LOCUS       NP_034974               3454 aa            linear   ROD 02-MAY-2024
DEFINITION  mucin-5AC precursor [Mus musculus].
ACCESSION   NP_034974 XP_133960 XP_980779 XP_998211
VERSION     NP_034974.2
DBSOURCE    REFSEQ: accession NM_010844.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 3454)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 3454)
  AUTHORS   Shi,J., Ma,C., Hao,X., Luo,H. and Li,M.
  TITLE     [Dickkopf-1 inhibits the secretion of MUC5AC induced by Mycoplasma
            pneumoniae P1-C in mouse lung epithelial cells]
  JOURNAL   Sheng Wu Gong Cheng Xue Bao 39 (1), 248-261 (2023)
   PUBMED   36738214
  REMARK    GeneRIF: [Dickkopf-1 inhibits the secretion of MUC5AC induced by
            Mycoplasma pneumoniae P1-C in mouse lung epithelial cells].
REFERENCE   3  (residues 1 to 3454)
  AUTHORS   Wu,F., Li,X., Looso,M., Liu,H., Ding,D., Gunther,S., Kuenne,C.,
            Liu,S., Weissmann,N., Boettger,T., Atzberger,A., Kolahian,S.,
            Renz,H., Offermanns,S., Gartner,U., Potente,M., Zhou,Y., Yuan,X.
            and Braun,T.
  TITLE     Spurious transcription causing innate immune responses is prevented
            by 5-hydroxymethylcytosine
  JOURNAL   Nat Genet 55 (1), 100-111 (2023)
   PUBMED   36539616
REFERENCE   4  (residues 1 to 3454)
  AUTHORS   Deng,J., Tang,H., Zhang,Y., Yuan,X., Ma,N., Hu,H., Wang,X., Liu,C.,
            Xu,G., Li,Y., Wang,S., Guo,L. and Wang,X.
  TITLE     House dust mite-induced endoplasmic reticulum stress mediates
            MUC5AC hypersecretion via TBK1 in airway epithelium
  JOURNAL   Exp Lung Res 49 (1), 49-62 (2023)
   PUBMED   36719141
  REMARK    GeneRIF: House dust mite-induced endoplasmic reticulum stress
            mediates MUC5AC hypersecretion via TBK1 in airway epithelium.
REFERENCE   5  (residues 1 to 3454)
  AUTHORS   Vial,Y., Lainey,E., Leblanc,T., Baudouin,V., Dourthe,M.E.,
            Gressens,P., Verloes,A., Cave,H. and Drunat,S.
  TITLE     De novo NUF2 variant in a novel inherited bone marrow failure
            syndrome including microcephaly and renal hypoplasia
  JOURNAL   Br J Haematol 199 (5), 739-743 (2022)
   PUBMED   36111525
  REMARK    GeneRIF: De novo NUF2 variant in a novel inherited bone marrow
            failure syndrome including microcephaly and renal hypoplasia.
REFERENCE   6  (residues 1 to 3454)
  AUTHORS   Tomasetto,C., Masson,R., Linares,J.L., Wendling,C., Lefebvre,O.,
            Chenard,M.P. and Rio,M.C.
  TITLE     pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of
            mucins
  JOURNAL   Gastroenterology 118 (1), 70-80 (2000)
   PUBMED   10611155
REFERENCE   7  (residues 1 to 3454)
  AUTHORS   Cressman,V.L., Hicks,E.M., Funkhouser,W.K., Backlund,D.C. and
            Koller,B.H.
  TITLE     The relationship of chronic mucin secretion to airway disease in
            normal and CFTR-deficient mice
  JOURNAL   Am J Respir Cell Mol Biol 19 (6), 853-866 (1998)
   PUBMED   9843919
REFERENCE   8  (residues 1 to 3454)
  AUTHORS   Inatomi,T., Tisdale,A.S., Zhan,Q., Spurr-Michaud,S. and Gipson,I.K.
  TITLE     Cloning of rat Muc5AC mucin gene: comparison of its structure and
            tissue distribution to that of human and mouse homologues
  JOURNAL   Biochem Biophys Res Commun 236 (3), 789-797 (1997)
   PUBMED   9245735
REFERENCE   9  (residues 1 to 3454)
  AUTHORS   Shekels,L.L., Lyftogt,C., Kieliszewski,M., Filie,J.D., Kozak,C.A.
            and Ho,S.B.
