LOCUS       NM_010739               2969 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus mucin 13, epithelial transmembrane (Muc13), transcript
            variant 2, mRNA.
ACCESSION   NM_010739
VERSION     NM_010739.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2969)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2969)
  AUTHORS   Rivet-Noor,C.R., Merchak,A.R., Render,C., Gay,N.M., Beiter,R.M.,
            Brown,R.M., Keeler,A., Moreau,G.B., Li,S., Olgun,D.G.,
            Steigmeyer,A.D., Ofer,R., Phan,T., Vemuri,K., Chen,L.,
            Mahoney,K.E., Shin,J.B., Malaker,S.A., Deppmann,C., Verzi,M.P. and
            Gaultier,A.
  TITLE     Stress-induced mucin 13 reductions drive intestinal microbiome
            shifts and despair behaviors
  JOURNAL   Brain Behav Immun 119, 665-680 (2024)
   PUBMED   38579936
  REMARK    GeneRIF: Stress-induced mucin 13 reductions drive intestinal
            microbiome shifts and despair behaviors.
REFERENCE   3  (bases 1 to 2969)
  AUTHORS   Breugelmans,T., Arras,W., Oosterlinck,B., Jauregui-Amezaga,A.,
            Somers,M., Cuypers,B., Laukens,K., De Man,J.G., De Schepper,H.U.,
            De Winter,B.Y. and Smet,A.
  TITLE     IL-22-Activated MUC13 Impacts on Colonic Barrier Function through
            JAK1/STAT3, SNAI1/ZEB1 and ROCK2/MAPK Signaling
  JOURNAL   Cells 12 (9), 1224 (2023)
   PUBMED   37174625
  REMARK    GeneRIF: IL-22-Activated MUC13 Impacts on Colonic Barrier Function
            through JAK1/STAT3, SNAI1/ZEB1 and ROCK2/MAPK Signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2969)
  AUTHORS   McGuckin,M.A., Davies,J.M., Felgner,P., Wong,K.Y., Giri,R., He,Y.,
            Moniruzzaman,M., Kryza,T., Sajiir,H., Hooper,J.D., Florin,T.H.,
            Begun,J., Oussalah,A., Hasnain,S.Z., Hensel,M. and Sheng,Y.H.
  TITLE     MUC13 Cell Surface Mucin Limits Salmonella Typhimurium Infection by
            Protecting the Mucosal Epithelial Barrier
  JOURNAL   Cell Mol Gastroenterol Hepatol 16 (6), 985-1009 (2023)
   PUBMED   37660948
  REMARK    GeneRIF: MUC13 Cell Surface Mucin Limits Salmonella Typhimurium
            Infection by Protecting the Mucosal Epithelial Barrier.
REFERENCE   5  (bases 1 to 2969)
  AUTHORS   Lewis,M.A., Ingham,N.J., Chen,J., Pearson,S., Di Domenico,F.,
            Rekhi,S., Allen,R., Drake,M., Willaert,A., Rook,V., Pass,J.,
            Keane,T., Adams,D.J., Tucker,A.S., White,J.K. and Steel,K.P.
  TITLE     Identification and characterisation of spontaneous mutations
            causing deafness from a targeted knockout programme
  JOURNAL   BMC Biol 20 (1), 67 (2022)
   PUBMED   35296311
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2969)
  AUTHORS   Sheng,Y.H., Lourie,R., Linden,S.K., Jeffery,P.L., Roche,D.,
            Tran,T.V., Png,C.W., Waterhouse,N., Sutton,P., Florin,T.H. and
            McGuckin,M.A.
  TITLE     The MUC13 cell-surface mucin protects against intestinal
            inflammation by inhibiting epithelial cell apoptosis
  JOURNAL   Gut 60 (12), 1661-1670 (2011)
   PUBMED   21636645
  REMARK    GeneRIF: protective role in the colonic epithelium by inhibiting
            toxin-induced apoptosis
REFERENCE   7  (bases 1 to 2969)
  AUTHORS   Tang,H., Zhang,X.Q., Naruse,T., Ohbo,K. and Suda,T.
  TITLE     Expression and function of NJ-1 surface antigen in megakaryopoiesis
  JOURNAL   Biochem Biophys Res Commun 292 (3), 667-674 (2002)
   PUBMED   11922618
  REMARK    GeneRIF: hypothesize that NJ-1(+)megakaryocytes (MKs) are immature
            MKs and the NJ-1 molecule is involved in MK adhesion to endothelial
            cells [NJ-1]
REFERENCE   8  (bases 1 to 2969)
  AUTHORS   Williams,S.J., Wreschner,D.H., Tran,M., Eyre,H.J., Sutherland,G.R.
            and McGuckin,M.A.
