LOCUS       NM_001403950            6832 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus mitochondrial tumor suppressor 1 (Mtus1), transcript
            variant 8, mRNA.
ACCESSION   NM_001403950 XM_006509240
VERSION     NM_001403950.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6832)
  AUTHORS   Mo,Q., Salley,J., Roshan,T., Baer,L.A., May,F.J., Jaehnig,E.J.,
            Lehnig,A.C., Guo,X., Tong,Q., Nuotio-Antar,A.M., Shamsi,F.,
            Tseng,Y.H., Stanford,K.I. and Chen,M.H.
  TITLE     Identification and characterization of a supraclavicular brown
            adipose tissue in mice
  JOURNAL   JCI Insight 2 (11), 93166 (2017)
   PUBMED   28570265
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6832)
  AUTHORS   Wang,Y., Dai,X., Liu,Y., Li,J., Liu,Z., Yin,P., Chen,J., Wang,Y.,
            Wang,N. and Zhang,P.
  TITLE     MTUS1 silencing promotes E-selectin production through p38
            MAPK-dependent CREB ubiquitination in endothelial cells
  JOURNAL   J Mol Cell Cardiol 101, 1-10 (2016)
   PUBMED   27789289
REFERENCE   3  (bases 1 to 6832)
  AUTHORS   Kukida,M., Mogi,M., Ohshima,K., Nakaoka,H., Iwanami,J., Kanno,H.,
            Tsukuda,K., Chisaka,T., Min,L.J., Wang,X.L., Bai,H.Y., Shan,B.S.,
            Higaki,A., Yamauchi,T., Okura,T., Higaki,J. and Horiuchi,M.
  TITLE     Angiotensin II Type 2 Receptor Inhibits Vascular Intimal
            Proliferation With Activation of PPARgamma
  JOURNAL   Am J Hypertens 29 (6), 727-736 (2016)
   PUBMED   26471325
  REMARK    GeneRIF: important role in AT2 receptor-mediated PPARgamma
            activation
REFERENCE   4  (bases 1 to 6832)
  AUTHORS   Bundschu,K. and Schuh,K.
  TITLE     Cardiovascular ATIP (Angiotensin receptor type 2 interacting
            protein) expression in mouse development
  JOURNAL   Dev Dyn 243 (5), 699-711 (2014)
   PUBMED   24288149
  REMARK    GeneRIF: ATIPs seem to be mainly involved in the developmental
            regulation of the cardiovascular system and may act in different
            AT2-dependent and -independent manners.
REFERENCE   5  (bases 1 to 6832)
  AUTHORS   Jing,F., Mogi,M., Min,L.J., Ohshima,K., Nakaoka,H., Tsukuda,K.,
            Wang,X., Iwanami,J. and Horiuchi,M.
  TITLE     Effect of angiotensin II type 2 receptor-interacting protein on
            adipose tissue function via modulation of macrophage polarization
  JOURNAL   PLoS One 8 (4), e60067 (2013)
   PUBMED   23565185
  REMARK    GeneRIF: ATIP1 could exert anti-inflammatory effects in adipose
            tissue via macrophage polarization associated with improvement of
            insulin resistance.
REFERENCE   6  (bases 1 to 6832)
  AUTHORS   Wruck,C.J., Funke-Kaiser,H., Pufe,T., Kusserow,H., Menk,M.,
            Schefe,J.H., Kruse,M.L., Stoll,M. and Unger,T.
  TITLE     Regulation of transport of the angiotensin AT2 receptor by a novel
            membrane-associated Golgi protein
  JOURNAL   Arterioscler Thromb Vasc Biol 25 (1), 57-64 (2005)
   PUBMED   15539617
REFERENCE   7  (bases 1 to 6832)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 6832)
  AUTHORS   Nouet,S., Amzallag,N., Li,J.M., Louis,S., Seitz,I., Cui,T.X.,
            Alleaume,A.M., Di Benedetto,M., Boden,C., Masson,M.,
            Strosberg,A.D., Horiuchi,M., Couraud,P.O. and Nahmias,C.
  TITLE     Trans-inactivation of receptor tyrosine kinases by novel
            angiotensin II AT2 receptor-interacting protein, ATIP
  JOURNAL   J Biol Chem 279 (28), 28989-28997 (2004)
   PUBMED   15123706
  REMARK    GeneRIF: Results identify ATIP1 (angiotensin II AT2
            receptor-interacting protein) as a novel early component of growth
            inhibitory signaling cascade.
REFERENCE   9  (bases 1 to 6832)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 6832)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156554.13 and AC116511.15.
