LOCUS       NM_008098               4042 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus myotrophin (Mtpn), mRNA.
ACCESSION   NM_008098
VERSION     NM_008098.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4042)
  AUTHORS   Bourke,L.M., Del Monte-Nieto,G., Outhwaite,J.E., Bharti,V.,
            Pollock,P.M., Simmons,D.G., Adam,A., Hur,S.S., Maghzal,G.J.,
            Whitelaw,E., Stocker,R., Suter,C.M., Harvey,R.P. and Harten,S.K.
  TITLE     Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart
            development in the mouse
  JOURNAL   Differentiation 94, 8-20 (2017)
   PUBMED   27930960
REFERENCE   2  (bases 1 to 4042)
  AUTHORS   Fujiwara,I., Remmert,K., Piszczek,G. and Hammer,J.A.
  TITLE     Capping protein regulatory cycle driven by CARMIL and V-1 may
            promote actin network assembly at protruding edges
  JOURNAL   Proc Natl Acad Sci U S A 111 (19), E1970-E1979 (2014)
   PUBMED   24778263
  REMARK    GeneRIF: Our data argue that a large pool of freely diffusing,
            inactive capping protein (CP:V-1) feeds, via CARMIL-driven complex
            exchange, the formation of weak-capping complexes (CP:CARMIL) at
            the plasma membrane of protruding edges.
REFERENCE   3  (bases 1 to 4042)
  AUTHORS   Campbell,G.R., Baudhuin,A., Vranizan,K. and Ngai,J.
  TITLE     Transcription factors expressed in olfactory bulb local progenitor
            cells revealed by genome-wide transcriptome profiling
  JOURNAL   Mol Cell Neurosci 46 (2), 548-561 (2011)
   PUBMED   21194568
REFERENCE   4  (bases 1 to 4042)
  AUTHORS   Li,Y., Xu,X., Liang,Y., Liu,S., Xiao,H., Li,F., Cheng,H. and Fu,Z.
  TITLE     miR-375 enhances palmitate-induced lipoapoptosis in
            insulin-secreting NIT-1 cells by repressing myotrophin (V1) protein
            expression
  JOURNAL   Int J Clin Exp Pathol 3 (3), 254-264 (2010)
   PUBMED   20224724
  REMARK    GeneRIF: miR-375 enhances palmitate-induced lipoapoptosis in
            insulin-secreting NIT-1 cells (a NOD-derived beta-cell line) by
            repressing myotrophin (V1) protein expression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4042)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 4042)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (bases 1 to 4042)
  AUTHORS   Fujigasaki,H., Song,S.Y., Kobayashi,T. and Yamakuni,T.
  TITLE     Murine central neurons express a novel member of the cdc10/SWI6
            motif-containing protein superfamily
  JOURNAL   Brain Res Mol Brain Res 40 (2), 203-213 (1996)
   PUBMED   8872304
REFERENCE   8  (bases 1 to 4042)
  AUTHORS   Pennica,D., Shaw,K.J., Luoh,S.M. and Wood,W.I.
  TITLE     Isolation of cDNA clones encoding the mouse protein V-1
  JOURNAL   Gene 158 (2), 305-306 (1995)
   PUBMED   7607560
REFERENCE   9  (bases 1 to 4042)
  AUTHORS   Taoka,M., Isobe,T., Okuyama,T., Watanabe,M., Kondo,H., Yamakawa,Y.,
            Ozawa,F., Hishinuma,F., Kubota,M., Minegishi,A. et al.
  TITLE     Murine cerebellar neurons express a novel gene encoding a protein
            related to cell cycle control and cell fate determination proteins
  JOURNAL   J Biol Chem 269 (13), 9946-9951 (1994)
   PUBMED   8144589
REFERENCE   10 (bases 1 to 4042)
  AUTHORS   Mukherjee,D.P., McTiernan,C.F. and Sen,S.
  TITLE     Myotrophin induces early response genes and enhances cardiac gene
            expression
  JOURNAL   Hypertension 21 (2), 142-148 (1993)
   PUBMED   8428777
  REMARK    GeneRIF: Rat neonatal cardiac myocytes incubated with myotrophin
            showed an increase in c-myc, c-fos, and c-jun RNA levels and an
            increase in connexin 43, atrial natriuretic factor, skeletal
            alpha-actin, and total myosin transcript levels.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA559569.1, BC054811.1, AK049398.1 and AC166251.6.
