LOCUS       NM_010843              14065 bp    mRNA    linear   ROD 08-FEB-2024
DEFINITION  Mus musculus mucin 17, cell surface associated (Muc17), mRNA.
ACCESSION   NM_010843 XM_006504541
VERSION     NM_010843.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 14065)
  AUTHORS   Schneider,H., Pelaseyed,T., Svensson,F. and Johansson,M.E.V.
  TITLE     Study of mucin turnover in the small intestine by in vivo labeling
  JOURNAL   Sci Rep 8 (1), 5760 (2018)
   PUBMED   29636525
  REMARK    GeneRIF: Muc17 (= Muc3) showed stable expression over time at the
            plasma membrane on villi tips, in crypts and at crypt openings. (In
            humans: Muc3 = Muc17)
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14065)
  AUTHORS   Harrow,J.L., Steward,C.A., Frankish,A., Gilbert,J.G.,
            Gonzalez,J.M., Loveland,J.E., Mudge,J., Sheppard,D., Thomas,M.,
            Trevanion,S. and Wilming,L.G.
  TITLE     The Vertebrate Genome Annotation browser 10 years on
  JOURNAL   Nucleic Acids Res 42 (Database issue), D771-D779 (2014)
   PUBMED   24316575
REFERENCE   3  (bases 1 to 14065)
  AUTHORS   Pelaseyed,T., Gustafsson,J.K., Gustafsson,I.J., Ermund,A. and
            Hansson,G.C.
  TITLE     Carbachol-induced MUC17 endocytosis is concomitant with NHE3
            internalization and CFTR membrane recruitment in enterocytes
  JOURNAL   Am J Physiol Cell Physiol 305 (4), C457-C467 (2013)
   PUBMED   23784542
REFERENCE   4  (bases 1 to 14065)
  AUTHORS   Bondow,B.J., Faber,M.L., Wojta,K.J., Walker,E.M. and Battle,M.A.
  TITLE     E-cadherin is required for intestinal morphogenesis in the mouse
  JOURNAL   Dev Biol 371 (1), 1-12 (2012)
   PUBMED   22766025
REFERENCE   5  (bases 1 to 14065)
  AUTHORS   Gaudier,E., Rival,M., Buisine,M.P., Robineau,I. and Hoebler,C.
  TITLE     Butyrate enemas upregulate Muc genes expression but decrease
            adherent mucus thickness in mice colon
  JOURNAL   Physiol Res 58 (1), 111-119 (2009)
   PUBMED   18198997
  REMARK    GeneRIF: Butyrate enemas upregulate Muc3 gene expression but
            decrease adherent mucus thickness in mice colon.
REFERENCE   6  (bases 1 to 14065)
  AUTHORS   Gum,J.R. Jr., Crawley,S.C., Hicks,J.W., Szymkowski,D.E. and
            Kim,Y.S.
  TITLE     MUC17, a novel membrane-tethered mucin
  JOURNAL   Biochem Biophys Res Commun 291 (3), 466-475 (2002)
   PUBMED   11855812
REFERENCE   7  (bases 1 to 14065)
  AUTHORS   Khatri,I.A., Ho,C., Specian,R.D. and Forstner,J.F.
  TITLE     Characteristics of rodent intestinal mucin Muc3 and alterations in
            a mouse model of human cystic fibrosis
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 280 (6), G1321-G1330 (2001)
   PUBMED   11352827
REFERENCE   8  (bases 1 to 14065)
  AUTHORS   Lammert,F., Carey,M.C. and Paigen,B.
  TITLE     Chromosomal organization of candidate genes involved in cholesterol
            gallstone formation: a murine gallstone map
  JOURNAL   Gastroenterology 120 (1), 221-238 (2001)
   PUBMED   11208732
  REMARK    Review article
REFERENCE   9  (bases 1 to 14065)
  AUTHORS   Crawley,S.C., Gum,J.R. Jr., Hicks,J.W., Pratt,W.S., Aubert,J.P.,
            Swallow,D.M. and Kim,Y.S.
  TITLE     Genomic organization and structure of the 3' region of human MUC3:
            alternative splicing predicts membrane-bound and soluble forms of
            the mucin
  JOURNAL   Biochem Biophys Res Commun 263 (3), 728-736 (1999)
   PUBMED   10512748
REFERENCE   10 (bases 1 to 14065)
  AUTHORS   Shekels,L.L., Hunninghake,D.A., Tisdale,A.S., Gipson,I.K.,
            Kieliszewski,M., Kozak,C.A. and Ho,S.B.
  TITLE     Cloning and characterization of mouse intestinal MUC3 mucin: 3'
            sequence contains epidermal-growth-factor-like domains
  JOURNAL   Biochem J 330 (Pt 3) (Pt 3), 1301-1308 (1998)
   PUBMED   9494100
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            MG954266.1 and AC242397.3.
