LOCUS       NM_001403954            3766 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus mitochondrial tumor suppressor 1 (Mtus1), transcript
            variant 10, mRNA.
ACCESSION   NM_001403954 XM_030243214
VERSION     NM_001403954.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3766)
  AUTHORS   Mo,Q., Salley,J., Roshan,T., Baer,L.A., May,F.J., Jaehnig,E.J.,
            Lehnig,A.C., Guo,X., Tong,Q., Nuotio-Antar,A.M., Shamsi,F.,
            Tseng,Y.H., Stanford,K.I. and Chen,M.H.
  TITLE     Identification and characterization of a supraclavicular brown
            adipose tissue in mice
  JOURNAL   JCI Insight 2 (11), 93166 (2017)
   PUBMED   28570265
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3766)
  AUTHORS   Wang,Y., Dai,X., Liu,Y., Li,J., Liu,Z., Yin,P., Chen,J., Wang,Y.,
            Wang,N. and Zhang,P.
  TITLE     MTUS1 silencing promotes E-selectin production through p38
            MAPK-dependent CREB ubiquitination in endothelial cells
  JOURNAL   J Mol Cell Cardiol 101, 1-10 (2016)
   PUBMED   27789289
REFERENCE   3  (bases 1 to 3766)
  AUTHORS   Kukida,M., Mogi,M., Ohshima,K., Nakaoka,H., Iwanami,J., Kanno,H.,
            Tsukuda,K., Chisaka,T., Min,L.J., Wang,X.L., Bai,H.Y., Shan,B.S.,
            Higaki,A., Yamauchi,T., Okura,T., Higaki,J. and Horiuchi,M.
  TITLE     Angiotensin II Type 2 Receptor Inhibits Vascular Intimal
            Proliferation With Activation of PPARgamma
  JOURNAL   Am J Hypertens 29 (6), 727-736 (2016)
   PUBMED   26471325
  REMARK    GeneRIF: important role in AT2 receptor-mediated PPARgamma
            activation
REFERENCE   4  (bases 1 to 3766)
  AUTHORS   Bundschu,K. and Schuh,K.
  TITLE     Cardiovascular ATIP (Angiotensin receptor type 2 interacting
            protein) expression in mouse development
  JOURNAL   Dev Dyn 243 (5), 699-711 (2014)
   PUBMED   24288149
  REMARK    GeneRIF: ATIPs seem to be mainly involved in the developmental
            regulation of the cardiovascular system and may act in different
            AT2-dependent and -independent manners.
REFERENCE   5  (bases 1 to 3766)
  AUTHORS   Jing,F., Mogi,M., Min,L.J., Ohshima,K., Nakaoka,H., Tsukuda,K.,
            Wang,X., Iwanami,J. and Horiuchi,M.
  TITLE     Effect of angiotensin II type 2 receptor-interacting protein on
            adipose tissue function via modulation of macrophage polarization
  JOURNAL   PLoS One 8 (4), e60067 (2013)
   PUBMED   23565185
  REMARK    GeneRIF: ATIP1 could exert anti-inflammatory effects in adipose
            tissue via macrophage polarization associated with improvement of
            insulin resistance.
REFERENCE   6  (bases 1 to 3766)
  AUTHORS   Wruck,C.J., Funke-Kaiser,H., Pufe,T., Kusserow,H., Menk,M.,
            Schefe,J.H., Kruse,M.L., Stoll,M. and Unger,T.
  TITLE     Regulation of transport of the angiotensin AT2 receptor by a novel
            membrane-associated Golgi protein
  JOURNAL   Arterioscler Thromb Vasc Biol 25 (1), 57-64 (2005)
   PUBMED   15539617
REFERENCE   7  (bases 1 to 3766)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 3766)
  AUTHORS   Nouet,S., Amzallag,N., Li,J.M., Louis,S., Seitz,I., Cui,T.X.,
            Alleaume,A.M., Di Benedetto,M., Boden,C., Masson,M.,
            Strosberg,A.D., Horiuchi,M., Couraud,P.O. and Nahmias,C.
  TITLE     Trans-inactivation of receptor tyrosine kinases by novel
            angiotensin II AT2 receptor-interacting protein, ATIP
  JOURNAL   J Biol Chem 279 (28), 28989-28997 (2004)
   PUBMED   15123706
  REMARK    GeneRIF: Results identify ATIP1 (angiotensin II AT2
            receptor-interacting protein) as a novel early component of growth
            inhibitory signaling cascade.
REFERENCE   9  (bases 1 to 3766)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 3766)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116511.15.
