LOCUS       NM_145960               1862 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus mitochondrial translational release factor 1 (Mtrf1),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_145960
VERSION     NM_145960.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1862)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1862)
  AUTHORS   Poche,R.A., Zhang,M., Rueda,E.M., Tong,X., McElwee,M.L., Wong,L.,
            Hsu,C.W., Dejosez,M., Burns,A.R., Fox,D.A., Martin,J.F., Zwaka,T.P.
            and Dickinson,M.E.
  TITLE     RONIN Is an Essential Transcriptional Regulator of Genes Required
            for Mitochondrial Function in the Developing Retina
  JOURNAL   Cell Rep 14 (7), 1684-1697 (2016)
   PUBMED   26876175
REFERENCE   3  (bases 1 to 1862)
  AUTHORS   Newbury,A.J. and Rosen,G.D.
  TITLE     Genetic, morphometric, and behavioral factors linked to the
            midsagittal area of the corpus callosum
  JOURNAL   Front Genet 3, 91 (2012)
   PUBMED   22666227
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1862)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124745.4, BB620002.1 and AK043981.1.
            
            On Dec 3, 2009 this sequence version replaced NM_145960.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077749.1, AK043981.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG   :: downstream AUG is associated
                                                  with N-terminal localization
                                                  signal
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC124745.4         85834-85835
            3-195               BB620002.1         1-193
            196-1862            AK043981.1         2-1668
FEATURES             Location/Qualifiers
     source          1..1862
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 42.63 cM"
     gene            1..1862
                     /gene="Mtrf1"
                     /gene_synonym="A830062K05Rik; MtRF-1"
                     /note="mitochondrial translational release factor 1"
                     /db_xref="GeneID:211253"
                     /db_xref="MGI:MGI:2384815"
     exon            1..265
                     /gene="Mtrf1"
                     /gene_synonym="A830062K05Rik; MtRF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            266..373
                     /gene="Mtrf1"
                     /gene_synonym="A830062K05Rik; MtRF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            374..799
                     /gene="Mtrf1"
                     /gene_synonym="A830062K05Rik; MtRF-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             382..1722
                     /gene="Mtrf1"
                     /gene_synonym="A830062K05Rik; MtRF-1"
                     /note="MRF-1"
                     /codon_start=1
                     /product="peptide chain release factor 1, mitochondrial"
                     /protein_id="NP_666072.3"
                     /db_xref="CCDS:CCDS27297.1"
                     /db_xref="GeneID:211253"
                     /db_xref="MGI:MGI:2384815"
                     /translation="MSHHLCIWLFRNPFLRACPQRHVFLSCQQFRQISLDTRPWNFRQ
                     KKTHVLYQLLNKSWSRGCCHQGTRKLWKHKALQKYMEDLNKEYQTLDQCLQGISENEG
                     DRRALHRRHAQLAPLAAVYQEIQEAEQAIEELESLCKSLNKQDEKQLQELVSEERQII
                     DQKIHRLYSELLERLVPKEKYDWSDVILEVTSGRTTGGDICQQFTREIFDMYQNYSYY
                     KHWKFELLNYTPADYGGLHHAAARISGDSVYKHLKYEGGIHRVQRIPEVGLSSRMQRI
                     HTGTMSVIVLPQPDEVDVKVDPKDLRVDTFRARGAGGQHVNTTDSAVRLVHIPTGLVV
                     ECQQERSQLKNKEIALRVLRARLYQQIIEKDRCQQQNARKLQVGTRAQSERIRTYNFT
                     QDRVTDHRIAYEVRDIKEFLRGEKCLDQLIERLLQSADEEAISEFLDESLQSVK"
     exon            800..891
                     /gene="Mtrf1"