            
            On Jul 30, 2020 this sequence version replaced NM_010843.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849380,
                              SAMN00849389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               MG954266.1         26898-27036         c
            140-241             MG954266.1         15198-15299         c
            242-9133            MG954266.1         5482-14373          c
            9134-12400          AC242397.3         32898-36164         c
            12401-12595         AC242397.3         30395-30589         c
            12596-12717         AC242397.3         27656-27777         c
            12718-12776         AC242397.3         27241-27299         c
            12777-12931         AC242397.3         26020-26174         c
            12932-13000         AC242397.3         24898-24966         c
            13001-13163         AC242397.3         24452-24614         c
            13164-13325         AC242397.3         21949-22110         c
            13326-13423         AC242397.3         21686-21783         c
            13424-13503         AC242397.3         20818-20897         c
            13504-14065         AC242397.3         18685-19246         c
FEATURES             Location/Qualifiers
     source          1..14065
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.22 cM"
     gene            1..14065
                     /gene="Muc17"
                     /gene_synonym="Muc3"
                     /note="mucin 17, cell surface associated"
                     /db_xref="GeneID:666339"
                     /db_xref="MGI:MGI:1203527"
     exon            1..139
                     /gene="Muc17"
                     /gene_synonym="Muc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..13545
                     /gene="Muc17"
                     /gene_synonym="Muc3"
                     /note="mucin 3, intestinal"
                     /codon_start=1
                     /product="mucin-17 precursor"
                     /protein_id="NP_034973.2"
                     /db_xref="GeneID:666339"
                     /db_xref="MGI:MGI:1203527"
                     /translation="MSTRRWVRQTAALCLLAFILHSLPRHIAAENGTTESGSVWDGGG
                     NSTQDDSQETQFRTVLKTKTTDGENSEAWPRQEYQQRSSSPSTTKAEVTTTADVTTTA
                     DVTTTAEITTTSDVTTTAEITNTDDVTTTGEVTTTADVTTTSDVPTTSEVTSTDDVIT
                     TAEVTTTAEMTPTDDVTTTSEVTTTGDVTTTGDVTITGDLTTTADVTTKADFTTTDDV
                     TTTADGSTTADLTTTAKVTTTDDVTTTGEITTTSEITTTSDVTTTAEITTTDIVTTTG
                     EVTTTADVTTTSDVTTTSEETPTADITTTADLTTTAEVTTTDDVTTTVEITTTSEITT
                     TSDVTTIAEITTTDIVTTTGEVTTTADVTTTSDVTTTSEETTTADITTTADLTTTAEI
                     TTTDDVTTTVEITTTSDVTTTTEITTTDIVTTTGEVTTTADVTTASDVTTTSEETPTA
                     DITTTADLTTTAEVTTTDDVTTTGEVTTTADVTTTSDVTTTSEETTTADVTTTSDVTT
                     TAEITTTDDITSTADVTTTADVTTTSDVPTTSEETTTADVTTTSDVTTTAEITTTDDI
                     TSTADVTTTADVTTTSDVTTTTEENPTADITTTADLTTTAEVTTTDDVTTTVEITTTS
                     EITTTSDVTTTAEITTTDIVTTTDEDTTTADVTTTSDVTTTSEETPTADITTTADLTT
                     TADVTTTSDVTTTSEETTTADVTTTSDVTTTAEITTTDDITSTADVTTTTNVTTTSDV
                     PTTSEVTSTDDVITTTEVTTTAEIIPTDDVTTTSEVTTTGDVTTTGDVTMTGDLTTTA
                     DVTTTADLTTTDEVTTTADGSTTADLTTTAEVTTTDDVTTTVQITTTSEITTTSDVTT
                     TAEITTTDNVTTTGEVTTTADVTTTSDVTTTSEETPTADITTTADLNTTAEVTTTEDV
                     TTTVEITTTSEITTTSDITTTAEITTTDIVTTTGEVTTTADVTTTNDVTTTSEETPTA
                     DITTTADLTTTAEITTTDDITSTADVTTTTDVTTTSDVPTTSEVTSTDDVITTTEVTT
                     TAEIIPTDDVTTTSEVTTTGDVTTTGDVTMTGDLTTTADVTTTADLTTTDEVTTTADG
                     STTADLTTTAEVTTTDDVTTTVQITTTSEITTTSDVTTTAEITTTDNVTTTGEVTTTA
                     DVTTTSDVTTTSEETPTADITTTADLTTTAEVTTTEDVTTTVEITTTSEITTTSDITT
                     TAEITTTDIVTTTGEVTTTADVTTTNDVTTTSEETPTADITTTADLTTTAEITTTDDV
                     TTTGEVTTTADVTTTSDVTTTSEETPTADITTTADLTTTAEITTTDDVTTTGEVTTTA