            
            On Apr 7, 2022 this sequence version replaced XM_006509240.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.10544.1,
                                           SRR10223971.8510.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-378               AC156554.13        123155-123532
            379-2605            AC156554.13        172596-174822
            2606-2801           AC156554.13        181009-181204
            2802-2951           AC156554.13        200752-200901
            2952-3083           AC116511.15        1888-2019
            3084-3122           AC116511.15        3918-3956
            3123-3337           AC116511.15        29410-29624
            3338-3404           AC116511.15        36550-36616
            3405-3619           AC116511.15        49485-49699
            3620-3725           AC116511.15        51138-51243
            3726-3799           AC116511.15        52288-52361
            3800-3895           AC116511.15        52473-52568
            3896-4012           AC116511.15        53541-53657
            4013-4110           AC116511.15        57359-57456
            4111-6832           AC116511.15        58371-61092
FEATURES             Location/Qualifiers
     source          1..6832
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 23.89 cM"
     gene            1..6832
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /note="mitochondrial tumor suppressor 1"
                     /db_xref="GeneID:102103"
                     /db_xref="MGI:MGI:2142572"
     exon            1..378
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            379..2605
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             542..4324
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /note="isoform 5 is encoded by transcript variant 8;
                     angiotensin II AT2 receptor-interacting protein 1;
                     microtubule-associated tumor suppressor 1 homolog;
                     coiled-coiled tumor supressor gene 1; AT2 receptor-binding
                     protein; mitochondrial tumor suppressor 1 homolog;
                     coiled-coiled tumor suppressor gene 1 protein;
                     angiotensin-II type 2 receptor-interacting protein"
                     /codon_start=1
                     /product="microtubule-associated tumor suppressor 1
                     homolog isoform 5"
                     /protein_id="NP_001390879.1"
                     /db_xref="GeneID:102103"
                     /db_xref="MGI:MGI:2142572"
                     /translation="MNDDNSDRTEDGSRYVFIRDKNSNPSEYYQTSLSAQCPSVSHGD
                     WNSDNPDAMVVDYEMDPAVDSSESVSLSHQCVEELAYPEPSSDFMGKHEFTMYSELTC
                     QSPALVNTGKPQDLHSNCDSLEAIQDEKFDPLKPCECRSDDDYACGDSPEVLELKQTY
                     GMKVDTANYTFIARHDIEQGQPLHAPGGLQTTVRDRNALSSCGRTPPHSSKMYVRGVN
                     YNRENFENLQATPSKTLNTTFTVISDVLMQTDSPDVGVQGQNSLGNVTKEYTDGTRRG
                     LIGEKEIQAVTLVSDGMEVPNGSASQEFYCVSEDDPNSETHSHGPYAQQEMGQNLRGT
                     LPNCHVDGECPVLVPAFEKSKTRVLGSECKVTVTEDPHIDSHDNDSDIQSSTEELTLR
                     SVSGQRGSPYEMGWGENGGAICTDKAGCMSTPVEQPPNLSFRLEPAEVKKYNNVENGP
                     RDAKRAPNLKGEPTNMPKPNLGKSATKTNTTVGSKVRKTEIISYPTPNFKNIKAKVIS
                     RSVLQPKDTSIMKDTPSPQVTGGSSPSPGPSKHLTMMNKAPRSDFKASKKAEIPINKT
                     HKQQFNKLITSQAAQVTTHSKNASLGVPRTTSATKSNQENVDKTGSPHAGSETGSVAA
                     FFQKIKGILPVKMKSSECLEVTYVSHIDQISPEKGEQDGEAPMEKQELGKQATNEIFE
                     SKSLLVGSAPKTSTTPGRSSSKPDSRSLRKTPGLKAKVGPTAACLRRKSESRTLGSDR
