LOCUS       NM_008642               4238 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus microsomal triglyceride transfer protein (Mttp),
            transcript variant 2, mRNA.
ACCESSION   NM_008642
VERSION     NM_008642.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4238)
  AUTHORS   Grubaugh,C.R., Dhingra,A., Prakash,B., Montenegro,D., Sparrow,J.R.,
            Daniele,L.L., Curcio,C.A., Bell,B.A., Hussain,M.M. and
            Boesze-Battaglia,K.
  TITLE     Microsomal triglyceride transfer protein is necessary to maintain
            lipid homeostasis and retinal function
  JOURNAL   FASEB J 38 (5), e23522 (2024)
   PUBMED   38445789
  REMARK    GeneRIF: Microsomal triglyceride transfer protein is necessary to
            maintain lipid homeostasis and retinal function.
REFERENCE   2  (bases 1 to 4238)
  AUTHORS   Chen,Z., Wang,S., Pottekat,A., Duffey,A., Jang,I., Chang,B.H.,
            Cho,J., Finck,B.N., Davidson,N.O. and Kaufman,R.J.
  TITLE     Conditional hepatocyte ablation of PDIA1 uncovers indispensable
            roles in both APOB and MTTP folding to support VLDL secretion
  JOURNAL   Mol Metab 80, 101874 (2024)
   PUBMED   38211723
  REMARK    GeneRIF: Conditional hepatocyte ablation of PDIA1 uncovers
            indispensable roles in both APOB and MTTP folding to support VLDL
            secretion.
REFERENCE   3  (bases 1 to 4238)
  AUTHORS   Nargis,T., Lin,X., Giordano,E., Ijaz,L., Suhail,S., Gurzenda,E.M.,
            Kiefer,D., Quadro,L., Hanna,N. and Hussain,M.M.
  TITLE     Characterization of lipoproteins in human placenta and fetal
            circulation as well as gestational changes in lipoprotein assembly
            and secretion in human and mouse placentas
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1868 (9), 159357 (2023)
   PUBMED   37315736
REFERENCE   4  (bases 1 to 4238)
  AUTHORS   Kobayashi,K., Iwasa,K., Azuma-Suzuki,R., Kawauchi,T. and
            Nabeshima,Y.I.
  TITLE     Feto-maternal cholesterol transport regulated by beta-Klotho-FGF15
            axis is essential for fetal growth
  JOURNAL   Life Sci Alliance 6 (10), e202301916 (2023)
   PUBMED   37541847
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4238)
  AUTHORS   Hooper,A.J., Burnett,J.R. and Watts,G.F.
  TITLE     Contemporary aspects of the biology and therapeutic regulation of
            the microsomal triglyceride transfer protein
  JOURNAL   Circ Res 116 (1), 193-205 (2015)
   PUBMED   25552696
  REMARK    Review article
REFERENCE   6  (bases 1 to 4238)
  AUTHORS   Hussain,M.M., Rava,P., Pan,X., Dai,K., Dougan,S.K., Iqbal,J.,
            Lazare,F. and Khatun,I.
  TITLE     Microsomal triglyceride transfer protein in plasma and cellular
            lipid metabolism
  JOURNAL   Curr Opin Lipidol 19 (3), 277-284 (2008)
   PUBMED   18460919
  REMARK    Review article
REFERENCE   7  (bases 1 to 4238)
  AUTHORS   Chang,B.H., Liao,W., Li,L., Nakamuta,M., Mack,D. and Chan,L.
  TITLE     Liver-specific inactivation of the abetalipoproteinemia gene
            completely abrogates very low density lipoprotein/low density
            lipoprotein production in a viable conditional knockout mouse
  JOURNAL   J Biol Chem 274 (10), 6051-6055 (1999)
   PUBMED   10037685
REFERENCE   8  (bases 1 to 4238)
  AUTHORS   Raabe,M., Flynn,L.M., Zlot,C.H., Wong,J.S., Veniant,M.M.,
            Hamilton,R.L. and Young,S.G.
  TITLE     Knockout of the abetalipoproteinemia gene in mice: reduced
            lipoprotein secretion in heterozygotes and embryonic lethality in
            homozygotes
  JOURNAL   Proc Natl Acad Sci U S A 95 (15), 8686-8691 (1998)
   PUBMED   9671739
REFERENCE   9  (bases 1 to 4238)
  AUTHORS   Nakamuta,M., Chang,B.H., Hoogeveen,R., Li,W.H. and Chan,L.