            
            On Apr 7, 2022 this sequence version replaced XM_030243214.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784643.1014257.1,
                                           SRR17784647.490790.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               AC116511.15        35203-35473
            272-338             AC116511.15        36550-36616
            339-553             AC116511.15        49485-49699
            554-659             AC116511.15        51138-51243
            660-733             AC116511.15        52288-52361
            734-829             AC116511.15        52473-52568
            830-946             AC116511.15        53541-53657
            947-1044            AC116511.15        57359-57456
            1045-3766           AC116511.15        58371-61092
FEATURES             Location/Qualifiers
     source          1..3766
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 23.89 cM"
     gene            1..3766
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /note="mitochondrial tumor suppressor 1"
                     /db_xref="GeneID:102103"
                     /db_xref="MGI:MGI:2142572"
     exon            1..271
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1258
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /note="isoform 6 is encoded by transcript variant 10;
                     angiotensin II AT2 receptor-interacting protein 1;
                     microtubule-associated tumor suppressor 1 homolog;
                     coiled-coiled tumor supressor gene 1; AT2 receptor-binding
                     protein; mitochondrial tumor suppressor 1 homolog;
                     coiled-coiled tumor suppressor gene 1 protein;
                     angiotensin-II type 2 receptor-interacting protein"
                     /codon_start=1
                     /product="microtubule-associated tumor suppressor 1
                     homolog isoform 6"
                     /protein_id="NP_001390883.1"
                     /db_xref="GeneID:102103"
                     /db_xref="MGI:MGI:2142572"
                     /translation="MGCPSSKMCLSPPCAATRREEALKQHKTLSQELVSLRGELVAAS
                     SACEKLEKARTDLQTAYQEFVQKLNQQHQTDRTELENRLKDLYTAECEKLQSIYIEEA
                     EKYKTQLQEQFDNLNAAHETTKLEIEASHSEKVELLKKTYETSLSEIKKSHEMEKKSL
                     EDLLNEKQESLEKQINDLKSENDALNERLKSEEQKQLSREKANSKNPQVMYLEQELES
                     LKAVLEIKNEKLHQQDMKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISR
                     QLSTEQAALQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPFQSPRN
                     SGSFSSPSISPR"
     exon            272..338
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            339..553
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            554..659
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            660..733
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            734..829
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            830..946
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1044
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..3766
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2090..2095
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /note="hexamer: TATAAA"
     polyA_site      2115
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
     regulatory      3739..3744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /note="hexamer: GATAAA"
     polyA_site      3766
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /note="major polyA site"
ORIGIN      
        1 acagaagctg cagtatcagc ttcagagagg agagagagga gtctgaggca gtaacctgcg
       61 ggacaggcgg ggaggccacc agggccaatg gcgctcctcc ctgtggagct ttgaatgtag
      121 gcagacccgg acggacggat gggtgggagg cgtggccacc tgtgcgcttc ttggacagtg
      181 cagggggtgg gggagttgga gagaccggag ctggaaaatg ggctgcccta gcagcaaaat
      241 gtgcctctct cctccctgtg cagcaacaag gcgggaggaa gcactgaagc aacacaaaac
      301 cctctctcaa gaacttgtca gcctccgggg agagctagtt gctgcttcaa gcgcctgtga
      361 gaagctagaa aaggctagga ctgacttaca gacagcgtat caagaatttg tccagaaact
      421 aaaccagcag catcagacag accggacgga actggagaac cggctgaagg acttatacac
