LOCUS       NM_031188                927 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus major urinary protein 1 (Mup1), transcript variant 2,
            mRNA.
ACCESSION   NM_031188
VERSION     NM_031188.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 927)
  AUTHORS   Kim,C.J., Singh,C., Lee,C., DiMagno,K., O'Donnell,M., Kaczmarek,M.,
            Ahmed,A., Salvo-Schaich,J., Perez,A., Letsou,W., Sepulveda,M.C.,
            Ramos,R.L. and Hadjiargyrou,M.
  TITLE     Mustn1 ablation in skeletal muscle results in increased glucose
            tolerance concomitant with upregulated GLUT expression in male mice
  JOURNAL   Physiol Rep 11 (9), e15674 (2023)
   PUBMED   37170065
  REMARK    GeneRIF: Mustn1 ablation in skeletal muscle results in increased
            glucose tolerance concomitant with upregulated GLUT expression in
            male mice.
REFERENCE   2  (bases 1 to 927)
  AUTHORS   Comerford,S.A., Hinnant,E.A., Chen,Y. and Hammer,R.E.
  TITLE     Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed
            bile duct development and loss of hepatocyte viability; a
            ribosomopathy-like phenotype that is partially p53-dependent
  JOURNAL   PLoS Genet 19 (1), e1010595 (2023)
   PUBMED   36656901
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 927)
  AUTHORS   Gao,R., Wang,H., Li,T., Wang,J., Ren,Z., Cai,N., Ai,H., Li,S.,
            Lu,Y., Zhu,Y., Shuai,X., He,X., Shi,G. and Chen,Y.
  TITLE     Secreted MUP1 that reduced under ER stress attenuates ER stress
            induced insulin resistance through suppressing protein synthesis in
            hepatocytes
  JOURNAL   Pharmacol Res 187, 106585 (2023)
   PUBMED   36455814
  REMARK    GeneRIF: Secreted MUP1 that reduced under ER stress attenuates ER
            stress induced insulin resistance through suppressing protein
            synthesis in hepatocytes.
REFERENCE   4  (bases 1 to 927)
  AUTHORS   Charkoftaki,G., Wang,Y., McAndrews,M., Bruford,E.A., Thompson,D.C.,
            Vasiliou,V. and Nebert,D.W.
  TITLE     Update on the human and mouse lipocalin (LCN) gene family,
            including evidence the mouse Mup cluster is result of an
            'evolutionary bloom'
  JOURNAL   Hum Genomics 13 (1), 11 (2019)
   PUBMED   30782214
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 927)
  AUTHORS   Sheehan,M.J., Lee,V., Corbett-Detig,R., Bi,K., Beynon,R.J.,
            Hurst,J.L. and Nachman,M.W.
  TITLE     Selection on Coding and Regulatory Variation Maintains
            Individuality in Major Urinary Protein Scent Marks in Wild Mice
  JOURNAL   PLoS Genet 12 (3), e1005891 (2016)
   PUBMED   26938775
  REMARK    GeneRIF: We find that differential transcription of the central Mup
            paralogs within and between individuals significantly increases the
            individuality of pheromone blends
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 927)
  AUTHORS   Groen,A. and Lagerwerf,A.J.
  TITLE     Genetically determined electrophoretic variants of the major
            urinary protein (Mup) complex in mouse urine
  JOURNAL   Anim Blood Groups Biochem Genet 10 (2), 107-114 (1979)
   PUBMED   507473
REFERENCE   7  (bases 1 to 927)
  AUTHORS   Watson,J., Kelly,K., Largen,M. and Taylor,B.A.
  TITLE     The genetic mapping of a defective LPS response gene in C3H/HeJ
            mice
  JOURNAL   J Immunol 120 (2), 422-424 (1978)
   PUBMED   202651
REFERENCE   8  (bases 1 to 927)
  AUTHORS   Watson,J., Largen,M. and McAdam,K.P.
  TITLE     Genetic control of endotoxic responses in mice
  JOURNAL   J Exp Med 147 (1), 39-49 (1978)
   PUBMED   342667
REFERENCE   9  (bases 1 to 927)
  AUTHORS   Taylor,B.A., Bedigian,H.G. and Meier,H.
  TITLE     Genetic studies of the Fv-1 locus of mice: linkage with Gpd-1 in
            recombinant inbred lines
  JOURNAL   J Virol 23 (1), 106-109 (1977)
   PUBMED   196096
REFERENCE   10 (bases 1 to 927)
  AUTHORS   Watson,J., Riblet,R. and Taylor,B.A.
  TITLE     The response of recombinant inbred strains of mice to bacterial
            lipopolysaccharides
  JOURNAL   J Immunol 118 (6), 2088-2093 (1977)
   PUBMED   325138
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR589880.3.
            
            On Jul 2, 2009 this sequence version replaced NM_031188.1.