  TITLE     Mouse microsomal triglyceride transfer protein large subunit: cDNA
            cloning, tissue-specific expression and chromosomal localization
  JOURNAL   Genomics 33 (2), 313-316 (1996)
   PUBMED   8660984
REFERENCE   10 (bases 1 to 4238)
  AUTHORS   Knecht,T.P. and Glass,C.K.
  TITLE     The influence of molecular biology on our understanding of
            lipoprotein metabolism and the pathobiology of atherosclerosis
  JOURNAL   Adv Genet 32, 141-198 (1995)
   PUBMED   7741021
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131122.4 and AK146553.1.
            
            On Sep 20, 2017 this sequence version replaced NM_008642.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146553.1, L47970.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-276               AC131122.4         60501-60776
            277-3189            AK146553.1         2-2914
            3190-4238           AC131122.4         101251-102299
FEATURES             Location/Qualifiers
     source          1..4238
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 64.06 cM"
     gene            1..4238
                     /gene="Mttp"
                     /gene_synonym="1810043K16Rik; MTP"
                     /note="microsomal triglyceride transfer protein"
                     /db_xref="GeneID:17777"
                     /db_xref="MGI:MGI:106926"
     exon            1..414
                     /gene="Mttp"
                     /gene_synonym="1810043K16Rik; MTP"
                     /inference="alignment:Splign:2.1.0"
     CDS             354..3038
                     /gene="Mttp"
                     /gene_synonym="1810043K16Rik; MTP"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; microsomal triglyceride transfer protein, large
                     subunit; microsomal triglyceride transfer protein B"
                     /codon_start=1
                     /product="microsomal triglyceride transfer protein large
                     subunit isoform 2 precursor"
                     /protein_id="NP_032668.2"
                     /db_xref="CCDS:CCDS38650.1"
                     /db_xref="GeneID:17777"
                     /db_xref="MGI:MGI:106926"
                     /translation="MILLAVLFLCFFSSYSASVKGHTTGLSLNNERLYKLTYSTEVFL
                     DGGKGKPQDSVGYKISSDVDVVLLWRNPDGDDDQVIQVTITAVNVENAGQQRGEKSIF
                     QGKSTPKIIGKDNLEALQRPMLLHLVRGKVKEFYSYENEPVGIENLKRGLASLFQMQL
                     SSGTTNEVDISGDCKVTYQAQQDKVVKIKALDTCKIERSGFTTANQVLGVSSKATSVT
                     TYKIEDSFVTAVLAEETRAFALNFQQTIAGKIVSKQKLELKTTEAGPRMIPGKQVAGV
                     IKAVDSKYKAIPIVGQVLERVCKGCPSLAEHWKSIRKNLEPENLSKAEAVQSFLAFIQ
                     HLRTSRREEILQILKAEKKEVLPQLVDAVTSAQTPDSLEAILDFLDFKSDSSIILQER
                     FLYACGFATHPDEELLRALLSKFKGSFASNDIRESVMIIIGALVRKLCQNEGCKLKAV
                     VEAKKLILGGLEKPEKKEDTTMYLLALKNALLPEGIPLLLKYAEAGEGPVSHLATTVL
                     QRYDVSFITDEVKKTLNRIYHQNRKVHEKTVRTTAAAVILKNPSYMDVKNILLSIGEL
                     PKEMNKYMLTVVQDILHFEMPASKMIRRVLKEMAVHNYDRFSKSGSSSAYTGYVERSP
                     RAASTYSLDILYSGSGILRRSNLNIFQYIGKAELHGSQVVIEAQGLEGLIAATPDEGE
                     ENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPVSVVKGLILLIDHSQDI
                     QLQSGLKANMEIQGGLAIDISGSMEFSLWYRESKTRVKNRVAVVITSDVTVDASFVKA
                     GVESRAETEAGLEFISTVQFSQYPFLVCMQMDKAEAPLRQFETKYERLSTGRGYVSRR
                     RKESLVAGCELPLHQENSEMCNVVFPPQPESDNSGGWF"
     exon            415..602
                     /gene="Mttp"
                     /gene_synonym="1810043K16Rik; MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            603..746
                     /gene="Mttp"
                     /gene_synonym="1810043K16Rik; MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            747..854