            
            On May 7, 2009 this sequence version replaced NM_008098.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054811.1, AK083888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                CA559569.1         1-87
            88-3806             BC054811.1         1-3719
            3807-3960           AK049398.1         3710-3863
            3961-4042           AC166251.6         33851-33932
FEATURES             Location/Qualifiers
     source          1..4042
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 15.27 cM"
     gene            1..4042
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /note="myotrophin"
                     /db_xref="GeneID:14489"
                     /db_xref="MGI:MGI:99445"
     exon            1..350
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..635
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /note="protein V-1; granule cell differentiation protein"
                     /codon_start=1
                     /product="myotrophin"
                     /protein_id="NP_032124.1"
                     /db_xref="CCDS:CCDS20002.1"
                     /db_xref="GeneID:14489"
                     /db_xref="MGI:MGI:99445"
                     /translation="MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAAD
                     CGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGL
                     TALEATDNQAIKALLQ"
     exon            351..464
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /inference="alignment:Splign:2.1.0"
     exon            465..548
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /inference="alignment:Splign:2.1.0"
     exon            549..4042
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3780..3785
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /note="hexamer: AATAAA"
     polyA_site      3806
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /note="major polyA site"
     regulatory      3941..3946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /note="hexamer: ATTAAA"
     polyA_site      3961
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
     regulatory      3998..4003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /note="hexamer: AATATA"
     polyA_site      4017
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
ORIGIN      
        1 ccgagcagag ctttctggag agaggaagag gaagaggaag tgggaggcgg gccctagcgg
       61 ggcgtgaacc ggaagtgtaa gcgtcctgct tctcctcagc taggcggaac ctgctctgct
      121 gggcccaacg gctgcagaag aactttctcc cgcccgaacc gtagccgcga cccgcagtct
      181 cgcccgctca gcggcctgag gcgcgtcgct ttctcgtgtc ccctcgtcgg gcctaatcgc
      241 cgctcctgcc cggcccgccg gcccaccccg ctgcagtcat gtgcgacaag gagttcatgt
      301 gggccctgaa aaacggagac ttggatgagg tgaaggacta tgtggctaag ggagaagatg
      361 tcaaccggac actagagggt ggaaggaagc ctcttcatta tgctgcagat tgtggacagc
      421 ttgaaatcct ggaatttctg ctgctgaaag gagcagatat taatgctcca gataaacatc
      481 atattacccc tcttctgtct gctgtctatg agggtcatgt ttcctgcgtg aaattgcttc
      541 tgtcaaaggg tgctgataag actgtgaaag gcccagatgg actgaccgcc cttgaagcca
      601 ctgacaacca ggcaatcaaa gctcttctcc agtgatagat ggatggacgg actgataact
      661 tgggaaggat gactctcctg tggcctcaca ctgctgcctg tctgtctgtc actttctatc
      721 tgccagcttc ttcagctaaa tactttaaga gggtgaaggg agagagaaat tcataacaaa
      781 tcagactgcc aggggagggg aataaaacat gttttggagg agcagtgggg aatgtgatga
      841 gacttttact gggattcctg atcaaaccag cctgtttttc atttccagta aaatatacag
      901 cttattccca agggagagca aaaatacagt ctattggaat cattggacct tctcagctcc
      961 ctagctaatt tattaattag tttattgaag gtctgactat acaaggccaa ctctacttat
     1021 ttggtagccc tagctgtgag cagtagtggc tgctgttatg tcaacatagg gtgctgagat
