LOCUS       NM_001289740            5307 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus maturin, neural progenitor differentiation regulator
            homolog (Xenopus) (Mturn), transcript variant 1, mRNA.
ACCESSION   NM_001289740 XM_006506530
VERSION     NM_001289740.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5307)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5307)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5307)
  AUTHORS   Zhou,J., Zhou,Q., Zhang,T. and Fan,J.
  TITLE     C7ORF41 Regulates Inflammation by Inhibiting NF-kappaB Signaling
            Pathway
  JOURNAL   Biomed Res Int 2021, 7413605 (2021)
   PUBMED   33506033
  REMARK    GeneRIF: C7ORF41 Regulates Inflammation by Inhibiting NF-kappaB
            Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5307)
  AUTHORS   Yan,F.J., Wang,X., Wang,S.E., Hong,H.T., Lu,J., Ye,Q., Zheng,Y.L.
            and Wang,Y.J.
  TITLE     C-Jun/C7ORF41/NF-kappaB axis mediates hepatic inflammation and
            lipid accumulation in NAFLD
  JOURNAL   Biochem J 477 (3), 691-708 (2020)
   PUBMED   31957809
  REMARK    GeneRIF: C7ORF41 overexpression significantly ameliorated hepatic
            inflammation and lipid accumulation in palmitic acid (PA)-treated
            hepatocytes, whereas C7ORF41 knockdown showed the opposite effects.
REFERENCE   5  (bases 1 to 5307)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 5307)
  AUTHORS   Sun,X., Lu,B., Hu,B., Xiao,W., Li,W. and Huang,Z.
  TITLE     Novel function of the chromosome 7 open reading frame 41 gene to
            promote leukemic megakaryocyte differentiation by modulating
            TPA-induced signaling
  JOURNAL   Blood Cancer J 4 (3), e198 (2014)
   PUBMED   24681962
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5307)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 5307)
  AUTHORS   Martinez-De Luna,R.I., Ku,R.Y., Lyou,Y. and Zuber,M.E.
  TITLE     Maturin is a novel protein required for differentiation during
            primary neurogenesis
  JOURNAL   Dev Biol 384 (1), 26-40 (2013)
   PUBMED   24095902
REFERENCE   9  (bases 1 to 5307)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY266709.1, AC084800.5 and BC052467.1.
            
            On Jan 28, 2014 this sequence version replaced XM_006506530.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the shorter isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052467.1, SRR1660825.965.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                BY266709.1         2-46
            46-46               AC084800.5         187017-187017
            47-116              BY266709.1         47-116
            117-5303            BC052467.1         1-5187
            5304-5307           AC084800.5         209200-209203
FEATURES             Location/Qualifiers
     source          1..5307
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 27.07 cM"
     gene            1..5307
                     /gene="Mturn"
                     /gene_synonym="2410066E13Rik; B230212L03Rik"
                     /note="maturin, neural progenitor differentiation
                     regulator homolog (Xenopus)"
                     /db_xref="GeneID:68235"
                     /db_xref="MGI:MGI:1915485"
     exon            1..308
                     /gene="Mturn"
                     /gene_synonym="2410066E13Rik; B230212L03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..542
                     /gene="Mturn"
                     /gene_synonym="2410066E13Rik; B230212L03Rik"
                     /note="isoform a is encoded by transcript variant 1;
                     UPF0452 protein C7orf41 homolog; maturin neural progenitor
                     differentiation regulator protein homolog"
                     /codon_start=1
                     /product="maturin isoform a"
                     /protein_id="NP_001276669.1"
