LOCUS       NP_084196               1353 aa            linear   ROD 14-JUN-2024
DEFINITION  microtubule-associated tumor suppressor candidate 2 homolog isoform
            a [Mus musculus].
ACCESSION   NP_084196 NP_001028773 XP_992146
VERSION     NP_084196.4
DBSOURCE    REFSEQ: accession NM_029920.8
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1353)
  AUTHORS   Du Puy,L., Beqqali,A., Monshouwer-Kloots,J., Haagsman,H.P.,
            Roelen,B.A. and Passier,R.
  TITLE     CAZIP, a novel protein expressed in the developing heart and
            nervous system
  JOURNAL   Dev Dyn 238 (11), 2903-2911 (2009)
   PUBMED   19806667
  REMARK    GeneRIF: These results suggest a role for CAZIP in development and
            function of the heart and nervous system in vertebrates.
REFERENCE   2  (residues 1 to 1353)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   3  (residues 1 to 1353)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   4  (residues 1 to 1353)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   5  (residues 1 to 1353)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133954.3, AC117725.23, AC158301.4 and AC109498.10.
            
            On or before Sep 6, 2006 this sequence version replaced
            NP_001028773.1, XP_992146.1, NP_084196.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147457.1, BC085194.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1353
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 87.82 cM"
     Protein         1..1353
                     /product="microtubule-associated tumor suppressor
                     candidate 2 homolog isoform a"
                     /note="microtubule-associated tumor suppressor candidate 2
                     homolog; cardiac zipper protein; tracking protein of 150
                     kDa; microtubule plus-end tracking protein TIP150"
                     /calculated_mol_wt=147225
     Region          1..30
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UHD3.1)"
     Region          81..101
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UHD3.1)"
     Region          125..259
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UHD3.1)"
     Region          274..615
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UHD3.1)"
     Region          <309..677
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Site            364
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3UHD3.1)"
     Site            365
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3UHD3.1)"
     Region          <516..974
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          626..964
                     /region_name="Mediates interaction with MAPRE1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UHD3.1)"
     Region          786..1134
                     /region_name="Localization to the growing distal tip of
                     microtubules. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UHD3.1)"
     Region          786..874
                     /region_name="Sufficient for interaction with KIF2C.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UHD3.1)"
     Region          799..823
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UHD3.1)"
     Region          847..972
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UHD3.1)"
     Region          975..>1306
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          1315..1353
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UHD3.1)"
     CDS             1..1353
                     /gene="Mtus2"
                     /gene_synonym="5730592G18Rik; A730013O20Rik;
                     C130038G02Rik; Cazip; Gm763; mKIAA0774"
                     /coded_by="NM_029920.8:921..4982"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS19881.1"
                     /db_xref="GeneID:77521"
                     /db_xref="MGI:MGI:1915388"
ORIGIN      
        1 msvplapkks cfgqlrdhre gaknnnesil rtgdtnanqi mlevssscde aksrdlddel
       61 gnsnlsrpqy hshfqkeplh lqgfgkgsqa gstsqresqa sltvhrqlse ehavkrgalq
      121 apqcvqgpsl sswrnavgqa speasakkda eiprhipkdk laktldneel krasscsaaa
      181 gsvpptdlqp vqldtlgpqd hvpargegpq rtpashspgk gfspgegtse gnsvylpkps
      241 tseakgssps dtkmegphgl dvyneritha eltpssasas kenpglrhpe vclgqgtgks
      301 kvelksvqpr neegltsaqa qgpgcheers mspverqell ekayreatsq gnsshrqlgv
      361 rrgssleemt gvsagvegsq qatptlsaap ageagtrltg kmsagvgrma retasgqtap
      421 dvgqaapvrr dptesvpsev sgeerrlgsg nsgstkllas gpsaggsrtd tsgllsprgs
      481 nlearkgkem vaenrnllen aaqtdntpag vdsafstpap llhpettvns shhptppgss
      541 sqelgvfsgd tgspsvaspp tdggqvlnts pkvpdrttcs sgipkppthp kdtpssqear
      601 ekletekmee raeakpilmp kpkhvrpkii tyirrnpqal sqgdaslvpv glpyapptcg
      661 mplpqeekaa srdlqpsanm yeklkpdlqk prvfpsglmv sgikppahhf sqmsekflqe
      721 vadhpgkeef csppythyev pptfyrsaml lkpqlglgam srlpstksri liasqrssas
      781 aihppgsltt aasfygsdps dlkkasnsna akaslpksgl rppgysrlpa aklaafgfvr
      841 sssisavpss qsldsvqpeq srpvtrstfg neeqaplkqa lpskdtpkga graapasssn
      901 attprrsllp apkststpag akkelqkdpe akkpavsspk rtasaatkph spgypkqrts
      961 aprnefppkp dlqareaerq laqrlrdrce wqarqlglar relkkaiqgf dalavstkhf
     1021 fgkseralak ekelsielan irdevafnta kceklqkeke tlerrfeeel rrlgwqqqae
     1081 vqelqerlqq qfqaesarlq aehqdqllrm rcqhqeqved itasheaall emennhtvai
     1141 tilqddhdhk vqelmsthef ekkeleenfe klrltlqdqv dtltfqsqsl rdrarrfeea
     1201 lrktteeqle ialapyqhle edmqslkqvl emknqqihlq ekkiielekl vekniileer
     1261 iqvlqqqned lkaridqntv vtrqlseena nlqeyveket qekkrlsrtn eellwklqtg
     1321 dptspiklsp tspvyrgsss gpssparvst tpr
//