                     /gene="Mttp"
                     /gene_synonym="1810043K16Rik; MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            855..971
                     /gene="Mttp"
                     /gene_synonym="1810043K16Rik; MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1111
                     /gene="Mttp"
                     /gene_synonym="1810043K16Rik; MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1262
                     /gene="Mttp"
                     /gene_synonym="1810043K16Rik; MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1420
                     /gene="Mttp"
                     /gene_synonym="1810043K16Rik; MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1589
                     /gene="Mttp"
                     /gene_synonym="1810043K16Rik; MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1697
                     /gene="Mttp"
                     /gene_synonym="1810043K16Rik; MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1910
                     /gene="Mttp"
                     /gene_synonym="1810043K16Rik; MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2119
                     /gene="Mttp"
                     /gene_synonym="1810043K16Rik; MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2217
                     /gene="Mttp"
                     /gene_synonym="1810043K16Rik; MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2339
                     /gene="Mttp"
                     /gene_synonym="1810043K16Rik; MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2567
                     /gene="Mttp"
                     /gene_synonym="1810043K16Rik; MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2692
                     /gene="Mttp"
                     /gene_synonym="1810043K16Rik; MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2863
                     /gene="Mttp"
                     /gene_synonym="1810043K16Rik; MTP"
                     /inference="alignment:Splign:2.1.0"
     exon            2864..4238
                     /gene="Mttp"
                     /gene_synonym="1810043K16Rik; MTP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttctctgtgt agccctggct gtcctgaaac tcactttgta gaccaggctg gcctcacact
       61 cagaaatcca cctgcctctg cctcccaagt gctgtgatta aaggcgtgcg ccaccactgc
      121 cctactgaaa caaatttctt aaaagcgaga gactacaaac tatagcccac ctgcgtttaa
      181 tcattaatag tgagcccttc catgaactta ggtcctgatt ttggagtttg gaatctgacc
      241 tttcccctat agataaacac tgttgtcgcc ggttctgaag agggtcactt ccttgctggc
      301 tgccaccact gctcagtgag tcccggggac tggatgtggc agagggagcc agcatgatcc
      361 tcttggcagt gctttttctc tgcttcttct cctcctactc tgcttccgtt aaaggtcaca
      421 caactggcct ctcattaaat aatgagcggc tatacaagct cacgtactcc actgaagtgt
      481 ttcttgatgg gggcaaagga aaaccgcaag acagcgtggg ctacaaaatc tcatctgatg
      541 tggacgttgt gttactgtgg aggaatcctg atggtgatga tgatcaagtg atccaagtca
      601 cgataacagc tgttaacgtt gaaaatgcgg gtcaacagag aggcgagaag agcatcttcc
      661 agggcaaaag tacacctaag atcataggga aggacaacct ggaggctctg cagagaccca
      721 tgcttcttca tctggtccgg gggaaggtca aggagttcta ctcctatgaa aacgagccag
      781 tgggcataga aaatctcaag agaggcttgg ctagcttatt ccagatgcag ctaagctctg
      841 gaactaccaa cgaggtagat atctctgggg attgtaaagt gacctaccag gcccagcaag
      901 acaaagtggt caaaattaag gctctggata catgcaaaat tgagcggtct ggatttacaa
      961 cggcaaacca ggtgctgggt gtcagttcaa aagccacatc tgtcactacc tacaagatag
     1021 aggacagctt tgtcaccgct gtgcttgcag aagagaccag ggcttttgcc ttgaacttcc
     1081 aacaaaccat agcaggaaaa atagtgtcga agcagaaatt ggagctgaag acaactgaag
     1141 ccggcccaag gatgatcccc gggaagcaag tggcaggtgt aattaaagca gttgattcca
     1201 aatacaaagc cattcccatt gtgggacagg tcctcgagcg tgtctgcaaa ggatgccctt
