LOCUS       NP_001369763             573 aa            linear   ROD 30-APR-2025
DEFINITION  mucin-13 precursor [Mus musculus].
ACCESSION   NP_001369763 XP_011244137
VERSION     NP_001369763.1
DBSOURCE    REFSEQ: accession NM_001382834.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 573)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 573)
  AUTHORS   Rivet-Noor,C.R., Merchak,A.R., Render,C., Gay,N.M., Beiter,R.M.,
            Brown,R.M., Keeler,A., Moreau,G.B., Li,S., Olgun,D.G.,
            Steigmeyer,A.D., Ofer,R., Phan,T., Vemuri,K., Chen,L.,
            Mahoney,K.E., Shin,J.B., Malaker,S.A., Deppmann,C., Verzi,M.P. and
            Gaultier,A.
  TITLE     Stress-induced mucin 13 reductions drive intestinal microbiome
            shifts and despair behaviors
  JOURNAL   Brain Behav Immun 119, 665-680 (2024)
   PUBMED   38579936
  REMARK    GeneRIF: Stress-induced mucin 13 reductions drive intestinal
            microbiome shifts and despair behaviors.
REFERENCE   3  (residues 1 to 573)
  AUTHORS   Breugelmans,T., Arras,W., Oosterlinck,B., Jauregui-Amezaga,A.,
            Somers,M., Cuypers,B., Laukens,K., De Man,J.G., De Schepper,H.U.,
            De Winter,B.Y. and Smet,A.
  TITLE     IL-22-Activated MUC13 Impacts on Colonic Barrier Function through
            JAK1/STAT3, SNAI1/ZEB1 and ROCK2/MAPK Signaling
  JOURNAL   Cells 12 (9), 1224 (2023)
   PUBMED   37174625
  REMARK    GeneRIF: IL-22-Activated MUC13 Impacts on Colonic Barrier Function
            through JAK1/STAT3, SNAI1/ZEB1 and ROCK2/MAPK Signaling.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 573)
  AUTHORS   McGuckin,M.A., Davies,J.M., Felgner,P., Wong,K.Y., Giri,R., He,Y.,
            Moniruzzaman,M., Kryza,T., Sajiir,H., Hooper,J.D., Florin,T.H.,
            Begun,J., Oussalah,A., Hasnain,S.Z., Hensel,M. and Sheng,Y.H.
  TITLE     MUC13 Cell Surface Mucin Limits Salmonella Typhimurium Infection by
            Protecting the Mucosal Epithelial Barrier
  JOURNAL   Cell Mol Gastroenterol Hepatol 16 (6), 985-1009 (2023)
   PUBMED   37660948
  REMARK    GeneRIF: MUC13 Cell Surface Mucin Limits Salmonella Typhimurium
            Infection by Protecting the Mucosal Epithelial Barrier.
REFERENCE   5  (residues 1 to 573)
  AUTHORS   Lewis,M.A., Ingham,N.J., Chen,J., Pearson,S., Di Domenico,F.,
            Rekhi,S., Allen,R., Drake,M., Willaert,A., Rook,V., Pass,J.,
            Keane,T., Adams,D.J., Tucker,A.S., White,J.K. and Steel,K.P.
  TITLE     Identification and characterisation of spontaneous mutations
            causing deafness from a targeted knockout programme
  JOURNAL   BMC Biol 20 (1), 67 (2022)
   PUBMED   35296311
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 573)
  AUTHORS   Sheng,Y.H., Lourie,R., Linden,S.K., Jeffery,P.L., Roche,D.,
            Tran,T.V., Png,C.W., Waterhouse,N., Sutton,P., Florin,T.H. and
            McGuckin,M.A.
  TITLE     The MUC13 cell-surface mucin protects against intestinal
            inflammation by inhibiting epithelial cell apoptosis
  JOURNAL   Gut 60 (12), 1661-1670 (2011)
   PUBMED   21636645
  REMARK    GeneRIF: protective role in the colonic epithelium by inhibiting
            toxin-induced apoptosis
REFERENCE   7  (residues 1 to 573)
  AUTHORS   Tang,H., Zhang,X.Q., Naruse,T., Ohbo,K. and Suda,T.
