LOCUS       NM_008645               4657 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus murinoglobulin 1 (Mug1), mRNA.
ACCESSION   NM_008645 XM_981403 XM_981434 XM_981474 XM_981525 XM_981566
            XM_981606
VERSION     NM_008645.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4657)
  AUTHORS   Chalise,U., Daseke,M.J. 2nd, Kalusche,W.J., Konfrst,S.R.,
            Rodriguez-Paar,J.R., Flynn,E.R., Cook,L.M., Becirovic-Agic,M. and
            Lindsey,M.L.
  TITLE     Macrophages secrete murinoglobulin-1 and galectin-3 to regulate
            neutrophil degranulation after myocardial infarction
  JOURNAL   Mol Omics 18 (3), 186-195 (2022)
   PUBMED   35230372
  REMARK    GeneRIF: Macrophages secrete murinoglobulin-1 and galectin-3 to
            regulate neutrophil degranulation after myocardial infarction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4657)
  AUTHORS   Krause,K., Azouz,F., Nakano,E., Nerurkar,V.R. and Kumar,M.
  TITLE     Deletion of Pregnancy Zone Protein and Murinoglobulin-1 Restricts
            the Pathogenesis of West Nile Virus Infection in Mice
  JOURNAL   Front Microbiol 10, 259 (2019)
   PUBMED   30814992
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4657)
  AUTHORS   Shemesh,C.S., Yu,R.Z., Gaus,H.J., Seth,P.P., Swayze,E.E.,
            Bennett,F.C., Geary,R.S., Henry,S.P. and Wang,Y.
  TITLE     Pharmacokinetic and Pharmacodynamic Investigations of ION-353382, a
            Model Antisense Oligonucleotide: Using Alpha-2-Macroglobulin and
            Murinoglobulin Double-Knockout Mice
  JOURNAL   Nucleic Acid Ther 26 (4), 223-235 (2016)
   PUBMED   27031383
  REMARK    GeneRIF: To investigate the pharmacokinetics (PKs) and
            pharmacodynamics (PDs) for ION-353382, an antisense oligonucleotide
            (ASO) targeting scavenger receptor class B type I (SRB1) mRNA,
            using alpha-2-macroglobulin (A2M), murinoglobulin double-knockout
            (DKO), and wild-type mice
REFERENCE   4  (bases 1 to 4657)
  AUTHORS   Bernhard,O.K., Kapp,E.A. and Simpson,R.J.
  TITLE     Enhanced analysis of the mouse plasma proteome using
            cysteine-containing tryptic glycopeptides
  JOURNAL   J Proteome Res 6 (3), 987-995 (2007)
   PUBMED   17330941
REFERENCE   5  (bases 1 to 4657)
  AUTHORS   Ghesquiere,B., Van Damme,J., Martens,L., Vandekerckhove,J. and
            Gevaert,K.
  TITLE     Proteome-wide characterization of N-glycosylation events by
            diagonal chromatography
  JOURNAL   J Proteome Res 5 (9), 2438-2447 (2006)
   PUBMED   16944957
REFERENCE   6  (bases 1 to 4657)
  AUTHORS   Van Leuven,F., Umans,L., Lorent,K., Hilliker,C., Serneels,L.,
            Overbergh,L., Stas,L. and Raymakers,L.
  TITLE     Molecular analysis of the human and mouse alpha 2M family
  JOURNAL   Ann N Y Acad Sci 737, 163-171 (1994)
   PUBMED   7524394
  REMARK    Review article
REFERENCE   7  (bases 1 to 4657)
  AUTHORS   Overbergh,L., Hilliker,C., Lorent,K., Van Leuven,F. and Van den
            Berghe,H.
