LOCUS       NM_175374               2621 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus mitochondrial translational release factor 1-like
            (Mtrf1l), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_175374
VERSION     NM_175374.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2621)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2621)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI510282.1, AK078897.1 and AK036424.1.
            
            On Mar 10, 2006 this sequence version replaced NM_175374.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036424.1, AK078897.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AI510282.1         284-316
            34-97               AK078897.1         2-65
            98-2621             AK036424.1         2-2525
FEATURES             Location/Qualifiers
     source          1..2621
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 1.91 cM"
     gene            1..2621
                     /gene="Mtrf1l"
                     /gene_synonym="9130004K12Rik"
                     /note="mitochondrial translational release factor 1-like"
                     /db_xref="GeneID:108853"
                     /db_xref="MGI:MGI:1918830"
     exon            1..418
                     /gene="Mtrf1l"
                     /gene_synonym="9130004K12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..1302
                     /gene="Mtrf1l"
                     /gene_synonym="9130004K12Rik"
                     /note="peptide chain release factor 1-like, mitochondrial"
                     /codon_start=1
                     /product="peptide chain release factor 1-like,
                     mitochondrial precursor"
                     /protein_id="NP_780583.1"
                     /db_xref="CCDS:CCDS56684.1"
                     /db_xref="GeneID:108853"
                     /db_xref="MGI:MGI:1918830"
                     /translation="MRSGFLSGARRLWARRAFSRTPPPSEELLARGGPLRAFLERRVG
                     SEAGGLDAGYPQLAAAARLLSEKERELRDTESLLHDENEDLKKLAESEIALCQKQITE
                     LKHQIISLLVPSEEMDGSDLILEVTAGVGGQEAMLFTSEMFDMYQQYAAFKRWHFETL
                     EYFPSELGGLRHASASVGGPEAYRHMKFEGGVHRVQRVPKTEKQGRIHTSTMTVAILP
                     QPTEIKLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGIISECQQERSQLKN
                     RELAMKKLRARLYSMHLEEETAKRYNARKIQVGTKGRSEKIRTYNFPQNRVTDHRINK
                     SLHDLESFMQGDCLLDDMIQSLKDCSDYEALVEMISRRD"
     exon            419..498
                     /gene="Mtrf1l"
                     /gene_synonym="9130004K12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            499..682
                     /gene="Mtrf1l"
                     /gene_synonym="9130004K12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            683..846
                     /gene="Mtrf1l"
                     /gene_synonym="9130004K12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            847..964
                     /gene="Mtrf1l"
                     /gene_synonym="9130004K12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1101
                     /gene="Mtrf1l"
                     /gene_synonym="9130004K12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..2621
                     /gene="Mtrf1l"
                     /gene_synonym="9130004K12Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1426..1431
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtrf1l"
                     /gene_synonym="9130004K12Rik"
                     /note="hexamer: TATAAA"
     polyA_site      1449
                     /gene="Mtrf1l"
                     /gene_synonym="9130004K12Rik"
                     /note="major polyA site"
     regulatory      1495..1500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtrf1l"
                     /gene_synonym="9130004K12Rik"
