LOCUS       NM_001286413            6474 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus mitochondrial tumor suppressor 1 (Mtus1), transcript
            variant 5, mRNA.
ACCESSION   NM_001286413
VERSION     NM_001286413.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6474)
  AUTHORS   Mo,Q., Salley,J., Roshan,T., Baer,L.A., May,F.J., Jaehnig,E.J.,
            Lehnig,A.C., Guo,X., Tong,Q., Nuotio-Antar,A.M., Shamsi,F.,
            Tseng,Y.H., Stanford,K.I. and Chen,M.H.
  TITLE     Identification and characterization of a supraclavicular brown
            adipose tissue in mice
  JOURNAL   JCI Insight 2 (11), 93166 (2017)
   PUBMED   28570265
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6474)
  AUTHORS   Wang,Y., Dai,X., Liu,Y., Li,J., Liu,Z., Yin,P., Chen,J., Wang,Y.,
            Wang,N. and Zhang,P.
  TITLE     MTUS1 silencing promotes E-selectin production through p38
            MAPK-dependent CREB ubiquitination in endothelial cells
  JOURNAL   J Mol Cell Cardiol 101, 1-10 (2016)
   PUBMED   27789289
REFERENCE   3  (bases 1 to 6474)
  AUTHORS   Kukida,M., Mogi,M., Ohshima,K., Nakaoka,H., Iwanami,J., Kanno,H.,
            Tsukuda,K., Chisaka,T., Min,L.J., Wang,X.L., Bai,H.Y., Shan,B.S.,
            Higaki,A., Yamauchi,T., Okura,T., Higaki,J. and Horiuchi,M.
  TITLE     Angiotensin II Type 2 Receptor Inhibits Vascular Intimal
            Proliferation With Activation of PPARgamma
  JOURNAL   Am J Hypertens 29 (6), 727-736 (2016)
   PUBMED   26471325
  REMARK    GeneRIF: important role in AT2 receptor-mediated PPARgamma
            activation
REFERENCE   4  (bases 1 to 6474)
  AUTHORS   Bundschu,K. and Schuh,K.
  TITLE     Cardiovascular ATIP (Angiotensin receptor type 2 interacting
            protein) expression in mouse development
  JOURNAL   Dev Dyn 243 (5), 699-711 (2014)
   PUBMED   24288149
  REMARK    GeneRIF: ATIPs seem to be mainly involved in the developmental
            regulation of the cardiovascular system and may act in different
            AT2-dependent and -independent manners.
REFERENCE   5  (bases 1 to 6474)
  AUTHORS   Jing,F., Mogi,M., Min,L.J., Ohshima,K., Nakaoka,H., Tsukuda,K.,
            Wang,X., Iwanami,J. and Horiuchi,M.
  TITLE     Effect of angiotensin II type 2 receptor-interacting protein on
            adipose tissue function via modulation of macrophage polarization
  JOURNAL   PLoS One 8 (4), e60067 (2013)
   PUBMED   23565185
  REMARK    GeneRIF: ATIP1 could exert anti-inflammatory effects in adipose
            tissue via macrophage polarization associated with improvement of
            insulin resistance.
REFERENCE   6  (bases 1 to 6474)
  AUTHORS   Wruck,C.J., Funke-Kaiser,H., Pufe,T., Kusserow,H., Menk,M.,
            Schefe,J.H., Kruse,M.L., Stoll,M. and Unger,T.
  TITLE     Regulation of transport of the angiotensin AT2 receptor by a novel
            membrane-associated Golgi protein
  JOURNAL   Arterioscler Thromb Vasc Biol 25 (1), 57-64 (2005)
   PUBMED   15539617
REFERENCE   7  (bases 1 to 6474)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 6474)
  AUTHORS   Nouet,S., Amzallag,N., Li,J.M., Louis,S., Seitz,I., Cui,T.X.,
            Alleaume,A.M., Di Benedetto,M., Boden,C., Masson,M.,
            Strosberg,A.D., Horiuchi,M., Couraud,P.O. and Nahmias,C.
  TITLE     Trans-inactivation of receptor tyrosine kinases by novel
            angiotensin II AT2 receptor-interacting protein, ATIP
  JOURNAL   J Biol Chem 279 (28), 28989-28997 (2004)
   PUBMED   15123706
  REMARK    GeneRIF: Results identify ATIP1 (angiotensin II AT2
            receptor-interacting protein) as a novel early component of growth
            inhibitory signaling cascade.