  TITLE     Identification of four genes coding for isoforms of murinoglobulin,
            the monomeric mouse alpha 2-macroglobulin: characterization of the
            exons coding for the bait region
  JOURNAL   Genomics 22 (3), 530-539 (1994)
   PUBMED   7528167
REFERENCE   8  (bases 1 to 4657)
  AUTHORS   Lorent,K., Overbergh,L., Delabie,J., Van Leuven,F. and Van den
            Berghe,H.
  TITLE     Distribution of mRNA coding for alpha-2-macroglobulin, the
            murinoglobulins, the alpha-2-macroglobulin receptor and the
            alpha-2-macroglobulin receptor associated protein during mouse
            embryogenesis and in adult tissues
  JOURNAL   Differentiation 55 (3), 213-223 (1994)
   PUBMED   7514554
REFERENCE   9  (bases 1 to 4657)
  AUTHORS   Overbergh,L., Torrekens,S., Van Leuven,F. and Van den Berghe,H.
  TITLE     Molecular characterization of the murinoglobulins
  JOURNAL   J Biol Chem 266 (25), 16903-16910 (1991)
   PUBMED   1840592
REFERENCE   10 (bases 1 to 4657)
  AUTHORS   Saito,A. and Sinohara,H.
  TITLE     Murinoglobulin, a novel protease inhibitor from murine plasma.
            Isolation, characterization, and comparison with murine
            alpha-macroglobulin and human alpha-2-macroglobulin
  JOURNAL   J Biol Chem 260 (2), 775-781 (1985)
   PUBMED   2578455
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116120.6, AK149376.1, AK144541.1 and D17910.1.
            
            On Sep 3, 2009 this sequence version replaced NM_008645.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051037.1, AK144541.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC116120.6         88014-88056
            44-2700             AK149376.1         8-2664
            2701-4654           AK144541.1         2659-4612
            4655-4657           D17910.1           294-296
FEATURES             Location/Qualifiers
     source          1..4657
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 57.52 cM"
     gene            1..4657
                     /gene="Mug1"
                     /note="murinoglobulin 1"
                     /db_xref="GeneID:17836"
                     /db_xref="MGI:MGI:99837"
     exon            1..184
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..4529
                     /gene="Mug1"
                     /codon_start=1
                     /product="murinoglobulin-1 precursor"
                     /protein_id="NP_032671.2"
                     /db_xref="CCDS:CCDS39618.1"
                     /db_xref="GeneID:17836"
                     /db_xref="MGI:MGI:99837"
                     /translation="MWKSRRAQLCLFSVLLAFLHSASLLNGDSKYMVLVPSQLYTETP
                     EKICLHLYQLNETVTVTASLVSQSGRKNLFDELVLDKDLFQCVSFIIPRLSSSDEEDF
                     LYVDIKGPTHEFSKRKAVLVKNKESVVFVQTDKPVYKPGQSVKFRVVSMDKMLRPLNE
                     LLPLAYIEDPKKNRIMQWRDIKTENGLKQMSFSLAAEPIQGPYKIVVHKESGEKEEHS
                     FTVMEFVLPRFNVDLKVPNAMSVNDEVLSVTACGKYTYGKPVPGHVKINVCRETETGC
                     REVNSQLDNNGCSTQEVNITELQSKKRNYEVQLFHVNATVTEEGTGLEFSRSGTTKIE
                     RITNKLIFLKADSHFRHGIPFFVKVRLVDIKGDPIPNEKVFIKAQELSYTSATTTDQH
                     GLAEFSIDTTCISGSSLHIKVNHKEEDSCSYFYCMEERHASAKHVAYAVYSLSKSYIY
                     LDTETSSILPCNQIHTVQAHFILKGDLGVLKELIFYYLVMAQGSIIQTGNHTHQVEPG
