LOCUS       NM_172979               3277 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus mucin 15 (Muc15), transcript variant 1, mRNA.
ACCESSION   NM_172979
VERSION     NM_172979.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3277)
  AUTHORS   Han,T., Zheng,H., Zhang,J., Yang,P., Li,H., Cheng,Z., Xiang,D. and
            Wang,R.
  TITLE     Downregulation of MUC15 by miR-183-5p.1 promotes liver
            tumor-initiating cells properties and tumorigenesis via regulating
            c-MET/PI3K/AKT/SOX2 axis
  JOURNAL   Cell Death Dis 13 (3), 200 (2022)
   PUBMED   35236826
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3277)
  AUTHORS   de Barros Mucci,D., Kusinski,L.C., Wilsmore,P., Loche,E.,
            Pantaleao,L.C., Ashmore,T.J., Blackmore,H.L., Fernandez-Twinn,D.S.,
            Carmo,M.D.G.T.D. and Ozanne,S.E.
  TITLE     Impact of maternal obesity on placental transcriptome and
            morphology associated with fetal growth restriction in mice
  JOURNAL   Int J Obes (Lond) 44 (5), 1087-1096 (2020)
   PUBMED   32203108
REFERENCE   3  (bases 1 to 3277)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   4  (bases 1 to 3277)
  AUTHORS   Favor,J., Bradley,A., Conte,N., Janik,D., Pretsch,W., Reitmeir,P.,
            Rosemann,M., Schmahl,W., Wienberg,J. and Zaus,I.
  TITLE     Analysis of Pax6 contiguous gene deletions in the mouse, Mus
            musculus, identifies regions distinct from Pax6 responsible for
            extreme small-eye and belly-spotting phenotypes
  JOURNAL   Genetics 182 (4), 1077-1088 (2009)
   PUBMED   19474196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731779.12, AK142590.1 and AK028832.1.
            
            On Mar 20, 2014 this sequence version replaced NM_172979.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142590.1, AK052840.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AL731779.12        41613-41726
            115-2730            AK142590.1         2-2617
            2731-3260           AK028832.1         1925-2454
            3261-3277           AK142590.1         3148-3164
FEATURES             Location/Qualifiers
     source          1..3277
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 56.75 cM"
     gene            1..3277
                     /gene="Muc15"
                     /gene_synonym="4732460E09; D730046L02Rik; MUC-15"
                     /note="mucin 15"
                     /db_xref="GeneID:269328"
                     /db_xref="MGI:MGI:2442110"
     exon            1..214
                     /gene="Muc15"
                     /gene_synonym="4732460E09; D730046L02Rik; MUC-15"
                     /inference="alignment:Splign:2.1.0"
     exon            215..936
                     /gene="Muc15"
                     /gene_synonym="4732460E09; D730046L02Rik; MUC-15"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..1247
                     /gene="Muc15"
                     /gene_synonym="4732460E09; D730046L02Rik; MUC-15"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="mucin-15 isoform a precursor"
                     /protein_id="NP_766567.1"
                     /db_xref="CCDS:CCDS16513.1"
                     /db_xref="GeneID:269328"
                     /db_xref="MGI:MGI:2442110"
                     /translation="MLTLAKIALISSLFISLPFARPQKQNPRRNVTQHTIEDVKIMRN
                     NSIHLERSINVTSENGSDISNLMVTTPSPLNLSTTFRTTNSTRTWLMTSSSESSRPSS
                     TYSVPPLVQGFVSKLPLNSSTADANPLQVSEHSNSTNSPSPENFTWSLDNDTMNSPED
                     ISTTVRPFPPPPKTTPVTPFTAEPTEWLPTNNDNFAGFTPYQEKTTLQPTLKFTNNSK
                     LFPNTSDTPKENKNTGIVFGAILGAILGASLLSLVGYLLCGQRKTDSFSHRRLYDDRN
                     EPVLRLDNAPEPYDVNFGNSSYYNPAVSDSSMPEGGESLQDGIPMDAIPPLRPSI"
     exon            937..1086
                     /gene="Muc15"
                     /gene_synonym="4732460E09; D730046L02Rik; MUC-15"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..3277
                     /gene="Muc15"
                     /gene_synonym="4732460E09; D730046L02Rik; MUC-15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3245..3250
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Muc15"
                     /gene_synonym="4732460E09; D730046L02Rik; MUC-15"
                     /note="hexamer: AATAAA"
     polyA_site      3267