                     DVTTTSDITTTSEETPTADITTTADLTTTAEVTTTDDVTTTGEVTTTADVTTTSDITT
                     TSEETPTADITTTADLTTTAEVTTTDDVTTTVEITTTSEITTTSDVTTTAEITTTDIV
                     TTTGEVTTTADVTTTSDVTTTSEQTPTADITTTADLTTTAEVTTTDDVTTTVEITTTS
                     EITTTSDVTTTAEITTTDIVTTTGEVTTTADITTTSDVTTTSEETTTADVTTTTDVTT
                     TSEETTTGDGKTTTAEITTTDDITTTADVTTTPDVTTTAAVTTTGEITPTDDVTTTSE
                     VTTTGDVTSTGDVTTTGEVTTTAEVTTTADVTTTSDVTTTSEETPTADITTTADLTTT
                     AEVTTTDDVTTTGEVTTTADVTTTSDTTTTSEETPTADITTTVDLTTTAEVTTTDDVT
                     TTVEITTTSEITTTSDVTTTAEITTSDIFTTTGEVTTTADITTTSDVTTTSEETPTAD
                     ITTTADLTTTAEITTTDDVTTTVEITTTSEITTTSEVTTTPDVTTTSDVTTTSEETPT
                     ADITTTADLTTTAEVTTTDDVTTTVEITTTSEITTTSDVTTTAEITTTDIVTTTGEVT
                     TTVDVTTTNDVTTTSEETPTADITTTADLTTTAEVTTTDDVTTTGEVTTTADVTTTSD
                     ITTTSEETPTADITTTVDLTTTVEITTTSEITTTSDVTTTAEITTTDIVTTTGEVTTT
                     ADVTTTSDVTTTSEETPTADITTTADLTTTAEVTTTDDVTTTVEITTTSEITTTSDVT
                     TTAEITTTDIVTTSGEVTTTADVTTTSDVTTTSEETTTADVTTTTDVTTTSEETTTGD
                     GTTTTAEITTTDDLTTTADVTTTPDVTTTAAVTTTAEITPTDDVTTTSEVTTTGDVTT
                     TGEVTTTAEVTTTDDVTTTGDVTTTGDLTTMADVTTTADFTTTDDVTTTADASTTADL
                     ATTAEVTTTDDVTTTVEITTTAEITTTAEVTTTDDVTTTGEVTTTADVTTTTDVTTTS
                     EVTTTADVTTTNDVTTTAEITTTDDITTTADVTTTADVTTTSYVPTTSEVTSTDDVTT
                     TAEVTTTAEITPTDDVTTTSEVTTTGDVTTTGDVTMTCDLTTSADVTTTADFTTTDDV
                     TTKADGSTTADLTTTAEVTTNDDVTTTGELTTTAEITTTSDVTTTAEITTTDIVTTTG
                     EVTTTADVTTTSDVTTTSEETTTADITTTADLTTTAEVTTTDDVTTTVEITTTSEITT
                     TSDVTTIAEITTTDIVTTTGEVTTTADVTTTNDVTTTSEETPTADITTTADLTTTAEV
                     TTTDDVTTTGEVTTTADVTTTSDVTTTSEETPTADITTTADLTTTAEVTTTDDVTTTV
                     EITTTSEITTTSDVTTTAEITTTDIVTTTGEVTTTADITTTSDVTTTSEETTTADVTT
                     TTDVTTTSEETTTGDGKTTTAEITTTDDITTTADVTTTPDVTTTAAVTTTGEITPTDD
                     VTTTSEVTTTGDVTTTGDVTTTGEVTTTAEVTTTDDVTTTGDVTTTGDLTTTADVTTT
                     AYFTTTDDVTTTADGSTTADLTTTAEVTTTDDVTTTVEITTTAEITTTDDVTTTGEVT
                     TTADVTTTSDVTTTSEETPTADITTTADLTTTAEVTTTDDVTTTVEITTTSEITTTSD
                     VTTTAEITTTDIVTTTGEVTTTADVTTTSDVTTTSEETPTADITTTADLTTTAEVTTT
                     DDVTTTVEITTTSEITTTSDVTTTAEITTTDIVTTTGEVTTTADVTTTSDVTTTSEET
                     PTADITTTADLTTTAEVTTTDDVTTTVEITTTAEITTTDDVTTTGEVTTTADVTTTAE
                     VITTSDVTTTADVTTMPDFTTTAEVTTTLDVTTNDEVTTTSVVTTTPEITTAGDVTTT
                     SEVTTSADLTTTPEITTTGDVTTTADVTTTADITTTSDVTTTADVTTTADITTTSDVT
                     TTADVTTIADLSTTPEITTTGDFSSTTDVTSTGDVTTTADVTTTADVTTTGDVTTTAE
                     VTTTAEVTTTAEATTTADLNTTPEITTTDDVTTTGDVTITAEVTTTAYVTTTTDFTTT
                     AEVNTTDDVTTIADLTTTAEVTTTNDVTSTAEITTTADLTTTTEVTTTADFITTGDVT
                     TTADVTTMADVTTTADVTTADLTTTVDVTTMDDVTTTAEVITSGDVTTTSEVTTTSNL
                     NTTPEITTTIDFTSTVDVTTTGDVTTTADVTTTSDVTTTSKVTTTGDVTTTADTTSTA
                     DVTTTADVITTAEVTTTADFTNTGDVTTSADVTTTADLTTMPDLTTTAEVTTTADVTT
                     TSEFTTTADVTTTADVTSTADVTTTAEVTTTGDVTTTADVTNTGDITTIGDVTTTTEI
                     TTTAYLTTTLEITTTGEVTSTADVTTSAEVTTTDEITTTDVVTTTGDVTPTAESTTTD
                     DVTTTSDVTTTGDFTTTADVTTTAYVTTTPDVTTTVEVTTTADFTTTGVVNTTADVTT
                     TADVTTTSEVTTTADLTTTPEITTTVDFTSTADVTTTADVITTPEVTTTSDVTTTAEV
                     ITTADVTTTADVTTTVEVTTTGDVTITADVTTTPEITTTVDFTSTADVTITADVTTTA
                     DVTTTSDVTITPDVTTTAEVTTTVEITTTDDVTTTGEVTTTADVTTTSDVTTTSEETT
                     TADITTTSDVSTTSEVTTTAYVTTTADTTSTAEVTTTADVTTTADVTTTADVTTTADV
                     TTTVEVTTTGDVTTTADVTTTAEVTTTAEITTTGDVTTTADVTTTAEVTTTAEITTTG
                     DVTTTADVTTTADVTTTADVTTTIDVTTTADVTTSAEVTTTADVTTTTEVTTTTEVAT
                     TPEPTTTPAPTTTAVNCMNGGFWTGDKCICPNGFGGDRCENIVNVVNCENGGTWDGLK
                     CQCTSLFYGPRCEELVESVEIEPTVAASVEVSVTVTSQEYSEKLQDRKSEEFSNFNKT
                     FTKQMALIYAGIPEYEGVIIKNLSKGSIVVDYDVILKAKYTPGFENTLDTVVKNLETK