                     EAPVKGKFALEIPVEFSMVPMAKMLIYTILPDGEVIADSVNFEIEKCLRNKVDLRFST
                     SQSLPASQTRLQVTASPQSLCGLRAVDQSVLLLKPESELSPSWIYNLPGMQQNKFVPS
                     SRLSEDQEDCILYSSWLAEKHTNLVPHGTEKDVYRYVEDMGLTAFTNLMIKLPIICFD
                     YGMVPISAPRVEFDLAFTPEISWSLRTTLSKRPEEPPRKDPSSNDPLTETIRKYFPET
                     WVWDIVTVNSTGLAEVEMTVPDTITEWKAGALCLSNDTGLGLSSVVPLQAFKPFFVEV
                     SLPYSVVRGEAFMLKATVMNYLPTSMQMSVQLEASPDFTAVPVGDDQDSYCLSANGRH
                     TSSWLVTPKSLGNVNFSVSAEAQQSSEPCGSEVATVPETGRKDTVVKVLIVEPEGIKQ
                     EHTFSSLFCASDAEISEKMSLVLPPTVVKDSARAHFSVMGDILSSAIRNTQNLLHMPY
                     GCGEQNMVLFAPNIYVLKYLNETQQLTQKIKTKALGFLRAGYQRELNYKHKDGSYSAF
                     GDQNGEREGNTWLTAFVLKSFAQARAFIFIDESHITHAFTWLSQKQKDNGCFRSSGSL
                     FNNAMKGGVDDEMTLSAYITMALLESSLPATHPVVSKALSCLESSWKTIEQERNASFV
                     YTKALMAYAFALAGNQNKRDEILKSLDEEAIKENNSIHWKRPQKSRKSEHHLYKPQAS
                     SAEVEMNAYVVLARLTAQPAPSPEDLTLSMSTIMWLTKQQNSNGGFSSTQDTVVALDA
                     LSKYGAVTFSRSQKTTLVTIQSTGSFSQKFQVENSNRLLLQQVALPDIPGDYTISVSG
                     EGCVYAQTMLRYNMHLEKQLSAFAIWVQTVPLTCNNPKGHNSFQISLEISYTGSRPAS
                     NMVIADVKMLSGFIPLKPTVKKLERLEHVSRTEVSNNNVLIYLDQVTNQTLAFSFIIQ
                     QDIPVRNLQPAIVKVYDYYETDEMAFAEYSSPCSTDKQNV"
     exon            185..368
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            369..528
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            529..581
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..602
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            603..771
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            772..856
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            857..944
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1062
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1172
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1334
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1562
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1626
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1775
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1925
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2084
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2166
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2344
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2573
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..2700
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..2822
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            2823..2874
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..2958
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..3135
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3223
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            3224..3380
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            3381..3455
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            3456..3636
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            3637..3860
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            3861..4079
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            4080..4207
