LOCUS       NM_001005865            4132 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus mitochondrial tumor suppressor 1 (Mtus1), transcript
            variant 4, mRNA.
ACCESSION   NM_001005865
VERSION     NM_001005865.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4132)
  AUTHORS   Mo,Q., Salley,J., Roshan,T., Baer,L.A., May,F.J., Jaehnig,E.J.,
            Lehnig,A.C., Guo,X., Tong,Q., Nuotio-Antar,A.M., Shamsi,F.,
            Tseng,Y.H., Stanford,K.I. and Chen,M.H.
  TITLE     Identification and characterization of a supraclavicular brown
            adipose tissue in mice
  JOURNAL   JCI Insight 2 (11), 93166 (2017)
   PUBMED   28570265
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4132)
  AUTHORS   Wang,Y., Dai,X., Liu,Y., Li,J., Liu,Z., Yin,P., Chen,J., Wang,Y.,
            Wang,N. and Zhang,P.
  TITLE     MTUS1 silencing promotes E-selectin production through p38
            MAPK-dependent CREB ubiquitination in endothelial cells
  JOURNAL   J Mol Cell Cardiol 101, 1-10 (2016)
   PUBMED   27789289
REFERENCE   3  (bases 1 to 4132)
  AUTHORS   Kukida,M., Mogi,M., Ohshima,K., Nakaoka,H., Iwanami,J., Kanno,H.,
            Tsukuda,K., Chisaka,T., Min,L.J., Wang,X.L., Bai,H.Y., Shan,B.S.,
            Higaki,A., Yamauchi,T., Okura,T., Higaki,J. and Horiuchi,M.
  TITLE     Angiotensin II Type 2 Receptor Inhibits Vascular Intimal
            Proliferation With Activation of PPARgamma
  JOURNAL   Am J Hypertens 29 (6), 727-736 (2016)
   PUBMED   26471325
  REMARK    GeneRIF: important role in AT2 receptor-mediated PPARgamma
            activation
REFERENCE   4  (bases 1 to 4132)
  AUTHORS   Bundschu,K. and Schuh,K.
  TITLE     Cardiovascular ATIP (Angiotensin receptor type 2 interacting
            protein) expression in mouse development
  JOURNAL   Dev Dyn 243 (5), 699-711 (2014)
   PUBMED   24288149
  REMARK    GeneRIF: ATIPs seem to be mainly involved in the developmental
            regulation of the cardiovascular system and may act in different
            AT2-dependent and -independent manners.
REFERENCE   5  (bases 1 to 4132)
  AUTHORS   Jing,F., Mogi,M., Min,L.J., Ohshima,K., Nakaoka,H., Tsukuda,K.,
            Wang,X., Iwanami,J. and Horiuchi,M.
  TITLE     Effect of angiotensin II type 2 receptor-interacting protein on
            adipose tissue function via modulation of macrophage polarization
  JOURNAL   PLoS One 8 (4), e60067 (2013)
   PUBMED   23565185
  REMARK    GeneRIF: ATIP1 could exert anti-inflammatory effects in adipose
            tissue via macrophage polarization associated with improvement of
            insulin resistance.
REFERENCE   6  (bases 1 to 4132)
  AUTHORS   Wruck,C.J., Funke-Kaiser,H., Pufe,T., Kusserow,H., Menk,M.,
            Schefe,J.H., Kruse,M.L., Stoll,M. and Unger,T.
  TITLE     Regulation of transport of the angiotensin AT2 receptor by a novel
            membrane-associated Golgi protein
  JOURNAL   Arterioscler Thromb Vasc Biol 25 (1), 57-64 (2005)
   PUBMED   15539617
REFERENCE   7  (bases 1 to 4132)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 4132)
  AUTHORS   Nouet,S., Amzallag,N., Li,J.M., Louis,S., Seitz,I., Cui,T.X.,
            Alleaume,A.M., Di Benedetto,M., Boden,C., Masson,M.,
            Strosberg,A.D., Horiuchi,M., Couraud,P.O. and Nahmias,C.
