LOCUS       NP_080934                669 aa            linear   ROD 11-MAR-2025
DEFINITION  protein MTO1 homolog, mitochondrial precursor [Mus musculus].
ACCESSION   NP_080934
VERSION     NP_080934.2
DBSOURCE    REFSEQ: accession NM_026658.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 669)
  AUTHORS   Morishima,T., Fakruddin,M., Kanamori,Y., Masuda,T., Ogawa,A.,
            Wang,Y., Schoonenberg,V.A.C., Butter,F., Arima,Y., Akaike,T.,
            Moroishi,T., Tomizawa,K., Suda,T., Wei,F.Y. and Takizawa,H.
  TITLE     Mitochondrial translation regulates terminal erythroid
            differentiation by maintaining iron homeostasis
  JOURNAL   Sci Adv 11 (8), eadu3011 (2025)
   PUBMED   39983002
REFERENCE   2  (residues 1 to 669)
  AUTHORS   Fakruddin,M., Wei,F.Y., Suzuki,T., Asano,K., Kaieda,T., Omori,A.,
            Izumi,R., Fujimura,A., Kaitsuka,T., Miyata,K., Araki,K., Oike,Y.,
            Scorrano,L., Suzuki,T. and Tomizawa,K.
  TITLE     Defective Mitochondrial tRNA Taurine Modification Activates Global
            Proteostress and Leads to Mitochondrial Disease
  JOURNAL   Cell Rep 22 (2), 482-496 (2018)
   PUBMED   29320742
REFERENCE   3  (residues 1 to 669)
  AUTHORS   Tischner,C., Hofer,A., Wulff,V., Stepek,J., Dumitru,I., Becker,L.,
            Haack,T., Kremer,L., Datta,A.N., Sperl,W., Floss,T., Wurst,W.,
            Chrzanowska-Lightowlers,Z., De Angelis,M.H., Klopstock,T.,
            Prokisch,H. and Wenz,T.
  TITLE     MTO1 mediates tissue specificity of OXPHOS defects via tRNA
            modification and translation optimization, which can be bypassed by
            dietary intervention
  JOURNAL   Hum Mol Genet 24 (8), 2247-2266 (2015)
   PUBMED   25552653
  REMARK    GeneRIF: MTO1 mediates tRNA modification and controls mitochondrial
            translation rate in a highly tissue-specific manner associated with
            tissue-specific oxidative phosphorylation defects.
REFERENCE   4  (residues 1 to 669)
  AUTHORS   Becker,L., Kling,E., Schiller,E., Zeh,R., Schrewe,A., Holter,S.M.,
            Mossbrugger,I., Calzada-Wack,J., Strecker,V., Wittig,I.,
            Dumitru,I., Wenz,T., Bender,A., Aichler,M., Janik,D., Neff,F.,
            Walch,A., Quintanilla-Fend,L., Floss,T., Bekeredjian,R.,
            Gailus-Durner,V., Fuchs,H., Wurst,W., Meitinger,T., Prokisch,H., de
            Angelis,M.H. and Klopstock,T.
  TITLE     MTO1-deficient mouse model mirrors the human phenotype showing
            complex I defect and cardiomyopathy
  JOURNAL   PLoS One 9 (12), e114918 (2014)
   PUBMED   25506927
  REMARK    GeneRIF: here described is an MTO1-deficient mouse model generated
            by gene trap mutagenesis that mirrors the human phenotype showing
            complex I defect and cardiomyopathy.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 669)
  AUTHORS   Li,R., Li,X., Yan,Q., Qin Mo,J. and Guan,M.X.
  TITLE     Identification and characterization of mouse MTO1 gene related to
            mitochondrial tRNA modification
  JOURNAL   Biochim Biophys Acta 1629 (1-3), 53-59 (2003)
   PUBMED   14522080
  REMARK    GeneRIF: These observations suggest that the mouse MTO1 is a
            structural and functional homolog of yeast MTO1, thereby playing a
            role in the mitochondrial tRNA modification and protein synthesis.
REFERENCE   6  (residues 1 to 669)
  AUTHORS   Li,X., Li,R., Lin,X. and Guan,M.X.
  TITLE     Isolation and characterization of the putative nuclear modifier
            gene MTO1 involved in the pathogenesis of deafness-associated
            mitochondrial 12 S rRNA A1555G mutation
  JOURNAL   J Biol Chem 277 (30), 27256-27264 (2002)
   PUBMED   12011058
REFERENCE   7  (residues 1 to 669)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY735135.1, CF173757.1, AF369902.1 and BB811598.1.
            
            On Mar 29, 2008 this sequence version replaced NP_080934.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK019088.1, SRR1660817.65081.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..669
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 43.65 cM"
     Protein         1..669
                     /product="protein MTO1 homolog, mitochondrial precursor"
                     /note="protein MTO1 homolog, mitochondrial; mitochondrial
                     translation optimization 1 homolog"
                     /calculated_mol_wt=71403
     transit_peptide 1..25
                     /note="Mitochondrion. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (Q923Z3.1)"
                     /calculated_mol_wt=2961
     mat_peptide     26..669
                     /product="Protein MTO1 homolog, mitochondrial.
                     /id=PRO_0000042690"
                     /note="propagated from UniProtKB/Swiss-Prot (Q923Z3.1)"
                     /calculated_mol_wt=71403
     Region          56..669
                     /region_name="MnmG"
                     /note="tRNA U34 5-carboxymethylaminomethyl modifying
                     enzyme MnmG/GidA [Translation, ribosomal structure and
                     biogenesis]; COG0445"
                     /db_xref="CDD:440214"
     Site            507
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2Z2; propagated from
                     UniProtKB/Swiss-Prot (Q923Z3.1)"
     CDS             1..669
                     /gene="Mto1"
                     /gene_synonym="2310039H01Rik; 5730419A02Rik"
                     /coded_by="NM_026658.2:88..2097"
                     /db_xref="CCDS:CCDS23363.1"
                     /db_xref="GeneID:68291"
                     /db_xref="MGI:MGI:1915541"
ORIGIN      
        1 mfllrgrghw aaaslgrrlp lrrlrsdsaa pctphfdvvv iggghagtea aaaaarcgsr
       61 tlllthrvdt igqmscnpsf ggigkghlmr evdaldglcs ricdqsgihy kvlnrrkgpa
      121 vwglraqidr klykqnmqke ilstplltvq kgavedlvla epepgypgks rvrgvvladg
      181 stiyaesvil ttgtflrgmi iiglemhpag rlgdqpsigl aqtleklgfm vgrlktgtpp
      241 rlakesinfs ilnkhtpddp sipfsflsds vwikpedqlp cylthtnprv daivlenlhl
      301 nshvqettkg prycpsiesk vlrfpnrlhq vwlepegmds dliypqglsv tlpaelqekm
      361 itcirgleka kmvhpgygvq ydyldprqis pslethlvqr lffagqingt tgyeeaaaqg
      421 viaginaslr vsrkppfvvs rtegyigvli ddlttlgtse pyrmftsrve frlslrpdna
      481 dtrltfrahk eagcvssqrf eralwmkssl eegisvlksi kfssskwkkl ipqipisinr
      541 slpvsaldvl kyeevdmesl vgvlpeplek ytacrelarr lkieasyesv lsyqlqeike
      601 vqqdealqlp heldyltird vslsqevrek lhlsrpqtig aasripgvtp aaiinllrfv
      661 rstrqsrqq
//