                     ALSPQRIRRVSGSGKPPCLKTALSSWVNLPRPLPISEASLICRAGSTRSVASTHSDLS
                     AYSSDCGHAAINKYEEKPPKQAFQNGSGPLYLKPLVPRAHSHLLKTSPKGPSRKSLFT
                     AFNSVEKGRQKNPRSLCIQTQTAPDVLSSERTLELAQYKTKCESQSGFILHLRQLLSR
                     GNTKFEALTVVIQHLLSEREEALKQHKTLSQELVSLRGELVAASSACEKLEKARTDLQ
                     TAYQEFVQKLNQQHQTDRTELENRLKDLYTAECEKLQSIYIEEAEKYKTQLQEQFDNL
                     NAAHETTKLEIEASHSEKVELLKKTYETSLSEIKKSHEMEKKSLEDLLNEKQESLEKQ
                     INDLKSENDALNERLKSEEQKQLSREKANSKNPQVMYLEQELESLKAVLEIKNEKLHQ
                     QDMKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAALQESLE
                     KESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPFQSPRNSGSFSSPSISPR"
     exon            2606..2801
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2802..2951
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2952..3083
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3084..3122
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3123..3337
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3338..3404
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3405..3619
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3620..3725
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3726..3799
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3800..3895
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3896..4012
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            4013..4110
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            4111..6832
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5156..5161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /note="hexamer: TATAAA"
     polyA_site      5181
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
     regulatory      6805..6810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /note="hexamer: GATAAA"
     polyA_site      6832
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /note="major polyA site"
ORIGIN      
        1 aacttcccca cctcccaact ccaaagccct tcgcgggaca gggaattctg gctgcgaggg
       61 gacccaggag gagccaatcc tccctctggc tagctagcct gtccgacggt cctggggccc
      121 caaagttggg cttggcagag cttagctttc ccaccaggac gtgaatggtt tggggtcgcg
      181 cgggacagcc agccaagcgc gcagtcagca gcggtggctt tgcgacacac gtggcaacag
      241 gtgcagcgcg atccaggacg tacgcccggg gcttgtggct tatgttgacg tttagccagg
      301 gagcccgacc cggctggcga ccgtagtgga gctccgcggg agtcatcgtg cctcaaggaa
      361 cccctgctcg tctctcaggg aacgacaagt catttcagct ttggagcatc tcagactaca
      421 gttgtggaag ccggctgaaa gcaatagaaa ggggaggagc tggaccattt ttcatttact
      481 ctcattaaaa aggaatttga agagaagata aaatggcaga gttttgaggt taatattcag
      541 gatgaatgat gataattcag ataggacaga agatggatcg cgttatgtat ttatccgaga
      601 taaaaactcg aatccatctg aatactacca aacatcgcta tctgcccagt gcccttcagt
      661 gagtcacggg gattggaact ctgacaaccc agatgccatg gtggtcgatt atgaaatgga
      721 tcctgcggtg gacagtagtg aaagtgtatc tttaagccat cagtgtgttg aagaacttgc
      781 ttacccagag ccttcaagtg atttcatggg gaagcatgag tttacaatgt acagtgagct
      841 tacctgccag tctcctgcac ttgtgaacac agggaagccc caagacctgc acagtaactg
      901 tgactcccta gaggcaatcc aggatgagaa gtttgatccc cttaagccct gtgagtgcag
      961 gtctgatgac gattatgctt gtggagattc ccctgaagtt ttggagctaa aacaaacata
     1021 tggcatgaaa gtggacacgg ctaactacac ctttatagca cgccatgata ttgaacaggg
     1081 tcagcctttg catgctcctg gaggtttgca gacaacagtg agagacagaa atgctttgtc
     1141 ctcctgcggt cggacaccac cccattcctc taagatgtat gtgagagggg ttaattataa
