LOCUS       NM_001081128            4487 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus 5-methyltetrahydrofolate-homocysteine
            methyltransferase (Mtr), mRNA.
ACCESSION   NM_001081128 XM_138431
VERSION     NM_001081128.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4487)
  AUTHORS   Hassan,Z., Coelho,D., Bossenmeyer-Pourie,C., Matmat,K., Arnold,C.,
            Savladori,A., Alberto,J.M., Umoret,R., Gueant,J.L. and Pourie,G.
  TITLE     Cognitive Impairment Is Associated with AMPAR Glutamatergic
            Dysfunction in a Mouse Model of Neuronal Methionine Synthase
            Deficiency
  JOURNAL   Cells 12 (9), 1267 (2023)
   PUBMED   37174668
  REMARK    GeneRIF: Cognitive Impairment Is Associated with AMPAR
            Glutamatergic Dysfunction in a Mouse Model of Neuronal Methionine
            Synthase Deficiency.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4487)
  AUTHORS   Imbard,A., Schwendimann,L., Lebon,S., Gressens,P., Blom,H.J. and
            Benoist,J.F.
  TITLE     Liver and brain differential expression of one-carbon metabolism
            genes during ontogenesis
  JOURNAL   Sci Rep 11 (1), 21132 (2021)
   PUBMED   34702858
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4487)
  AUTHORS   Partearroyo,T., Murillo-Cuesta,S., Vallecillo,N.,
            Bermudez-Munoz,J.M., Rodriguez-de la Rosa,L., Mandruzzato,G.,
            Celaya,A.M., Zeisel,S.H., Pajares,M.A., Varela-Moreiras,G. and
            Varela-Nieto,I.
  TITLE     Betaine-homocysteine S-methyltransferase deficiency causes
            increased susceptibility to noise-induced hearing loss associated
            with plasma hyperhomocysteinemia
  JOURNAL   FASEB J 33 (5), 5942-5956 (2019)
   PUBMED   30753104
REFERENCE   4  (bases 1 to 4487)
  AUTHORS   Dutchak,P.A., Laxman,S., Estill,S.J., Wang,C., Wang,Y., Wang,Y.,
            Bulut,G.B., Gao,J., Huang,L.J. and Tu,B.P.
  TITLE     Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1
            Inhibitor NPRL2
  JOURNAL   Cell Rep 12 (3), 371-379 (2015)
   PUBMED   26166573
REFERENCE   5  (bases 1 to 4487)
  AUTHORS   Cherukad,J., Wainwright,V. and Watson,E.D.
  TITLE     Spatial and temporal expression of folate-related transporters and
            metabolic enzymes during mouse placental development
  JOURNAL   Placenta 33 (5), 440-448 (2012)
   PUBMED   22365888
REFERENCE   6  (bases 1 to 4487)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 4487)
  AUTHORS   Mills,M., Yang,N., Weinberger,R., Vander Woude,D.L., Beggs,A.H.,
            Easteal,S. and North,K.
  TITLE     Differential expression of the actin-binding proteins,
            alpha-actinin-2 and -3, in different species: implications for the
            evolution of functional redundancy
  JOURNAL   Hum Mol Genet 10 (13), 1335-1346 (2001)
   PUBMED   11440986
REFERENCE   8  (bases 1 to 4487)
  AUTHORS   Swanson,D.A., Liu,M.L., Baker,P.J., Garrett,L., Stitzel,M., Wu,J.,
            Harris,M., Banerjee,R., Shane,B. and Brody,L.C.
  TITLE     Targeted disruption of the methionine synthase gene in mice
  JOURNAL   Mol Cell Biol 21 (4), 1058-1065 (2001)
   PUBMED   11158293
REFERENCE   9  (bases 1 to 4487)
  AUTHORS   Gwynn,B., Ciciotte,S.L., Hunter,S.J., Washburn,L.L., Smith,R.S.,
            Andersen,S.G., Swank,R.T., Dell'Angelica,E.C., Bonifacino,J.S.,
            Eicher,E.M. and Peters,L.L.
  TITLE     Defects in the cappuccino (cno) gene on mouse chromosome 5 and
            human 4p cause Hermansky-Pudlak syndrome by an AP-3-independent
            mechanism
  JOURNAL   Blood 96 (13), 4227-4235 (2000)
   PUBMED   11110696
REFERENCE   10 (bases 1 to 4487)
  AUTHORS   Zhang,Z.X., Leclerc,D., Gravel,R. and Rozen,R.
