LOCUS       NP_001390879            1260 aa            linear   ROD 19-NOV-2024
DEFINITION  microtubule-associated tumor suppressor 1 homolog isoform 5 [Mus
            musculus].
ACCESSION   NP_001390879 XP_006509303
VERSION     NP_001390879.1
DBSOURCE    REFSEQ: accession NM_001403950.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1260)
  AUTHORS   Mo,Q., Salley,J., Roshan,T., Baer,L.A., May,F.J., Jaehnig,E.J.,
            Lehnig,A.C., Guo,X., Tong,Q., Nuotio-Antar,A.M., Shamsi,F.,
            Tseng,Y.H., Stanford,K.I. and Chen,M.H.
  TITLE     Identification and characterization of a supraclavicular brown
            adipose tissue in mice
  JOURNAL   JCI Insight 2 (11), 93166 (2017)
   PUBMED   28570265
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1260)
  AUTHORS   Wang,Y., Dai,X., Liu,Y., Li,J., Liu,Z., Yin,P., Chen,J., Wang,Y.,
            Wang,N. and Zhang,P.
  TITLE     MTUS1 silencing promotes E-selectin production through p38
            MAPK-dependent CREB ubiquitination in endothelial cells
  JOURNAL   J Mol Cell Cardiol 101, 1-10 (2016)
   PUBMED   27789289
REFERENCE   3  (residues 1 to 1260)
  AUTHORS   Kukida,M., Mogi,M., Ohshima,K., Nakaoka,H., Iwanami,J., Kanno,H.,
            Tsukuda,K., Chisaka,T., Min,L.J., Wang,X.L., Bai,H.Y., Shan,B.S.,
            Higaki,A., Yamauchi,T., Okura,T., Higaki,J. and Horiuchi,M.
  TITLE     Angiotensin II Type 2 Receptor Inhibits Vascular Intimal
            Proliferation With Activation of PPARgamma
  JOURNAL   Am J Hypertens 29 (6), 727-736 (2016)
   PUBMED   26471325
  REMARK    GeneRIF: important role in AT2 receptor-mediated PPARgamma
            activation
REFERENCE   4  (residues 1 to 1260)
  AUTHORS   Bundschu,K. and Schuh,K.
  TITLE     Cardiovascular ATIP (Angiotensin receptor type 2 interacting
            protein) expression in mouse development
  JOURNAL   Dev Dyn 243 (5), 699-711 (2014)
   PUBMED   24288149
  REMARK    GeneRIF: ATIPs seem to be mainly involved in the developmental
            regulation of the cardiovascular system and may act in different
            AT2-dependent and -independent manners.
REFERENCE   5  (residues 1 to 1260)
  AUTHORS   Jing,F., Mogi,M., Min,L.J., Ohshima,K., Nakaoka,H., Tsukuda,K.,
            Wang,X., Iwanami,J. and Horiuchi,M.
  TITLE     Effect of angiotensin II type 2 receptor-interacting protein on
            adipose tissue function via modulation of macrophage polarization
  JOURNAL   PLoS One 8 (4), e60067 (2013)
   PUBMED   23565185
  REMARK    GeneRIF: ATIP1 could exert anti-inflammatory effects in adipose
            tissue via macrophage polarization associated with improvement of
            insulin resistance.
REFERENCE   6  (residues 1 to 1260)
  AUTHORS   Wruck,C.J., Funke-Kaiser,H., Pufe,T., Kusserow,H., Menk,M.,
            Schefe,J.H., Kruse,M.L., Stoll,M. and Unger,T.
  TITLE     Regulation of transport of the angiotensin AT2 receptor by a novel
            membrane-associated Golgi protein
  JOURNAL   Arterioscler Thromb Vasc Biol 25 (1), 57-64 (2005)
   PUBMED   15539617
REFERENCE   7  (residues 1 to 1260)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (residues 1 to 1260)
  AUTHORS   Nouet,S., Amzallag,N., Li,J.M., Louis,S., Seitz,I., Cui,T.X.,
            Alleaume,A.M., Di Benedetto,M., Boden,C., Masson,M.,
            Strosberg,A.D., Horiuchi,M., Couraud,P.O. and Nahmias,C.
