LOCUS       NM_028151               3309 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus Mtr4 exosome RNA helicase (Mtrex), mRNA.
ACCESSION   NM_028151
VERSION     NM_028151.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3309)
  AUTHORS   Wu,Y.W., Deng,Z.Q., Rong,Y., Bu,G.W., Wu,Y.K., Wu,X., Cheng,H. and
            Fan,H.Y.
  TITLE     RNA surveillance by the RNA helicase MTR4 determines volume of
            mouse oocytes
  JOURNAL   Dev Cell 60 (1), 85-100 (2025)
   PUBMED   39378876
REFERENCE   2  (bases 1 to 3309)
  AUTHORS   Cajigas,I., Chakraborty,A., Swyter,K.R., Luo,H., Bastidas,M.,
            Nigro,M., Morris,E.R., Chen,S., VanGompel,M.J.W., Leib,D.,
            Kohtz,S.J., Martina,M., Koh,S., Ay,F. and Kohtz,J.D.
  TITLE     The Evf2 Ultraconserved Enhancer lncRNA Functionally and Spatially
            Organizes Megabase Distant Genes in the Developing Forebrain
  JOURNAL   Mol Cell 71 (6), 956-972 (2018)
   PUBMED   30146317
REFERENCE   3  (bases 1 to 3309)
  AUTHORS   Onderak,A.M. and Anderson,J.T.
  TITLE     Loss of the RNA helicase SKIV2L2 impairs mitotic progression and
            replication-dependent histone mRNA turnover in murine cell lines
  JOURNAL   RNA 23 (6), 910-926 (2017)
   PUBMED   28351885
  REMARK    GeneRIF: Skiv2l2 knockdown cells accumulated replication-dependent
            histone mRNAs, among other RNAs, that could impede mitotic
            progression and indirectly trigger differentiation.
REFERENCE   4  (bases 1 to 3309)
  AUTHORS   Lim,J., Giri,P.K., Kazadi,D., Laffleur,B., Zhang,W., Grinstein,V.,
            Pefanis,E., Brown,L.M., Ladewig,E., Martin,O., Chen,Y., Rabadan,R.,
            Boyer,F., Rothschild,G., Cogne,M., Pinaud,E., Deng,H. and Basu,U.
  TITLE     Nuclear Proximity of Mtr4 to RNA Exosome Restricts DNA Mutational
            Asymmetry
  JOURNAL   Cell 169 (3), 523-537 (2017)
   PUBMED   28431250
  REMARK    GeneRIF: Study reports that the noncoding RNA processing activity
            of RNA exosome, a 3'-5' RNA exonuclease, controls sense and
            antisense strand DNA mutagenesis, and prevents an increased
            asymmetric mutagenesis burden using a mechanism that relies on the
            unexpected DNA/RNA hybrid unwinding activities of the Mtr4 and
            senataxin RNA helicases.
REFERENCE   5  (bases 1 to 3309)
  AUTHORS   Xing,J., Weng,L., Yuan,B., Wang,Z., Jia,L., Jin,R., Lu,H., Li,X.C.,
            Liu,Y.J. and Zhang,Z.
  TITLE     Identification of a role for TRIM29 in the control of innate
            immunity in the respiratory tract
  JOURNAL   Nat Immunol 17 (12), 1373-1380 (2016)
   PUBMED   27695001
  REMARK    Erratum:[Nat Immunol. 2016 Nov 16;17(12):1479. doi:
            10.1038/ni1216-1479a.. PMID: 27849197]
REFERENCE   6  (bases 1 to 3309)
  AUTHORS   Dorweiler,J.E., Ni,T., Zhu,J., Munroe,S.H. and Anderson,J.T.