      481 cgcagagtgt gagaagcttc agagcattta cattgaggag gcagaaaaat ataaaactca
      541 actgcaagag cagtttgaca acttaaacgc cgcccatgag accactaagc ttgagattga
      601 agctagccac tcggagaagg tggaattgct gaagaagacc tatgaaacct ccctttcaga
      661 aatcaagaag agccatgaga tggagaagaa gtcactggag gatctgctta atgagaagca
      721 ggaatcgctg gagaaacaaa tcaatgatct gaagagtgaa aacgatgctt taaacgaaag
      781 gttgaaatca gaggagcaaa agcaactgtc aagagagaag gcgaattcaa aaaaccctca
      841 ggtcatgtat ctggagcaag aactagaaag cctgaaggct gtgttagaga tcaagaatga
      901 gaagctgcac cagcaggaca tgaagctaat gaagatggaa aagctggtgg acaataacac
      961 agcattggtt gacaagctga agcgattcca gcaggaaaac gaggagttaa aagctcgcat
     1021 ggacaaacac atggcaattt caaggcaact ttccaccgag caggccgcgc tgcaggagtc
     1081 ccttgagaag gagtcgaagg tcaacaagag actgtccatg gagaacgagg aacttctgtg
     1141 gaaactgcac aacggagacc tgtgcagccc caagagatcc cccacctcct cggccatccc
     1201 tttccagtcc cccaggaatt ctggttcctt ctccagcccc agcatctcac ccagatgacg
     1261 gcttctgaac gcaggagact ctctgaaggc actgaggtgc gcttctgcgg gactgacccg
     1321 aagttcagag ttcatgggaa ctcgagttgc tgcgttagct ctctggaata tccccaggat
     1381 atcgggagag cagccgccaa ccgtttcagc tacgtacgaa tagagagctc caataggaga
     1441 cttttaactt ggtccaaaag cctcctccaa aaacagattt cggaactgaa gtggacatag
     1501 ttgcacaaag cacttacgga acgagggaac cttgttcttt gccttccttc acctaagcat
     1561 aggggaaaac tctcagggcc ctattaagat aaagatttat aacctttata atgttcttca
     1621 ccagagacac cttcttgtga tttttatttc agtctgactg tgggcaaggg gggtgtgtgt
     1681 gtgagtgaaa tgggtgtact ggcgtgtcac gtgactgtca tagccccgcc ccctgctgtg
     1741 tattaaaagt caacagctgt atatagcttg gcctgtatta accaagtcat aatcggcaca
     1801 cgagcgtcaa caaaagccat agaagagaaa gcaatagtgc ttgaatttcc ccccaactca
     1861 tctcagcact gtgccacggc agggctcggg caagacagga aaagcctttg gtttcttgat
     1921 gactgtacat ttatttctct gttgttagtt tttccatgtt cggcattatc cgttgatagc
     1981 agtttttttt tccccctgta gattttcacg agcctaattg ctatactctg attcattttc
     2041 tcaggctatg agcaaatgta gttccctaat ttttctaaat acaaatctgt ataaagagta
     2101 agggggcagt accaatggat gtttctggtt tatttttttc ccttgaaccc aagctagctt
     2161 catagcgcta atcctccgtc taccctcctg ttgttctaac ctccgccttg ccttctcctc
     2221 catgtagagc cacggaagca aagcgccctc cttcctaccc acagagtgtg cttttccagg
     2281 gccagtttat cttggaggtg ctgaacctgt ttcccaaata agctaagctc tggttctgac
     2341 actacacaat tttagaaacc ccggggggga aaccagtaaa ggcattttag catgtactaa
     2401 tccacatgag cacagagtta agccaacagt tctgtgttga gtagatccaa gagcgggaat
     2461 gctgacttgg gcccctctga gcattcttcc agccactgga atggaacaga gtggccaaag
     2521 agtgagaggt atggcttctg cagctccttc acactgcatt caaaattcag atcttcgctt
     2581 accatctccc taggctccaa ggctctgtga aagttagaag gatagctgtg gctccccacc
     2641 acccaaccca caaacttccc tgtgcatgcc ggcattgcga tgtcagtatt tactaattca
     2701 tggtcaatgc tgctcagata acccctatag cgaggacaga ttcaggatac tagaggtgag
     2761 tcatcctaga cttctgcact acagagctaa ctgatagtca tgatgcatgc tttttattag
     2821 gggttgtgtt tgaagtctct tatctccaat agtttatgat gtatgtaacc taccatgttt
     2881 gctcccgata aataggaatg attgcagctt cactgccacc tcctggaata gctctgctcc
     2941 tggtcccaag ttgttctcaa tgatgttagc caaagtcagg tttgtcattt atgccctagt
     3001 tatggtaaag ctcaagtgtt gacctgccat ccctcatacc acgtagatgt ctgggaagtc
     3061 aaatcttaca gcaattaaaa tgcctagaga gcatttaagg gtttttttgt tttgtttttt
     3121 aaaccaaaca ttttatgtac aatacaaaat tgttgacaca tcgtttaaaa aaaatgtggg
     3181 tgtgtgaaca actgtagttt atagcaatgg gaaagtgtat tttactttga tcaaataaat
     3241 aatgctggaa tattcaatgt aagaatggca gcctctgaca tacttactct tcaaagcgtt
     3301 aagttatatg ctcccccttc tcatccctcc ttagttaagg cagccaggcg ccctatgcta
     3361 ttatacagaa cttagaaccc aatgccaaaa tttgttgtgg ctgaaattgg ctcacagagc
     3421 ttgagtttaa gattaagctt ttcaaattca aaatacatgt gtcagagaac gaaactttgg
     3481 ctagtttgaa tgattcttct gcaaggcgaa aagaaaattg gaacagctgt ggtcttaagt
     3541 gttttttcaa gaccggtctt agccaaagct gaatcttctt cagtccattc atctatgtta
     3601 tattaaaggc taaggtgtta atagtgtaca tgcagttatt tttgaataga ggggtttaaa
     3661 tcagtactct gagtgtggcg atttcaatgt aaaaagatgt gattttgata cctttataaa
     3721 tgaacttgtg ctagctttga taaagtgaca tatctaagca tttgaa
//
