LOCUS       NM_013605               2243 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus mucin 1, transmembrane (Muc1), mRNA.
ACCESSION   NM_013605
VERSION     NM_013605.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2243)
  AUTHORS   Moldovan,G.E., Massri,N., Vegter,E.L., Pauneto-Delgado,I.N.,
            Burns,G.W., Joshi,N., Gu,B., Arora,R. and Fazleabas,A.T.
  TITLE     YAP1 and WWTR1 are required for murine pregnancy initiation
  JOURNAL   Reproduction 169 (1), e240355 (2025)
   PUBMED   39503541
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2243)
  AUTHORS   Kane,E., Mak,T.C.S. and Latreille,M.
  TITLE     MicroRNA-7 regulates endocrine progenitor delamination and
            endocrine cell mass in developing pancreatic islets
  JOURNAL   iScience 27 (7), 110332 (2024)
   PUBMED   39055950
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2243)
  AUTHORS   Darrigrand,J.F., Salowka,A., Torres-Cano,A., Tapia-Rojo,R., Zhu,T.,
            Garcia-Manyes,S. and Spagnoli,F.M.
  TITLE     Acinar-ductal cell rearrangement drives branching morphogenesis of
            the murine pancreas in an IGF/PI3K-dependent manner
  JOURNAL   Dev Cell 59 (3), 326-338 (2024)
   PUBMED   38237591
REFERENCE   4  (bases 1 to 2243)
  AUTHORS   Gannoun,L., De Schrevel,C., Belle,M., Dauguet,N., Achouri,Y.,
            Loriot,A., Vanderaa,C., Cordi,S., Dili,A., Heremans,Y., Rooman,I.,
            Leclercq,I.A., Jacquemin,P., Gatto,L. and Lemaigre,F.P.
  TITLE     Axon guidance genes control hepatic artery development
  JOURNAL   Development 150 (16) (2023)
   PUBMED   37497580
REFERENCE   5  (bases 1 to 2243)
  AUTHORS   Li,R., Wang,T., Marquardt,R.M., Lydon,J.P., Wu,S.P. and DeMayo,F.J.
  TITLE     TRIM28 modulates nuclear receptor signaling to regulate uterine
            function
  JOURNAL   Nat Commun 14 (1), 4605 (2023)
   PUBMED   37528140
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2243)
  AUTHORS   Vos,H.L., Devarayalu,S., de Vries,Y. and Bornstein,P.
  TITLE     Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene
            family
  JOURNAL   J Biol Chem 267 (17), 12192-12196 (1992)
   PUBMED   1601886
REFERENCE   7  (bases 1 to 2243)
  AUTHORS   Braga,V.M., Pemberton,L.F., Duhig,T. and Gendler,S.J.
  TITLE     Spatial and temporal expression of an epithelial mucin, Muc-1,
            during mouse development
  JOURNAL   Development 115 (2), 427-437 (1992)
   PUBMED   1425334
REFERENCE   8  (bases 1 to 2243)
  AUTHORS   Parry,G., Li,J., Stubbs,J., Bissell,M.J., Schmidhauser,C.,
            Spicer,A.P. and Gendler,S.J.
  TITLE     Studies of Muc-1 mucin expression and polarity in the mouse mammary
            gland demonstrate developmental regulation of Muc-1 glycosylation
            and establish the hormonal basis for mRNA expression
  JOURNAL   J Cell Sci 101 (Pt 1), 191-199 (1992)
   PUBMED   1569123
REFERENCE   9  (bases 1 to 2243)
  AUTHORS   Vos,H.L., de Vries,Y. and Hilkens,J.
  TITLE     The mouse episialin (Muc1) gene and its promoter: rapid evolution
            of the repetitive domain in the protein
  JOURNAL   Biochem Biophys Res Commun 181 (1), 121-130 (1991)
   PUBMED   1958179
REFERENCE   10 (bases 1 to 2243)
  AUTHORS   Spicer,A.P., Parry,G., Patton,S. and Gendler,S.J.