  TITLE     Mouse gastric mucin: cloning and chromosomal localization
  JOURNAL   Biochem J 311 (Pt 3) (Pt 3), 775-785 (1995)
   PUBMED   7487932
REFERENCE   10 (residues 1 to 3454)
  AUTHORS   Holmberg,M., Leonardsson,G. and Ny,T.
  TITLE     The species-specific differences in the cAMP regulation of the
            tissue-type plasminogen activator gene between rat, mouse and human
            is caused by a one-nucleotide substitution in the cAMP-responsive
            element of the promoters
  JOURNAL   Eur J Biochem 231 (2), 466-474 (1995)
   PUBMED   7543410
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC175658.3 and AC175742.5.
            
            On Mar 8, 2019 this sequence version replaced NP_034974.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN00849376, SAMN00849377
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            inferred exon combination        :: based on alignments, homology
            RefSeq Select criteria           :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3454
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 87.23 cM"
     Protein         1..3454
                     /product="mucin-5AC precursor"
                     /note="gastric mucin"
                     /calculated_mol_wt=369197
     sig_peptide     1..27
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2877
     Region          73..226
                     /region_name="VWD"
                     /note="von Willebrand factor (vWF) type D domain;
                     smart00216"
                     /db_xref="CDD:214566"
     Region          264..333
                     /region_name="C8"
                     /note="C8 domain; pfam08742"
                     /db_xref="CDD:462584"
     Region          337..393
                     /region_name="TIL"
                     /note="trypsin inhibitor-like cysteine rich domain;
                     cd19941"
                     /db_xref="CDD:410995"
     Site            order(346,350,363,367)
                     /site_type="other"
                     /note="reactive site [polypeptide binding]"
                     /db_xref="CDD:410995"
     Region          421..585
                     /region_name="VWD"
                     /note="von Willebrand factor (vWF) type D domain;
                     smart00216"
                     /db_xref="CDD:214566"
     Region          622..692
                     /region_name="C8"
                     /note="This domain contains 8 conserved cysteine residues;
                     smart00832"
                     /db_xref="CDD:214843"
     Region          702..759
                     /region_name="TIL"
                     /note="trypsin inhibitor-like cysteine rich domain;
                     cd19941"
                     /db_xref="CDD:410995"
     Site            order(711,715,729,733)
                     /site_type="other"
                     /note="reactive site [polypeptide binding]"
                     /db_xref="CDD:410995"
     Region          800..861
                     /region_name="TIL"
                     /note="trypsin inhibitor-like cysteine rich domain;
                     cd19941"
                     /db_xref="CDD:410995"
     Site            order(809,821,832,837)
                     /site_type="other"
                     /note="reactive site [polypeptide binding]"
                     /db_xref="CDD:410995"
     Region          890..1049
                     /region_name="VWD"
