LOCUS       NM_198625               4733 bp    mRNA    linear   ROD 26-SEP-2023
DEFINITION  Mus musculus MTSS I-BAR domain containing 2 (Mtss2), transcript
            variant 1, mRNA.
ACCESSION   NM_198625 XM_146515
VERSION     NM_198625.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4733)
  AUTHORS   Youlten SE, Kemp JP, Logan JG, Ghirardello EJ, Sergio CM, Dack MRG,
            Guilfoyle SE, Leitch VD, Butterfield NC, Komla-Ebri D, Chai RC,
            Corr AP, Smith JT, Mohanty ST, Morris JA, McDonald MM, Quinn JMW,
            McGlade AR, Bartonicek N, Jansson M, Hatzikotoulas K, Irving MD,
            Beleza-Meireles A, Rivadeneira F, Duncan E, Richards JB, Adams DJ,
            Lelliott CJ, Brink R, Phan TG, Eisman JA, Evans DM, Zeggini E,
            Baldock PA, Bassett JHD, Williams GR and Croucher PI.
  TITLE     Osteocyte transcriptome mapping identifies a molecular landscape
            controlling skeletal homeostasis and susceptibility to skeletal
            disease
  JOURNAL   Nat Commun 12 (1), 2444 (2021)
   PUBMED   33953184
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4733)
  AUTHORS   Chatzi C, Zhang Y, Hendricks WD, Chen Y, Schnell E, Goodman RH and
            Westbrook GL.
  TITLE     Exercise-induced enhancement of synaptic function triggered by the
            inverse BAR protein, Mtss1L
  JOURNAL   Elife 8, e45920 (2019)
   PUBMED   31232686
  REMARK    GeneRIF: These results link short-term effects of exercise to
            activity-dependent expression of Mtss1L, which we propose as a
            novel effector of activity-dependent rearrangement of synapses.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4733)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4733)
  AUTHORS   Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S,
            Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ,
            Jones AR, Amaral DG, Sestan N, Gage FH and Lein ES.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   5  (bases 1 to 4733)
  AUTHORS   Zeng XC, Luo X, Wang SX and Zhan X.
  TITLE     Fibronectin-mediated cell spreading requires ABBA-Rac1 signaling
  JOURNAL   J Cell Biochem 114 (4), 773-781 (2013)
   PUBMED   23060091
  REMARK    GeneRIF: ABBA promotes cell spreading.
REFERENCE   6  (bases 1 to 4733)
  AUTHORS   Saarikangas J, Mattila PK, Varjosalo M, Bovellan M, Hakanen J,
            Calzada-Wack J, Tost M, Jennen L, Rathkolb B, Hans W, Horsch M,
            Hyvonen ME, Perala N, Fuchs H, Gailus-Durner V, Esposito I, Wolf E,
            de Angelis MH, Frilander MJ, Savilahti H, Sariola H, Sainio K,
            Lehtonen S, Taipale J, Salminen M and Lappalainen P.
  TITLE     Missing-in-metastasis MIM/MTSS1 promotes actin assembly at
            intercellular junctions and is required for integrity of kidney
            epithelia
  JOURNAL   J Cell Sci 124 (Pt 8), 1245-1255 (2011)
   PUBMED   21406566
REFERENCE   7  (bases 1 to 4733)
  AUTHORS   Saarikangas J, Hakanen J, Mattila PK, Grumet M, Salminen M and
            Lappalainen P.
  TITLE     ABBA regulates plasma-membrane and actin dynamics to promote radial
            glia extension
  JOURNAL   J Cell Sci 121 (Pt 9), 1444-1454 (2008)
   PUBMED   18413296
  REMARK    GeneRIF: This study identifies ABBA as a novel regulator of actin
            and plasma membrane dynamics in radial glial cells.
REFERENCE   8  (bases 1 to 4733)
  AUTHORS   Li H, Bishop KM and O'Leary DD.
  TITLE     Potential target genes of EMX2 include Odz/Ten-M and other gene
            families with implications for cortical patterning
  JOURNAL   Mol Cell Neurosci 33 (2), 136-149 (2006)
   PUBMED   16919471
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY729026.1, BC060632.1 and CN528075.1.
            
            [WARNING] On Dec 27, 2023 this sequence was replaced by
            NM_198625.3.