  TITLE     Molecular cloning and analysis of the mouse homologue of the
            tumor-associated mucin, MUC1, reveals conservation of potential
            O-glycosylation sites, transmembrane, and cytoplasmic domains and a
            loss of minisatellite-like polymorphism
  JOURNAL   J Biol Chem 266 (23), 15099-15109 (1991)
   PUBMED   1714452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ066040.1, AC132327.3, BG079301.2 and AW913641.1.
            
            On Aug 14, 2013 this sequence version replaced NM_013605.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005441.1, SRR11927932.2929583.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               CJ066040.1         2-101
            101-122             AC132327.3         86555-86576
            123-1371            AC132327.3         87310-88558
            1372-1967           BG079301.2         1-596
            1968-2183           AW913641.1         247-462
            2184-2243           AC132327.3         90721-90780
FEATURES             Location/Qualifiers
     source          1..2243
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.02 cM"
     gene            1..2243
                     /gene="Muc1"
                     /gene_synonym="CD227; EMA; Muc-1"
                     /note="mucin 1, transmembrane"
                     /db_xref="GeneID:17829"
                     /db_xref="MGI:MGI:97231"
     exon            1..122
                     /gene="Muc1"
                     /gene_synonym="CD227; EMA; Muc-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1960
                     /gene="Muc1"
                     /gene_synonym="CD227; EMA; Muc-1"
                     /note="mucin-1; episialin"
                     /codon_start=1
                     /product="mucin-1 precursor"
                     /protein_id="NP_038633.1"
                     /db_xref="CCDS:CCDS17496.1"
                     /db_xref="GeneID:17829"
                     /db_xref="MGI:MGI:97231"
                     /translation="MTPGIRAPFFLLLLLASLKGFLALPSEENSVTSSQDTSSSLAST
                     TTPVHSSNSDPATRPPGDSTSSPVQSSTSSPATRAPEDSTSTAVLSGTSSPATTAPVN
                     SASSPVAHGDTSSPATSLSKDSNSSPVVHSGTSSAPATTAPVDSTSSPVVHGGTSSPA
                     TSPPGDSTSSPDHSSTSSPATRAPEDSTSTAVLSGTSSPATTAPVDSTSSPVAHDDTS
                     SPATSLSEDSASSPVAHGGTSSPATSPLRDSTSSPVHSSASIQNIKTTSDLASTPDHN
                     GTSVTTTSSALGSATSPDHSGTSTTTNSSESVLATTPVYSSMPFSTTKVTSGSAIIPD
                     HNGSSVLPTSSVLGSATSLVYNTSAIATTPVSNGTQPSVPSQYPVSPTMATTSSHSTI
                     ASSSYYSTVPFSTFSSNSSPQLSVGVSFFFLSFYIQNHPFNSSLEDPSSNYYQELKRN
                     ISGLFLQIFNGDFLGISSIKFRSGSVVVESTVVFREGTFSASDVKSQLIQHKKEADDY
                     NLTISEVKVNEMQFPPSAQSRPGVPGWGIALLVLVCILVALAIVYFLALAVCQCRRKS
                     YGQLDIFPTQDTYHPMSEYPTYHTHGRYVPPGSTKRSPYEEVSAGNGSSSLSYTNPAV
                     VTTSANL"
     exon            123..1426
                     /gene="Muc1"
                     /gene_synonym="CD227; EMA; Muc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1479
                     /gene="Muc1"
                     /gene_synonym="CD227; EMA; Muc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1613
                     /gene="Muc1"
                     /gene_synonym="CD227; EMA; Muc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1735
                     /gene="Muc1"
                     /gene_synonym="CD227; EMA; Muc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1885