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            4208..4298
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            4299..4367
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            4368..4470
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            4471..4512
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     exon            4513..4657
                     /gene="Mug1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4636..4641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mug1"
                     /note="hexamer: AATAAA"
     polyA_site      4657
                     /gene="Mug1"
                     /note="major polyA site"
ORIGIN      
        1 gagaggactc ataaataagc cggctgtaga ggactctgga gacagtgtta aggaggagac
       61 accataagcc ctgtcctcct gtcctttctt accacaccat gtggaagagc agacgggctc
      121 agttgtgcct tttttcggtt ctccttgcct tcctgcattc tgcttcttta ctcaacggag
      181 actcgaagta tatggtgctg gtcccttctc agctctacac tgagacccct gagaaaatct
      241 gcctccatct ataccagctg aatgaaacag tgaccgtcac agcttccttg gtatctcaat
      301 caggaaggaa aaacctgttc gatgagctgg tgcttgacaa ggacttgttc caatgtgttt
      361 ccttcattat ccctagactc tcctcttctg atgaggagga ttttctctac gtggacatca
      421 aagggccaac ccacgaattc agcaaaagga aagcagtgct tgtgaagaac aaagaaagtg
      481 ttgtctttgt gcagacagat aagcccgtgt acaagccagg acaatcagtt aaatttcggg
      541 ttgtctctat ggataaaatg ctacgtcccc tgaatgagtt gcttcctctg gcttacattg
      601 aggatccgaa aaagaaccga attatgcagt ggagggatat taagactgag aatgggctta
      661 agcaaatgtc cttcagcctg gcagcagagc ccattcaggg cccctacaag atagtggtgc
      721 acaaagagtc aggggagaag gaagaacact cctttactgt gatggaattt gtgcttccca
      781 gatttaatgt cgacctgaag gtcccaaatg ccatgtctgt gaatgatgaa gtgctcagtg
      841 tgactgcatg tgggaaatat acctatggga agcctgttcc aggacatgtg aagataaacg
      901 tctgccgtga gactgagact ggatgcagag aagtcaattc tcagctagac aacaatggct
      961 gcagtacaca agaagtgaac atcactgagc tccaatcaaa gaaaaggaat tatgaggttc
     1021 agcttttcca tgtgaatgca actgttacag aagaagggac aggattggag ttcagtcgat
     1081 ctggaacaac taaaattgaa agaatcacaa acaagctcat atttctgaag gcagattcac
     1141 acttcagaca tggaattcca ttctttgtga aagtccgcct agtggatatc aagggagacc
     1201 ctatcccaaa tgagaaagtc ttcatcaaag cacaagaact tagctatacc agtgctacta
     1261 ccactgatca gcatggcctg gcagagttct ccatagatac cacatgcatc tcgggctctt
     1321 ccctccatat caaagtcaac cacaaagagg aagattcatg ttcctatttc tattgcatgg
     1381 aggaaagaca tgcaagtgca aagcatgtgg cctatgctgt ttactccctc agcaagagct
     1441 acatctacct tgacacagag accagcagca tcttgccctg caaccagatt cacacagttc
     1501 aggcacattt tattctgaag ggggacttgg gagtgctgaa agagctcatt ttctactacc
     1561 tggtcatggc gcagggaagc atcatccaga ctggaaacca tactcaccag gtggagccag
     1621 gagaagctcc agtaaaagga aaatttgcct tggagatccc tgtggagttt agcatggtcc
     1681 ccatggctaa aatgctcatc tacacgatct tgcctgatgg agaagtgatt gcagattctg
     1741 taaactttga aattgaaaag tgtcttcgca acaaagtgga cctgcgcttc agcacttctc
     1801 aaagtcttcc cgcctcacaa acccgtctgc aggtcacagc ttctcctcag tccctctgtg
     1861 gcctgagagc tgtggaccag agtgtgctac tcctgaaacc cgagtctgag ctctcccctt
     1921 cctggatata caatctgcca ggtatgcagc aaaacaaatt cgttccaagt tcccgtctgt
     1981 ctgaagacca agaagactgt atactgtaca gttcatggtt ggctgagaag cacacaaact
