LOCUS       NM_001382834            2815 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus mucin 13, epithelial transmembrane (Muc13), transcript
            variant 1, mRNA.
ACCESSION   NM_001382834 XM_011245835
VERSION     NM_001382834.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2815)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2815)
  AUTHORS   Rivet-Noor,C.R., Merchak,A.R., Render,C., Gay,N.M., Beiter,R.M.,
            Brown,R.M., Keeler,A., Moreau,G.B., Li,S., Olgun,D.G.,
            Steigmeyer,A.D., Ofer,R., Phan,T., Vemuri,K., Chen,L.,
            Mahoney,K.E., Shin,J.B., Malaker,S.A., Deppmann,C., Verzi,M.P. and
            Gaultier,A.
  TITLE     Stress-induced mucin 13 reductions drive intestinal microbiome
            shifts and despair behaviors
  JOURNAL   Brain Behav Immun 119, 665-680 (2024)
   PUBMED   38579936
  REMARK    GeneRIF: Stress-induced mucin 13 reductions drive intestinal
            microbiome shifts and despair behaviors.
REFERENCE   3  (bases 1 to 2815)
  AUTHORS   Breugelmans,T., Arras,W., Oosterlinck,B., Jauregui-Amezaga,A.,
            Somers,M., Cuypers,B., Laukens,K., De Man,J.G., De Schepper,H.U.,
            De Winter,B.Y. and Smet,A.
  TITLE     IL-22-Activated MUC13 Impacts on Colonic Barrier Function through
            JAK1/STAT3, SNAI1/ZEB1 and ROCK2/MAPK Signaling
  JOURNAL   Cells 12 (9), 1224 (2023)
   PUBMED   37174625
  REMARK    GeneRIF: IL-22-Activated MUC13 Impacts on Colonic Barrier Function
            through JAK1/STAT3, SNAI1/ZEB1 and ROCK2/MAPK Signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2815)
  AUTHORS   McGuckin,M.A., Davies,J.M., Felgner,P., Wong,K.Y., Giri,R., He,Y.,
            Moniruzzaman,M., Kryza,T., Sajiir,H., Hooper,J.D., Florin,T.H.,
            Begun,J., Oussalah,A., Hasnain,S.Z., Hensel,M. and Sheng,Y.H.
  TITLE     MUC13 Cell Surface Mucin Limits Salmonella Typhimurium Infection by
            Protecting the Mucosal Epithelial Barrier
  JOURNAL   Cell Mol Gastroenterol Hepatol 16 (6), 985-1009 (2023)
   PUBMED   37660948
  REMARK    GeneRIF: MUC13 Cell Surface Mucin Limits Salmonella Typhimurium
            Infection by Protecting the Mucosal Epithelial Barrier.
REFERENCE   5  (bases 1 to 2815)
  AUTHORS   Lewis,M.A., Ingham,N.J., Chen,J., Pearson,S., Di Domenico,F.,
            Rekhi,S., Allen,R., Drake,M., Willaert,A., Rook,V., Pass,J.,
            Keane,T., Adams,D.J., Tucker,A.S., White,J.K. and Steel,K.P.
  TITLE     Identification and characterisation of spontaneous mutations
            causing deafness from a targeted knockout programme
  JOURNAL   BMC Biol 20 (1), 67 (2022)
   PUBMED   35296311
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2815)
  AUTHORS   Sheng,Y.H., Lourie,R., Linden,S.K., Jeffery,P.L., Roche,D.,
            Tran,T.V., Png,C.W., Waterhouse,N., Sutton,P., Florin,T.H. and
            McGuckin,M.A.
  TITLE     The MUC13 cell-surface mucin protects against intestinal
            inflammation by inhibiting epithelial cell apoptosis
  JOURNAL   Gut 60 (12), 1661-1670 (2011)
   PUBMED   21636645
  REMARK    GeneRIF: protective role in the colonic epithelium by inhibiting
            toxin-induced apoptosis
REFERENCE   7  (bases 1 to 2815)
  AUTHORS   Tang,H., Zhang,X.Q., Naruse,T., Ohbo,K. and Suda,T.
  TITLE     Expression and function of NJ-1 surface antigen in megakaryopoiesis
  JOURNAL   Biochem Biophys Res Commun 292 (3), 667-674 (2002)
   PUBMED   11922618
  REMARK    GeneRIF: hypothesize that NJ-1(+)megakaryocytes (MKs) are immature
            MKs and the NJ-1 molecule is involved in MK adhesion to endothelial
            cells [NJ-1]
REFERENCE   8  (bases 1 to 2815)
  AUTHORS   Williams,S.J., Wreschner,D.H., Tran,M., Eyre,H.J., Sutherland,G.R.
            and McGuckin,M.A.