REFERENCE   9  (bases 1 to 6474)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 6474)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156554.13 and AC116511.15.
            
            On Apr 7, 2022 this sequence version replaced NM_001286413.1.
            
            Transcript Variant: This variant (5) differs in the 5' UTR,
            compared to variant 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089009.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               AC156554.13        142727-142896
            171-2397            AC156554.13        172596-174822
            2398-2593           AC156554.13        181009-181204
            2594-2725           AC116511.15        1888-2019
            2726-2764           AC116511.15        3918-3956
            2765-2979           AC116511.15        29410-29624
            2980-3046           AC116511.15        36550-36616
            3047-3261           AC116511.15        49485-49699
            3262-3367           AC116511.15        51138-51243
            3368-3441           AC116511.15        52288-52361
            3442-3537           AC116511.15        52473-52568
            3538-3654           AC116511.15        53541-53657
            3655-3752           AC116511.15        57359-57456
            3753-6474           AC116511.15        58371-61092
FEATURES             Location/Qualifiers
     source          1..6474
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 23.89 cM"
     gene            1..6474
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /note="mitochondrial tumor suppressor 1"
                     /db_xref="GeneID:102103"
                     /db_xref="MGI:MGI:2142572"
     exon            1..170
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            171..2397
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..3966
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /note="isoform 1 is encoded by transcript variant 5;
                     angiotensin II AT2 receptor-interacting protein 1;
                     microtubule-associated tumor suppressor 1 homolog;
                     coiled-coiled tumor supressor gene 1; AT2 receptor-binding
                     protein; mitochondrial tumor suppressor 1 homolog;
                     coiled-coiled tumor suppressor gene 1 protein;
                     angiotensin-II type 2 receptor-interacting protein"
                     /codon_start=1
                     /product="microtubule-associated tumor suppressor 1
                     homolog isoform 1"
                     /protein_id="NP_001273342.1"
                     /db_xref="CCDS:CCDS40328.1"
                     /db_xref="GeneID:102103"
                     /db_xref="MGI:MGI:2142572"
                     /translation="MNDDNSDRTEDGSRYVFIRDKNSNPSEYYQTSLSAQCPSVSHGD
                     WNSDNPDAMVVDYEMDPAVDSSESVSLSHQCVEELAYPEPSSDFMGKHEFTMYSELTC
                     QSPALVNTGKPQDLHSNCDSLEAIQDEKFDPLKPCECRSDDDYACGDSPEVLELKQTY
                     GMKVDTANYTFIARHDIEQGQPLHAPGGLQTTVRDRNALSSCGRTPPHSSKMYVRGVN
                     YNRENFENLQATPSKTLNTTFTVISDVLMQTDSPDVGVQGQNSLGNVTKEYTDGTRRG
                     LIGEKEIQAVTLVSDGMEVPNGSASQEFYCVSEDDPNSETHSHGPYAQQEMGQNLRGT
                     LPNCHVDGECPVLVPAFEKSKTRVLGSECKVTVTEDPHIDSHDNDSDIQSSTEELTLR
                     SVSGQRGSPYEMGWGENGGAICTDKAGCMSTPVEQPPNLSFRLEPAEVKKYNNVENGP
                     RDAKRAPNLKGEPTNMPKPNLGKSATKTNTTVGSKVRKTEIISYPTPNFKNIKAKVIS