                     /note="von Willebrand factor (vWF) type D domain;
                     smart00216"
                     /db_xref="CDD:214566"
     Region          1086..1160
                     /region_name="C8"
                     /note="This domain contains 8 conserved cysteine residues;
                     smart00832"
                     /db_xref="CDD:214843"
     Region          1395..1481
                     /region_name="Mucin2_WxxW"
                     /note="Mucin-2 protein WxxW repeating region; pfam13330"
                     /db_xref="CDD:463846"
     Region          1605..1691
                     /region_name="Mucin2_WxxW"
                     /note="Mucin-2 protein WxxW repeating region; pfam13330"
                     /db_xref="CDD:463846"
     Region          1766..1856
                     /region_name="Mucin2_WxxW"
                     /note="Mucin-2 protein WxxW repeating region; pfam13330"
                     /db_xref="CDD:463846"
     Region          <2052..2254
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          2308..2394
                     /region_name="Mucin2_WxxW"
                     /note="Mucin-2 protein WxxW repeating region; pfam13330"
                     /db_xref="CDD:463846"
     Region          2469..2559
                     /region_name="Mucin2_WxxW"
                     /note="Mucin-2 protein WxxW repeating region; pfam13330"
                     /db_xref="CDD:463846"
     Region          2734..2902
                     /region_name="VWD"
                     /note="von Willebrand factor (vWF) type D domain;
                     smart00216"
                     /db_xref="CDD:214566"
     Region          2947..3010
                     /region_name="C8"
                     /note="C8 domain; pfam08742"
                     /db_xref="CDD:462584"
     Region          3007..>3157
                     /region_name="PHA02682"
                     /note="ORF080 virion core protein; Provisional"
                     /db_xref="CDD:177464"
     Region          3339..3411
                     /region_name="CT"
                     /note="C-terminal cystine knot-like domain (CTCK);
                     smart00041"
                     /db_xref="CDD:214482"
     CDS             1..3454
                     /gene="Muc5ac"
                     /gene_synonym="2210005L13Rik; MGM"
                     /coded_by="NM_010844.3:44..10408"
                     /db_xref="GeneID:17833"
                     /db_xref="MGI:MGI:104697"
ORIGIN      
        1 mgvgrrklvp fwvlalalac sqctgqaqqd slksyhehrs dvphpqghvg tplnrvtiip
       61 plktipvvra fnpghtrrvc stwgnfhykt fdgqvfyfpg lcnyvfsahc gdayedfniq
      121 lrrvqesntt tlsrvtmkld glvveltkss vlvnnhpvql pfsqsgvlie lsngylkvva
      181 rlgllfvwne ddsllleldt kytnktcglc gdfngspksn eflsnnvrlt plefgnlqkm
      241 dgpteqcqdp lpvpqkncsa rsgicemilk gelfsgcaal vdissyveac rqdvclcesl
      301 dpsdcichtl aeysrqcaha ggqpqdwrgp nlcsqtcpln mqhqecgspc vdtcsnpqhs
      361 qvcedhciag cfcpegmvld dinqmgcvpv sqcaclyngt lyapgtnyst dctntcsggq
      421 wscqdipcag tcsvmggshm stfdgrqytv hgdctyvlsk pcdsnaftvl velrkcglte
      481 setclktvtl nlgggqteim vkatgevfvn qiytqlpvst anatffrpst ffivgetnlg
      541 lqleiqlspi mqtsvrlkpg lrgltcglcg nfnsmqaddf qtisgvvegt aaaffntfkt
      601 qaacpnvkni fqdpcslsve nekyaqhwcs lltnasgpfs qchatvnpst ffsncmydtc
      661 nceksedcmc aalssyvrac aakgvllsdw rdgictkpti tcpksmtyqy histcqptcr
