LOCUS       NP_666072                446 aa            linear   ROD 30-APR-2024
DEFINITION  peptide chain release factor 1, mitochondrial [Mus musculus].
ACCESSION   NP_666072
VERSION     NP_666072.3
DBSOURCE    REFSEQ: accession NM_145960.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 446)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 446)
  AUTHORS   Poche,R.A., Zhang,M., Rueda,E.M., Tong,X., McElwee,M.L., Wong,L.,
            Hsu,C.W., Dejosez,M., Burns,A.R., Fox,D.A., Martin,J.F., Zwaka,T.P.
            and Dickinson,M.E.
  TITLE     RONIN Is an Essential Transcriptional Regulator of Genes Required
            for Mitochondrial Function in the Developing Retina
  JOURNAL   Cell Rep 14 (7), 1684-1697 (2016)
   PUBMED   26876175
REFERENCE   3  (residues 1 to 446)
  AUTHORS   Newbury,A.J. and Rosen,G.D.
  TITLE     Genetic, morphometric, and behavioral factors linked to the
            midsagittal area of the corpus callosum
  JOURNAL   Front Genet 3, 91 (2012)
   PUBMED   22666227
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 446)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124745.4, BB620002.1 and AK043981.1.
            
            On Dec 3, 2009 this sequence version replaced NP_666072.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077749.1, AK043981.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG   :: downstream AUG is associated
                                                  with N-terminal localization
                                                  signal
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 42.63 cM"
     Protein         1..446
                     /product="peptide chain release factor 1, mitochondrial"
                     /note="MRF-1"
                     /calculated_mol_wt=44817
     transit_peptide 1..62
                     /note="Mitochondrion. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (Q8K126.1)"
                     /calculated_mol_wt=7659
     mat_peptide     63..446
                     /product="Peptide chain release factor 1, mitochondrial.
                     /id=PRO_0000030334"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K126.1)"
                     /calculated_mol_wt=44817
     Region          105..427
                     /region_name="PrfA"
                     /note="Protein chain release factor RF1 [Translation,
                     ribosomal structure and biogenesis]; COG0216"
                     /db_xref="CDD:439986"
     Region          298..362
                     /region_name="GGQ domain.
                     /evidence=ECO:0000250|UniProtKB:Q80VP5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K126.1)"
     Region          312..314
                     /region_name="GGQ. /evidence=ECO:0000250|UniProtKB:O75570"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K126.1)"
     Site            314
                     /site_type="methylation"
                     /note="N5-methylglutamine.
                     /evidence=ECO:0000250|UniProtKB:O75570; propagated from
                     UniProtKB/Swiss-Prot (Q8K126.1)"
     CDS             1..446
                     /gene="Mtrf1"
                     /gene_synonym="A830062K05Rik; MtRF-1"
                     /coded_by="NM_145960.4:382..1722"
                     /db_xref="CCDS:CCDS27297.1"
                     /db_xref="GeneID:211253"
                     /db_xref="MGI:MGI:2384815"
ORIGIN      
        1 mshhlciwlf rnpflracpq rhvflscqqf rqisldtrpw nfrqkkthvl yqllnkswsr
       61 gcchqgtrkl wkhkalqkym edlnkeyqtl dqclqgisen egdrralhrr haqlaplaav
      121 yqeiqeaeqa ieeleslcks lnkqdekqlq elvseerqii dqkihrlyse llerlvpkek
      181 ydwsdvilev tsgrttggdi cqqftreifd myqnysyykh wkfellnytp adygglhhaa
      241 arisgdsvyk hlkyeggihr vqripevgls srmqrihtgt msvivlpqpd evdvkvdpkd
      301 lrvdtfrarg aggqhvnttd savrlvhipt glvvecqqer sqlknkeial rvlrarlyqq
      361 iiekdrcqqq narklqvgtr aqserirtyn ftqdrvtdhr iayevrdike flrgekcldq
      421 lierllqsad eeaiseflde slqsvk
//