  TITLE     Certain adenylated non-coding RNAs, including 5' leader sequences
            of primary microRNA transcripts, accumulate in mouse cells
            following depletion of the RNA helicase MTR4
  JOURNAL   PLoS One 9 (6), e99430 (2014)
   PUBMED   24926684
  REMARK    GeneRIF: Results identify novel role for Mtr4 in targeting the 5'
            leader sequences of microRNAs for degradation.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3309)
  AUTHORS   Osman,B.A., Kawashima,A., Tamba,M., Satoh,E., Kato,Y., Iki,A.,
            Konishi,K., Matsuda,M. and Okamura,N.
  TITLE     Localization of a novel RNA-binding protein, SKIV2L2, to the
            nucleus in the round spermatids of mice
  JOURNAL   J Reprod Dev 57 (4), 457-467 (2011)
   PUBMED   21467735
  REMARK    GeneRIF: SKIV2L2 is an RNA-binding protein localized to the nucleus
            in the round spermatids of mice
REFERENCE   8  (bases 1 to 3309)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 3309)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 3309)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC165265.2.
            
            On Nov 17, 2006 this sequence version replaced NM_028151.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012158.1, BC029230.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               AC165265.2         119837-119987       c
            152-289             AC165265.2         114237-114374       c
            290-356             AC165265.2         112967-113033       c
            357-419             AC165265.2         111175-111237       c
            420-532             AC165265.2         110196-110308       c
            533-707             AC165265.2         106963-107137       c
            708-798             AC165265.2         105707-105797       c
            799-923             AC165265.2         103517-103641       c
            924-1022            AC165265.2         102423-102521       c
            1023-1125           AC165265.2         101502-101604       c
            1126-1257           AC165265.2         99592-99723         c
            1258-1337           AC165265.2         97593-97672         c
            1338-1448           AC165265.2         96006-96116         c
            1449-1550           AC165265.2         94080-94181         c
            1551-1676           AC165265.2         91372-91497         c
            1677-1827           AC165265.2         88080-88230         c
            1828-2000           AC165265.2         84495-84667         c
            2001-2069           AC165265.2         83886-83954         c
            2070-2198           AC165265.2         80042-80170         c
            2199-2309           AC165265.2         79362-79472         c
            2310-2498           AC165265.2         75707-75895         c
            2499-2662           AC165265.2         73586-73749         c
            2663-2768           AC165265.2         69043-69148         c
            2769-2825           AC165265.2         67203-67259         c
            2826-2988           AC165265.2         65506-65668         c
            2989-3093           AC165265.2         61618-61722         c
            3094-3309           AC165265.2         60387-60602         c
FEATURES             Location/Qualifiers
     source          1..3309
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 63.93 cM"
     gene            1..3309
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /note="Mtr4 exosome RNA helicase"
                     /db_xref="GeneID:72198"
                     /db_xref="MGI:MGI:1919448"
     exon            1..151
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..3146
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /EC_number="3.6.4.13"
                     /note="ATP-dependent helicase SKIV2L2; superkiller
                     viralicidic activity 2-like 2; TRAMP-like complex