  TITLE     The methionine synthase (Mtr) gene maps to proximal mouse
            chromosome 13
  JOURNAL   Mamm Genome 8 (10), 787-788 (1997)
   PUBMED   9321480
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB630813.1, BC145683.1 and AI894170.1.
            
            On Sep 22, 2011 this sequence version replaced NM_001081128.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145683.1, SRR17253011.2722523.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               BB630813.1         4-116
            114-4205            BC145683.1         1-4092
            4206-4487           AI894170.1         1-282               c
FEATURES             Location/Qualifiers
     source          1..4487
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 4.52 cM"
     gene            1..4487
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /note="5-methyltetrahydrofolate-homocysteine
                     methyltransferase"
                     /db_xref="GeneID:238505"
                     /db_xref="MGI:MGI:894292"
     exon            1..252
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            253..467
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..4019
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /EC_number="2.1.1.13"
                     /note="vitamin-B12 dependent methionine synthase;
                     cobalamin-dependent methionine synthase"
                     /codon_start=1
                     /product="methionine synthase"
                     /protein_id="NP_001074597.1"
                     /db_xref="CCDS:CCDS36591.1"
                     /db_xref="GeneID:238505"
                     /db_xref="MGI:MGI:894292"
                     /translation="MKKTLQDEIEAILRKRIMVLDGGMGTMIQRYKLSEEHFQGQEFK
                     DHSRPLKGNNDILSITQPDIIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAY
                     RMNKCSADVARKAAEEITLQTGVKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELV
                     DAYQEQAKGLLDGRVDILLIETIFDTANAKAALFAIQNLFEENYAPPRPIFISGTIVD
                     KSGRTLSGQTGEAFVTSVSHSDPLCIGLNCSLGAAEMRPFIETIGKCTTAYVLCYPNA
                     GLPNTFGDYDETPSTMATHLKDFAVDGLVNIVGGCCGSTPDHIREIAEAVKKCKPRVP
                     PASVFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALSIAKA
                     QVEMGAQVLDINMDDGMLDGPSAMTRFCNSIASEPDIAKVPLCIDSSNFAVIEAGLKC
                     CQGKCIVNSISLKEGEGDFLEKARKIKKFGAAVVVMAFDEEGQATETDVKVNVCTRAY
                     HLLVDKVGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATRVIKETLPGVRISGGLS
                     NLSFSFRGMEAIREAMHGVFLYHAIKFGMDMGIVNAGNLPVYDAIHKDLLQLCEDLIW
                     NKDSEATEKLLRYAQTHGTGGKKVIQTDEWRNGSIEERLEYALVKGIEKHIVEDTEEA
                     RLNGEKYPRPLNIIEGPLMNGMKVVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFME
                     KEREEARLINGSVEEEDPYQGTIVLATVKGDVHDIGKNIVGVVLACNNFRVIDLGVMT
                     PCDKILQAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIKIPLLIGGATTSRTHT
                     AVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLRDDYFEEILEEYEDIRQDHYESLKE
                     RKYVPLSQARKHGFHIDWLSEPHPVKPTFIGTQVFEDYNLQKLVDYIDWKPFFDVWQL
                     RGKYPNRGFPKIFNDKAVGEEARKVYNDAQNMLNILISQKKLQARGVVGFWPAQSVQD
                     DIHLYAEGVVPQAAEPIATFYGLRQQAEKDSSSTDPYHCLSDFIAPLHSGVCDYLGLF
                     AVACFGVEELSKTYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELWAYSRSEQL
                     GVPDLRRLRYEGIRPAPGYPSQPDHTEKLTMWRLASIEQATGIRLTESLAMAPASAVS
                     GLYFSNVKAKYFAVGKISKDQTEDYALRKNMPVAEVEKWLGPILGYDTD"
     exon            468..557
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            558..627
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            628..720