     1201 tcgagagaac tttgaaaacc tccaagccac accatccaag accctaaaca caacctttac
     1261 agtgatctct gatgtgctga tgcaaactga cagtccagac gttggagttc agggtcagaa
     1321 ttctttagga aatgtcacca aagagtacac agatgggaca aggcgaggac tcattggaga
     1381 aaaagagata caagctgtga cactggtttc ggatggcatg gaggtcccca acggatctgc
     1441 atcacaggag ttctattgtg tatctgaaga tgacccaaac agtgagacac attcacacgg
     1501 cccgtatgct caacaggaaa tgggccaaaa tttaagagga acactgccca actgtcatgt
     1561 cgatggtgaa tgcccagtac tggtgccagc ttttgagaag agtaaaacca gagtcctggg
     1621 ctctgagtgt aaagtcactg tgactgaaga cccacacatc gattcccacg acaatgactc
     1681 agacatccaa agtagtactg aagagctgac cctgagaagt gtttcagggc agaggggttc
     1741 accttatgaa atgggttggg gcgagaacgg cggagccatt tgcacagata aagcaggttg
     1801 catgtcaaca ccagttgagc aaccccccaa tctgagcttc agacttgaac ctgctgaagt
     1861 gaagaagtac aataatgtgg agaatggacc aagagatgct aaacgtgcac caaacttgaa
     1921 aggggaacca acaaatatgc caaaacctaa tttgggaaaa tcagctacca aaacaaatac
     1981 cactgtaggc agtaaagtca ggaagacaga aattataagt tatcctacac caaacttcaa
     2041 aaacattaaa gccaaagtta tatccagatc agtgttgcaa cccaaagaca cttccataat
     2101 gaaggacaca cccagccctc aggtaacagg gggctcttca ccatcaccag ggccttctaa
     2161 acacttgaca atgatgaaca aagcaccaag atctgacttt aaagccagca aaaaagcaga
     2221 aatcccaatt aacaagacac acaagcaaca gtttaataaa ctcattacca gccaggctgc
     2281 gcaagttaca actcattcta aaaatgcttc actcggggtt ccaagaacaa catctgccac
     2341 gaaatcgaat caggagaatg ttgacaagac aggttctcct catgcaggga gtgagaccgg
     2401 gtctgtagct gccttcttcc agaagatcaa aggcattctc cccgtgaaaa tgaaaagctc
     2461 agagtgtttg gaagtgactt acgtttccca catcgatcag attagccctg aaaagggtga
     2521 gcaggacggt gaggctccca tggaaaagca agagctggga aaacaagcca cgaatgagat
     2581 ttttgaatcc aagtctctat tggtgggctc tgcacccaaa acttccacca cgccaggaag
     2641 gagcagttcc aagccagact cgcggagcct gaggaaaaca ccaggtctaa aagccaaagt
     2701 gggtcccact gctgcctgcc tgaggaggaa gagtgagagt agaaccctag gctccgacag
     2761 ggccttatcg cctcagagga tcaggcgcgt gtccggctct ggaaagcctc cgtgcttgaa
     2821 aactgcactc tcttcttggg tgaatttgcc tagaccactt cctatatccg aagcatcctt
     2881 gatatgcagg gcaggaagca cccggtcagt ggccagcacc cacagcgacc tgagcgccta
     2941 cagcagtgac tgtggtcatg ctgccatcaa caaatatgaa gagaaacctc ccaaacaagc
     3001 atttcagaat gggtcaggac ccttgtatct gaagcctttg gtacccagag ctcactcgca
     3061 cttgctcaaa acttctccaa aaggtccttc aaggaagagt ctgtttacag cttttaattc
     3121 agttgaaaag ggcaggcaga agaatcccag gagcctatgc atccagaccc agacagctcc
     3181 agatgtgctg tcctccgaga gaacgcttga gttggcccaa tacaagacaa aatgtgaaag
     3241 ccaaagtgga ttcatcctgc acctcagaca gcttctttcc cgtggtaaca ccaagtttga
     3301 agcgctgacc gttgtgatcc agcacctcct gtctgagcgg gaggaagcac tgaagcaaca
     3361 caaaaccctc tctcaagaac ttgtcagcct ccggggagag ctagttgctg cttcaagcgc
     3421 ctgtgagaag ctagaaaagg ctaggactga cttacagaca gcgtatcaag aatttgtcca
     3481 gaaactaaac cagcagcatc agacagaccg gacggaactg gagaaccggc tgaaggactt
     3541 atacaccgca gagtgtgaga agcttcagag catttacatt gaggaggcag aaaaatataa
     3601 aactcaactg caagagcagt ttgacaactt aaacgccgcc catgagacca ctaagcttga
     3661 gattgaagct agccactcgg agaaggtgga attgctgaag aagacctatg aaacctccct
     3721 ttcagaaatc aagaagagcc atgagatgga gaagaagtca ctggaggatc tgcttaatga
     3781 gaagcaggaa tcgctggaga aacaaatcaa tgatctgaag agtgaaaacg atgctttaaa
     3841 cgaaaggttg aaatcagagg agcaaaagca actgtcaaga gagaaggcga attcaaaaaa
     3901 ccctcaggtc atgtatctgg agcaagaact agaaagcctg aaggctgtgt tagagatcaa
     3961 gaatgagaag ctgcaccagc aggacatgaa gctaatgaag atggaaaagc tggtggacaa