  TITLE     Trans-inactivation of receptor tyrosine kinases by novel
            angiotensin II AT2 receptor-interacting protein, ATIP
  JOURNAL   J Biol Chem 279 (28), 28989-28997 (2004)
   PUBMED   15123706
  REMARK    GeneRIF: Results identify ATIP1 (angiotensin II AT2
            receptor-interacting protein) as a novel early component of growth
            inhibitory signaling cascade.
REFERENCE   9  (bases 1 to 4132)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 4132)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116511.15.
            
            On Apr 7, 2022 this sequence version replaced NM_001005865.3.
            
            Transcript Variant: This variant (4) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. This results in
            shorter protein (isoform 4) with a distinct N-terminus, compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030510.1, AK031693.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-422               AC116511.15        10110-10531
            423-637             AC116511.15        29410-29624
            638-704             AC116511.15        36550-36616
            705-919             AC116511.15        49485-49699
            920-1025            AC116511.15        51138-51243
            1026-1099           AC116511.15        52288-52361
            1100-1195           AC116511.15        52473-52568
            1196-1312           AC116511.15        53541-53657
            1313-1410           AC116511.15        57359-57456
            1411-4132           AC116511.15        58371-61092
FEATURES             Location/Qualifiers
     source          1..4132
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 23.89 cM"
     gene            1..4132
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /note="mitochondrial tumor suppressor 1"
                     /db_xref="GeneID:102103"
                     /db_xref="MGI:MGI:2142572"
     exon            1..422
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             302..1624
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /note="isoform 4 is encoded by transcript variant 4;
                     angiotensin II AT2 receptor-interacting protein 1;
                     microtubule-associated tumor suppressor 1 homolog;
                     coiled-coiled tumor supressor gene 1; AT2 receptor-binding
                     protein; mitochondrial tumor suppressor 1 homolog;
                     coiled-coiled tumor suppressor gene 1 protein;
                     angiotensin-II type 2 receptor-interacting protein"
                     /codon_start=1
                     /product="microtubule-associated tumor suppressor 1
                     homolog isoform 4"
                     /protein_id="NP_001005865.2"
                     /db_xref="CCDS:CCDS40330.1"
                     /db_xref="GeneID:102103"
                     /db_xref="MGI:MGI:2142572"
                     /translation="MLLSPKFSLSTIHVRLTAKGLLRNLRLPSGLRKNTVIFHTVEKG
                     RQKNPRSLCIQTQTAPDVLSSERTLELAQYKTKCESQSGFILHLRQLLSRGNTKFEAL
                     TVVIQHLLSEREEALKQHKTLSQELVSLRGELVAASSACEKLEKARTDLQTAYQEFVQ
                     KLNQQHQTDRTELENRLKDLYTAECEKLQSIYIEEAEKYKTQLQEQFDNLNAAHETTK
                     LEIEASHSEKVELLKKTYETSLSEIKKSHEMEKKSLEDLLNEKQESLEKQINDLKSEN
