LOCUS       NM_016804               1258 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus metaxin 2 (Mtx2), mRNA.
ACCESSION   NM_016804
VERSION     NM_016804.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1258)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1258)
  AUTHORS   Li,T., Bao,Y., Xia,Y., Meng,H., Zhou,C., Huang,L., Wang,X.,
            Lai,E.Y., Jiang,P. and Mao,J.
  TITLE     Loss of MTX2 causes mitochondrial dysfunction, podocyte injury,
            nephrotic proteinuria and glomerulopathy in mice and patients
  JOURNAL   Int J Biol Sci 20 (3), 937-952 (2024)
   PUBMED   38250156
  REMARK    GeneRIF: Loss of MTX2 causes mitochondrial dysfunction, podocyte
            injury, nephrotic proteinuria and glomerulopathy in mice and
            patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1258)
  AUTHORS   He,B., Yu,H., Liu,S., Wan,H., Fu,S., Liu,S., Yang,J., Zhang,Z.,
            Huang,H., Li,Q., Wang,F., Jiang,Z., Liu,Q. and Jiang,H.
  TITLE     Mitochondrial cristae architecture protects against mtDNA release
            and inflammation
  JOURNAL   Cell Rep 41 (10), 111774 (2022)
   PUBMED   36476853
REFERENCE   4  (bases 1 to 1258)
  AUTHORS   Yakushiji-Kaminatsui,N., Lopez-Delisle,L., Bolt,C.C., Andrey,G.,
            Beccari,L. and Duboule,D.
  TITLE     Similarities and differences in the regulation of HoxD genes during
            chick and mouse limb development
  JOURNAL   PLoS Biol 16 (11), e3000004 (2018)
   PUBMED   30475793
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1258)
  AUTHORS   Kobayashi,M., Ohno,T., Ihara,K., Murai,A., Kumazawa,M., Hoshino,H.,
            Iwanaga,K., Iwai,H., Hamana,Y., Ito,M., Ohno,K. and Horio,F.
  TITLE     Searching for genomic region of high-fat diet-induced type 2
            diabetes in mouse chromosome 2 by analysis of congenic strains
  JOURNAL   PLoS One 9 (5), e96271 (2014)
   PUBMED   24789282
  REMARK    GeneRIF: Exome sequencing analysis between SM/J and A/J mice
            identified 4 genes (Itga6, Zak, Gpr155, and Mtx2) with
            nonsynonymous coding SNPs. These four genes might be candidate
            genes for type 2 diabetes caused by gene-gene interactions.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1258)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   7  (bases 1 to 1258)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 1258)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 1258)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 1258)
  AUTHORS   Armstrong,L.C., Saenz,A.J. and Bornstein,P.
  TITLE     Metaxin 1 interacts with metaxin 2, a novel related protein
            associated with the mammalian mitochondrial outer membrane
  JOURNAL   J Cell Biochem 74 (1), 11-22 (1999)
   PUBMED   10381257
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY126313.1, AK169048.1 and AK083055.1.
            
            On Apr 30, 2009 this sequence version replaced NM_016804.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB041562.1, AK169048.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                BY126313.1         10-60
            52-1246             AK169048.1         48-1242
            1247-1258           AK083055.1         1209-1220
FEATURES             Location/Qualifiers
     source          1..1258
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 44.13 cM"
     gene            1..1258
                     /gene="Mtx2"
                     /gene_synonym="1500012G02Rik"
                     /note="metaxin 2"
                     /db_xref="GeneID:53375"
                     /db_xref="MGI:MGI:1859652"
     exon            1..232
                     /gene="Mtx2"
                     /gene_synonym="1500012G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            233..280
                     /gene="Mtx2"
                     /gene_synonym="1500012G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            281..327
                     /gene="Mtx2"
                     /gene_synonym="1500012G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            328..400
                     /gene="Mtx2"
                     /gene_synonym="1500012G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            401..477
                     /gene="Mtx2"
                     /gene_synonym="1500012G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            478..570
                     /gene="Mtx2"
                     /gene_synonym="1500012G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            571..609
                     /gene="Mtx2"
                     /gene_synonym="1500012G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            610..735
                     /gene="Mtx2"
                     /gene_synonym="1500012G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            736..812
                     /gene="Mtx2"
                     /gene_synonym="1500012G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            813..1258
                     /gene="Mtx2"
                     /gene_synonym="1500012G02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1230..1235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtx2"
                     /gene_synonym="1500012G02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1249
                     /gene="Mtx2"
                     /gene_synonym="1500012G02Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcgacgccgg aagtgcttgg tcggcctggc ggtaaccttg cgggccgagc caccgctgcc
       61 gaggtgagct ctgctcgtct tagcgttggc ccagcgaagc tcgtcagctg ccgggggaag
      121 gccgccgagg tcgcgcggga gggcgccgag cgccgcggag ctcaggcgcg cgcgcaggac
      181 ctcgcagccg acatgtctct ggtggcggaa gcgttcgtct cccagatcgc agctacagaa
      241 ccttggcctg aaaatgcgac cttgtatcag caactgagag gggagcaaat tttgctttct
      301 gacaatgcag catctcttgc tgtgcaggca tttttgcaga tgtgtaatct gcctgtcaaa
      361 gtggtgtgta gggcaaatgc ggaatatatg tctccatctg gaaaagttcc ttttattcat
      421 gtgggaaatc aagtagtgtc agaacttggc ccaatagtcc aatttgttaa agccaagggc
      481 cattctctta gtgatgggtt ggatgaagtc caaaaagcag aaatgaaagc ctacatggaa
      541 ttagtcaaca atatgctgct gactgcagag ctgtatctcc agtggtgtga tgaagctaca
      601 gtaggggaga tcactattgc taggtatgga tctccttacc cttggcctct gaaccacatt
      661 ttggcctatc agaagcagtg ggaagtgaaa cgtaagatga aagctattgg atggggtaac
      721 aagactctgg accaggtctt agaagatgta gaccagtgct gtcaagccct ttcccagaga
      781 ctgggaacac aaccatactt cttcaataag caacctactg aacttgacgc tctggttttt
      841 ggccatttgt ataccattct taccacacaa ttgaccagcg atgaactttc tgagaaggtg
      901 aaaaactata gcaacctcct ggctttctgt agaagaattg aacagcacta ctttgaagac
      961 tggggtaaag gcaggttgtc ttagagccat ataccaatta gatattttaa aaaaaaccta
     1021 acttttgaaa tatgtattac ttgaacaata tggtagtagt tgcaggatct caaaaccaaa
     1081 accactgttt tttgaaacct caaaaaattt gcataatgtc atatacatgt cctttgtact
     1141 gttatttgtg tacactttgc ttttgaattg tttgatttgt tacattaaat tctatatctt
     1201 gacattttct ttctttatga gcatataaaa ataaacctta agcaactgag tttgtttc
//