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            721..827
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            828..890
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            891..985
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1086
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1148
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1216
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1296
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1409
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1550
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1736
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1916
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2033
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2174
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2264
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2417
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2525
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2626
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            2627..2694
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2815
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2897
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..2996
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3072
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            3073..3228
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            3229..3425
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            3426..3626
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            3627..3819
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            3820..3932
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     exon            3933..4486
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4481
                     /gene="Mtr"
                     /gene_synonym="D830038K18Rik; MS"
ORIGIN      
        1 ttcctttagt ctgtcgctgc ggccttgctc tgtagcgggg agctctgcgc ttgggagttc
       61 cgtaagaagc gcgtgcccga ggcacggtac ccggaggccc ggtgtgtcgg ctctggagct
      121 tcggggatct tgtcagttcg tcaggccaga aaacgctggc tggagccgcc cgcggtggaa
      181 ttctttggag atcaagcctt ccctgcttga ggaggactct tggcggcgcg tcgcctgcgc
      241 tgttgtcact cggaaagatg aagaaaaccc tgcaggatga gattgaagcc attcttcgga
      301 agaggatcat ggtgctagac ggtgggatgg ggaccatgat ccagcggtac aaactaagtg
      361 aagaacattt ccaaggtcaa gagtttaaag atcacagcag gccactgaaa ggcaacaatg
      421 acatcttaag tataactcag cctgatatta tttaccagat tcataaggaa tacttgctgg
      481 ctggagcaga tatcatcgaa acaaacactt tcagcagtac tagtatcgcc caggctgact
      541 atggccttga acacttggcc taccggatga acaagtgctc tgcagatgtg gccagaaaag
      601 ccgctgagga gataactctg cagacaggag tcaagaggtt tgtggctgga gctctgggtc
      661 cgactaataa gacactttct gtctccccat ctgtggaaag gccagattat aggaacatca
      721 catttgatga gcttgttgac gcataccagg agcaggccaa gggactgctg gatggcaggg
      781 tcgacatctt actcattgaa acaatttttg atacagctaa tgccaaagca gccttgtttg
      841 cgatccagaa cctctttgaa gagaattatg ctcctcctcg gcctatcttt atttctggga
      901 ccattgttga taaaagtgga aggactcttt ctgggcagac gggagaggct tttgtcacca
      961 gcgtgtctca ttcggacccc ctgtgcattg gattaaattg ttctctgggt gcagctgaaa
     1021 tgaggccttt cattgaaaca attggaaaat gtacaacagc ctatgtcctc tgttacccaa
     1081 atgcaggtct tcccaacact tttggcgact atgatgaaac accatccacg atggccacgc
     1141 acctgaagga ctttgctgtg gatggcttgg tgaatatagt tggtggatgc tgtggttcaa
     1201 cacctgatca catcagggaa attgcggaag ctgtgaaaaa gtgtaagcca agagtccccc
     1261 ctgctagtgt ttttgaagga catatgttac tgtctggtct agagcccttc aggattggac
     1321 catacaccaa ctttgttaac attggagagc gctgtaatgt ggcaggatcc aggaaatttg
     1381 ctaaactcat catggcagga aactatgaag aagccctgag cattgccaaa gcacaggtgg
     1441 aaatgggagc tcaggtgctc gatatcaaca tggacgacgg catgctggat ggtcccagtg