                     IKNATEVQVQDVNNNCSALLCFNSTATKVQNSATVSVNPEETCKKEAGEDFAKFVTLG
                     QKGDKWFCITPCSAGYSTSKNCSYGKCQLQRSGPQCLCLITDTHWYSGENCDWGIQKS
                     LVYGLGGAGVAVLLVILVILLVFSIRFRKDAQRQRSRVSEMYKWGEEEGRASPGTFHN
                     FGFDHNEERENYMPLDSVYNTFQPSLNHINPERKIQIQRPQVVMTSL"
     exon            140..241
                     /gene="Muc17"
                     /gene_synonym="Muc3"
                     /inference="alignment:Splign:2.1.0"
     exon            242..12400
                     /gene="Muc17"
                     /gene_synonym="Muc3"
                     /inference="alignment:Splign:2.1.0"
     exon            12401..12595
                     /gene="Muc17"
                     /gene_synonym="Muc3"
                     /inference="alignment:Splign:2.1.0"
     exon            12596..12717
                     /gene="Muc17"
                     /gene_synonym="Muc3"
                     /inference="alignment:Splign:2.1.0"
     exon            12718..12776
                     /gene="Muc17"
                     /gene_synonym="Muc3"
                     /inference="alignment:Splign:2.1.0"
     exon            12777..12931
                     /gene="Muc17"
                     /gene_synonym="Muc3"
                     /inference="alignment:Splign:2.1.0"
     exon            12932..13000
                     /gene="Muc17"
                     /gene_synonym="Muc3"
                     /inference="alignment:Splign:2.1.0"
     exon            13001..13163
                     /gene="Muc17"
                     /gene_synonym="Muc3"
                     /inference="alignment:Splign:2.1.0"
     exon            13164..13325
                     /gene="Muc17"
                     /gene_synonym="Muc3"
                     /inference="alignment:Splign:2.1.0"
     exon            13326..13423
                     /gene="Muc17"
                     /gene_synonym="Muc3"
                     /inference="alignment:Splign:2.1.0"
     exon            13424..13503
                     /gene="Muc17"
                     /gene_synonym="Muc3"
                     /inference="alignment:Splign:2.1.0"
     exon            13504..14065
                     /gene="Muc17"
                     /gene_synonym="Muc3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attcattttg ccagcttcca agaagagcgc aaagcaggct ctgccatgtc gacgcggagg
       61 tgggtgaggc agactgccgc gctctgcctg ctggctttca tcctccactc cctgccccga
      121 cacattgctg ctgagaatgg gaccaccgag agcggaagtg tgtgggatgg aggaggaaat
      181 agcacccaag acgacagcca ggagactcag ttccggacgg tgttgaagac caaaaccaca
      241 gacggggaaa acagtgaggc atggccacgg caggagtacc agcaaagatc cagttcccca
      301 tccaccacaa aggctgaagt caccaccact gctgatgtca caaccaccgc tgatgtcaca
      361 accactgccg aaatcacaac tacttctgat gtcaccacca ctgctgagat cacaaacact
      421 gatgatgtca ccaccacagg tgaagtcacc acaactgctg atgtcacaac cactagtgat
      481 gtccccacca cttctgaagt caccagcact gatgatgtca tcaccactgc tgaagtcaca
      541 accactgctg aaatgacacc cactgatgat gttacaacca cttctgaagt caccaccact
      601 ggtgatgtca caaccactgg tgatgtcaca ataactggtg atctcaccac aacggctgat
      661 gtaaccacca aagctgactt cacaaccact gatgatgtca ccacaacagc tgatggctcc
      721 acaactgctg acctcaccac cactgctaaa gtcacaacca ctgatgatgt caccaccacc
      781 ggtgaaatca caaccacttc cgaaatcaca accacttctg atgttaccac cactgctgaa
      841 atcacaacca ctgatattgt caccaccaca ggtgaagtca ccacaactgc tgatgtcaca
      901 accactagtg atgtcaccac cacttctgaa gagaccccaa ctgctgatat caccacaact
      961 gctgacctca ccaccactgc tgaagtcaca accactgatg atgtcaccac cactgtagaa
     1021 atcacaacca cctctgaaat cacaaccact tctgatgtta ccaccattgc tgaaatcaca
     1081 accactgata ttgtcaccac cacaggtgaa gtcaccacaa ctgctgatgt cacaaccact
     1141 agtgatgtca ccaccacttc tgaagagacc acaactgctg atatcaccac aactgctgac
     1201 ctcaccacca ctgctgaaat cacaaccact gatgatgtca ccaccactgt agaaatcaca
     1261 accacttctg atgttaccac cactactgaa atcacaacca ctgatattgt caccaccaca