                     helicase"
                     /codon_start=1
                     /product="exosome RNA helicase MTR4"
                     /protein_id="NP_082427.1"
                     /db_xref="CCDS:CCDS26778.1"
                     /db_xref="GeneID:72198"
                     /db_xref="MGI:MGI:1919448"
                     /translation="MADAFGDELFSVFEDDSTSAAGAKKDKEKEKWKGPPGSADKAGK
                     RLDTKLQSESASGGKNKRDLDVEGTDEPIFGKKPRIEDSINEDLSLADLMPRVKVQSV
                     ETVEGCTHEVALPADEDYIPLKPRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAH
                     TSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTINP
                     TASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVH
                     YVFLSATIPNARQFAEWICHLHKQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENG
                     DFREDNFNTAMQVLRDAGDLAKGDQKGRKGGTKGPSNVFKIVKMIMERNFQPVIIFSF
                     SKKDCEAYALQMTKLDFNTDEEKKMVEEVFNNAIDCLSDEDKKLPQVEHVLPLLKRGI
                     GIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKYDGKDFR
                     WISSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSAFHLTYN
                     MVLNLLRVEEINPEYMLEKSFYQFQHYRAIPGVVEKVKNSEEQYNKIVIPNEENVVIY
                     YKIRQQLAKLGKEIEEYIHKPKYCLPFLQPGRLVKVKNEGDDFGWGVVVNFSKKSNVK
                     PNSGELDPLYVVEVLLRCSKESLKNSATEAAKPAKPDEKGEMQVVPVLVHLLSAISTV
                     RLYIPKDLRPVDNRQSVLKSIQEVQRRFPDGVPLLDPIDDMGIQDQGLKKVIQKVEAF
                     EHRMYSHPLHNDPNLETVYTLCERKAQIALDIKSAKRELKKARTVLQMDELKCRKRVL
                     RRLGFATSSDVIEMKGRVACEISSADELLLTEMMFNGLFNDLSSEQATALLSCFVFQE
                     NSSEMPKLTEQLAGPLRQMQECAKRIAKVSAEAKLEIDEETYLSSFKPHLMDVVYTWA
                     TGATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELENKFAEGITKIKR
                     DIVFAASLYL"
     exon            152..289
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            290..356
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            357..419
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            420..532
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            533..707
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..798
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            799..923
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1022
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1125
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1257
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1337
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1448
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1550
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1676
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1827
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..2000
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2069
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2198
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2309
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2498
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2662
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2768
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..2825
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2826..2988
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            2989..3093
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
     exon            3094..3309
                     /gene="Mtrex"
                     /gene_synonym="2610528A15Rik; mKIAA0052; Skiv2l2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attcggtctc agagttccga aagatggcgg atgctttcgg ggatgagctt ttcagcgttt
       61 tcgaggatga ttcgacctct gcagcaggag ccaagaaaga caaagagaaa gagaaatgga
      121 aggggccacc agggtctgca gacaaggccg ggaaacgact ggataccaaa ttacaatcag
      181 agtcagccag tggggggaaa aacaaaagag atctagatgt tgaaggcact gatgaaccta