            
            Transcript Variant: This variant (2) uses an alternate splice
            junction at the 5' end of a coding exon compared to variant 1, that
            causes a frameshift. The resulting isoform (b) has a shorter and
            distinct C-terminus compared to isoform a. Variants 2 and 3 both
            encode isoform b.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091775.1, BI329730.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               CR589880.3         23540-23746         c
            208-341             CR589880.3         23068-23201         c
            342-415             CR589880.3         22225-22298         c
            416-526             CR589880.3         21497-21607         c
            527-628             CR589880.3         21052-21153         c
            629-674             CR589880.3         20842-20887         c
            675-927             CR589880.3         19798-20050         c
FEATURES             Location/Qualifiers
     source          1..927
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 32.85 cM"
     gene            1..927
                     /gene="Mup1"
                     /gene_synonym="Ltn-1; Lvtn-1; Mup-1; Mup-a; Mup10; Mup7;
                     Up-1"
                     /note="major urinary protein 1"
                     /db_xref="GeneID:17840"
                     /db_xref="MGI:MGI:97233"
     exon            1..207
                     /gene="Mup1"
                     /gene_synonym="Ltn-1; Lvtn-1; Mup-1; Mup-a; Mup10; Mup7;
                     Up-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..654
                     /gene="Mup1"
                     /gene_synonym="Ltn-1; Lvtn-1; Mup-1; Mup-a; Mup10; Mup7;
                     Up-1"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; major urinary protein 7; major urinary protein
                     10; MUP 1"
                     /codon_start=1
                     /product="major urinary protein 1 isoform b precursor"
                     /protein_id="NP_112465.2"
                     /db_xref="CCDS:CCDS18231.1"
                     /db_xref="GeneID:17840"
                     /db_xref="MGI:MGI:97233"
                     /translation="MKMLLLLCVGLTLVCVHAEEASSTGRNFNVEKINGEWHTIILAS
                     DKREKIEDNGNFRLFLEQIHVLENSLVLKFHTVRDEECSELSMVADKTEKAGEYSVTY
                     DGFNTFTIPKTDYDNFLMAHLINEKDGETFQLMGLYGREPDLSSDIKERFAQLCEKHG
                     ILRENIIDLSNANRCLQARE"
     exon            208..341
                     /gene="Mup1"
                     /gene_synonym="Ltn-1; Lvtn-1; Mup-1; Mup-a; Mup10; Mup7;
                     Up-1"
                     /inference="alignment:Splign:2.1.0"
     exon            342..415
                     /gene="Mup1"
                     /gene_synonym="Ltn-1; Lvtn-1; Mup-1; Mup-a; Mup10; Mup7;
                     Up-1"
                     /inference="alignment:Splign:2.1.0"
     exon            416..526
                     /gene="Mup1"
                     /gene_synonym="Ltn-1; Lvtn-1; Mup-1; Mup-a; Mup10; Mup7;
                     Up-1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..628
                     /gene="Mup1"
                     /gene_synonym="Ltn-1; Lvtn-1; Mup-1; Mup-a; Mup10; Mup7;
                     Up-1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..674
                     /gene="Mup1"
                     /gene_synonym="Ltn-1; Lvtn-1; Mup-1; Mup-a; Mup10; Mup7;
                     Up-1"
                     /inference="alignment:Splign:2.1.0"
     exon            675..927
                     /gene="Mup1"
                     /gene_synonym="Ltn-1; Lvtn-1; Mup-1; Mup-a; Mup10; Mup7;
                     Up-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgaacccag agagtatata agaacaagca aaggggctgg ggagtggagt gtagccacga
       61 tcacaagaaa gacgtggtcc tgacagacag acaatcctat tccctaccaa aatgaagatg
      121 ctgctgctgc tgtgtgtggg actgacccta gtctgtgtcc atgcagaaga agctagttct
      181 acgggaagga actttaatgt agaaaagatt aatggggaat ggcatactat tatcctggcc
      241 tctgacaaaa gagaaaagat agaagataat ggcaacttta gactttttct ggagcaaatc
      301 catgtcttgg agaattcctt agttcttaaa ttccatactg taagagatga agagtgctcg
      361 gaattatcta tggttgctga caaaacagaa aaggctggtg aatattctgt gacgtatgat
      421 ggattcaata catttactat acctaagaca gactatgata actttcttat ggctcatctc
      481 attaacgaaa aggatgggga aaccttccag ctgatggggc tctatggccg agaaccagat
      541 ttgagttcag acatcaagga aaggtttgca caactatgtg agaagcatgg aatccttaga
      601 gaaaatatca ttgacctatc caatgccaat cgctgcctcc aggcccgaga atgaagaatg
      661 gcctgagcct ccagtgttga gtggagactt ctcaccagga ctccaccatc atcccttcct
      721 atccatacag catccccagt ataaattctg tgatctgcat tccatcctgt ctcactgaga
      781 agtccaattc cagtctatcc acatgttacc taggatacct catcaagaat caaagacttc
      841 tttaaatttt tctttgatat acccatgaca atttttcatg aatttcttcc tcttcctgtt
      901 caataaatga ttacccttgc acttaaa
//