     1081 aagcaattag ctatagcctt ctgccttaag aatgcactct cctgggggct cctggctagt
     1141 taagagcggt tagtgaccaa aatctctcta gaatgacgtt aatctttaca taagagctta
     1201 gataaggtaa ggagcagcgc actcctgaat tgctggatga ctaaactttg gattttctct
     1261 cccctttcac atcaatttca tgtctcttta gataaaactg actagtttta tttataaaat
     1321 gttaaattct aggagcctaa aggaggaatc attccagtag gcttatttct ttttttctcc
     1381 tttagactca gacatttata taacattgaa acactttgag actccttctg gtagtaaagg
     1441 agatttaaaa ataaaatcat agccataagc gtgttagtat cttataaaga gagaacagtt
     1501 gtcttagtac ctatggagtt tcttcatttg ctatttgagt gagccagcct tcgttgtgtt
     1561 tggagaatga agaatattct ttggaatgcc tctcaaaaac ccaccatgga tgctgatttt
     1621 atagtgcacc aaaggtatca ctggggtgag atgtactgta tttggacaga tgggacctca
     1681 tcccttcaaa aacattcttg ttaccatgtt ctcctgagct ggtaatagac tcttgctggg
     1741 ccagtaccac cccacctgca tggtgttttt atcttaacaa tcattctttg catacatgtg
     1801 acaacttcaa aatgcattct gtgttcttat aatacagtgc cctaaaacgg tattcctagg
     1861 acctgcagat aagagaaact tatctctaac tttttctttc atgaacaata aaatgaatta
     1921 aaacatacaa ccttaaattt gatggcctac actttaagta ttaagatgtc ttttgctttt
     1981 aatttgccat ctatacagga ttacaaaaac tattagaatc tttccatagc caatcatgca
     2041 ataattgaat gtacctcaaa tttttaaagg gtaggtgatg ggatagggac ttataatcac
     2101 attagggata ataatattaa aaacctaact gatttttttt aaggcattgt agcattatat
     2161 agcagggtta aactattact aagaacaatc agcctggcta ataactatta atcagttgat
     2221 aattggttgg ggtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgttctcc
     2281 catgaactct tttttatcct gtggcttttt cactttcaac tagcctgccc ctgtagtttt
     2341 tctatgtcca agaaaacaat cacaaaacag tagtttaaat actttgatat atttggctag
     2401 ctctgctgtt ttaatgcagc ctactagagt tggatatcct acacttaatc ttaaccaaaa
     2461 ggccaagcag ctatagagtt ggacattctg ctaggaagtg gaaggcacat gatcagtcta
     2521 tgagtcaata taatgcaaca gggtgttttg agacctttgt tttcacctct tggcatacta
     2581 ttttaaaggc ttgaatttta ccctttacac aattttcaat ttttctttca aagtcttctg
     2641 ttatagttgg ctattgcaga gtgtatattg tcttatcatt ccagaacttg ggtctgcttt
     2701 ctacagtcat tatggtacca aaaccatatg attctttgta cagtttatcc cagtgttcct
     2761 tgtaatgcag tagaggctat tttgccttcc ccctttgttg gccattttgt aaacccatag
     2821 ctatgaagtg attgcttgag aaaatagcat ataaacatag actaggatag actgaccagg
     2881 atggtttaca gtttctttaa aaaaataata aacaaaaata aacaaaaaaa aaactaggtt
     2941 atttataatg tatttctgaa ccacttggca gagaaattca tgacacttaa tgttaatatt
     3001 tttgaataaa tgaagctaaa atgtctgctt ttggtacaac acgcattaat aaaaggttaa
     3061 gttttgtttt ccactgaagt actatttaac atctcagaaa aaaaccctgc atgttctata
     3121 gttttatatt aaaatccatc atttcatatg cactgtatca aaaacaggtt acttgcctga
     3181 acatggttag tgtactaaca ggtctgccca cccctaccct cacccccagc ttcatgccag
     3241 catatgtaga tttgagttct aacacagcac ttgcatatcc catgtgcaca agctcacctt
     3301 tccagaacca gctgggcgca gaagaaaggc agtaactgca gcatgtgaaa gctaaaacaa
     3361 gtagccttct agtcatttct ttctttcccc agccagataa aaggagcttc aatatatgtg
     3421 tacttgattt ttattcactt cagctgagct gctgtttcct tcatgtaata ttgtatactg
     3481 ggttgtgtat agaagaagct ggtaagagtg ccctccttca taaataagca attgcagtgt
     3541 tttgcatgca aatttaaaaa aatttaaatt gtcctgattc tattttgtaa atggagaaac
     3601 aatctttcta agcagtatgg aggaagacta gtgctttgtg cacttttggt atatttgagt
     3661 tcatgtttcc acaatgtcat tcccttgaca cagttgggtt tctcataagt atcctagttc
     3721 atgtacatcc gaatgctaac taatactgtg tttaagtttc gtgttgcaag aacaaatgga
     3781 ataaacttga attgtgctat agataacatg ttagcaacat atttatcccc agtcactgtt
     3841 gccttccttt ccagacgtcc ttaacgatat gaaaatcttg actaacttga gattttaata
     3901 ccattttatc ctacttctag aagaaatgaa gaaaccaatt attaaagagc taacgatact
     3961 agatgctgct catagaaaag cttttttttt taacttcaat ataagttttc tgatacacat
     4021 tgttgctgta tatgggtcca gg
//