            
            On Jul 16, 2015 this sequence version replaced NM_198625.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060632.1, SRR11927938.4126222.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BY729026.1         2-9
            9-4717              BC060632.1         1-4709
            4718-4733           CN528075.1         254-269
FEATURES             Location/Qualifiers
     source          1..4733
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.66 cM"
     gene            1..4733
                     /gene="Mtss2"
                     /gene_synonym="ABBA; Mtss1l"
                     /note="MTSS I-BAR domain containing 2"
                     /db_xref="GeneID:244654"
                     /db_xref="MGI:MGI:3039591"
     exon            1..315
                     /gene="Mtss2"
                     /gene_synonym="ABBA; Mtss1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..2394
                     /gene="Mtss2"
                     /gene_synonym="ABBA; Mtss1l"
                     /note="isoform 1 is encoded by transcript variant 1;
                     MTSS1-like protein; protein MTSS 2; metastasis suppressor
                     1-like"
                     /codon_start=1
                     /product="protein MTSS 2 isoform 1"
                     /protein_id="NP_941027.1"
                     /db_xref="CCDS:CCDS22664.1"
                     /db_xref="GeneID:244654"
                     /db_xref="MGI:MGI:3039591"
                     /translation="METAEKECGALGGLFQAIVNDMKSSYPIWEDFNSKAAKLHSQLR
                     TTVLAAVAFLDAFQKVADMATNTRGATRDIGSALTRMCMRHRSIETKLRQFTNALLES
                     LINPLQERIEDWKKSANQLDKDHAKEYKRARHEIKKKSSDTLKLQKKARKGKGDLQPQ
                     LDSALQDVNDMYLLLEETEKQAVRRALIEERGRFCTFITFLQPVVNGELTMLGEITHL
                     QGIIDDLVVLTADPHKLPPASEQVIKDLKGSDYSWSYQTPPSSPSSSNSRKSSMCSLA
                     QPATTRLSSVSSHDSGFVSQDPTYSKPPSPMPSDITSQKSSSSASSEASETCQSVSEC
                     SSPTSDWTKAGPHEQPSATTLQRRKDRVEHLRDTEPGPTGGGTVGSSGEEVPRTRMSP
                     ATIAAKHGEEVSPAASDLAMVLTRGLSLEHQKSSRDSLQYSSGYSTQTTTPSCSEDTI
                     PSQGSDYDCYSVNGDADSEGPPEFDKSSTIPRNSNIAQNYRRLIQTKRPASTAGLPTA
                     GLPTAMGLPSGAPPGVATIRRTPSTKPTVRRALSSAGPIPIRPPIVPVKTPTVPDSPG
                     YVGPTRAGSEECVFYTDEVASPLAPDLAKASPKRLSLPNTAWGSQSPEVASYGGGAAV
                     GLATEDEEQQLAANRHSLVEKLGELVAGAHALGEGQFPFPTALSATPSEETPTPPPAA
                     TSDPPAEDMLVAIRRGVRLRRTVTNDRSAPRIL"
     exon            316..377
                     /gene="Mtss2"
                     /gene_synonym="ABBA; Mtss1l"
                     /inference="alignment:Splign:2.1.0"
     exon            378..451
                     /gene="Mtss2"
                     /gene_synonym="ABBA; Mtss1l"
                     /inference="alignment:Splign:2.1.0"
     exon            452..536
                     /gene="Mtss2"
                     /gene_synonym="ABBA; Mtss1l"
                     /inference="alignment:Splign:2.1.0"
     exon            537..628
                     /gene="Mtss2"
                     /gene_synonym="ABBA; Mtss1l"
                     /inference="alignment:Splign:2.1.0"
     exon            629..703
                     /gene="Mtss2"
                     /gene_synonym="ABBA; Mtss1l"
                     /inference="alignment:Splign:2.1.0"
     exon            704..861
                     /gene="Mtss2"
                     /gene_synonym="ABBA; Mtss1l"
                     /inference="alignment:Splign:2.1.0"