     1321 ggtgaagtca ccacaactgc tgatgtcaca accgctagtg atgtcaccac cacttctgaa
     1381 gagaccccaa ctgctgatat caccacaact gctgacctca ccaccactgc tgaagtcaca
     1441 accactgatg atgtcaccac cacaggtgaa gtcaccacaa ctgctgatgt cacaaccact
     1501 agtgatgtca ccaccacttc tgaagagacc acaactgctg atgtcacaac cacttctgat
     1561 gttaccacca ctgctgaaat cacaaccact gatgatatca ccagtacggc tgatgtcacc
     1621 acaactgctg atgtcacaac cactagtgat gtccccacca cttctgaaga gaccacaact
     1681 gctgatgtca caaccactag tgatgtcacc accactgctg aaatcacaac cactgatgat
     1741 atcaccagta cggctgatgt caccacaact gctgatgtca caaccactag tgatgtcacc
     1801 accactactg aagagaaccc aactgctgat atcaccacaa ctgctgacct caccaccact
     1861 gctgaagtca caaccactga tgatgtcacc accactgtag aaatcacaac aacttccgaa
     1921 atcacaacca cttctgatgt taccaccact gctgaaatca caaccactga tattgtcacc
     1981 accacagatg aagacaccac aactgctgat gtcacaacca ctagtgatgt caccaccact
     2041 tctgaagaga ccccaactgc tgatatcacc acaactgctg acctcaccac cactgctgat
     2101 gtcacaacca ctagtgatgt caccaccact tctgaagaga ccacaactgc tgatgtcaca
     2161 accactagtg atgtcaccac cactgctgaa atcacaacca ctgatgatat caccagtacg
     2221 gctgatgtca ccacaactac taatgtcaca accactagtg atgtccccac cacttctgaa
     2281 gtcacgagca ctgatgatgt catcaccact actgaagtca caaccactgc tgaaatcata
     2341 cccactgatg atgttacaac cacttctgaa gtcaccacca ctggtgatgt cacaaccact
     2401 ggtgatgtca caatgactgg tgatctcacc acaacggctg atgtcaccac cacagctgac
     2461 ttgacaacca ctgatgaggt caccacaaca gctgatggct ccacaactgc tgacctcacc
     2521 accactgctg aagtcacaac cactgatgat gtcacaacca ctgtacaaat cacaacaact
     2581 tccgaaatca caaccacttc tgatgttacc accactgctg aaatcacaac cactgataat
     2641 gtcaccacca caggtgaagt caccacaact gctgatgtca caaccactag tgatgtcacc
     2701 accacttctg aagagacccc aactgctgat atcaccacaa ctgctgacct caacaccact
     2761 gctgaagtca caaccactga agatgtcacc accactgtag aaatcacaac cacttccgaa
     2821 atcacaacca cttctgatat taccaccact gctgaaatca caaccactga tattgtcacc
     2881 accacaggtg aagtcaccac aactgctgat gtcacaacca ctaatgatgt caccaccact
     2941 tctgaagaga ccccaactgc tgatatcacc acaactgctg acctcaccac cactgctgaa
     3001 atcacaacca ctgatgatat caccagtacg gctgatgtca ccacaactac tgatgtcaca
     3061 accactagtg atgtccccac cacttctgaa gtcacgagca ctgatgatgt catcaccact
     3121 actgaagtca caaccactgc tgaaatcata ccgactgatg atgttacaac cacttctgaa
     3181 gtcaccacca ctggtgatgt cacaaccact ggtgatgtca caatgactgg tgatctcacc
     3241 acaacggctg atgtcaccac cacagctgac ttgacaacca ctgatgaggt caccacaaca
     3301 gctgatggct ccacaactgc tgacctcacc acaactgctg aagtcacaac cactgatgat
     3361 gtcacaacca ctgtacaaat cacaacaact tccgaaatca caaccacttc tgatgttacc
     3421 accactgctg aaatcacaac cactgataat gtcaccacca caggtgaagt caccacaact
     3481 gctgatgtca caaccactag tgatgtcacc accacttctg aagagacccc aactgctgat
     3541 atcaccacaa ctgctgacct caccaccact gctgaagtca caaccactga agatgtcacc
     3601 accactgtag aaatcacaac cacttccgaa atcacaacca cttctgatat taccaccact
     3661 gctgaaatca caaccactga tattgtcacc accacaggtg aagtcaccac aactgctgat
     3721 gtcacaacca ctaatgatgt caccaccact tctgaagaga ccccaactgc tgatatcacc
     3781 acaactgctg acctcaccac cactgctgaa atcacaacca ctgatgatgt caccaccaca
     3841 ggtgaagtaa ccacaactgc tgatgtcaca accactagtg atgtcaccac cacttctgaa
     3901 gagaccccaa ctgctgatat caccacaact gctgacctca ccaccactgc tgaaatcaca
     3961 accactgatg atgtcaccac cacaggtgaa gtcaccacaa ctgctgatgt cacaaccact
     4021 agtgatatca ccaccacttc tgaagagacc ccaactgctg atatcaccac aactgctgac
     4081 ctcaccacca ctgctgaagt cacaaccact gatgatgtca ccaccacagg tgaagtcacc
     4141 acaactgctg atgtcacaac cactagtgat atcaccacca cttctgaaga gaccccaact
     4201 gctgatatca ccacaactgc tgacctcacc accactgctg aagtcacaac cactgatgat
     4261 gtcaccacca ctgtagaaat cacaaccact tccgaaatca caaccacttc tgatgttacc
     4321 acaactgctg aaatcacaac cactgatatt gtcaccacca caggtgaagt caccacaact
     4381 gctgatgtca caaccactag tgatgtcacc accacttctg aacagacccc aactgctgat
     4441 atcaccacaa ctgctgacct caccaccact gctgaagtca caaccactga tgatgtcacc