                     DALNERLKSEEQKQLSREKANSKNPQVMYLEQELESLKAVLEIKNEKLHQQDMKLMKM
                     EKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAALQESLEKESKVNKR
                     LSMENEELLWKLHNGDLCSPKRSPTSSAIPFQSPRNSGSFSSPSISPR"
     exon            423..637
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            638..704
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..919
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1025
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1099
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1195
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1312
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1410
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..4132
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2456..2461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /note="hexamer: TATAAA"
     polyA_site      2481
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
     regulatory      4105..4110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /note="hexamer: GATAAA"
     polyA_site      4132
                     /gene="Mtus1"
                     /gene_synonym="ATBP135; Atip1; B430010I23Rik;
                     B430305I03Rik; Cctsg1-440; MD44; mKIAA1288; MTSG1"
                     /note="major polyA site"
ORIGIN      
        1 gtaattcagg ctgcttgctt cctgagctgc tcctcacaga tcttgctcag acgaagggca
       61 ttgtttgtta gcaacatctg gaagagcaaa cggaagcctg gagctctggg atagctaact
      121 ctagctaccc ccccccccac gcacccccca atctgggtgg cctggcatta gcatgtaagc
      181 ttgtttttct ctggctgtat ctcttggcct ggaagaaccc cgagttgcca agagacacag
      241 tatgtgatgg tccctggaaa agctgcttcc cctgcgaagt tctcccactg gcttcgaaga
      301 catgctgttg tctcccaaat tctccttatc caccatccac gtccgcctaa ccgccaaagg
      361 actgcttcga aacctccggc ttccttcggg gctcaggaaa aacactgtca ttttccacac
      421 agttgaaaag ggcaggcaga agaatcccag gagcctatgc atccagaccc agacagctcc
      481 agatgtgctg tcctccgaga gaacgcttga gttggcccaa tacaagacaa aatgtgaaag
      541 ccaaagtgga ttcatcctgc acctcagaca gcttctttcc cgtggtaaca ccaagtttga
      601 agcgctgacc gttgtgatcc agcacctcct gtctgagcgg gaggaagcac tgaagcaaca
      661 caaaaccctc tctcaagaac ttgtcagcct ccggggagag ctagttgctg cttcaagcgc
      721 ctgtgagaag ctagaaaagg ctaggactga cttacagaca gcgtatcaag aatttgtcca
      781 gaaactaaac cagcagcatc agacagaccg gacggaactg gagaaccggc tgaaggactt
      841 atacaccgca gagtgtgaga agcttcagag catttacatt gaggaggcag aaaaatataa
      901 aactcaactg caagagcagt ttgacaactt aaacgccgcc catgagacca ctaagcttga
      961 gattgaagct agccactcgg agaaggtgga attgctgaag aagacctatg aaacctccct
     1021 ttcagaaatc aagaagagcc atgagatgga gaagaagtca ctggaggatc tgcttaatga
     1081 gaagcaggaa tcgctggaga aacaaatcaa tgatctgaag agtgaaaacg atgctttaaa
     1141 cgaaaggttg aaatcagagg agcaaaagca actgtcaaga gagaaggcga attcaaaaaa
     1201 ccctcaggtc atgtatctgg agcaagaact agaaagcctg aaggctgtgt tagagatcaa
     1261 gaatgagaag ctgcaccagc aggacatgaa gctaatgaag atggaaaagc tggtggacaa
     1321 taacacagca ttggttgaca agctgaagcg attccagcag gaaaacgagg agttaaaagc
     1381 tcgcatggac aaacacatgg caatttcaag gcaactttcc accgagcagg ccgcgctgca
     1441 ggagtccctt gagaaggagt cgaaggtcaa caagagactg tccatggaga acgaggaact