                     /gene="Muc15"
                     /gene_synonym="4732460E09; D730046L02Rik; MUC-15"
                     /note="major polyA site"
ORIGIN      
        1 cttggctgct ctattacaca agcaagatac tgccagccag ccagcaggcc ggccagcccc
       61 acccaatttt gtttctctag catctgcctg tgtcctgctc aatgccacac tgtcagactt
      121 aagccacctg cttttccgtg tgctgaggtc ttactgtagc caggtcaaca gcgctatttt
      181 cttcaccatc tgtaaatacc tgttagttct gaagattcct catactaaaa ccaatatcaa
      241 cgaaggacac tatgttgacc ttagccaaaa ttgcattgat ttcaagtctg ttcatttcat
      301 taccatttgc gaggcctcag aaacaaaatc cacgaagaaa tgtaactcag cacactatag
      361 aagatgtgaa aataatgaga aacaactcca ttcatttgga aagaagcata aatgtaactt
      421 cagagaatgg aagtgatatc tccaatctca tggtgacaac tccttctcct ttgaatttat
      481 ctacaacctt cagaacaaca aattccacca gaacctggct aatgactagc tcatctgaga
      541 gttccagacc ctcctccaca tattctgttc ctcccttggt tcagggcttt gtttccaagt
      601 tgcctttgaa ctcatccaca gcagacgcaa atcctttaca ggtctccgaa cattccaatt
      661 ctacaaattc cccatcacca gaaaacttta cttggtcttt ggacaatgac acaatgaaca
      721 gtcctgaaga tatttccact acagtaagac ccttccctcc acctccaaag accacacctg
      781 tgaccccttt cacagctgaa cctactgaat ggctccccac aaacaatgac aactttgctg
      841 gttttacccc gtatcaagaa aaaacaactt tacaacctac actaaaattc accaataatt
      901 caaaactttt cccaaataca tcagacaccc caaaagagaa taagaacaca ggaatagtat
      961 ttggagccat tttaggagcc atcctgggtg cttcactgct tagccttgtt ggctacttat
     1021 tgtgtggaca acggaaaaca gattcatttt cccatcggcg cctttatgat gacagaaacg
     1081 aaccagttct gcgattagac aatgcaccag aaccttatga tgtcaatttt ggaaattcta
     1141 gttactacaa cccagctgtg agtgattcat ccatgccaga agggggagaa agcctgcaag
     1201 atggcattcc tatggatgct atacctccac ttcgcccctc aatataaaat taggagaaag
     1261 atggctgcag agggcacaag ttcatctcca ttttgacctt tcaacaaatt catcattcaa
     1321 gaggttctgc aagatcactg ctgtgctgct tgcacaggga atgctgcaca aacaggaaat
     1381 gtgcaggaaa agcagggtgc atctgtcatc gaaaagcttt cttttcttgc agtcttcagc
     1441 tgggctgaag catgtgttat acaaccataa tttttatttt ggtttatttt ccaaggaaac
     1501 ctttgtggga taaggtaaaa ttaatgcaac attaccatgg cagcgctgac tgataacaat
     1561 aaccgttctt cacacaaaat ctgggaacca aaactagatt ttctttaaat agtttgtttt
     1621 taaacaagaa acaggagtta actctttatt cttcttgtct gtaattcagg accacagaat
     1681 aaaacaagca ttttcttggg ggcatagttt gggtgataat tttttttctg ggttgtttca
     1741 aagtcagaaa tactatatgg cagaatgttt ggttctgaga aattaaggca ataagaacga
     1801 aaagcttgtc tcctaataca ttcactcttc tgcaacagta catgtggtta gtccctttgg
     1861 ctggcatgtt gacaataggg gcattcaaca ggactgaggg agaaaactga ctctagccag
     1921 gaaagtgata tcttccctga aagtcctcaa agttttaaga acttcagctt gcatgagtac
     1981 acatcaggtt tcagttaatt gggcacctta gaatctcaat tggaaacatg aggaaaaggg
     2041 tgagggatat acttgtacat agtacaaatt ttacttgtta gctagaaata gaatttgtag
     2101 tatattatag acgtctgttc agtcacatgt gaaatatctg tctttctaga ggcatggagc
     2161 acagggaaaa cagcaacgag agttagcatg caaacacatc atcatttgga cacgtaacga
     2221 tagaagagac ttaattctgg ttttagtttg ttttcgatca actcctgcct ttgacagtct
     2281 gagcctcaaa gactagagga tcaaataaag ttaaattccc aaggagtgaa tgatgaacaa
     2341 agaaagtagt atcttagata tcttatagtc tttattgttg agtcaataca cggtatgagt
     2401 ggcacttgca tgtgcgtgtg catgtgtgtg tgtgtgtgtg tgtgtgtgta acacagaaaa
     2461 cattttagaa agtcagaatt gtaaaatgaa taatgaaaga aaatactcac cccatattgc
     2521 cataaaaata gcgaagaaaa ctgtccctcc attatcaaac aaatatgtta ccttaataga
     2581 aaaaaataga aatattaatt atactagtgg ttgtactaaa atagaagtta ttgttagcat
     2641 taggtactgt ggtttctccc taggtcctat caccgtattg tatagtcttt taatctattg
     2701 acctggtacc ttcactggtt ttccagtagt ttatgtaatt tcctcacagg agagatgagg
     2761 aaacaacaga tttttctttt tctcacctcc ctctgatttc tttgtacctc actttcattt
     2821 tggcctttaa gttgttctag attcccaaag aagccatttt gcactacagt caaacatact
     2881 aacaccctga aatgtaagaa gttagtgtgt aacttaaaac aacaagtttt gcttcatttt
     2941 gtttcctgtt agtgaaagtt cccagaacag gaaagttata aaatagagaa ctctgatagt
     3001 gagcaagtgt cttcgattga aagttgtcat atcaatattc cgatctttta tttcttgcaa
     3061 aatgtgccat gggtccagta gtgatttatt tcatgtaatg agtttcatct taagttgttt
     3121 taagatgttt cataaatcat taagcatatt ttaatcagct gttaccttat ataaagtttg
     3181 ataaagcatg taaagtcaat attatagaat ataattttta gaattgcaag gattgataga
     3241 ttttaataaa attaagattt aataaaatct gatttat
//