     4501 accactgtag aaatcacaac cacctctgaa atcacaacca cttctgacgt taccaccact
     4561 gctgaaatca caaccactga tattgtcacc accacaggtg aagtcaccac aactgctgat
     4621 atcacaacca ctagtgatgt caccaccact tctgaagaga ccacaactgc tgatgtcaca
     4681 accactactg atgtcaccac cacttctgaa gagaccacaa ctggtgatgg caaaaccacc
     4741 actgctgaaa tcacaaccac tgatgatatc actactacgg ctgatgtcac cacaactcct
     4801 gatgtcacca ccactgctgc agtcacaacc actggtgaaa tcacacccac tgatgatgtt
     4861 acaaccactt ctgaagtcac caccactggt gatgtcacaa gcactggtga tgtcaccacc
     4921 actggtgaag tgaccaccac tgctgaagtc accacaactg ctgatgtcac aaccactagt
     4981 gatgtcacca ccacttctga agagacccca actgctgata tcaccacaac tgctgacctc
     5041 accaccactg cagaagtcac aacgactgat gatgtcacca ccacaggtga agtcaccaca
     5101 actgctgatg tcacaaccac tagtgatacc accaccactt ctgaagagac cccaactgct
     5161 gatatcacca caactgttga cctcaccacc actgctgaag tcacaaccac tgatgatgtc
     5221 accaccactg tagaaatcac aaccacttcc gaaatcacaa ccacttctga tgttaccacc
     5281 actgctgaaa tcacaacctc tgatattttc accaccacag gtgaagtcac cacaactgct
     5341 gatatcacaa ccactagtga tgtcaccacc acttctgaag agaccccaac tgctgatatc
     5401 accacaactg ctgacctaac caccactgct gaaatcacaa ccactgatga tgtcaccacc
     5461 actgtagaaa tcacaaccac ttccgaaatc acaaccactt ctgaagtcac cacaactcct
     5521 gatgtcacaa ccactagtga tgtcaccacc acttctgaag agaccccaac tgctgatatc
     5581 accacaactg ctgacctcac aaccactgct gaagtcacaa ccactgatga tgtcaccacc
     5641 actgtagaaa tcacaaccac ttccgaaatc acaaccactt ctgatgtcac caccactgct
     5701 gaaatcacaa ccactgatat tgtcaccacc acaggtgaag tcaccacaac tgttgatgtc
     5761 acaaccacta atgatgtcac caccacttct gaagagaccc caactgctga tatcaccaca
     5821 actgctgacc tcaccaccac tgcagaagtc acaacgactg atgatgtcac caccacaggt
     5881 gaagtcacca caactgctga tgtcacaacc actagtgata tcaccaccac ttctgaagag
     5941 accccaactg ctgacatcac cacaactgtt gacctcacca ccactgtaga aatcacaacc
     6001 acttccgaaa tcacaaccac ttctgatgtt accaccactg ctgaaatcac aaccactgat
     6061 attgtcacca ccacaggtga agtcaccaca actgctgatg tcacaaccac tagtgatgtc
     6121 accaccactt ctgaagagac cccaactgct gatatcacca caactgctga cctcaccacc
     6181 actgctgaag tcacaaccac tgatgatgtc accaccactg tagaaataac aaccacctct
     6241 gaaatcacaa ccacttctga tgttaccacc actgctgaaa tcacaaccac tgatattgtc
     6301 accacctcag gtgaagtcac cacaactgct gatgtcacaa ccactagtga tgtcaccacc
     6361 acttctgaag agaccacaac tgctgatgtc acaaccacta ctgatgtcac caccacttct
     6421 gaagagacca caactggtga tggcacaacc accactgctg aaatcacaac cactgatgat
     6481 ctcactacta cggctgatgt caccacaact cctgatgtca ccaccactgc tgcagtcaca
     6541 accactgctg aaatcacacc cactgatgat gttacaacca cttctgaagt caccaccact
     6601 ggtgatgtca caaccactgg tgaagtgacc accactgctg aagtcaccac aactgatgat
     6661 gtcacaacca ctggtgatgt caccacgact ggtgatctca ccacaatggc tgatgtcacc
     6721 accacagctg acttcacaac cactgatgat gtcaccacaa cagctgatgc ctccacaact
     6781 gctgacctcg ccaccactgc tgaagtcaca accactgatg atgtcaccac cactgtagaa
     6841 atcacaacca ctgctgaaat cacaaccact gctgaagtca caaccactga tgatgtcacc
     6901 accacaggtg aagtcaccac aactgctgat gtcacaacca ctactgatgt caccaccact
     6961 tctgaagtga ccacaactgc tgatgtcaca accactaatg atgtcaccac cactgctgaa
     7021 atcacaacca ctgatgatat caccactacg gctgatgtca ccacaactgc tgatgtcaca
     7081 accactagtt atgtccccac cacttctgaa gtcaccagca ctgatgatgt caccaccact
     7141 gctgaagtca caaccactgc tgaaatcaca cccactgatg atgttacaac cacttctgaa
     7201 gtcaccacca ctggtgatgt cacaaccact ggtgatgtca caatgacttg tgatctcacc
     7261 acatcggctg atgtcaccac cacagctgac tttacaacca ctgatgatgt caccacaaaa
     7321 gctgatggct ccacaactgc tgacctcacc accactgctg aagtaacaac caatgatgat
     7381 gtcaccacca ccggtgaact cacaaccact gctgaaatca caaccacttc tgatgttacc
     7441 accactgctg aaatcacaac cactgatatt gtcaccacca caggtgaagt caccacaact
     7501 gctgatgtca caaccactag tgatgtcacc accacttctg aagagaccac aactgctgat
     7561 atcaccacaa ctgctgacct caccaccact gctgaagtca caaccactga tgatgtcacc
     7621 accactgtag aaatcacaac cacctctgaa atcacaacca cttctgatgt taccaccatt
     7681 gctgaaatca caaccactga tattgtcacc accacaggtg aagtcaccac aactgctgat