  TITLE     Muc13, a novel human cell surface mucin expressed by epithelial and
            hemopoietic cells
  JOURNAL   J Biol Chem 276 (21), 18327-18336 (2001)
   PUBMED   11278439
REFERENCE   9  (bases 1 to 2815)
  AUTHORS   Miyake,K., Yamashita,Y., Ogata,M., Sudo,T. and Kimoto,M.
  TITLE     RP105, a novel B cell surface molecule implicated in B cell
            activation, is a member of the leucine-rich repeat protein family
  JOURNAL   J Immunol 154 (7), 3333-3340 (1995)
   PUBMED   7897216
REFERENCE   10 (bases 1 to 2815)
  AUTHORS   Dougherty,G.J., Kay,R.J. and Humphries,R.K.
  TITLE     Molecular cloning of 114/A10, a cell surface antigen containing
            highly conserved repeated elements, which is expressed by murine
            hemopoietic progenitor cells and interleukin-3-dependent cell lines
  JOURNAL   J Biol Chem 264 (11), 6509-6514 (1989)
   PUBMED   2784793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132274.1 and AC155268.1.
            
            On May 26, 2020 this sequence version replaced XM_011245835.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132274.1, BC024321.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1912              AK132274.1         2-1913
            1913-2815           AC155268.1         103464-104366       c
FEATURES             Location/Qualifiers
     source          1..2815
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 24.21 cM"
     gene            1..2815
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /note="mucin 13, epithelial transmembrane"
                     /db_xref="GeneID:17063"
                     /db_xref="MGI:MGI:103190"
     exon            1..87
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1760
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /note="lymphocyte antigen 64; mucin-13; MUC-13; cell
                     surface antigen 114/A10"
                     /codon_start=1
                     /product="mucin-13 precursor"
                     /protein_id="NP_001369763.1"
                     /db_xref="GeneID:17063"
                     /db_xref="MGI:MGI:103190"
                     /translation="MKGFLLLSLSLLLVTVGSSSQASSTTSSSGGTSPPTTVQSQSPG
                     SSSQASTTTSSSGGASPPTTVQSQSPGSSSQASTTTSSSGGASPPTTVQSQSPGSSSQ
                     ASTTTSSSGGASPPTTVQSQSPGSSSQASTTTSSSGGASPPTTVQSQSPGSSSQASTT
                     TSSSGGASPPTTVQSQSPGSSSQVSTTTSSSGGASPPTTVQSQSPGSSSQPGPTQPSG
                     GASSSTVPSGGSTGPSDLCNPNPCKGTASCVKLHSKHFCLCLEGYYYNSSLSSCVKGT
                     TFPGDISMSVSETANLEDENSVGYQELYNSVTDFFETTFNKTDYGQTVIIKVSTAPSR
                     SARSAMRDATKDVSVSVVNIFGADTKETEKSVSSAIETAIKTSGNVKDYVSINLCDHY
                     GCVGNDSSKCQDILQCTCKPGLDRLNPQVPFCVAVTCSQPCNAEEKEQCLKMDNGVMD
                     CVCMPGYQRANGNRKCEECPFGYSGMNCKDQFQLILTIVGTIAGALILILLIAFIVSA
                     RSKNKKKDGEEQRLIEDDFHNLRLRQTGFSNLGADNSIFPKVRTGVPSQTPNPYANQR
                     SMPRPDY"
     exon            88..732
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /inference="alignment:Splign:2.1.0"
     exon            733..861
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /inference="alignment:Splign:2.1.0"
     exon            862..968
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1024
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1191
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1314
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1441
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1479
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1564
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1760
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..2815
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2796..2801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /note="hexamer: AATAAA"