      241 tttttggcaa gaagccgaga atagaagact caattaatga agatttaagc ctggcggacc
      301 tgatgcccag agtcaaggta cagtcagtgg aaacagttga aggctgcaca catgaggtcg
      361 ctcttcctgc agatgaggat tatataccac ttaaacctcg agttgggaag gcagcaaagg
      421 aatacccatt cattcttgat gctttccaaa gagaagccat tcagtgtgtt gataataacc
      481 agtctgtgct agtatctgct catacgtcag cagggaagac cgtgtgtgcc gagtatgcta
      541 ttgcattggc tttaagagaa aaacagcgtg taatatttac cagccctatt aaggctctaa
      601 gtaatcagaa ataccgtgaa atgtatgaag aatttcaaga tgtggggctg atgacgggag
      661 atgttactat taatcccaca gcatcttgtc tcgttatgac tacagagatt ttgagaagta
      721 tgctgtatag aggctctgaa gttatgcgag aagttgcttg ggtcatattt gatgaaattc
      781 attacatgag agattcagag cgtggtgtag tatgggaaga aactattatt ttgcttccag
      841 ataatgttca ctatgtcttt ctttcggcta ctattccaaa tgctcgacag tttgctgaat
      901 ggatttgtca cctacataaa cagccctgtc atgttattta cactgattat cgacccactc
      961 cactgcaaca ctacatattt ccagcagggg gagatggcct tcacctggtg gttgatgaaa
     1021 atggtgactt cagagaagat aattttaaca ctgcaatgca agtgctgcgg gatgcaggtg
     1081 atttggccaa aggagaccag aagggacgga aaggaggaac aaaaggtcca tcaaatgtgt
     1141 tcaagattgt gaagatgatt atggagagaa atttccagcc tgtgatcatc ttcagtttca
     1201 gtaagaagga ctgtgaagca tatgctcttc agatgacgaa gctagacttc aacacagatg
     1261 aagaaaagaa gatggttgaa gaagttttca ataatgcaat tgactgcttg tctgatgaag
     1321 ataaaaagct ccctcaggtt gaacatgtgc ttccactttt gaagcggggg attggtattc
     1381 accatggtgg cttacttcct attttgaaag aaactataga aattctcttt tctgaaggat
     1441 tgataaaggc tttatttgcc acagagactt ttgctatggg aattaacatg ccagctagaa
     1501 ctgttttatt tacaaatgcc cgtaaatatg acggaaagga cttcagatgg atttcctctg
     1561 gcgagtacat ccagatgtct ggtcgcgcag gaaggagagg catggacgac agagggattg
     1621 tgattcttat ggtagacgag aagatgagcc caactattgg aaagcagctg cttaaggggt
     1681 cagctgatcc tctgaacagt gctttccatc tgacctataa catggttttg aacttactaa
     1741 gagtagaaga aattaacccc gagtacatgc ttgaaaaatc cttctaccag tttcagcatt
     1801 atagagcaat tccaggggtc gtagaaaagg taaagaactc agaagagcag tataataaaa
     1861 tagtcattcc caatgaagaa aatgtggtca tctattacaa gattagacag caacttgcca
     1921 agctgggaaa agagattgaa gaatatattc ataaaccaaa gtactgctta ccctttctac
     1981 agccaggccg tttggtaaag gtgaaaaatg aaggcgatga tttcggctgg ggagtagtag
     2041 tgaacttctc aaaaaagtca aatgtcaagc ccaattctgg cgaactggat cccttgtatg
     2101 tggtggaagt cctcctgcgc tgtagcaagg aaagcctgaa gaactcagcc accgaggcag
     2161 caaagccagc gaagccagac gagaaagggg agatgcaggt tgttccagtt ttggtgcatc
     2221 tcctgtctgc catcagcact gtcaggctct atattccaaa agaccttcga cctgtggaca
     2281 acagacagag tgtcttaaaa tccatacagg aagttcaaag gcgctttccc gacggcgttc
     2341 ctctgttaga tccgatcgat gatatgggca tccaagatca aggactgaag aaagtcatcc
     2401 agaaagtaga ggcctttgag catcgcatgt actcacaccc actccacaat gatcctaact
     2461 tggaaactgt ttatacactg tgtgaaagaa aggcccagat tgcactagat atcaagtctg
     2521 caaagagaga actgaagaag gcaagaactg ttctgcaaat ggacgagctc aaatgccgca
     2581 agcgcgtgct gagacggctg ggctttgcga catcgtcgga tgtcatagag atgaaaggac
     2641 gggtggcttg tgaaataagc agtgcggacg agctccttct aacggagatg atgttcaatg
     2701 ggcttttcaa tgacctttct tcagagcagg caaccgcact gttaagctgt tttgtgtttc
     2761 aagagaattc tagtgagatg cccaaactaa cagagcagtt agctggacca ctccgacaaa
     2821 tgcaggaatg tgctaaaagg attgcaaaag tttcagcaga ggcaaagctg gagattgatg
     2881 aagaaactta cctaagctca ttcaagcctc acctgatgga tgtggtgtat acctgggcaa
     2941 ctggggccac atttgcccat atctgcaaaa tgacagatgt tttcgaaggc agtataattc
     3001 gttgtatgag gcgtctggaa gaactgcttc gacagatgtg tcaagcagca aaagccattg
     3061 gaaacacaga gctggagaac aaatttgctg aaggaattac caaaatcaag agggatattg
     3121 tatttgctgc cagcctctac ttatagagtt cagcgttatc caccacctgt ctgattgcaa
     3181 ctgactacaa acgcttccca gtgttcagtg gttcacaagc tttttattat atttaagtca
     3241 acatcattct gagaaggcat gtaacataca catttgtaca tagcgtcttt caataaaaat
     3301 gtacaggtg
//