                     /note="hexamer: TATAAA"
     polyA_site      1519
                     /gene="Mtrf1l"
                     /gene_synonym="9130004K12Rik"
     regulatory      2049..2054
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtrf1l"
                     /gene_synonym="9130004K12Rik"
                     /note="hexamer: GATAAA"
     polyA_site      2068
                     /gene="Mtrf1l"
                     /gene_synonym="9130004K12Rik"
ORIGIN      
        1 ttggaggcgg ggcaaacgcg tccagacctc cctgcccgct tgccttttga ctttagagga
       61 cctccaggct gtactacgct ttgccggaag ttctcgtaac atttccggca gaacatttct
      121 ggatcggaga ccttcctaga gtgtttgtat attttctgct aggtgggcgg cccagccagg
      181 atgcggagcg ggtttctgag cggtgcccgg cgcctgtggg cccgccgcgc cttcagccgc
      241 acgccgccgc cttccgagga gctcctcgcc cgcggcgggc ccctgcgggc cttcctggag
      301 cgccgcgtgg gctcggaggc cggtggtctg gacgctgggt acccccagct ggccgcggcc
      361 gcccgactgc tgagcgagaa ggagcgggag ctgcgggaca cggagtcatt gctgcacgat
      421 gaaaatgaag atttaaagaa acttgcggag agtgaaatag ctttgtgtca aaaacaaata
      481 actgagctga agcatcagat tatctcactg ttggttcctt cggaagaaat ggatgggagt
      541 gacttgatcc tggaggtgac tgcgggtgtg ggtggtcagg aagccatgct tttcacttct
      601 gagatgtttg acatgtacca gcagtacgct gcatttaaaa gatggcattt tgaaacactg
      661 gaatatttcc ccagtgaact aggtggcctt agacatgcgt cagccagcgt tggcggccca
      721 gaagcctata gacacatgaa gtttgaagga ggagtgcaca gagtccagag ggtgccaaag
      781 acggagaagc agggccgcat ccacacgagc accatgacag tggcaattct gccccagcct
      841 actgagatta aactggtgat caatcctaaa gatttgagaa tcgatactaa aagagcgagt
      901 ggggctggcg gtcagcacgt aaacaccaca gacagtgctg ttcggatagt tcatctgcct
      961 acaggtatta tttctgaatg ccagcaagag agatctcagc tgaagaacag ggagctggct
     1021 atgaaaaagt tacgtgcaag gctatatagc atgcatctgg aggaagaaac tgctaaaaga
     1081 tacaacgctc ggaagatcca ggttggaact aaaggaagat cagagaaaat aagaacatac
     1141 aactttccac agaacagggt cacagatcac agaataaaca agtcactgca cgaccttgag
     1201 agctttatgc aaggagactg tcttctggat gacatgattc agtcactgaa ggactgttcg
     1261 gattatgagg ctctagtaga aatgatttcc agaagagact aagcttcttt gtaaagatat
     1321 atttctatgt aggctaggaa cgttctagtg caaatccatt gtgtgcaaat acttagccag
     1381 gattcactgg aggaatgtta agtaacagtt tcttggacaa ttctctataa aaaaaaaatt
     1441 agacacaaag gaagacagtt gttttatgca aaatatttaa tcagaaattt caaatataaa
     1501 gcagatatgt tcatgttaag atgacggaag gacacagaag ccgacagtgg gatgaacaag
     1561 aagcgacgaa gtcaagcacg ttagggctga tagtgctgtg aacagcctac acggagttct
     1621 agtgaaagga agcattacgc ggtgctccct ccctgtgatg gagtcaggca tgttgtaagg
     1681 gtagcccctc aatgatggaa atgttcctgg gttaccctgc agctggtccc ttgggccttg
     1741 caaacagaac ctcaagccct tgggagctgg tagccaaaca tctcctatca agatgtgagc
     1801 tttactgaat agtacgcgtt ggtgggcttc tatatcagtt ccccagaaaa acagaaccaa
     1861 taggatgtgt ctacacaaat tcactataag gatggtccca catagagaac catgtgtcca
     1921 agtctatagt gtgatgcagc tgggtggaga caagaagagt tcatggttca ctctacttgg
     1981 gagtttgcta gggagatttc tttggattag aggttggatt ttctctactc aggcctttat
     2041 tccagttgga taaaacatgt tagcatgact gatatttcac tcatttaaat gccagtgaaa
     2101 cctccaaacc ttgaggagac ccaaaataat gttaacaaat attagggttc tctagagtca
     2161 cagaccttat gaatctcacc ccaccccccg cctctacaaa tgtaaagaga gttcattgga
     2221 atgatttaac agtctacagt ccaacaatgg ctatgtgaat ggaaagtcca agaatctagt
     2281 agttgctcag tcccacaggg cttggtgcct cagctagtct tcgggatatg tgggaatctg
     2341 aagaagtaga tttcaatgcc agtgaaggaa tggatgtaat agccaggcaa ggacaagcag
     2401 gcaaagaacc aaacttcctt tcatctattg cccttacata ggcttctagc ggaaggtgtg
     2461 gccccagatt agaggtatct tcccagcttc atgaccaaag gcatgttgtc ttgcctcaaa
     2521 aaccagaagg tgtaaccttc atttctggat tgtagttcat tccatatata gtcaagttga
     2581 caactagcca tttacagtca caataaaggc tagccaagtc t
//