                     /gene_synonym="A830062K05Rik; MtRF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            892..973
                     /gene="Mtrf1"
                     /gene_synonym="A830062K05Rik; MtRF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1081
                     /gene="Mtrf1"
                     /gene_synonym="A830062K05Rik; MtRF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1254
                     /gene="Mtrf1"
                     /gene_synonym="A830062K05Rik; MtRF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1372
                     /gene="Mtrf1"
                     /gene_synonym="A830062K05Rik; MtRF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1509
                     /gene="Mtrf1"
                     /gene_synonym="A830062K05Rik; MtRF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1608
                     /gene="Mtrf1"
                     /gene_synonym="A830062K05Rik; MtRF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1862
                     /gene="Mtrf1"
                     /gene_synonym="A830062K05Rik; MtRF-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1783..1788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtrf1"
                     /gene_synonym="A830062K05Rik; MtRF-1"
                     /note="hexamer: AATAAA"
     polyA_site      1803
                     /gene="Mtrf1"
                     /gene_synonym="A830062K05Rik; MtRF-1"
                     /note="major polyA site"
ORIGIN      
        1 actaggagag ggcgatccac tttggacgtc gcagcttcca ggagtcagct ccaaatccgt
       61 tccacgcgtg gtccttccag agcagtatcc tacccgcttc gtcatttcat tcttgtttac
      121 cgttacggac acctaaggac catttctctg caaagtggag gaggagccag gaacaaaccg
      181 taacccggaa gcagtagcct gggactgatc atgcttgcag taccttgagc tgaaatgttg
      241 cggtgcacag gaggctcagt tatcaattcg gctaaaagag aagcatcctc aagaagtgat
      301 cccaaggtgg agaatgagaa gtgctgatct tggaacagac aagctgttat gatacaaact
      361 ctgcctgcag ccactactga gatgagtcat cacctgtgta tttggctttt tcggaatcca
      421 tttctccgtg cgtgccccca gagacatgtc ttcctttctt gtcagcagtt ccgacagata
      481 agccttgata caaggccgtg gaattttaga caaaagaaga ctcatgttct ctatcagctc
      541 ttaaacaaga gttggtccag gggctgctgt catcaaggca caaggaagct ttggaaacac
      601 aaagccctac agaagtatat ggaagacctg aataaagagt accaaaccct tgaccagtgt
      661 ctgcagggta tctctgagaa tgaaggagac cgaagggcct tacacagaag gcatgctcag
      721 ttggcaccac ttgcggctgt ttaccaagaa attcaggagg ccgaacaagc cattgaagaa
      781 ttagagtcat tgtgtaaaag tctaaataaa caagatgaaa agcagttgca agaacttgtg
      841 tcagaagaaa ggcaaatcat tgatcagaag atccacagac tgtatagtga gcttttggag
      901 cgtttagtgc ctaaggagaa gtatgattgg agtgacgtta ttctagaagt gacatctgga
      961 agaactactg gaggtgatat ctgccaacag tttacccggg aaatatttga tatgtaccag
     1021 aattattcat actataagca ctggaaattt gagctgctga attatacacc agccgattat
     1081 ggtggactac atcatgcagc tgcccggatt tccggtgaca gtgtttataa gcatttgaag
     1141 tatgaaggcg gaatccatcg agttcagcgc atcccggagg tgggcctgtc atcacggatg
     1201 cagcgcattc acacgggaac aatgtcagtg attgtccttc cacagccaga tgaggtagat
     1261 gtgaaagtgg atcccaagga tctgcgagta gacacatttc gagccagagg agcagggggg
     1321 cagcatgtta acaccaccga cagtgccgtg aggcttgtcc acattcccac gggactggta
     1381 gtagagtgcc aacaagaacg atcacagctg aaaaataaag aaatagcttt gcgtgtgttg
     1441 agagccagac tctaccaaca gataatcgag aaagacaggt gtcagcagca gaatgctaga
     1501 aaactgcagg tgggaacaag agcccagtcg gagagaattc ggacatataa tttcacccag
     1561 gatagagtca ctgaccacag gatagcgtat gaagttcgtg acattaagga atttttacgt
     1621 ggtgagaagt gcctggatca gctaattgag agattgcttc aatcagcaga tgaagaggcc
     1681 atttccgaat ttttggatga aagccttcaa tcagtgaaat aaattatttg ttatataaat
     1741 gaagtggact ttgatcaaga aaaaaaaagg tgtggaaatc ttaataaata ttcataaagt
     1801 atagatgtgc ctacagagtt tttatagaac tcattttaat aaaagaaact cacatttctt
     1861 gc
//