     7741 gtcacaacca ctaatgatgt caccaccact tctgaagaga ccccaactgc tgatatcacc
     7801 acaactgctg acctcaccac cactgctgaa gtcacaacca ctgatgatgt caccaccaca
     7861 ggtgaagtca ccacaactgc tgatgtcaca accactagtg atgtcaccac cacttctgaa
     7921 gagaccccaa ctgctgatat caccacaact gctgacctca ccaccactgc tgaagtcaca
     7981 accactgatg atgtcaccac cactgtagaa atcacaacca cctctgaaat cacaaccact
     8041 tctgatgtta ccaccactgc tgaaatcaca accactgata ttgtcaccac cacaggtgaa
     8101 gtcaccacaa ctgctgatat cacaaccact agtgatgtca ccaccacttc tgaagagacc
     8161 acaactgctg atgtcacaac cactactgat gtcaccacca cttctgaaga gaccacaact
     8221 ggtgatggca aaaccaccac tgctgaaatc acaaccactg atgatatcac tactacggct
     8281 gatgtcacca caactcctga tgtcaccacc actgctgcag tcacaaccac tggtgaaatc
     8341 acacccactg atgatgttac aaccacttct gaagtcacca ccactggtga tgtcacaacc
     8401 actggtgatg tcaccaccac tggtgaagtg accaccactg ctgaagtcac cacaactgat
     8461 gatgtcacaa ccactggtga tgtcaccacg actggtgatc tcaccacaac ggctgatgtc
     8521 accaccacag cttacttcac aaccactgat gatgtcacca caacagctga tggctccaca
     8581 actgctgacc tcaccaccac tgctgaagtc acaaccactg atgatgtcac caccactgta
     8641 gaaatcacaa ccactgctga aatcacaacc actgatgatg tcaccaccac aggtgaagtc
     8701 accacaactg ctgatgtcac aaccactagt gatgtcacca ccacttctga agagacccca
     8761 actgctgata tcaccacaac tgctgacctc accaccactg ctgaagtcac aaccactgat
     8821 gatgtcacca ccactgtaga aatcacaacc acttccgaaa tcacaaccac ttctgatgtt
     8881 accaccactg ctgaaatcac aaccactgat attgtcacca ccacaggtga agtcaccaca
     8941 actgctgatg tcacaaccac tagtgatgtc accaccactt ctgaagagac cccaactgct
     9001 gatatcacca caactgctga cctcaccacc actgctgaag tcacaaccac tgatgatgtc
     9061 accaccactg tagaaatcac aaccacttcc gaaatcacaa ccacttctga tgttaccacc
     9121 actgctgaaa tcacaaccac tgatattgtc accaccacag gtgaagtcac cacaactgct
     9181 gatgtcacaa ccactagtga tgtcaccacc acttctgaag agaccccaac tgctgatatt
     9241 accacaactg ctgacctcac caccactgct gaagtcacaa ccactgatga tgtcaccacc
     9301 actgtagaaa tcacaaccac tgctgaaatc acaaccactg atgatgtcac caccacaggt
     9361 gaagtcacca caactgctga tgtcaccacc acggctgaag tcataaccac ttctgatgtc
     9421 accactactg ctgatgtcac cacaatgcct gatttcacca ccacggctga agtcaccacc
     9481 actcttgatg tcaccaccaa tgatgaagtc accaccactt ctgtagtcac caccacgcct
     9541 gaaatcacaa ccgctggtga tgtcaccacc acttctgaag tcaccaccag tgctgacctc
     9601 accaccacac ctgaaatcac aaccactggt gatgtaacca ccaccgctga tgttaccaca
     9661 actgcagata tcacaaccac tagtgatgtc accaccactg ctgatgtcac cacaactgca
     9721 gatatcacaa ccactagtga tgtcaccacc actgctgatg tcaccactat tgctgaccta
     9781 tcaaccacac ctgaaatcac aaccactggt gatttcagca gcacaactga tgtcacctcg
     9841 acaggtgatg taaccacaac tgctgatgtc acaaccactg ctgatgtcac cactactggt
     9901 gatgtcacaa ccactgcaga agtaaccacc actgctgaag tcacaaccac tgctgaagcc
     9961 accacaactg ctgacctcaa caccacacct gaaatcacaa ccactgatga tgtcaccacc
    10021 actggtgatg tcaccatcac tgctgaagta accaccactg catatgttac cacaacgact
    10081 gatttcacca ctactgctga ggtcaacacc actgatgatg tcaccacaat agctgacctc
    10141 accaccactg ctgaagtcac aaccactaat gatgtcacct ctactgctga aatcaccacg
    10201 actgctgacc tcaccaccac tactgaagtc acaaccactg ctgatttcat caccactggt
    10261 gatgtcacca ccactgcaga tgtcaccacc atggctgatg tcaccactac agctgatgtc
    10321 acaactgctg acctcaccac cactgttgat gtcaccacta tggatgatgt caccacaact
    10381 gctgaagtca taaccagtgg tgatgtcacc accacttctg aggtcaccac cacctctaac
    10441 ctcaacacca cacctgaaat cacaaccact attgatttca ccagcaccgt tgatgtcacc
    10501 accacaggtg atgtcaccac aactgctgat gtcacaacca ctagtgatgt caccaccact
    10561 tctaaagtca ccaccactgg tgatgtcacc accactgctg ataccacctc cactgctgat
    10621 gtcacaacca ctgctgatgt catcaccact gctgaagtca caaccactgc tgacttcacc
    10681 aacactggtg atgtcaccac cagtgctgat gtcaccacca ctgcagatct caccacaatg
    10741 cctgatttaa ccactactgc tgaagtcacc accacagctg atgtcaccac cacttctgag
    10801 ttcaccacca ctgctgatgt caccacaact gctgatgtca cctccactgc tgatgtcact
    10861 accactgctg aagtcaccac cactggtgat gtcaccacca ctgctgatgt cacaaacact