     4021 taacacagca ttggttgaca agctgaagcg attccagcag gaaaacgagg agttaaaagc
     4081 tcgcatggac aaacacatgg caatttcaag gcaactttcc accgagcagg ccgcgctgca
     4141 ggagtccctt gagaaggagt cgaaggtcaa caagagactg tccatggaga acgaggaact
     4201 tctgtggaaa ctgcacaacg gagacctgtg cagccccaag agatccccca cctcctcggc
     4261 catccctttc cagtccccca ggaattctgg ttccttctcc agccccagca tctcacccag
     4321 atgacggctt ctgaacgcag gagactctct gaaggcactg aggtgcgctt ctgcgggact
     4381 gacccgaagt tcagagttca tgggaactcg agttgctgcg ttagctctct ggaatatccc
     4441 caggatatcg ggagagcagc cgccaaccgt ttcagctacg tacgaataga gagctccaat
     4501 aggagacttt taacttggtc caaaagcctc ctccaaaaac agatttcgga actgaagtgg
     4561 acatagttgc acaaagcact tacggaacga gggaaccttg ttctttgcct tccttcacct
     4621 aagcataggg gaaaactctc agggccctat taagataaag atttataacc tttataatgt
     4681 tcttcaccag agacaccttc ttgtgatttt tatttcagtc tgactgtggg caaggggggt
     4741 gtgtgtgtga gtgaaatggg tgtactggcg tgtcacgtga ctgtcatagc cccgccccct
     4801 gctgtgtatt aaaagtcaac agctgtatat agcttggcct gtattaacca agtcataatc
     4861 ggcacacgag cgtcaacaaa agccatagaa gagaaagcaa tagtgcttga atttcccccc
     4921 aactcatctc agcactgtgc cacggcaggg ctcgggcaag acaggaaaag cctttggttt
     4981 cttgatgact gtacatttat ttctctgttg ttagtttttc catgttcggc attatccgtt
     5041 gatagcagtt tttttttccc cctgtagatt ttcacgagcc taattgctat actctgattc
     5101 attttctcag gctatgagca aatgtagttc cctaattttt ctaaatacaa atctgtataa
     5161 agagtaaggg ggcagtacca atggatgttt ctggtttatt tttttccctt gaacccaagc
     5221 tagcttcata gcgctaatcc tccgtctacc ctcctgttgt tctaacctcc gccttgcctt
     5281 ctcctccatg tagagccacg gaagcaaagc gccctccttc ctacccacag agtgtgcttt
     5341 tccagggcca gtttatcttg gaggtgctga acctgtttcc caaataagct aagctctggt
     5401 tctgacacta cacaatttta gaaaccccgg gggggaaacc agtaaaggca ttttagcatg
     5461 tactaatcca catgagcaca gagttaagcc aacagttctg tgttgagtag atccaagagc
     5521 gggaatgctg acttgggccc ctctgagcat tcttccagcc actggaatgg aacagagtgg
     5581 ccaaagagtg agaggtatgg cttctgcagc tccttcacac tgcattcaaa attcagatct
     5641 tcgcttacca tctccctagg ctccaaggct ctgtgaaagt tagaaggata gctgtggctc
     5701 cccaccaccc aacccacaaa cttccctgtg catgccggca ttgcgatgtc agtatttact
     5761 aattcatggt caatgctgct cagataaccc ctatagcgag gacagattca ggatactaga
     5821 ggtgagtcat cctagacttc tgcactacag agctaactga tagtcatgat gcatgctttt
     5881 tattaggggt tgtgtttgaa gtctcttatc tccaatagtt tatgatgtat gtaacctacc
     5941 atgtttgctc ccgataaata ggaatgattg cagcttcact gccacctcct ggaatagctc
     6001 tgctcctggt cccaagttgt tctcaatgat gttagccaaa gtcaggtttg tcatttatgc
     6061 cctagttatg gtaaagctca agtgttgacc tgccatccct cataccacgt agatgtctgg
     6121 gaagtcaaat cttacagcaa ttaaaatgcc tagagagcat ttaagggttt ttttgttttg
     6181 ttttttaaac caaacatttt atgtacaata caaaattgtt gacacatcgt ttaaaaaaaa
     6241 tgtgggtgtg tgaacaactg tagtttatag caatgggaaa gtgtatttta ctttgatcaa
     6301 ataaataatg ctggaatatt caatgtaaga atggcagcct ctgacatact tactcttcaa
     6361 agcgttaagt tatatgctcc cccttctcat ccctccttag ttaaggcagc caggcgccct
     6421 atgctattat acagaactta gaacccaatg ccaaaatttg ttgtggctga aattggctca
     6481 cagagcttga gtttaagatt aagcttttca aattcaaaat acatgtgtca gagaacgaaa
     6541 ctttggctag tttgaatgat tcttctgcaa ggcgaaaaga aaattggaac agctgtggtc
     6601 ttaagtgttt tttcaagacc ggtcttagcc aaagctgaat cttcttcagt ccattcatct
     6661 atgttatatt aaaggctaag gtgttaatag tgtacatgca gttatttttg aatagagggg
     6721 tttaaatcag tactctgagt gtggcgattt caatgtaaaa agatgtgatt ttgatacctt
     6781 tataaatgaa cttgtgctag ctttgataaa gtgacatatc taagcatttg aa
//