     polyA_site      2815
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /note="major polyA site"
ORIGIN      
        1 acatttcctc cttggattat caagcaagag cagctaccat gaaaggcttc ctgcttctct
       61 ctctcagtct ccttttggtg accgtgggta gttcatctca ggcctctagt acaacatcgt
      121 cttctggtgg caccagtcct cccaccacag tacaaagtca atctccaggt agttcatctc
      181 aggcctctac tacaacatcg tcttctggtg gcgccagtcc tcccaccacg gtacagagtc
      241 aatctccagg tagttcatct caggcctcta ctacaacatc gtcttctggt ggcgccagtc
      301 ctcccaccac ggtacagagt caatctccag gtagttcatc tcaggcctct actacaacat
      361 cgtcttctgg tggcgccagt cctcccacca cggtacagag tcaatctcca ggtagttcat
      421 ctcaggcctc tactacaaca tcgtcttctg gtggcgccag tcctcccacc acggtacaga
      481 gtcaatctcc aggtagttca tctcaggcct ctactacaac atcgtcttct ggtggcgcca
      541 gtcctcccac cacggtacag agtcaatctc caggtagttc atctcaggtc tctactacaa
      601 catcgtcttc tggtggcgcc agtcctccca ccacggtaca gagtcaatct ccaggtagtt
      661 catctcagcc cggaccaact cagccttctg gtggtgccag ctcttccacc gtgcctagcg
      721 gtggaagcac aggtcccagt gatctctgca accctaaccc ctgtaaagga actgcttctt
      781 gtgttaagct gcatagcaaa cacttctgct tgtgtttaga aggctattac tacaactcgt
      841 ctctgtcgtc atgtgtgaaa ggaacgacat tccctgggga cattagcatg agtgtgtctg
      901 aaacagccaa cttggaagat gaaaactctg tgggctatca agagttgtac aacagtgtta
      961 ccgatttttt tgaaacaaca tttaataaga ctgactatgg acagactgta attattaaag
     1021 tgagcacagc cccttcacgg tcagcaagat ctgcaatgcg tgatgctaca aaggacgtca
     1081 gtgtatccgt agtaaatata tttggagcag acacaaaaga aactgaaaag agtgtatctt
     1141 ctgcaatcga aactgcaatt aagactagtg gcaatgtgaa agactatgtc agtataaatt
     1201 tgtgtgatca ttatggttgt gtagggaatg acagcagtaa atgccaggac attttacaat
     1261 gcacgtgcaa acctgggctg gacaggctga acccacaggt tcctttttgt gttgctgtaa
     1321 cgtgctctca gccctgcaat gcagaggaga aggagcagtg cttaaagatg gataacggag
     1381 taatggattg tgtgtgcatg ccgggctacc agagggcaaa cgggaacagg aagtgtgaag
     1441 agtgtccatt tggctacagc gggatgaatt gcaaagacca atttcagctg atcctcacca
     1501 tcgtgggcac cattgctgga gccctcatcc tcatcttgct gattgctttt atcgtctctg
     1561 cgaggtcaaa gaacaaaaag aaggatggag aagagcagag gctgattgag gatgacttcc
     1621 ataacctacg actgaggcag accggcttct ccaacttagg agcggacaac agcatcttcc
     1681 ccaaagtcag aacaggggtc ccgagtcaga cccctaatcc ctacgcaaac cagcgaagca
     1741 tgcctcgccc tgactactag aatgataaga atttggaacc ctccctagcc cagcccaccc
     1801 aagctacggt cttaaggaca aggagaaatg ggcagagaca aagtttgacc tccagcattc
     1861 ctctgcgtgg tttgccaacc cctctgggtg tggacctgtg tgaagaccga agcttgccga
     1921 agacacacct atcaaattaa atgcgcatag accctatgag cctttgtaag agttgatttt
     1981 ctccagttag tacagaatgc tatggcaatt ggtgtggggc ttttctttcc tggtgggtca
     2041 actcttagcg tttccaatct tagagggagc accctcataa ctcatccctg agcagtgcca
     2101 ctcctgagct ctggactctg gccactcttg aacagctagc tgcttgtgat agggcctcac
     2161 cccaagagga caggcaagag atggaagcat gtcccagctt tctcaggagg actttgggga
     2221 cccaggcaaa tgacaataag aaggcttgga ctggctctgt cctctgtggg gacattcaag
     2281 tctttgagat gttagttggt aggaaagcag ggaggagaaa caggagcata ggaggtagag
     2341 agaggccaag gaagctatgc cggaaggctg agggagggag aaggtagcag gtggcgtctt
     2401 ctcccttgat gatgtccctc ctcaggcagc aaatgggtac tctccggtgc tgccatcccc
     2461 aagacataga tcctgggaaa gccacaaaag cagcagtcag tgtgaagccc ctgtgacagc
     2521 acaggccttc tatctggaac tctgacagag gagcctggtg tccactcaat gatgcttcac
     2581 tgaacctctg ctccatgatg gaggcttagc agtggccaca cacacacaca cacacacaca
     2641 cacacacaca cacacacacg ataaatataa atacatccat catctgtctt tttaaatgtt
     2701 aattgtgccc tcgtgtctgt ctgacgtctg gtcctctcga aaggtatttt tgttattatt
     2761 tgttcttaat tgttcattgt ggaaggcaat gctttaataa aatatatttg gtgga
//