     1501 caatgaccag attttgcaac tccattgctt ctgagcctga cattgccaag gtgcccctgt
     1561 gcattgactc ttctaacttt gccgtgattg aagctgggtt gaagtgctgc caagggaagt
     1621 gcatagtcaa cagcatcagc ctcaaggagg gggaggggga cttcctggag aaggcccgga
     1681 agattaagaa gtttggagct gctgtggtgg ttatggcttt tgatgaggaa ggacaagcaa
     1741 cagaaacaga tgttaaagtc aatgtgtgca ccagagctta ccatctactt gtggacaaag
     1801 tgggcttcaa tccaaatgac atcatctttg accccaacat ccttaccatt ggtactggaa
     1861 tggaggaaca taacttgtat gctatcaatt ttatccatgc aacaagagtc attaaggaaa
     1921 ccttaccagg agtcagaata agtggaggtc tttccaactt atccttctcc ttccgaggga
     1981 tggaagccat tcgagaagca atgcatggtg tgttccttta tcacgcgatc aagtttggta
     2041 tggacatggg gatagtcaat gccggcaacc tccctgtgta tgatgctatc cacaaggacc
     2101 ttcttcagct ctgtgaagac ctcatctgga acaaagactc tgaggctact gagaaactct
     2161 tgcgatatgc ccagactcat ggcacaggag ggaagaaagt catccagaca gatgagtgga
     2221 ggaatggctc cattgaagag cgcctggagt atgctcttgt gaagggcatt gaaaagcaca
     2281 ttgttgaaga tactgaagaa gccaggttaa acggggaaaa ataccctcgg cctctgaata
     2341 taattgaagg gcccctaatg aatggcatga aagtggttgg tgatcttttt ggagctggaa
     2401 agatgtttct acctcaggtt ataaagtcag cccgtgtcat gaagaaggct gttggccacc
     2461 ttatcccttt catggaaaaa gaaagagaag aagccagatt gattaatggt tcggttgaag
     2521 aagaggaccc ttaccaaggc accattgtgc tggccactgt taaaggggac gtgcatgaca
     2581 tcggcaagaa catagttggc gtggtgctgg cctgtaacaa tttcagagtt attgatttag
     2641 gagtcatgac tccctgtgat aagatacttc aagctgctct ggaccacaaa gcagatataa
     2701 ttggcttgtc aggactcatc actccatcct tggatgagat gatttttgtt gccaaggaaa
     2761 tggagaggtt ggctataaag attccattgt tgataggagg agcaaccact tcaagaaccc
     2821 acacagcagt taaaattgca ccacggtaca gcgcgcctgt gatccacgtc ctagatgcat
     2881 ccaagagtgt ggtggtgtgt tctcagctgt tagatgaaaa tctgagagat gactactttg
     2941 aagaaatact ggaagagtat gaagatatta gacaggacca ctatgagtct ctcaaagaga
     3001 gaaaatacgt acccctaagt caagccagaa aacacggttt ccacattgat tggctctctg
     3061 aacctcatcc agtgaagccc acgtttattg ggacccaggt ctttgaggac tacaacctgc
     3121 aaaagctggt ggactacatt gactggaagc ctttctttga cgtctggcag ctccggggca
     3181 agtacccgaa ccgaggattt cccaagatat ttaatgacaa agcagtaggt gaagaagcca
     3241 gaaaggtata caatgatgct cagaatatgc tgaacatact gattagtcaa aagaaactgc
     3301 aggccagggg tgtggttgga ttctggccag cacagagtgt ccaggatgac atccacctgt
     3361 atgcagaggg ggtggtgccc caggccgctg agcccatagc caccttctat ggactgaggc
     3421 agcaggctga gaaggactct tctagtacag acccctacca ctgcctctca gacttcattg
     3481 ctcctttgca ttctggtgtc tgtgactact tgggtctgtt tgctgttgcc tgctttgggg
     3541 ttgaagagct gagtaagacc tatgaggatg atggcgatga ctacagcagc atcatggtga
     3601 aggcgctggg cgacaggctg gcagaggcct ttgcagagga gctccatgag agagttcgcc
     3661 gagaactgtg ggcctactct aggagtgagc agttgggcgt cccagacttg cgcagactcc
     3721 ggtatgaggg catccggcca gctcctggtt accccagcca gcctgaccat actgagaagc
     3781 ttaccatgtg gagactggcc agcatcgagc aggccacagg catcaggctg acagaatcct
     3841 tggcaatggc acccgcttca gcagtgtcag ggctgtactt ctccaacgta aaggccaaat
     3901 attttgctgt ggggaaaatt tccaaagatc agactgagga ttatgctttg aggaagaaca
     3961 tgccagtggc cgaggtggag aaatggcttg gtcccattct gggctatgac acagactgat
     4021 ccctctctca cactccttta ctctttcctg tttttccttt aaacttttat gtttgctgac
     4081 ctcagggggg ataatccagc gtgccttaga aataacaaca aaagcgcctt tgccctgcgc
     4141 tgccctgccc tgccctctgc cctgctggga gaggctggtt gactgcgatg cagagcaggc
     4201 ctctagggtt ctggaaaaga agcacttttc cagggacctt aaatgagaag caacaaagtg
     4261 ccaaggctca tggtgttcct gggccctcat gattggggca agcggaagac atcttttgca
     4321 ttcaaagcag ggcacccagc ttttccccat ttttaccttt gacccaggaa ggcatttgtt
     4381 cctgggtttg tctatctgtc agttagttgg ttggtttggt ttggtttggt ttagtttttt
     4441 gtctgttttt attggctgcc tcatatatta aaaatgattc tgaaaaa
//