     1261 ctctggcgga gcactggaag tccatcagaa agaacctgga gcctgaaaac ctgtccaagg
     1321 ccgaggccgt ccagagcttc ctggccttca ttcagcacct ccggacttcg aggagagaag
     1381 agatcctcca gattctgaag gcagagaaga aagaagtgct ccctcagctg gtggatgccg
     1441 tcacctctgc tcagactcca gactcgctag aagccatcct ggactttttg gatttcaaaa
     1501 gtgacagcag tatcatactc caggaaaggt tcctctatgc ctgtggcttt gccacccacc
     1561 ctgatgaaga actcctacga gccctcctta gtaagttcaa aggttccttt gcaagcaacg
     1621 acatcagaga gtcggttatg atcatcattg gagccctggt caggaagctg tgtcagaatg
     1681 aaggctgcaa gctcaaggca gtggtggaag ctaagaagct gatcctggga ggacttgaaa
     1741 aaccagagaa gaaagaagac accacaatgt acctgctggc cctgaagaat gccttgcttc
     1801 ccgaaggcat cccgctcctt ctgaagtatg ctgaggctgg agaagggccc gtcagccacc
     1861 tggccaccac tgttctccag agatacgatg tctccttcat cacagatgag gtgaagaaga
     1921 ccttgaacag gatataccac cagaatcgta aggttcatga gaagacggtg cgcacaactg
     1981 ccgctgctgt catcttaaag aacccatcct acatggatgt gaagaacatc ctgctgtcca
     2041 ttggggaact cccgaaagag atgaacaaat acatgctcac tgttgtgcaa gacatcctgc
     2101 attttgaaat gcctgcaagc aaaatgatcc gtcgagttct caaggagatg gctgttcaca
     2161 attatgaccg tttctccaag agtggatcct cttctgccta tactggctac gtagaacgta
     2221 gcccccgtgc agcgtccaca tacagccttg acatccttta ctctggctct ggcattctga
     2281 ggagaagtaa cctgaacatc ttccagtaca tcgggaaggc agagcttcat ggtagtcagg
     2341 tggtgattga agcccaaggg ctggaaggct taattgcagc cactcctgat gaaggagagg
     2401 agaaccttga ctcttatgct ggcatgtcag ccatcctgtt tgatgttcag cttaggcctg
     2461 tcacattttt taatggatac agtgatttga tgtccaaaat gctgtcggca tccggcgacc
     2521 ctgtcagcgt ggtgaaaggg cttattctgt taatagacca ttctcaggat attcagctgc
     2581 aatctggact aaaggccaat atggagatcc agggtggtct agctattgat atttctggtt
     2641 caatggaatt cagtctgtgg tatcgagagt ctaaaacccg agtgaaaaat cgggtggctg
     2701 tggtgataac cagcgacgtc acagtggatg cctcttttgt gaaagctggt gtggaaagca
     2761 gagcggagac agaggctggg ctggagttca tctccacagt gcagttctca cagtacccgt
     2821 tcttggtctg catgcagatg gacaaggctg aagccccact caggcaattc gagacaaagt
     2881 atgaaaggct atctacaggc aggggatatg tctctcggag aagaaaagag agcctagtgg
     2941 ccggatgtga actccccctc catcaagaga actctgagat gtgcaacgtg gtattcccac
     3001 ctcagccaga aagcgataac tccggtggat ggttttgatt cccgtgggtt cccttccacc
     3061 agaacgatat gctttgacgt gcctgaccct tgctctctga gagcacagtg tttacatatt
     3121 tacctgtatt taagatgttt gtaaagagca gtggagaact tcagttgatt aaagttgaac
     3181 ctattcagga gaagacccac agtgtccctc tgagtcacca tatgacactt agcaacatgc
     3241 ctacttcttg tactttgcaa aagtcctaac tagtacagtg agtctagttt tgcattgaga
     3301 aactagtatt tgtataaaaa caaaacaaaa acccacacca taaaagctta ggtaaatgtg
     3361 aattttattc aacatctttt cagtgaaagt gaatccttga tagaccccta agctcgtttt
     3421 ctatgaagcc cactgcctaa gaagggccgg ggtgaaagga acccaagcaa accatttttc
     3481 ttttgttgtt gttgttttgt tttgtttgct tttcttctct ttcttttact tttttttccc
     3541 ccttctggtg tatatgggaa ggttctaaga aaggatacag ataagactta aaagaatttt
     3601 gttagtcaat cttaagaatt aatatttatg ttttctgata gttttataag cgacaaggcg
     3661 agagacggaa ttaaaatgta ctgtgacatc tctctgctgg ccccacagtg agaccacttg
     3721 gaagtcattc acccttttaa aaaactggaa ctgtcataca gggataaaaa ttattgagcc
     3781 tcagagcatc cattagattt ttctctggat gtgtcttttt gatagtgtaa tgtggtacat
     3841 ggttctttgt aggggacacc cttgtagcta ccactctatc tatacctcaa ttgttggaaa
     3901 taatccatca atttgactgc aatttatgca gtcaataaaa gttgggatga tcattgctta
     3961 aaaaatgatg gatttgtatt tcaaaactat gaaattaaat aaaaaccatg tctatttgtg
     4021 tgaattaaaa ggccacacca agcatttaaa catatttatt agtaaagcag atgtgtttat
     4081 tatagtacct caccaccccc ccccccccaa tgccaggtac ttgttagtcc actaaacaaa
     4141 tgggagttta aaatggaagt ggaaacacac gaagtggacg tttagctgag gtagaaaata
     4201 aattgtgatg atgacaaata aacatttata atttactg
//
