LOCUS       NM_146071               2555 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus mucin 20 (Muc20), transcript variant 2, mRNA.
ACCESSION   NM_146071
VERSION     NM_146071.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2555)
  AUTHORS   Jones,M.R., Lingampally,A., Ahmadvand,N., Chong,L., Wu,J.,
            Wilhem,J., Vazquez-Armendariz,A.I., Ansari,M., Herold,S.,
            Ornitz,D.M., Schiller,H.B., Chao,C.M., Zhang,J.S., Carraro,G. and
            Bellusci,S.
  TITLE     FGFR2b signalling restricts lineage-flexible alveolar progenitors
            during mouse lung development and converges in mature alveolar type
            2 cells
  JOURNAL   Cell Mol Life Sci 79 (12), 609 (2022)
   PUBMED   36445537
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2555)
  AUTHORS   Peluso,G., Tian,E., Abusleme,L., Munemasa,T., Mukaibo,T. and Ten
            Hagen,K.G.
  TITLE     Loss of the disease-associated glycosyltransferase Galnt3 alters
            Muc10 glycosylation and the composition of the oral microbiome
  JOURNAL   J Biol Chem 295 (5), 1411-1425 (2020)
   PUBMED   31882545
REFERENCE   3  (bases 1 to 2555)
  AUTHORS   Jones,M.R., Dilai,S., Lingampally,A., Chao,C.M., Danopoulos,S.,
            Carraro,G., Mukhametshina,R., Wilhelm,J., Baumgart-Vogt,E., Al
            Alam,D., Chen,C., Minoo,P., Zhang,J.S. and Bellusci,S.
  TITLE     A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b
            Signaling on Epithelial Tip Progenitor Cells During Early Mouse
            Lung Branching Morphogenesis
  JOURNAL   Front Genet 9, 746 (2019)
   PUBMED   30728831
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2555)
  AUTHORS   Ray,J.P., Staron,M.M., Shyer,J.A., Ho,P.C., Marshall,H.D.,
            Gray,S.M., Laidlaw,B.J., Araki,K., Ahmed,R., Kaech,S.M. and
            Craft,J.
  TITLE     The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling,
            Differentiation, and Metabolism of T Helper 1 and Follicular B
            Helper T Cells
  JOURNAL   Immunity 43 (4), 690-702 (2015)
   PUBMED   26410627
REFERENCE   5  (bases 1 to 2555)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   6  (bases 1 to 2555)
  AUTHORS   Higuchi,T., Orita,T., Katsuya,K., Yamasaki,Y., Akiyama,K., Li,H.,
            Yamamoto,T., Saito,Y. and Nakamura,M.
  TITLE     MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras
            pathway by binding to a multifunctional docking site of met
  JOURNAL   Mol Cell Biol 24 (17), 7456-7468 (2004)
   PUBMED   15314156
  REMARK    GeneRIF: Results suggest that MUC20 is a novel regulator of the Met
            signaling cascade which has a role in suppression of the Grb2-Ras
            pathway.
REFERENCE   7  (bases 1 to 2555)
  AUTHORS   Higuchi,T., Orita,T., Nakanishi,S., Katsuya,K., Watanabe,H.,
            Yamasaki,Y., Waga,I., Nanayama,T., Yamamoto,Y., Munger,W.,
            Sun,H.W., Falk,R.J., Jennette,J.C., Alcorta,D.A., Li,H.,
            Yamamoto,T., Saito,Y. and Nakamura,M.
  TITLE     Molecular cloning, genomic structure, and expression analysis of
            MUC20, a novel mucin protein, up-regulated in injured kidney
  JOURNAL   J Biol Chem 279 (3), 1968-1979 (2004)
   PUBMED   14565953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB661244.1 and AK165477.1.
            
            On Mar 17, 2009 this sequence version replaced NM_146071.1.