     2041 tagtaccaca tggaactgag aaggatgtct atagatatgt ggaggacatg ggtttaacag
     2101 cattcaccaa cttgatgatc aaacttccta taatttgttt tgactatggc atggttccaa
     2161 tatcagcacc tcgtgtggaa tttgatcttg catttacccc tgaaatttct tggagtttac
     2221 gcacaacatt gagtaaaaga cctgaagagc caccacgtaa agatccatca tcgaatgatc
     2281 cacttacaga gaccattcga aaatattttc ctgaaacctg ggtctgggat atagtcacag
     2341 taaactccac aggactggct gaagtggaaa tgactgtccc tgacaccatc actgaatgga
     2401 aggcaggagc tctctgcttg tccaatgaca ctggccttgg cctctcttct gtggtacctc
     2461 tccaagcctt caagcccttc tttgtggagg tctcattgcc ctattctgtg gtccgtggag
     2521 aagccttcat gctcaaggcc actgtgatga actatctccc cacaagcatg cagatgagtg
     2581 tgcagctgga agcctctcct gatttcacag ctgtcccagt gggagacgac caagattctt
     2641 actgcctcag tgccaatggg aggcacacct catcctggct ggtaactccc aagtctttag
     2701 ggaatgtgaa tttctctgtg tctgcggaag cacaacagtc ctcagagccc tgtggttctg
     2761 aggtggccac agttcctgaa actgggagaa aggacacagt agtcaaagtc ctgatagttg
     2821 agcctgaagg aatcaagcaa gagcatacct tcagctcact gttctgtgca tcagatgctg
     2881 agatatctga aaaaatgtcc ctggtcctcc caccaacagt agtgaaagat tcagcaagag
     2941 cccatttctc tgtgatgggt gatatcttga gttcagccat aagaaacaca caaaaccttc
     3001 tccatatgcc ctatggctgt ggggagcaga acatggtcct ttttgctccc aacatctacg
     3061 tactgaaata tctgaatgaa acccaacagc tgactcagaa gatcaagact aaagcccttg
     3121 ggttcctcag agctggttat cagagagagc tgaactacaa acacaaggat ggctcctaca
     3181 gtgccttcgg ggatcaaaat ggcgaaagag aaggaaacac ttggctcaca gcctttgtgc
     3241 tcaagtcttt tgcccaagct cgagccttca tcttcatcga tgaatcacac atcacccatg
     3301 ccttcacctg gctctcccaa aagcagaagg acaatggctg cttccggagc tccggatcat
     3361 tgttcaacaa tgccatgaag gggggagtag atgatgaaat gaccctctct gcctacataa
     3421 ccatggccct tctggaaagt tcactcccag ccacgcatcc tgttgtctcc aaagccctga
     3481 gctgcctgga gtcatcctgg aagaccatag aacaagaacg aaatgccagc tttgtgtaca
     3541 ccaaggcttt gatggcctat gcttttgctc tggcggggaa ccagaataag agagatgaaa
     3601 tcctgaagtc acttgatgag gaagctataa aagaaaacaa ctctatccac tggaaaagac
     3661 ctcagaaatc caggaaatct gaacaccatt tgtacaaacc ccaggcttcc tctgctgaag
     3721 tagagatgaa tgcatatgtg gtcctggctc gcctcactgc ccagccagcc ccatcccctg
     3781 aggatctgac tttgtcaatg agcaccatca tgtggctcac aaagcaacag aattccaatg
     3841 gtggcttctc ctccacacag gacactgtgg tggcccttga tgctctgtcc aaatatggag
     3901 cagtgacttt ttcgagaagt cagaaaacga ctttggtgac tatccaatct acagggtcat
     3961 tttcccaaaa gttccaagtg gagaacagta atcgcctgtt actacagcag gtcgcattac
     4021 cagacattcc tggggactat accatcagtg tgtcagggga aggatgtgtg tatgctcaga
     4081 ctatgctgag atacaacatg cacttggaga agcagctgtc tgcatttgct atatgggtac
     4141 agacagtacc tctaacttgt aataacccca aaggccacaa cagcttccag atctcactag
     4201 aaatcagtta cacaggcagc cggccagcct ccaacatggt gattgctgat gtgaagatgc
     4261 tatctggttt catcccattg aaaccaacag tgaaaaagct tgaaagatta gagcacgtga
     4321 gcagaacaga agtgagcaac aacaatgtct taatatattt ggatcaggtg accaatcaga
     4381 cactggcctt ctccttcatc attcaacaag atatcccagt aaggaacctg cagcctgcca
     4441 ttgtgaaagt ctatgactac tatgagacag atgaaatggc ttttgctgaa tacagcagcc
     4501 cctgcagcac agacaaacaa aatgtttgaa actcctattt gtagacaagg cattgctgga
     4561 atccccagac ccaggaacct tcaagatggt gatttgtgtt tgtctctgaa atacaactac
     4621 tgaacaagct tgataaataa atgcctagtc ctcgaga
//
