LOCUS       NM_009267                651 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus mucin-like 2 (Mucl2), mRNA.
ACCESSION   NM_009267
VERSION     NM_009267.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 651)
  AUTHORS   Aure,M.H., Symonds,J.M., Villapudua,C.U., Dodge,J.T., Werner,S.,
            Knosp,W.M. and Hoffman,M.P.
  TITLE     FGFR2 is essential for salivary gland duct homeostasis and
            MAPK-dependent seromucous acinar cell differentiation
  JOURNAL   Nat Commun 14 (1), 6485 (2023)
   PUBMED   37838739
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 651)
  AUTHORS   Kont,V., Laan,M., Kisand,K., Merits,A., Scott,H.S. and Peterson,P.
  TITLE     Modulation of Aire regulates the expression of tissue-restricted
            antigens
  JOURNAL   Mol Immunol 45 (1), 25-33 (2008)
   PUBMED   17599412
  REMARK    GeneRIF: The data underline a direct role for Aire in
            tissue-restricted antigens expression and suggest that modulation
            of Aire has a potential to control central tolerance and
            autoimmunity.
REFERENCE   3  (bases 1 to 651)
  AUTHORS   Ozyildirim,A.M., Wistow,G.J., Gao,J., Wang,J., Dickinson,D.P.,
            Frierson,H.F. Jr. and Laurie,G.W.
  TITLE     The lacrimal gland transcriptome is an unusually rich source of
            rare and poorly characterized gene transcripts
  JOURNAL   Invest Ophthalmol Vis Sci 46 (5), 1572-1580 (2005)
   PUBMED   15851553
REFERENCE   4  (bases 1 to 651)
  AUTHORS   Akiyama,T., Maeda,S., Yamane,S., Ogino,K., Kasai,M., Kajiura,F.,
            Matsumoto,M. and Inoue,J.
  TITLE     Dependence of self-tolerance on TRAF6-directed development of
            thymic stroma
  JOURNAL   Science 308 (5719), 248-251 (2005)
   PUBMED   15705807
REFERENCE   5  (bases 1 to 651)
  AUTHORS   Myal,Y., Iwasiow,B., Yarmill,A. and Shiu,R.P.
  TITLE     A new member of the hormonally regulated rodent submaxillary gland
            glycoprotein gene family: cDNA cloning and tissue specific
            expression
  JOURNAL   Mol Cell Endocrinol 120 (2), 133-138 (1996)
   PUBMED   8832572
REFERENCE   6  (bases 1 to 651)
  AUTHORS   Dickinson,D.P., Abel,K., Near,J., Taylor,B.A. and Gross,K.W.
  TITLE     Genetic and tissue-specific variation in the expression of a
            closely linked murine multigene family on chromosome 15 that
            encodes salivary and lacrimal proteins
  JOURNAL   Biochem Genet 27 (9-10), 613-637 (1989)
   PUBMED   2482730
REFERENCE   7  (bases 1 to 651)
  AUTHORS   Dickinson,D.P., Mirels,L., Tabak,L.A. and Gross,K.W.
  TITLE     Rapid evolution of variants in a rodent multigene family encoding
            salivary proteins
  JOURNAL   Mol Biol Evol 6 (1), 80-102 (1989)
   PUBMED   2921944
REFERENCE   8  (bases 1 to 651)
  AUTHORS   Windass,J.D., Mullins,J.J., Beecroft,L.J., George,H., Meacock,P.A.,
            Williams,B.R. and Brammar,W.J.
  TITLE     Molecular cloning of cDNAs from androgen-independent mRNA species
            of DBA/2 mouse sub-maxillary glands
  JOURNAL   Nucleic Acids Res 12 (3), 1361-1376 (1984)
   PUBMED   6546617
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK616968.1 and CK616337.1.
            
            On Jul 25, 2009 this sequence version replaced NM_009267.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF538299.1, BY706230.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-635               CK616968.1         2-636
            636-651             CK616337.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..651
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15"
     gene            1..651
                     /gene="Mucl2"
                     /gene_synonym="Spt-1; Spt1"
                     /note="mucin-like 2"
                     /db_xref="GeneID:20770"
                     /db_xref="MGI:MGI:98392"
     exon            1..129
                     /gene="Mucl2"
                     /gene_synonym="Spt-1; Spt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..488
                     /gene="Mucl2"
                     /gene_synonym="Spt-1; Spt1"
                     /note="16.5 kDa submandibular gland glycoprotein; salivary
                     protein 1; mucin-like protein 2"
                     /codon_start=1
                     /product="mucin-like protein 2 precursor"
                     /protein_id="NP_033293.2"
                     /db_xref="CCDS:CCDS57015.1"
                     /db_xref="GeneID:20770"
                     /db_xref="MGI:MGI:98392"
                     /translation="MKFLALLVLLGVSTILVSCQDPETNSTETSGTADSAGENTGSET
                     QADSTDQNQEVDSSDSVEEENVNTDDTNTANEASEEDNKEELNDNSTGDNTSDQNSGV
                     DNTETEDESNAKTKLENMKTVIKSGVEKLKNFLQRG"
     exon            130..168
                     /gene="Mucl2"
                     /gene_synonym="Spt-1; Spt1"
                     /inference="alignment:Splign:2.1.0"
     exon            169..438
                     /gene="Mucl2"
                     /gene_synonym="Spt-1; Spt1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..639
                     /gene="Mucl2"
                     /gene_synonym="Spt-1; Spt1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      610..615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mucl2"
                     /gene_synonym="Spt-1; Spt1"
                     /note="hexamer: AATAAA"
     polyA_site      639
                     /gene="Mucl2"
                     /gene_synonym="Spt-1; Spt1"
                     /note="major polyA site"
ORIGIN      
        1 gtcaagagtc ttccttgtct cctggtattg gagcttgatc ttgtgtgttt cctgctcttc
       61 tacttgtcac catgaagttc ctggcactcc ttgtgttgct tggtgtttcc actatcctag
      121 tctcttgcca ggacccggag acaaacagta ctgaaacttc tggaactgct gattctgctg
      181 gtgaaaatac tggctctgaa actcaggcag atagtactga tcaaaatcaa gaagttgatt
      241 cctctgattc agtcgaagaa gaaaatgtga acactgatga taccaacact gctaatgagg
      301 cctctgagga agacaacaag gaagagttaa atgataacag taccggggat aatacctctg
      361 atcagaacag tggcgttgac aacactgaaa cggaagacga gtccaatgca aaaactaaac
      421 ttgaaaacat gaaaaccgtt attaaaagtg gggttgaaaa actaaagaat ttcttacaac
      481 gtggatgagt ttgcatcttc tactactgat ctttctgaaa cagactagca cattcttgat
      541 ttgatttcct ccagttattt atcctgacta ttctccctct ctctcattgc taacttttat
      601 cttttatcaa ataaattgta atcatgagca gcatcaaaaa aaaaaaaaaa a
//