  TITLE     Muc13, a novel human cell surface mucin expressed by epithelial and
            hemopoietic cells
  JOURNAL   J Biol Chem 276 (21), 18327-18336 (2001)
   PUBMED   11278439
REFERENCE   9  (bases 1 to 2969)
  AUTHORS   Miyake,K., Yamashita,Y., Ogata,M., Sudo,T. and Kimoto,M.
  TITLE     RP105, a novel B cell surface molecule implicated in B cell
            activation, is a member of the leucine-rich repeat protein family
  JOURNAL   J Immunol 154 (7), 3333-3340 (1995)
   PUBMED   7897216
REFERENCE   10 (bases 1 to 2969)
  AUTHORS   Dougherty,G.J., Kay,R.J. and Humphries,R.K.
  TITLE     Molecular cloning of 114/A10, a cell surface antigen containing
            highly conserved repeated elements, which is expressed by murine
            hemopoietic progenitor cells and interleukin-3-dependent cell lines
  JOURNAL   J Biol Chem 264 (11), 6509-6514 (1989)
   PUBMED   2784793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            J04634.1 and BY441725.1.
            
            On Dec 7, 2007 this sequence version replaced NM_010739.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04634.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2855              J04634.1           1-2855
            2856-2856           BY441725.1         258-258
            2857-2969           J04634.1           2856-2968
FEATURES             Location/Qualifiers
     source          1..2969
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 24.21 cM"
     gene            1..2969
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /note="mucin 13, epithelial transmembrane"
                     /db_xref="GeneID:17063"
                     /db_xref="MGI:MGI:103190"
     exon            1..96
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /inference="alignment:Splign:2.1.0"
     exon            97..243
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1916
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /note="lymphocyte antigen 64; mucin-13; MUC-13; cell
                     surface antigen 114/A10"
                     /codon_start=1
                     /product="mucin-13 precursor"
                     /protein_id="NP_034869.1"
                     /db_xref="CCDS:CCDS28134.1"
                     /db_xref="GeneID:17063"
                     /db_xref="MGI:MGI:103190"
                     /translation="MKGFLLLSLSLLLVTVGSSSQASSTTSSSGGTSPPTTVQSQSPG
                     SSSQASTTTSSSGGASPPTTVQSQSPGSSSQASTTTSSSGGASPPTTVQSQSPGSSSQ
                     ASTTTSSSGGASPPTTVQSQSPGSSSQASTTTSSSGGASPPTTVQSQSPGSSSQASTT
                     TSSSGGASPPTTVQSQSPGSSSQVSTTTSSSGGASPPTTVQSQSPGSSSQPGPTQPSG
                     GASSSTVPSGGSTGPSDLCNPNPCKGTASCVKLHSKHFCLCLEGYYYNSSLSSCVKGT
                     TFPGDISMSVSETANLEDENSVGYQELYNSVTDFFETTFNKTDYGQTVIIKVSTAPSR
                     SARSAMRDATKDVSVSVVNIFGADTKETEKSVSSAIETAIKTSGNVKDYVSINLCDHY
                     GCVGNDSSKCQDILQCTCKPGLDRLNPQVPFCVAVTCSQPCNAEEKEQCLKMDNGVMD
                     CVCMPGYQRANGNRKCEECPFGYSGMNCKDQFQLILTIVGTIAGALILILLIAFIVSA
                     RSKNKKKDGEEQRLIEDDFHNLRLRQTGFSNLGADNSIFPKVRTGVPSQTPNPYANQR
                     SMPRPDY"
     exon            244..888
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1017
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1124
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1180
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1347
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1470
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1597
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1635
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1720
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1916
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2969
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2091..2097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