     exon            862..969
                     /gene="Mtss2"
                     /gene_synonym="ABBA; Mtss1l"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1067
                     /gene="Mtss2"
                     /gene_synonym="ABBA; Mtss1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1188
                     /gene="Mtss2"
                     /gene_synonym="ABBA; Mtss1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1263
                     /gene="Mtss2"
                     /gene_synonym="ABBA; Mtss1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1440
                     /gene="Mtss2"
                     /gene_synonym="ABBA; Mtss1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1606
                     /gene="Mtss2"
                     /gene_synonym="ABBA; Mtss1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..4718
                     /gene="Mtss2"
                     /gene_synonym="ABBA; Mtss1l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgcccgcg ccgaggctgc gccgcgaact gcccgcgccg cgcccccagc cccaccgagc
       61 catggcccgc gctgccggcc cacggcccgc aaccccggag cgcggcgcgg ccggccgctg
      121 agagcgcggc cccgaggcag ggagccccgg cgcggcctcg gagcagcgcc cgcggcggtc
      181 cggcccctcc cctgcacggc tccccgcgcc ccttgcgcgc cctgccgccg cgcgcccggc
      241 cccagcatgg agacggcgga gaaggagtgt ggcgccttgg gcgggctctt ccaggccatc
      301 gtcaacgaca tgaagagctc ctaccccatc tgggaggact tcaactccaa ggctgcgaag
      361 ctccactctc agctgaggac cactgtgctg gctgctgtgg ccttcctcga tgccttccag
      421 aaagtagctg acatggccac caacaccaga ggggccacgc gggacattgg ctcagcgctc
      481 acgcgcatgt gcatgcgcca ccgcagcatc gagaccaagc tgcggcagtt caccaacgcg
      541 ctgctggaga gcctcatcaa tccactgcag gagcgcatcg aagactggaa gaagtcagcc
      601 aaccaactgg acaaggacca tgcgaaagag tataaacgag ccaggcatga aatcaaaaag
      661 aagtcatccg acacgctgaa gctacagaag aaagcacgca aagggaaagg agacctgcag
      721 ccccagctgg acagtgccct tcaagacgtc aacgacatgt acttgctact ggaagagacg
      781 gagaagcagg ctgtgcgccg tgcgctgatt gaggagcggg gccgtttctg cacctttatc
      841 accttcctcc agccggtggt gaacggcgag ctgaccatgc tgggagagat cactcacctg
      901 cagggcatca ttgacgacct ggtagtgctg actgcagatc cccacaaact gcctcccgcc
      961 agtgagcagg tgatcaaaga cctgaagggt tctgactata gctggtcgta ccagacccca
     1021 ccctcgtcac ccagcagctc caactcccgg aagtccagca tgtgcagcct ggcacagccg
     1081 gccaccaccc gcctctccag tgtctcctcc cacgactctg gcttcgtctc ccaggacccc
     1141 acctactcca agcccccttc gcccatgcct tccgacatca ccagccagaa atcctccagc
     1201 tctgcgtcct ccgaggcctc agaaacctgt cagtcagtta gcgagtgcag ctccccaacc
     1261 tcggactgga ccaaggctgg tccccacgaa caaccctcag ccaccaccct gcagcggagg
     1321 aaggatcgtg tggaacacct ccgagacact gagccaggcc ctactggtgg aggcactgtg
     1381 ggctccagtg gagaggaggt gccacgaacc cggatgtctc ctgccaccat agcagccaaa
     1441 catggtgagg aggtatcccc tgctgccagc gacctagcca tggtgctgac ccgcggactg
     1501 agcctggaac accagaagag cagccgagac tcgctgcagt attccagtgg ctacagcaca
     1561 cagaccacca caccttcctg ctccgaggac accatcccct cccaaggctc agactacgac
     1621 tgctactctg tgaatgggga tgcagacagt gaaggccccc ctgagttcga caaatcatct
     1681 accattcctc gaaacagcaa catagcccag aactaccgcc gcctgatcca gaccaagcgc
     1741 ccagcctcca ccgccgggct gcccacggca gggctgccca cagccatggg gctgccctcc
     1801 ggtgcacctc ccggtgtggc caccatccgc cgcacaccct ctaccaagcc cactgtgcgc
     1861 cgcgccctct ccagcgctgg ccccatcccc atccgcccac ccatcgtccc tgtgaagaca
     1921 cccaccgtgc ccgactcccc tggctatgtg gggcccacac gggcaggcag tgaggagtgc