    10921 ggtgatatca ccacaatagg tgatgtcacc acaactactg aaatcaccac cactgcctac
    10981 ctcactacca cacttgaaat cacaaccact ggtgaagtca ccagtactgc tgatgtcacc
    11041 accagtgctg aagtcacaac cactgatgaa atcacaacca ctgatgtagt cacaaccact
    11101 ggtgatgtca cacccactgc tgaaagcaca accactgatg atgtcacaac cacttctgat
    11161 gttaccacca ctggtgattt caccaccact gctgatgtca ccacaactgc ttatgtcaca
    11221 accactcctg atgtcaccac cactgttgaa gtcacaacca ctgctgactt caccaccact
    11281 ggtgttgtca acaccactgc tgatgtcacc accacagctg atgtcaccac cacttctgag
    11341 gtcaccacca ctgctgacct caccaccact cctgaaatta caaccactgt tgatttcacc
    11401 agcaccgctg atgtcaccac aactgctgat gtcatcacca ctcctgaagt cacaaccact
    11461 agtgatgtca ccaccactgc tgaagtaatc accactgctg atgtcaccac cactgctgat
    11521 gtcaccacca ctgttgaagt cacaaccact ggtgatgtca ccatcactgc tgatgtcacc
    11581 accacacctg aaatcacaac caccgttgat ttcaccagca ccgctgatgt caccatcact
    11641 gctgatgtca ccacaacagc tgatgtcaca accactagtg atgtcaccat cactcctgat
    11701 gtcaccacca ctgctgaagt caccaccact gtagaaatca caaccactga tgatgtcacc
    11761 accacaggtg aagtcaccac aactgctgat gtcacaacca ctagtgatgt caccaccact
    11821 tctgaagaga ccacaactgc tgatatcaca accactagtg atgtttccac cacttctgaa
    11881 gtcacaacca ctgcttatgt caccaccact gctgatacca cctccactgc tgaagtcaca
    11941 accactgctg atgtcacaac cactgctgat gtcaccacca ctgctgatgt taccaccact
    12001 gctgatgtca ccaccactgt tgaagtcaca accactggtg atgtcaccac cactgctgat
    12061 gtcaccacca ctgctgaagt cacaaccact gctgaaatca caaccactgg tgatgtcacc
    12121 accactgctg atgtcaccac cactgctgaa gtcacaacca ctgctgaaat cacaaccact
    12181 ggtgatgtca ccaccactgc tgatgtcacc accactgcag atgtcaccac aacagctgat
    12241 gtcacaacca ctattgatgt caccacaacg gccgatgtca ccacttctgc tgaagtaacc
    12301 accactgctg atgtcaccac cactactgaa gttacaacca ctacagaagt tgccaccact
    12361 cctgagccca ctaccacccc agcacctacc actactgccg tgaattgtat gaacggaggg
    12421 ttctggacag gtgacaagtg catctgcccc aacggcttcg ggggggatcg ctgtgagaat
    12481 atagtcaacg tggtcaactg cgagaatgga ggcacgtggg acgggctcaa atgtcagtgc
    12541 accagcctct tctatgggcc acggtgtgag gaactggtgg agagcgtaga gatagagccg
    12601 acagtcgccg cgtccgtgga agtgagtgtg acagtaacca gtcaagaata cagtgagaag
    12661 ctacaggacc gaaagtctga agaattcagt aacttcaata agacattcac aaaacagatg
    12721 gctctgattt atgctggcat accggagtat gaaggggtta tcatcaaaaa tctgagcaaa
    12781 ggcagtatcg tggtggatta tgatgtcatc ctgaaggcca agtacacccc aggatttgaa
    12841 aacacattag ataccgtcgt caaaaacctg gagacaaaaa tcaagaacgc aacagaagtt
    12901 caagtacaag atgtcaataa taactgttca gctttactgt gtttcaactc cactgccacc
    12961 aaggtgcaaa acagtgccac agtcagtgtc aatcctgagg agacatgcaa gaaggaggct
    13021 ggagaggact ttgcaaagtt tgtcacactg gggcagaagg gcgataagtg gttctgtatc
    13081 acgccttgct ctgcgggcta cagcacctcc aagaactgca gctacggcaa atgtcagctg
    13141 cagcgaagtg gaccccagtg cctctgcctg atcacggata ctcactggta cagcggggaa
    13201 aactgcgact ggggcatcca gaaaagcctg gtgtatggac ttgggggagc cggcgtggca
    13261 gtgctgttgg tgatcctcgt gatcctcctc gtgttctcca tccgcttcag aaaagatgcg
    13321 caaaggcaac ggtccagagt gtctgagatg tacaagtggg gtgaagagga aggcagagca
    13381 tctcccggaa ccttccacaa ctttggtttt gaccacaatg aagaacgaga aaactacatg
    13441 cccctggact ctgtgtacaa caccttccag ccttccctaa accacataaa cccagaaaga
    13501 aagatccaga ttcagaggcc ccaggtagtc atgacatcgt tgtaaacact aacacaaaag
    13561 cggttttgca tggatctgtg gacctgagga ctgaggagaa gcgtgtttag ccaagcgtgg
    13621 tggaacacac cctacattga gaattccgca tagagactta ctgggaaata gaccctgcag
    13681 ttacctagaa tgggtaccag agagatgatg ctggaagcgc cgacagtatg gaaactgcag
    13741 tggtcatgtt acgatggtag gcgaaacctc ccagaatccc atgcccagag atgtctccta
    13801 cccgtggtcc ggcaatcagc accaaggaca gtgcctggcc cgctgccatc gtcggttgtt
    13861 ttaactttgg gttgcatttt accatcagca aagcacgctt ctaagaaaga ttacctccca
    13921 tctccatggc aagcactgtt tttaacatag accatctgtc tttacaaggg catgcttagt
    13981 tttaaatttc tttttaagac tgggtatgat taaagctttt attttattgc attcaatgta
    14041 aatacaatta tatgcttatt tttaa
//