                     RSVLQPKDTSIMKDTPSPQVTGGSSPSPGPSKHLTMMNKAPRSDFKASKKAEIPINKT
                     HKQQFNKLITSQAAQVTTHSKNASLGVPRTTSATKSNQENVDKTGSPHAGSETGSVAA
                     FFQKIKGILPVKMKSSECLEVTYVSHIDQISPEKGEQDGEAPMEKQELGKQATNEIFE
                     SKSLLVGSAPKTSTTPGRSSSKPDSRSLRKTPGLKAKVGPTAACLRRKSESRTLGSDR
                     ALSPQRIRRVSGSGGHAAINKYEEKPPKQAFQNGSGPLYLKPLVPRAHSHLLKTSPKG
                     PSRKSLFTAFNSVEKGRQKNPRSLCIQTQTAPDVLSSERTLELAQYKTKCESQSGFIL
                     HLRQLLSRGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVSLRGELVAASSACEKL
                     EKARTDLQTAYQEFVQKLNQQHQTDRTELENRLKDLYTAECEKLQSIYIEEAEKYKTQ
                     LQEQFDNLNAAHETTKLEIEASHSEKVELLKKTYETSLSEIKKSHEMEKKSLEDLLNE
                     KQESLEKQINDLKSENDALNERLKSEEQKQLSREKANSKNPQVMYLEQELESLKAVLE
                     IKNEKLHQQDMKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQ
                     AALQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPFQSPRNSGSFSS
                     PSISPR"
     exon            2398..2593
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2725
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2764
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2979
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3046
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3047..3261
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3262..3367
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3368..3441
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3442..3537
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3538..3654
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3655..3752
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3753..6474
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4798..4803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /note="hexamer: TATAAA"
     polyA_site      4823
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
     regulatory      6447..6452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /note="hexamer: GATAAA"
     polyA_site      6474
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /note="major polyA site"
ORIGIN      
        1 ggttcacccg tgcgctggcg atggaagatt ctgaggagat gtttgaacat tcgttctcag
       61 gagactttag gtgctgtgtg gtacatactt tcttttgaac acgtatggat ttcaagacca
      121 gtgaaacagg actgtctccc agctgtcaga gtagctggaa gtctgactag ggaacgacaa
      181 gtcatttcag ctttggagca tctcagacta cagttgtgga agccggctga aagcaataga
      241 aaggggagga gctggaccat ttttcattta ctctcattaa aaaggaattt gaagagaaga
      301 taaaatggca gagttttgag gttaatattc aggatgaatg atgataattc agataggaca
      361 gaagatggat cgcgttatgt atttatccga gataaaaact cgaatccatc tgaatactac
      421 caaacatcgc tatctgccca gtgcccttca gtgagtcacg gggattggaa ctctgacaac
      481 ccagatgcca tggtggtcga ttatgaaatg gatcctgcgg tggacagtag tgaaagtgta
      541 tctttaagcc atcagtgtgt tgaagaactt gcttacccag agccttcaag tgatttcatg
      601 gggaagcatg agtttacaat gtacagtgag cttacctgcc agtctcctgc acttgtgaac
      661 acagggaagc cccaagacct gcacagtaac tgtgactccc tagaggcaat ccaggatgag
      721 aagtttgatc cccttaagcc ctgtgagtgc aggtctgatg acgattatgc ttgtggagat
      781 tcccctgaag ttttggagct aaaacaaaca tatggcatga aagtggacac ggctaactac
      841 acctttatag cacgccatga tattgaacag ggtcagcctt tgcatgctcc tggaggtttg
      901 cagacaacag tgagagacag aaatgctttg tcctcctgcg gtcggacacc accccattcc
      961 tctaagatgt atgtgagagg ggttaattat aatcgagaga actttgaaaa cctccaagcc