     1981 gtcttctaca cagacgaagt ggcctcacct ttggctccag acctggccaa agcctcccca
     2041 aagaggctca gcctgcctaa cacagcctgg ggcagccagt ccccagaggt agctagctac
     2101 ggcggcgggg ctgcggtcgg gctggccacc gaggacgaag agcagcaact ggctgccaac
     2161 aggcacagcc tagtagagaa gcttggggag ctggtggccg gtgcccacgc cctgggtgag
     2221 ggccagttcc ccttccctac cgccctgtca gccactcctt cggaggaaac gcccactcca
     2281 ccccctgctg ccaccagtga ccccccggcc gaagacatgc tggtggccat tcgtcgcggg
     2341 gtccggctgc gcaggaccgt caccaacgac aggtcggcgc cccgcatctt atgatggtgc
     2401 cgcccacccc tccccgtctg ggcctggcac aaggaggtga ccggatctgt gagcagcggc
     2461 cagccactct gagtggcggc ccagccagaa gacagaaagc aaagcgtcag gagtgaggca
     2521 cagccacttt acggaaagac aaccaggctg gatcccagca tctcgcggga agcgacttcc
     2581 ctcacacacc tcgccaggac agagcctgtt ttatactttc cttacctact caaacctcct
     2641 cttccttcct ccaggccctg ctacatccaa accccagagc ccataaccaa gggctgggcc
     2701 tgctacatgg ggccctacct ggcctggggt ccacaactct cttcctctgg cccggctgtc
     2761 ctccggggcc atatgcccag ctctttcctt gaatgctggc tccctcttct ccctgcctgg
     2821 accctgtccc atttcctctt gcctttgccc tgcctctccc aggctcctct ctttggggca
     2881 cagggtggtc acggaggggc caggtaccca atcagctgag gatctttgtg tgactgggtt
     2941 tagggacagt caggcattgg gaagccaggc ttgctcatgg gaaagagccc tggagggagg
     3001 gaacgtaggg gccttgtctc aggggaccct ccagttccct gtgaagagta actagtgggg
     3061 tgaggcaagg cagacaggga atgagtccag aggtaccagg tgttttggat gccctgttct
     3121 tgtctggaca ctttggagct tttactctag gggcgccttc gggttacagt gtcacctgtt
     3181 gctggagata agggctggag cattagatgg tgtgggggtt attttatgac tgtaataaaa
     3241 tggagctgac cctagacaaa gaactatgtg gggcaagctg gtggtacagg gtgtacgtct
     3301 gagtgcctga gagaggggtg tgggagccct cagtgggctc gaggccagag aagggtagaa
     3361 tcactccccc caaaccgggg gaagctgctc ttctcgccag tgtctgaagt gtcggtagaa
     3421 taaggctggt gagggtaggc cagggactct ggccagtctg ttgagatctg agcaagctgc
     3481 aggcccggct tggagcaagt attagaaggt tggtttgact ttctgttgcc agaggcaaca
     3541 ccatcccaag aaagtctatg cctacaggcc tagctggggc tggcagcagg gaccagagga
     3601 agagtgggtc ctgcctccct gtcagcccaa gtctgagcaa gactaagcac gtaagtgtaa
     3661 gccagaggag agattcggga ggtagagcag gcagcagact ccaaggtagc attctgcccg
     3721 acccccacag ggagtccaga gagcgtacct tggtcttgaa ggaatggagt tggggctgac
     3781 ctgggcccaa ggtcatgggt gctccagtgc agggcagccc agtaggtctg gtaaagcagg
     3841 gattcctgta tgtggatgga gttaccacag ggctccccga ggctgcttag cgagttatct
     3901 ccagggtctg agacctggcc caccaaactc agttgtcacc agagccccga gtatagagtc
     3961 caggaaaaca aatggccaga tgtggaaccc tgaggcatat tttggctgca tcttccccaa
     4021 aagagctgtc aaggctgatg gaaagggatg caggatgtca agtgggcaga tgtggtccct
     4081 atacccaggg tgtggttggg tcctagagaa gggggtccaa gaggatgggc tcactgccat
     4141 ctgaggactc caggccctga tgggaaggga ggccagggac ttcccaggaa gaggatgggg
     4201 tggcatgccc acccccagtt ttagccttcc cctccccccc agggctgtac atattccatc
     4261 cccttgtctg acccacaagt atcctcctcc accaaccacc acttcctcta gtgctcacct
     4321 ctctcatagg cccgccctcg ggatccgagc caaccatcct gcatcacaga ctggtttggg
     4381 ggcttcttca cgtacatttt attttatttt atttcatttc atttgtacag caaaacattc
     4441 ttttcaaatg tgtcttttga ctgaagtaac ttttctggtg ctgttaactt gtattttttt
     4501 tttttaattt attttgccgc ccctccttgt tcctactcac cctcccctaa cccccagccc
     4561 cagcccatca cttttattct gttctttctg ccaagtttgg gataaattct cccgcccacc
     4621 ccggtttcca tcctctcctt gatttaaata gtcactgcta caaagtaaca aatgcactgt
     4681 gaagatccca gtattaataa agcagtactg tagttaacaa aaaaaaaaaa aaa
//