                     /db_xref="CCDS:CCDS20158.2"
                     /db_xref="GeneID:68235"
                     /db_xref="MGI:MGI:1915485"
                     /translation="MDFQQLADVAEKWCSSTPFELIAAEETERRMDFYADPGVSFYVL
                     CPDNGCGDSFHVWSESEDCLPFLQLAQDYISSCGKKTLHEVLEKVFKSFRPLLGLPDA
                     DDDAFEEYSADVEEEEPEADHPQMGVSQQ"
     exon            309..431
                     /gene="Mturn"
                     /gene_synonym="2410066E13Rik; B230212L03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            432..5307
                     /gene="Mturn"
                     /gene_synonym="2410066E13Rik; B230212L03Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5280..5285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mturn"
                     /gene_synonym="2410066E13Rik; B230212L03Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      5303
                     /gene="Mturn"
                     /gene_synonym="2410066E13Rik; B230212L03Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggggcggccc cggactggcg gggccccggg gtgcttgggt tcctttcaag gcgggcggtg
       61 ggggtggggg cggggcggag gcggagcggg cggtgtaaac agacccggga gccgtgagcc
      121 ccggaggagg cgcgggcggc gccgccatgg acttccagca gctggcagat gtcgcggaga
      181 agtggtgttc cagcacgccc tttgagctca tcgccgccga ggagacggag cgcaggatgg
      241 acttctacgc cgacccgggc gtctccttct acgtactgtg tccggacaac ggctgcggcg
      301 acagctttca cgtgtggagc gagagcgagg actgcctgcc cttcttgcag ctggcccaag
      361 attacatctc ttcctgcggc aagaagaccc tccatgaagt cttggaaaaa gtcttcaaat
      421 ccttcagacc tttgctgggg cttccagacg cagatgacga cgcgtttgaa gagtacagtg
      481 cggatgtgga ggaggaggag ccagaggcgg accacccgca aatgggggtc agtcagcagt
      541 aaactcctag gtcaccttgc agaaggggag taagccctgt gcaccccatg gggtccggtc
      601 ctccggacag agttcggtgc tcctggggta gcccttttgc attagcactt caaaacagga
      661 catcccgctc ctggcatcag aatgaaaatg aaataccctt taaatgacca cacaatatct
      721 gtgacgaggt ttgctcggca gtgaccggaa ttgccgcccc accttggtgg ggtctctatg
      781 gagatgtctt ggtagctttt gcccctttga agttagagtc cgtccgtgtt gtggctgcct
      841 gttccctctc gagtttatgt tggaggatta atgtttcctg actggaatgt agagaactct
      901 gaatgtatta aggatgtgtt ctgagtcctc acaggtgacc ttgctgagga aaagcatgac
      961 ggaggagaaa cgcagcctgc actgtttgtg taccttttaa gtgtccgtaa gtgaaaggct
     1021 tcgcttagaa agcatgagtt ttcatatcta gtcatgcgca tgcgcatgag caagcgcaga
     1081 gggtgagggc ggctgaggct ccttcaggga gttcaccact gtctgcgttg gttccccggg
     1141 cgcgcagccg ccagccactg gtcagtgtag atgcttcctg ggtgtttgat agttttttta
     1201 aagcatgctg cttccaaagc cgcttttaaa ttctaatagt ggaaagtgta gatggggtga
     1261 aagatgtaaa cgattggttt cttgacactg tctataagcc tgcatatgaa acagtaacct
     1321 tttctcttta tgacgagacg gcagcttact taatcgtgag aacagcccgg atctgagcaa
     1381 gtgcccctta agctttgaag ccataggtaa atctaacagg aaaagaaact aggatagaaa
     1441 tattaataaa atgaaatcat ttgctttcct aatcttttat tctttagaga atgtcaagag
     1501 gggctcccag tgagttaatt tatttaaaat tataattaat tactctaggg gacctacttg
     1561 cagtgaaatt tttaaaggga cctgaaagta agaatcttaa ttacgagatc gcttgggttg
     1621 caagagggtg agttaatgat caggacacac agacaactcc caggcgtgac tgctctcatc
     1681 attagccagt aagtacttag caagatattc tctgatgcca ctgtgagacc cttccacgcg
     1741 tgtctcaggt tctcataact tagggtgcaa gtgtcccttg acagtgcttg actgctctgt
     1801 gcatcgagtg tgggcgtgtt tcaaacgcac acccacacca cttatgttgc tggtatttta
     1861 aatttaaaaa agaaggagat gatgaagaag aaggagatgt ccacgaccac ttgcgctgac
     1921 aggagcttgt gtggatggcc agcgtgtatg ggcattctct gtttaatgca ggggcagttc
     1981 gaagagtccc atgctccttg gtgtattgta gatttcagct gctgggtgat gtcacacact
     2041 ggtttccatc tgtgcttttg tacctgtgtg ttttattgtc tggaagaaac ttactaatac
     2101 caagccaagt gagttctctt gaagtagccc attagcaatg tcacactgag tgctccttcc
     2161 agggtgcaag gtccagcctt tgagtcctgc ccatcgcccc actttgtgag catacagcag