     1021 acaccatcca agaccctaaa cacaaccttt acagtgatct ctgatgtgct gatgcaaact
     1081 gacagtccag acgttggagt tcagggtcag aattctttag gaaatgtcac caaagagtac
     1141 acagatggga caaggcgagg actcattgga gaaaaagaga tacaagctgt gacactggtt
     1201 tcggatggca tggaggtccc caacggatct gcatcacagg agttctattg tgtatctgaa
     1261 gatgacccaa acagtgagac acattcacac ggcccgtatg ctcaacagga aatgggccaa
     1321 aatttaagag gaacactgcc caactgtcat gtcgatggtg aatgcccagt actggtgcca
     1381 gcttttgaga agagtaaaac cagagtcctg ggctctgagt gtaaagtcac tgtgactgaa
     1441 gacccacaca tcgattccca cgacaatgac tcagacatcc aaagtagtac tgaagagctg
     1501 accctgagaa gtgtttcagg gcagaggggt tcaccttatg aaatgggttg gggcgagaac
     1561 ggcggagcca tttgcacaga taaagcaggt tgcatgtcaa caccagttga gcaacccccc
     1621 aatctgagct tcagacttga acctgctgaa gtgaagaagt acaataatgt ggagaatgga
     1681 ccaagagatg ctaaacgtgc accaaacttg aaaggggaac caacaaatat gccaaaacct
     1741 aatttgggaa aatcagctac caaaacaaat accactgtag gcagtaaagt caggaagaca
     1801 gaaattataa gttatcctac accaaacttc aaaaacatta aagccaaagt tatatccaga
     1861 tcagtgttgc aacccaaaga cacttccata atgaaggaca cacccagccc tcaggtaaca
     1921 gggggctctt caccatcacc agggccttct aaacacttga caatgatgaa caaagcacca
     1981 agatctgact ttaaagccag caaaaaagca gaaatcccaa ttaacaagac acacaagcaa
     2041 cagtttaata aactcattac cagccaggct gcgcaagtta caactcattc taaaaatgct
     2101 tcactcgggg ttccaagaac aacatctgcc acgaaatcga atcaggagaa tgttgacaag
     2161 acaggttctc ctcatgcagg gagtgagacc gggtctgtag ctgccttctt ccagaagatc
     2221 aaaggcattc tccccgtgaa aatgaaaagc tcagagtgtt tggaagtgac ttacgtttcc
     2281 cacatcgatc agattagccc tgaaaagggt gagcaggacg gtgaggctcc catggaaaag
     2341 caagagctgg gaaaacaagc cacgaatgag atttttgaat ccaagtctct attggtgggc
     2401 tctgcaccca aaacttccac cacgccagga aggagcagtt ccaagccaga ctcgcggagc
     2461 ctgaggaaaa caccaggtct aaaagccaaa gtgggtccca ctgctgcctg cctgaggagg
     2521 aagagtgaga gtagaaccct aggctccgac agggccttat cgcctcagag gatcaggcgc
     2581 gtgtccggct ctggtggtca tgctgccatc aacaaatatg aagagaaacc tcccaaacaa
     2641 gcatttcaga atgggtcagg acccttgtat ctgaagcctt tggtacccag agctcactcg
     2701 cacttgctca aaacttctcc aaaaggtcct tcaaggaaga gtctgtttac agcttttaat
     2761 tcagttgaaa agggcaggca gaagaatccc aggagcctat gcatccagac ccagacagct
     2821 ccagatgtgc tgtcctccga gagaacgctt gagttggccc aatacaagac aaaatgtgaa
     2881 agccaaagtg gattcatcct gcacctcaga cagcttcttt cccgtggtaa caccaagttt
     2941 gaagcgctga ccgttgtgat ccagcacctc ctgtctgagc gggaggaagc actgaagcaa
     3001 cacaaaaccc tctctcaaga acttgtcagc ctccggggag agctagttgc tgcttcaagc
     3061 gcctgtgaga agctagaaaa ggctaggact gacttacaga cagcgtatca agaatttgtc
     3121 cagaaactaa accagcagca tcagacagac cggacggaac tggagaaccg gctgaaggac
     3181 ttatacaccg cagagtgtga gaagcttcag agcatttaca ttgaggaggc agaaaaatat
     3241 aaaactcaac tgcaagagca gtttgacaac ttaaacgccg cccatgagac cactaagctt
     3301 gagattgaag ctagccactc ggagaaggtg gaattgctga agaagaccta tgaaacctcc
     3361 ctttcagaaa tcaagaagag ccatgagatg gagaagaagt cactggagga tctgcttaat
     3421 gagaagcagg aatcgctgga gaaacaaatc aatgatctga agagtgaaaa cgatgcttta
     3481 aacgaaaggt tgaaatcaga ggagcaaaag caactgtcaa gagagaaggc gaattcaaaa
     3541 aaccctcagg tcatgtatct ggagcaagaa ctagaaagcc tgaaggctgt gttagagatc
     3601 aagaatgaga agctgcacca gcaggacatg aagctaatga agatggaaaa gctggtggac
     3661 aataacacag cattggttga caagctgaag cgattccagc aggaaaacga ggagttaaaa