     1501 tctgtggaaa ctgcacaacg gagacctgtg cagccccaag agatccccca cctcctcggc
     1561 catccctttc cagtccccca ggaattctgg ttccttctcc agccccagca tctcacccag
     1621 atgacggctt ctgaacgcag gagactctct gaaggcactg aggtgcgctt ctgcgggact
     1681 gacccgaagt tcagagttca tgggaactcg agttgctgcg ttagctctct ggaatatccc
     1741 caggatatcg ggagagcagc cgccaaccgt ttcagctacg tacgaataga gagctccaat
     1801 aggagacttt taacttggtc caaaagcctc ctccaaaaac agatttcgga actgaagtgg
     1861 acatagttgc acaaagcact tacggaacga gggaaccttg ttctttgcct tccttcacct
     1921 aagcataggg gaaaactctc agggccctat taagataaag atttataacc tttataatgt
     1981 tcttcaccag agacaccttc ttgtgatttt tatttcagtc tgactgtggg caaggggggt
     2041 gtgtgtgtga gtgaaatggg tgtactggcg tgtcacgtga ctgtcatagc cccgccccct
     2101 gctgtgtatt aaaagtcaac agctgtatat agcttggcct gtattaacca agtcataatc
     2161 ggcacacgag cgtcaacaaa agccatagaa gagaaagcaa tagtgcttga atttcccccc
     2221 aactcatctc agcactgtgc cacggcaggg ctcgggcaag acaggaaaag cctttggttt
     2281 cttgatgact gtacatttat ttctctgttg ttagtttttc catgttcggc attatccgtt
     2341 gatagcagtt tttttttccc cctgtagatt ttcacgagcc taattgctat actctgattc
     2401 attttctcag gctatgagca aatgtagttc cctaattttt ctaaatacaa atctgtataa
     2461 agagtaaggg ggcagtacca atggatgttt ctggtttatt tttttccctt gaacccaagc
     2521 tagcttcata gcgctaatcc tccgtctacc ctcctgttgt tctaacctcc gccttgcctt
     2581 ctcctccatg tagagccacg gaagcaaagc gccctccttc ctacccacag agtgtgcttt
     2641 tccagggcca gtttatcttg gaggtgctga acctgtttcc caaataagct aagctctggt
     2701 tctgacacta cacaatttta gaaaccccgg gggggaaacc agtaaaggca ttttagcatg
     2761 tactaatcca catgagcaca gagttaagcc aacagttctg tgttgagtag atccaagagc
     2821 gggaatgctg acttgggccc ctctgagcat tcttccagcc actggaatgg aacagagtgg
     2881 ccaaagagtg agaggtatgg cttctgcagc tccttcacac tgcattcaaa attcagatct
     2941 tcgcttacca tctccctagg ctccaaggct ctgtgaaagt tagaaggata gctgtggctc
     3001 cccaccaccc aacccacaaa cttccctgtg catgccggca ttgcgatgtc agtatttact
     3061 aattcatggt caatgctgct cagataaccc ctatagcgag gacagattca ggatactaga
     3121 ggtgagtcat cctagacttc tgcactacag agctaactga tagtcatgat gcatgctttt
     3181 tattaggggt tgtgtttgaa gtctcttatc tccaatagtt tatgatgtat gtaacctacc
     3241 atgtttgctc ccgataaata ggaatgattg cagcttcact gccacctcct ggaatagctc
     3301 tgctcctggt cccaagttgt tctcaatgat gttagccaaa gtcaggtttg tcatttatgc
     3361 cctagttatg gtaaagctca agtgttgacc tgccatccct cataccacgt agatgtctgg
     3421 gaagtcaaat cttacagcaa ttaaaatgcc tagagagcat ttaagggttt ttttgttttg
     3481 ttttttaaac caaacatttt atgtacaata caaaattgtt gacacatcgt ttaaaaaaaa
     3541 tgtgggtgtg tgaacaactg tagtttatag caatgggaaa gtgtatttta ctttgatcaa
     3601 ataaataatg ctggaatatt caatgtaaga atggcagcct ctgacatact tactcttcaa
     3661 agcgttaagt tatatgctcc cccttctcat ccctccttag ttaaggcagc caggcgccct
     3721 atgctattat acagaactta gaacccaatg ccaaaatttg ttgtggctga aattggctca
     3781 cagagcttga gtttaagatt aagcttttca aattcaaaat acatgtgtca gagaacgaaa
     3841 ctttggctag tttgaatgat tcttctgcaa ggcgaaaaga aaattggaac agctgtggtc
     3901 ttaagtgttt tttcaagacc ggtcttagcc aaagctgaat cttcttcagt ccattcatct
     3961 atgttatatt aaaggctaag gtgttaatag tgtacatgca gttatttttg aatagagggg
     4021 tttaaatcag tactctgagt gtggcgattt caatgtaaaa agatgtgatt ttgatacctt
     4081 tataaatgaa cttgtgctag ctttgataaa gtgacatatc taagcatttg aa
//
