaa agattaatgg ggaatggcat
      181 actattatcc tggcctctga caaaagagaa aagatagaag ataatggcaa ctttagactt
      241 tttctggagc aaatccatgt cttggagaat tccttagttc ttaaattcca tactgtaaga
      301 gatgaagagt gctcggaatt atctatggtt gctgacaaaa cagaaaaggc tggtgaatat
      361 tctgtgacgt atgatggatt caatacattt actataccta agacagacta tgataacttt
      421 cttatggctc atctcattaa cgaaaaggat ggggaaacct tccagctgat ggggctctat
      481 ggccgagaac cagatttgag ttcagacatc aaggaaaggt ttgcacaact atgtgagaag
      541 catggaatcc ttagagaaaa tatcattgac ctatccaatg ccaatcgctg cctccaggcc
      601 cgagaatgaa gaatggcctg agcctccagt gttgagtgga gacttctcac caggactcca
      661 ccatcatccc ttcctatcca tacagcatcc ccagtataaa ttctgtgatc tgcattccat
      721 cctgtctcac tgagaagtcc aattccagtc tatccacatg ttacctagga tacctcatca
      781 agaatcaaag acttctttaa atttttcttt gatataccca tgacaatttt ttcatgaatt
      841 tcttcctctt cctgttcaat aaatgattac ccttgcactt aaa
//