     3721 gctcgcatgg acaaacacat ggcaatttca aggcaacttt ccaccgagca ggccgcgctg
     3781 caggagtccc ttgagaagga gtcgaaggtc aacaagagac tgtccatgga gaacgaggaa
     3841 cttctgtgga aactgcacaa cggagacctg tgcagcccca agagatcccc cacctcctcg
     3901 gccatccctt tccagtcccc caggaattct ggttccttct ccagccccag catctcaccc
     3961 agatgacggc ttctgaacgc aggagactct ctgaaggcac tgaggtgcgc ttctgcggga
     4021 ctgacccgaa gttcagagtt catgggaact cgagttgctg cgttagctct ctggaatatc
     4081 cccaggatat cgggagagca gccgccaacc gtttcagcta cgtacgaata gagagctcca
     4141 ataggagact tttaacttgg tccaaaagcc tcctccaaaa acagatttcg gaactgaagt
     4201 ggacatagtt gcacaaagca cttacggaac gagggaacct tgttctttgc cttccttcac
     4261 ctaagcatag gggaaaactc tcagggccct attaagataa agatttataa cctttataat
     4321 gttcttcacc agagacacct tcttgtgatt tttatttcag tctgactgtg ggcaaggggg
     4381 gtgtgtgtgt gagtgaaatg ggtgtactgg cgtgtcacgt gactgtcata gccccgcccc
     4441 ctgctgtgta ttaaaagtca acagctgtat atagcttggc ctgtattaac caagtcataa
     4501 tcggcacacg agcgtcaaca aaagccatag aagagaaagc aatagtgctt gaatttcccc
     4561 ccaactcatc tcagcactgt gccacggcag ggctcgggca agacaggaaa agcctttggt
     4621 ttcttgatga ctgtacattt atttctctgt tgttagtttt tccatgttcg gcattatccg
     4681 ttgatagcag tttttttttc cccctgtaga ttttcacgag cctaattgct atactctgat
     4741 tcattttctc aggctatgag caaatgtagt tccctaattt ttctaaatac aaatctgtat
     4801 aaagagtaag ggggcagtac caatggatgt ttctggttta tttttttccc ttgaacccaa
     4861 gctagcttca tagcgctaat cctccgtcta ccctcctgtt gttctaacct ccgccttgcc
     4921 ttctcctcca tgtagagcca cggaagcaaa gcgccctcct tcctacccac agagtgtgct
     4981 tttccagggc cagtttatct tggaggtgct gaacctgttt cccaaataag ctaagctctg
     5041 gttctgacac tacacaattt tagaaacccc gggggggaaa ccagtaaagg cattttagca
     5101 tgtactaatc cacatgagca cagagttaag ccaacagttc tgtgttgagt agatccaaga
     5161 gcgggaatgc tgacttgggc ccctctgagc attcttccag ccactggaat ggaacagagt
     5221 ggccaaagag tgagaggtat ggcttctgca gctccttcac actgcattca aaattcagat
     5281 cttcgcttac catctcccta ggctccaagg ctctgtgaaa gttagaagga tagctgtggc
     5341 tccccaccac ccaacccaca aacttccctg tgcatgccgg cattgcgatg tcagtattta
     5401 ctaattcatg gtcaatgctg ctcagataac ccctatagcg aggacagatt caggatacta
     5461 gaggtgagtc atcctagact tctgcactac agagctaact gatagtcatg atgcatgctt
     5521 tttattaggg gttgtgtttg aagtctctta tctccaatag tttatgatgt atgtaaccta
     5581 ccatgtttgc tcccgataaa taggaatgat tgcagcttca ctgccacctc ctggaatagc
     5641 tctgctcctg gtcccaagtt gttctcaatg atgttagcca aagtcaggtt tgtcatttat
     5701 gccctagtta tggtaaagct caagtgttga cctgccatcc ctcataccac gtagatgtct
     5761 gggaagtcaa atcttacagc aattaaaatg cctagagagc atttaagggt ttttttgttt
     5821 tgttttttaa accaaacatt ttatgtacaa tacaaaattg ttgacacatc gtttaaaaaa
     5881 aatgtgggtg tgtgaacaac tgtagtttat agcaatggga aagtgtattt tactttgatc
     5941 aaataaataa tgctggaata ttcaatgtaa gaatggcagc ctctgacata cttactcttc
     6001 aaagcgttaa gttatatgct cccccttctc atccctcctt agttaaggca gccaggcgcc
     6061 ctatgctatt atacagaact tagaacccaa tgccaaaatt tgttgtggct gaaattggct
     6121 cacagagctt gagtttaaga ttaagctttt caaattcaaa atacatgtgt cagagaacga
     6181 aactttggct agtttgaatg attcttctgc aaggcgaaaa gaaaattgga acagctgtgg
     6241 tcttaagtgt tttttcaaga ccggtcttag ccaaagctga atcttcttca gtccattcat
     6301 ctatgttata ttaaaggcta aggtgttaat agtgtacatg cagttatttt tgaatagagg
     6361 ggtttaaatc agtactctga gtgtggcgat ttcaatgtaa aaagatgtga ttttgatacc
     6421 tttataaatg aacttgtgct agctttgata aagtgacata tctaagcatt tgaa
//