     2221 ggagagtgag ctctctgtct tgtaggtact gtccagggca ggtaaccttc ttttacatat
     2281 ggttggtcac acaaatatat ggcttttatg gctaaatgag gatgcctgag cagtttgctc
     2341 cattctgagg taacctgcaa ttttatacac agaggcttca aatctaaatt tacatgtgtt
     2401 tgaacattaa tataagatga atttttatca aaaatgtatt taaactttga ccagatatac
     2461 tcggtgttat cacattaatg ttctctattt gtacaagttg agctaagacc ccctcctagt
     2521 ggtgcagcgg gctgctaaaa actctcctct tctgcccagg ggtgaggaag agagaatatc
     2581 cctggatgtg gttgatttcc acggcaaacc ccagaggcat ccacacatcc atcgtccttg
     2641 ccagcctcct tccctctgct gttgtgtgtg tcccttccag ggtgggcctg tgcgcacacc
     2701 cgagcctacc cgttccacag tgagacagat gtgacccctc ccagcctgcg gaggcaggca
     2761 ttctagtggc agccatagca tgggggaagg gtctttggga gttaggagag acacttgcct
     2821 ttgactgcag gactctgata agtcatgtga cttctctatg aaacagggcg atttactctt
     2881 ctagctttga acactatcct aatgcagctg cgtaggaaag gaagtgtgtg ttcagaagag
     2941 caacagccca ggacacggag ggacatggga aagagatact ttgtaatttt gccaaagatg
     3001 gtgtctttaa gatgctggcc atgcagctac tttagaatat ggtggccagc agatatccag
     3061 atccctggag cctggggtgg gctctatccc aggcaactga tgagattctg tcactttgag
     3121 aggtgggtaa gcagaggtcc cagaagatgg cttgtctcgg ttgaatgtca gtgtcaggca
     3181 gagccgctcc tcgccccact atgctgaagg gtttggaagt ggtatgcagg gaacccaaga
     3241 ggggagacta gtgtgaagac tagctggagg ggaatggcag tgaacacttt gcttgtccta
     3301 tcactcagga aagtgacagt gaaggcttgg taggtagcag acagagacag tgagagcaaa
     3361 catacaggga aggactgatg gcatgctgac cgatgtgacc agctgaaatc tgaactagcc
     3421 actgacagca ctcaagaggc ggatcctatc actgagtgat ccacggagac attttcctcc
     3481 tatctgtcag gttactttcc tctgcctggt gatggcactg agccaagcag tcttcagaca
     3541 tcgaagaaca gagccagggc gcagcgtgag gcccagtgca gtgcctagca tcactagggt
     3601 tcagtcagac cgaagggtcc acttgggact cctgggctct ctgcagcaca gggtacattc
     3661 tgtgtttcca tgaccagagc acaaactgtc tgctacgtga ggaaattgtc cttcatgcta
     3721 atgcctgaac taggttttca gtgcgcttaa gtcagactgg gtctggggct accacccctg
     3781 ctcagtatag gcagaactgt tctgtagcac aatgcatgtc tctgaatatt gtttcggttt
     3841 cttctccgag cacaaaacgt atgttcaggg tgtcgtgatc ccagactgga acttttagtt
     3901 gttgcatgtt aaaactcacc agttgggaaa cagttgaatc aaatctggtt tttttttcca
     3961 gtgagaggaa cgtagggatg ggcaagactt aatgtgtgtt gggagcaggt ggacaggtgc
     4021 agtgaagagt taggtctcca tccatccgag ttgtaaacaa agcacatagc ccacccacac
     4081 ttaccttctg ggacacagga cgacttgtgt ccttggctgt ctctagagaa ttggttgctt
     4141 agaggatgct ggtaatggct ctgtgacttt catgatgccc cctgccaagc cagaggcaca
     4201 gcaagtgtcc tgcacacctg gtggaattcc tccccttaaa aataaaatca gccgcttgcc
     4261 aggggagctc gccttcaaga gtactggctc aaggggctgt gacaacagag tgtgggccat
     4321 acctgctctc tcctccactg gtgctctggt gtcagtgaaa ctcaggtggg ggctcttgtc
     4381 tctggaacaa accttgaggg agatgccatg catggcttct tgcatcctct ccagagatgc
     4441 ataaaatgta tttacattag aaacactcct ccttcataca aaccaagtca ctttggtttg
     4501 atggtagcta gcgagatgtg agaagctgag gtcttttagg tttcgtacag agtaggtttt
     4561 gtacagagta gctgtaaaac ttgctgggac gctggcagcc tgtggtccac ggccatgacc
     4621 tggagcattt cctgttagaa accccattca ccacactgca ggctgagagg ttccgagcag
     4681 tcaaaggtgt gtcccaagct acataggaat tcacgtccag tttgattagg actgtgttca
     4741 agtcgtctgg tattggggga aagctgacag tgtgcgcttc ataaacaacc tttccctggg
     4801 ctttcctttt tgtatctcaa ggttctacct taaccagaac cttttgaact ggcagagacc
     4861 aacgctctat acacatgcca gctgtctaaa aggcactaaa ataaatattc agtgctgggc
     4921 aaatccgaac ccagctttca gaccagtgct tatttgtgta caagtgagat ttctccagag
     4981 aagcaaatca gaaggaacaa aagcaaggga ctttgttgtt tgtttctgtt ttttattttt
     5041 atttttagac agtgagtttt tcctgtgtga tgtgtgtgct ttctttgagt ctgtatttcc
     5101 tttcagagag ctctcttgta aatgacaaac tgtgaaatgg gttgccaaaa actgtgtcct
     5161 ttgttagatg cttcagaggg aactgtgtaa attctctctg caccttgtcc catctgcttc
     5221 ctcctccctc ccatgagagc aaggaccaca tccaaggatg taattaccat acgcttgcta
     5281 ttaaagagcc ttccagccct ggtgcta
//