     regulatory      2952..2957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
ORIGIN      
        1 cacatggtga agggtcaaga atcaaccctt cccaccatcc tctggcagct acatgagcac
       61 tgtggtgtgc acacacaaaa taagaagggg tcagagttaa tgagtggact tcggacttga
      121 aagacagtta aaactccagg cagcgaagga gaggacacat ttcctccttg gattatcaag
      181 caagagcagc taccatgaaa ggcttcctgc ttctctctct cagtctcctt ttggtgaccg
      241 tgggtagttc atctcaggcc tctagtacaa catcgtcttc tggtggcacc agtcctccca
      301 ccacagtaca aagtcaatct ccaggtagtt catctcaggc ctctactaca acatcgtctt
      361 ctggtggcgc cagtcctccc accacggtac agagtcaatc tccaggtagt tcatctcagg
      421 cctctactac aacatcgtct tctggtggcg ccagtcctcc caccacggta cagagtcaat
      481 ctccaggtag ttcatctcag gcctctacta caacatcgtc ttctggtggc gccagtcctc
      541 ccaccacggt acagagtcaa tctccaggta gttcatctca ggcctctact acaacatcgt
      601 cttctggtgg cgccagtcct cccaccacgg tacagagtca atctccaggt agttcatctc
      661 aggcctctac tacaacatcg tcttctggtg gcgccagtcc tcccaccacg gtacagagtc
      721 aatctccagg tagttcatct caggtctcta ctacaacatc gtcttctggt ggcgccagtc
      781 ctcccaccac ggtacagagt caatctccag gtagttcatc tcagcccgga ccaactcagc
      841 cttctggtgg tgccagctct tccaccgtgc ctagcggtgg aagcacaggt cccagtgatc
      901 tctgcaaccc taacccctgt aaaggaactg cttcttgtgt taagctgcat agcaaacact
      961 tctgcttgtg tttagaaggc tattactaca actcgtctct gtcgtcatgt gtgaaaggaa
     1021 cgacattccc tggggacatt agcatgagtg tgtctgaaac agccaacttg gaagatgaaa
     1081 actctgtggg ctatcaagag ttgtacaaca gtgttaccga tttttttgaa acaacattta
     1141 ataagactga ctatggacag actgtaatta ttaaagtgag cacagcccct tcacggtcag
     1201 caagatctgc aatgcgtgat gctacaaagg acgtcagtgt atccgtagta aatatatttg
     1261 gagcagacac aaaagaaact gaaaagagtg tatcttctgc aatcgaaact gcaattaaga
     1321 ctagtggcaa tgtgaaagac tatgtcagta taaatttgtg tgatcattat ggttgtgtag
     1381 ggaatgacag cagtaaatgc caggacattt tacaatgcac gtgcaaacct gggctggaca
     1441 ggctgaaccc acaggttcct ttttgtgttg ctgtaacgtg ctctcagccc tgcaatgcag
     1501 aggagaagga gcagtgctta aagatggata acggagtaat ggattgtgtg tgcatgccgg
     1561 gctaccagag ggcaaacggg aacaggaagt gtgaagagtg tccatttggc tacagcggga
     1621 tgaattgcaa agaccaattt cagctgatcc tcaccatcgt gggcaccatt gctggagccc
     1681 tcatcctcat cttgctgatt gcttttatcg tctctgcgag gtcaaagaac aaaaagaagg
     1741 atggagaaga gcagaggctg attgaggatg acttccataa cctacgactg aggcagaccg
     1801 gcttctccaa cttaggagcg gacaacagca tcttccccaa agtcagaaca ggggtcccga
     1861 gtcagacccc taatccctac gcaaaccagc gaagcatgcc tcgccctgac tactagaatg
     1921 ataagaattt ggaaccctcc ctagcccagc ccacccaagc tacggtctta aggacaagga
     1981 gaaatgggca gagacaaagt ttgacctcca gcattcctct gcgtggtttg ccaacccctc
     2041 tgggtgtgga cctgtgtgaa gaccgaagct tgccgaagac acacctatca aattaaatgc
     2101 gcatagaccc tatgagcctt tgtaagagtt gattttctcc agttagtaca gaatgctatg
     2161 gcaattggtg tggggctttt ctttcctggt gggtcaactc ttagcgtttc caatcttaga
     2221 gggagcaccc tcataactca tccctgagca gtgccactcc tgagctctgg actctggcca
     2281 ctcttgaaca gctagctgct tgtgataggg cctcacccca agaggacagg caagagatgg
     2341 aagcatgtcc cagctttctc aggaggactt tggggaccca ggcaaatgac aataagaagg
     2401 cttggactgg ctctgtcctc tgtggggaca ttcaagtctt tgagatgtta gttggtagga
     2461 aagcagggag gagaaacagg agcataggag gtagagagag gccaaggaag ctatgccgga
     2521 aggctgaggg agggagaagg tagcaggtgg cgtcttctcc cttgatgatg tccctcctca
     2581 ggcagcaaat gggtactctc cggtgctgcc atccccaaga catagatcct gggaaagcca
     2641 caaaagcagc agtcagtgtg aagcccctgt gacagcacag gccttctatc tggaactctg
     2701 acagaggagc ctggtgtcca ctcaatgatg cttcactgaa cctctgctcc atgatggagg
     2761 cttagcagtg gccacacaca cacacacaca cacacacaca cacacacaca cacacgataa
     2821 atataaatac atccatcatc tgtcttttta aatgttaatt gtgccctcgt gtctgtctga
     2881 cgtctggtcc tctcgaaagg tatttttgtt attatttgtt cttaattgtt cattgtggaa
     2941 ggcaatgctt taataaaata tatttggtg
//