  TITLE     Trans-inactivation of receptor tyrosine kinases by novel
            angiotensin II AT2 receptor-interacting protein, ATIP
  JOURNAL   J Biol Chem 279 (28), 28989-28997 (2004)
   PUBMED   15123706
  REMARK    GeneRIF: Results identify ATIP1 (angiotensin II AT2
            receptor-interacting protein) as a novel early component of growth
            inhibitory signaling cascade.
REFERENCE   9  (residues 1 to 1260)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (residues 1 to 1260)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156554.13 and AC116511.15.
            
            On Apr 7, 2022 this sequence version replaced XP_006509303.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.10544.1,
                                           SRR10223971.8510.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1260
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 23.89 cM"
     Protein         1..1260
                     /product="microtubule-associated tumor suppressor 1
                     homolog isoform 5"
                     /note="angiotensin II AT2 receptor-interacting protein 1;
                     microtubule-associated tumor suppressor 1 homolog;
                     coiled-coiled tumor supressor gene 1; AT2 receptor-binding
                     protein; mitochondrial tumor suppressor 1 homolog;
                     coiled-coiled tumor suppressor gene 1 protein;
                     angiotensin-II type 2 receptor-interacting protein"
                     /calculated_mol_wt=139536
     Region          <905..1205
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1260
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /coded_by="NM_001403950.1:542..4324"
                     /note="isoform 5 is encoded by transcript variant 8"
                     /db_xref="GeneID:102103"
                     /db_xref="MGI:MGI:2142572"
ORIGIN      
        1 mnddnsdrte dgsryvfird knsnpseyyq tslsaqcpsv shgdwnsdnp damvvdyemd
       61 pavdssesvs lshqcveela ypepssdfmg kheftmysel tcqspalvnt gkpqdlhsnc
      121 dsleaiqdek fdplkpcecr sdddyacgds pevlelkqty gmkvdtanyt fiarhdieqg
      181 qplhapgglq ttvrdrnals scgrtpphss kmyvrgvnyn renfenlqat psktlnttft
      241 visdvlmqtd spdvgvqgqn slgnvtkeyt dgtrrglige keiqavtlvs dgmevpngsa
      301 sqefycvsed dpnsethshg pyaqqemgqn lrgtlpnchv dgecpvlvpa feksktrvlg
      361 seckvtvted phidshdnds diqssteelt lrsvsgqrgs pyemgwgeng gaictdkagc
      421 mstpveqppn lsfrlepaev kkynnvengp rdakrapnlk geptnmpkpn lgksatktnt
      481 tvgskvrkte iisyptpnfk nikakvisrs vlqpkdtsim kdtpspqvtg gsspspgpsk
      541 hltmmnkapr sdfkaskkae ipinkthkqq fnklitsqaa qvtthsknas lgvprttsat
      601 ksnqenvdkt gsphagsetg svaaffqkik gilpvkmkss eclevtyvsh idqispekge
      661 qdgeapmekq elgkqatnei fesksllvgs apktsttpgr ssskpdsrsl rktpglkakv
      721 gptaaclrrk sesrtlgsdr alspqrirrv sgsgkppclk talsswvnlp rplpiseasl
      781 icragstrsv asthsdlsay ssdcghaain kyeekppkqa fqngsgplyl kplvprahsh
      841 llktspkgps rkslftafns vekgrqknpr slciqtqtap dvlssertle laqyktkces
      901 qsgfilhlrq llsrgntkfe altvviqhll sereealkqh ktlsqelvsl rgelvaassa
      961 ceklekartd lqtayqefvq klnqqhqtdr telenrlkdl ytaeceklqs iyieeaekyk
     1021 tqlqeqfdnl naahettkle ieashsekve llkktyetsl seikksheme kksledllne
     1081 kqeslekqin dlksendaln erlkseeqkq lsrekanskn pqvmyleqel eslkavleik
     1141 neklhqqdmk lmkmeklvdn ntalvdklkr fqqeneelka rmdkhmaisr qlsteqaalq
     1201 eslekeskvn krlsmeneel lwklhngdlc spkrsptssa ipfqsprnsg sfsspsispr
//