            
            Transcript Variant: This variant (2) differs in the 3' coding
            region and 3' UTR, compared to variant 1. The encoded isoform (b)
            has a distinct C-terminus and is shorter than isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK165477.1, AB098732.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BB661244.1         2-9
            9-2555              AK165477.1         1-2547
FEATURES             Location/Qualifiers
     source          1..2555
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 23.34 cM"
     gene            1..2555
                     /gene="Muc20"
                     /note="mucin 20"
                     /db_xref="GeneID:224116"
                     /db_xref="MGI:MGI:2385039"
     exon            1..119
                     /gene="Muc20"
                     /inference="alignment:Splign:2.1.0"
     exon            120..1853
                     /gene="Muc20"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1945
                     /gene="Muc20"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2555
                     /gene="Muc20"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2300
                     /gene="Muc20"
                     /note="major polyA site"
ORIGIN      
        1 agcaggcagg tccggcagac agcggtggtc agggccaggc acgatgggct ctgtctgggg
       61 cctggctgtg cccctccttg tcttctgctg gaaggttggc gtcagtgtga gctctccagg
      121 tctcgacatt agcagatcag ttcctttggt gacaaccaac aacatggaag tgtccacctt
      181 cactcaaagg gacaggccca gctcagagag agctttccag accaccaacc tgattcagta
      241 tgtacctcta gacacgcaaa ctctcagcac tgaatctgct tctaatgctt taagtgcaac
      301 tagtatcagt tcagaggtca attccagaga cactcagacc acctcttttg taacaaagac
      361 caggaagaca catactacca ctcctgcagc atcatcccta gaggcccaga ccacctctcc
      421 taatttgtca accctgaata ttcagattac ctccccaata gcatcgtccc tggatgctca
      481 gaccattttt cctgtatcat tatccctgag tacccagacc acttctcctg caccatcatt
      541 cctggatacc caaaccactt cccctgaacc atcatctctg accacttccc ctgcaccatc
      601 atctctgatc acttctccta ctccatcatc tctaactaca tcccctgcac catcattcct
      661 ggatacccag accacttccc ctgcaccatc atctctgacc acttcccctg caccatcatc
      721 cctagatacc cagaccatct cacctattga attgacccta aagacccaaa ccatttccac
      781 tgtaacggag accagaacgg tttcaataag aataccttct gacctcacgg ttatgcacac
      841 catccctaca gagacattgg caccaagcaa cagccccaga actgggatga gcactgtcca
      901 aactggcaca gtgtgggact ccatagaagc cgtctttgac accctttgta ccgatgacag
      961 ctctgaagag gcaaggaaga tcacagttga cctcctgacg ttggcacaca cctccacgga
     1021 agtggagtac ctgtcttcag agagcagctc ttcctctgac agttcagctg gggtcctcag
     1081 cagctcacga gtcctgggac ccgacagtgc aactccagcc aaggggttgg ttgccttcaa
     1141 catcactcat attaaactca gcaactgcat cacagaaata gaaacaacca tcaccatctc
     1201 tggggcccca ggcgcgagcc tcagccctac agaagcgacg gcagctttgt tcacttctga
     1261 gatattaact ttgcctccac ccactgaggc aaaaccaatt ttccccgaga ccacaagctt
     1321 atctgggatc ctgtcaactg ctggcacccc ggcccttgcc accacccttg aggggacagt
     1381 ctccactagt gcaatcacag aaagcgaaac agcagtggcc cagactctta cctctgttgg
     1441 aacttcggtg acagttagaa ggaaccccct ggaaaacact tcaacactct ctattgagac
     1501 acaaagccac actgaggtct tgggcaccat cacagtcccc atggttgctg gatcaacaat
     1561 gggagaagca gcctccttcg tgagtttcac ggctctcgac agcagcagtc tctcagtggt
     1621 ggtcaccacc gagagctctg ctacctcaga gactttaacc acaggcaata caaccaacag
     1681 ctccttcctc acagagagcc accctccttt ttctatctat tcaactacag ctagcaccag
     1741 caaaaaccca aacatcacct taaccaagac cacagcctca ccaaagcccc cgacgcatcc
     1801 tacaacatct gcatccactg cttggataag gaaaaccaca aaacatgatc caggtgaaga
     1861 tggaggcttc ctccttgtac ggctgaccgt ggcctcccct aaggacctca ctgagcacaa
     1921 cgccagagag aagctgatga accagctccg ccgtgaactg cacgcccgca tgccacttgt
     1981 ccacatgtcc ttcctgagca tcaggagggg ttgaggaatg ctagctgcaa ccaggcatgg
     2041 cctctgtgcc agaagaacgg tgatgccacc gaggcccaaa cgctaccaac agaccacagc
     2101 cacagttctg tgctatggac tccaaagttt ctcatgaagg ccagctggct cgagagccct
     2161 cccccatacc tgaccacaag accttggtcc acttatgcct gagtgtatgt gcaaggggag
     2221 gggctgacct cttttcagag atgtccctca catcctctgc ctggttattg tatttcggta
     2281 aagggagacc tgatcactca cctgtgctct tctgttttgt actcagtgac cctcagtata
     2341 acctcagaga ttatctgtag ggatcccagg tgccttagat gtttttacta cgtgggaatt
     2401 tggggagtga tttcctgttg cctgatttgg tttgacattt ttaccaagac ttgccctgga
     2461 gcctgttgaa ccttgagcaa tctgtattag tcagctgcca ctagagcaaa atgtgagatc
     2521 aacagcttat aatgaaaaaa agcttatttc tgctc
//