      721 alnekdvtch vsfipvdgct cpkgtflddl gkcvqatscp cyykgstvpn gesvqdsgai
      781 ctctqgaltc iggpaptpvc dapmiyfdch natpgdtgag cqkschtldm tcyssecvpg
      841 cvcpnglvad gnggcvvted cpcvhneaty rpgetiqvgc nnctcenrmw qctdkpclat
      901 cavygdghyi tfdgqrysfn gdceytllqd ncggngssqd afrvitenip cgttgttcsk
      961 sikiflgnye lklsdskmev vqkdvgqepp yfvhqmgnyl vvetdiglvl lwdkktsifl
     1021 rlspefkgrv cglcgnfddn aindfttrsq svvsdmlefg nswklspscp dvlvpkdpct
     1081 anpyrkswaq kqcsiinset fsachahvep akyyeacvnd acacdsggdc ecfcttvaay
     1141 aqachevgvc vswrtpdicp lfcdyynpeg qcewhyqpcg apcmrtcqnp tgqclqdlrg
     1201 legcypkcpp tapifdegtm qcvsnctvtf pcrvngklyr pgasvpsdkn cdscictesg
     1261 vrcthnagac vctyngqqfh pgeiiyhttd giggcisahc rangtiersv dtcnsttptp
     1321 pttfsfstpp vmtsmqpsst hssptpsvgs sgasskaast tssilsvksp vtapmtmsts
     1381 asavttsgcr eeclwspwmd vsrpgrgids gdfdtlenlr ahgypicqvp kavecraeas
     1441 pgvplpelqq hlecsttvgl icynsdqlsg lcdnyqikvq cctpvscpts qtthvisssr
     1501 ttnldnttss vpvtstehpy sstvtsgsst htpglspsss vpssptpass tpapvssttv
     1561 kttlpitspt peptpaissv sistsgstmp ssettheckq elcnwtnwld gsypgsgrns
     1621 gdfdtfvnlr skgykfcekp rnvecraqff pntpleelgq nvtcsreegl iclnknqlpp
     1681 mcynyeirie cctvvnncst asvtthptsh gvstktetnw tthvyssptk dtsshsatid
     1741 tktwtsgish tttqpvtthc qlqcnwtkwf dtdfpvpgph ggdletysni ersgerlchr
     1801 eeitqlqcra knyperemed lgqvvkcdps vglvcnnrdq ggdsgmclny evrllcchip
     1861 egcsmtthvt llsstseivt sstpgttsmh vasstsmpqt sspntgktst isttqtsspn
     1921 tgktsttstt qtsspntgkt stisttqtss pntgktstts ttqtsspntg ktstisttqt
     1981 sspntgkast pstphtsspn tgktstistt qtsspntgkt sttsttqtss pntgktstis
     2041 ttqtsspntg kastpstpht sspntgktst isttqtsspn tgkastpstp qtsspntgkt
     2101 stisttqtss pntgkgstps tpqtsspntg ktstisttqt sspntgktst tsttqtsspn
     2161 tgktstistt qtsspntgka stpstphtss pntgktstis ttqtsspntg kastpstpqt
     2221 sspntgktst isttqtsspn tgkgstpstp qtsspntgkt sttsttqtss pntgkastis
     2281 ttqtistsgs tmpssetthe ckqelcnwtn wldgsypgsg rnsgdfdtfv nlrskgykfc
     2341 ekprnvecra qffpntplee lgqnvtcsre egliclnknq lppmcynyei riecctvvnn
     2401 cstasvtthp tshgvstkte tnwtthvyss ptkdtsshsa tidtktwtsg ishtttqpvt
     2461 thcqlqcnwt kwfdtdfpvp gphggdlety sniersgerl chreeitqlq craknypere
     2521 medlgqvvkc dpsvglvcnn rdqggdsgmc lnyevrllcc hipedcprtd qtspvtlshk
     2581 pssavvspss vspslstshr vhsttpcfcs vsgqlyplgs iiynqtdldg hcyyamcsqd
     2641 cqvvkrvsqd cpstmpppat tlststtppv tgrdrcnvfp prlrgetwpm pncsqatceg
     2701 nnvislsprq cpelnepsca ngypplkvdd qdgccqhyqc qcvcsgwgdp hyitfdgtyy
     2761 tfldnctyvl vqqivpvfgy frvlidnyyc dvgdsvscpq siiveyhqdr vvltrrpvsg
     2821 vmtnqiifnn kvvspgfqqn givtsrvgik myvtiqeigv rvmfsglifs vevpfnlfan
     2881 ntegqcgtct ndkkdecrlp ggsiasscse mslhwkvpnq pscqgppptp tsvvprpspt
     2941 pcppsplcel ilsntfklch dvipplqfyq gclfdychml dlevvcsgle lyaslcaaqg
     3001 vcipwrsqtn ntcsftcpdn qvyqpcgpsn phycyrddsi spsltlqeag pktegcfcpd
     3061 sttlfstnds icvpscqwcl gprgepvepg htisidcqdc ickeatltcq kkacpqptcp
     3121 epgfvpvpva leagqccpqf scacnsshcp pplhcpknss livtyeegac cptqncssqk
     3181 gcevngtlyq pgdvvssslc erclcevssn plsdvfmvsc etelcntqcp kgseyqampg
     3241 qccgkcipkt cpfknnsgst yfyqpgelwa epgnpcvthk cekfqdvlmv vtmktecpki
     3301 ncpqgqaqlr edgccydcpl pnqqkctvhq rqqiirqqnc ssegpvsisy cqgncgdsis
     3361 mysleankve htceccqelq tsqrnvtlrc ddgssqtfsy tqvekcgclg qqchalgdts
     3421 haesseqefk skeseehgqq lafrvsedml gpfq
//