  TITLE     Expression and function of NJ-1 surface antigen in megakaryopoiesis
  JOURNAL   Biochem Biophys Res Commun 292 (3), 667-674 (2002)
   PUBMED   11922618
  REMARK    GeneRIF: hypothesize that NJ-1(+)megakaryocytes (MKs) are immature
            MKs and the NJ-1 molecule is involved in MK adhesion to endothelial
            cells [NJ-1]
REFERENCE   8  (residues 1 to 573)
  AUTHORS   Williams,S.J., Wreschner,D.H., Tran,M., Eyre,H.J., Sutherland,G.R.
            and McGuckin,M.A.
  TITLE     Muc13, a novel human cell surface mucin expressed by epithelial and
            hemopoietic cells
  JOURNAL   J Biol Chem 276 (21), 18327-18336 (2001)
   PUBMED   11278439
REFERENCE   9  (residues 1 to 573)
  AUTHORS   Miyake,K., Yamashita,Y., Ogata,M., Sudo,T. and Kimoto,M.
  TITLE     RP105, a novel B cell surface molecule implicated in B cell
            activation, is a member of the leucine-rich repeat protein family
  JOURNAL   J Immunol 154 (7), 3333-3340 (1995)
   PUBMED   7897216
REFERENCE   10 (residues 1 to 573)
  AUTHORS   Dougherty,G.J., Kay,R.J. and Humphries,R.K.
  TITLE     Molecular cloning of 114/A10, a cell surface antigen containing
            highly conserved repeated elements, which is expressed by murine
            hemopoietic progenitor cells and interleukin-3-dependent cell lines
  JOURNAL   J Biol Chem 264 (11), 6509-6514 (1989)
   PUBMED   2784793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132274.1 and AC155268.1.
            
            On May 26, 2020 this sequence version replaced XP_011244137.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132274.1, BC024321.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..573
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 24.21 cM"
     Protein         1..573
                     /product="mucin-13 precursor"
                     /note="lymphocyte antigen 64; mucin-13; MUC-13; cell
                     surface antigen 114/A10"
                     /calculated_mol_wt=56915
     sig_peptide     1..17
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P19467.1)"
                     /calculated_mol_wt=1804
     Region          16..237
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P19467.1)"
     mat_peptide     18..573
                     /product="Mucin-13. /id=PRO_0000019285"
                     /note="propagated from UniProtKB/Swiss-Prot (P19467.1)"
                     /calculated_mol_wt=56915
     Site            266
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P19467.1)"
     Region          274..391
                     /region_name="SEA"
                     /note="Domain found in sea urchin sperm protein,
                     enterokinase, agrin; smart00200"
                     /db_xref="CDD:214554"
     Site            316
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P19467.1)"
     Site            397
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P19467.1)"
     Site            481..508
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P19467.1)"
     Region          548..573
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P19467.1)"
     CDS             1..573
                     /gene="Muc13"
                     /gene_synonym="114/A10; 14/A10; Lrrp; Ly64; NJ-1"
                     /coded_by="NM_001382834.1:39..1760"
                     /db_xref="GeneID:17063"
                     /db_xref="MGI:MGI:103190"
ORIGIN      
        1 mkgflllsls lllvtvgsss qassttsssg gtsppttvqs qspgsssqas tttsssggas
       61 ppttvqsqsp gsssqasttt sssggasppt tvqsqspgss sqastttsss ggasppttvq
      121 sqspgsssqa stttsssgga sppttvqsqs pgsssqastt tsssggaspp ttvqsqspgs
      181 ssqvstttss sggasppttv qsqspgsssq pgptqpsgga ssstvpsggs tgpsdlcnpn
      241 pckgtascvk lhskhfclcl egyyynssls scvkgttfpg dismsvseta nledensvgy
      301 qelynsvtdf fettfnktdy gqtviikvst apsrsarsam rdatkdvsvs vvnifgadtk
      361 eteksvssai etaiktsgnv kdyvsinlcd hygcvgndss kcqdilqctc kpgldrlnpq
      421 vpfcvavtcs qpcnaeekeq clkmdngvmd cvcmpgyqra ngnrkceecp fgysgmnckd
      481 qfqliltivg tiagalilil liafivsars knkkkdgeeq rlieddfhnl rlrqtgfsnl
      541 gadnsifpkv rtgvpsqtpn pyanqrsmpr pdy
//