                     /gene="Muc1"
                     /gene_synonym="CD227; EMA; Muc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2243
                     /gene="Muc1"
                     /gene_synonym="CD227; EMA; Muc-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2218..2223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Muc1"
                     /gene_synonym="CD227; EMA; Muc-1"
                     /note="hexamer: AATAAA"
     polyA_site      2243
                     /gene="Muc1"
                     /gene_synonym="CD227; EMA; Muc-1"
                     /note="major polyA site"
ORIGIN      
        1 ctcacacacg gagcgccagc cttgagtttg ttttctagcc ccttcccgcc tgttcaccac
       61 caccatgacc ccgggcattc gggctccttt cttcctgctg ctacttctag caagtctaaa
      121 aggttttctt gcccttccaa gtgaggaaaa cagtgtcacc tcatctcagg acaccagcag
      181 ttccttagca tcgactacca ctccagtcca cagcagcaac tcagacccag ccaccagacc
      241 tccaggggac tccaccagct ctccagtcca gagtagcacc tcttctccag ccaccagagc
      301 tcctgaagac tctaccagta ctgcagtcct cagtggcacc tcctccccag ccaccacagc
      361 tccagtgaac tccgccagct ctccagtagc ccatggtgac acctcttccc cagccactag
      421 cctttcaaaa gactccaaca gctctccagt agtccacagt ggcacctctt cagctccggc
      481 caccacagct ccagtggatt ccaccagctc tccagtagtc cacggtggta cctcgtcccc
      541 agccaccagc cctccagggg actccaccag ctctccagac catagtagca cctcttctcc
      601 agccaccaga gctcccgaag actctaccag tactgcagtc ctcagtggca cctcctcccc
      661 agccaccaca gctccagtgg actccaccag ctctccagta gcccatgatg acacctcttc
      721 cccagccact agcctttcag aagactccgc cagctctcca gtagcccacg gtggcacctc
      781 ttctccagcc accagccctc taagggactc caccagttct ccagtccaca gtagtgcctc
      841 catccaaaac atcaagacta catcagactt agctagcact ccagaccaca atggcacctc
      901 agtcacaact accagctctg cactgggctc agccaccagt ccagaccaca gtggtacctc
      961 aactacaact aacagctctg aatcagtctt ggccaccact ccagtttaca gtagcatgcc
     1021 attctctact accaaagtga cgtcaggctc agctatcatt ccagaccaca atggctcctc
     1081 ggtgctacct accagttctg tgttgggctc agctaccagt ctagtctata atacctctgc
     1141 aatagctaca actccagtca gcaatggcac tcagccttca gtgccaagtc aataccctgt
     1201 ttctcctacc atggccacca cctccagcca cagcactatt gccagcagct cttactatag
     1261 cacagtacca ttttctacct tctccagtaa cagttcaccc cagttgtctg ttggggtctc
     1321 cttcttcttc ttgtcttttt acattcaaaa ccacccattt aattcttctc tggaagaccc
     1381 cagctccaac tactaccaag aactgaagag gaacatttct ggattgtttc tgcagatttt
     1441 taacggagat tttctgggga tctctagcat caagttcagg tcaggctccg tggtggtaga
     1501 atcgactgtg gttttccggg agggtacttt tagtgcctct gacgtgaagt cacagcttat
     1561 acagcataag aaggaggcag atgactataa tctgactatt tcagaagtca aagtgaatga
     1621 gatgcagttc cctccctctg cccagtcccg gccgggggta ccaggctggg gcattgccct
     1681 gctggtgctg gtctgtattt tggttgcttt ggctatcgtc tatttccttg ccctggcagt
     1741 gtgccagtgc cgccgaaaga gctatgggca gctggacatc tttccaaccc aggacaccta
     1801 ccatcctatg agtgaatacc ctacctacca cactcacgga cgctacgtgc cccctggcag
     1861 taccaagcgt agcccctatg aggaggtttc ggcaggtaat ggcagtagca gtctctctta
     1921 taccaaccca gctgtggtga ccacttctgc caacttgtag gagcaagtca ccccacccac
     1981 ttggggcagc tttggcggtc tgctccctca gtggtcactg ccagacccct gcactctgat
     2041 ctgggctggt gagccaggac ttctggtagg ctgttcatgc cctttgtcaa gcgcctcaac
     2101 tacgtaagcc tggtgaagcc cagccctgcc ctgggggaca ctggggcagt tagtggtggc
     2161 tctcagaagg actggcctgg aaaactggag acagggatgg gaacccaaac atagctgaat
     2221 aaaagatggc ctcctgttag tta
//
