LOCUS       NM_145712               1244 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus melatonin receptor 1B (Mtnr1b), mRNA.
ACCESSION   NM_145712
VERSION     NM_145712.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1244)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1244)
  AUTHORS   Zhao,S., Dong,Y., Li,Y., Wang,Z., Chen,Y. and Dong,Y.
  TITLE     Melatonin Alleviates Lipopolysaccharide-Induced Abnormal Pregnancy
            through MTNR1B Regulation of m6A
  JOURNAL   Int J Mol Sci 25 (2), 733 (2024)
   PUBMED   38255808
  REMARK    GeneRIF: Melatonin Alleviates Lipopolysaccharide-Induced Abnormal
            Pregnancy through MTNR1B Regulation of m6A.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1244)
  AUTHORS   Meng,Z., Guo,S., Dong,X., Wang,Q., Hu,D., Liu,X., Jiang,Y., Ji,L.,
            Zhang,J., Zhu,W., Zhou,W. and Song,W.
  TITLE     Astrocyte-Ablation of Mtnr1b Increases Anxiety-Like Behavior in
            Adult Male Mice
  JOURNAL   J Integr Neurosci 22 (6), 154 (2023)
   PUBMED   38176947
  REMARK    GeneRIF: Astrocyte-Ablation of Mtnr1b Increases Anxiety-Like
            Behavior in Adult Male Mice.
REFERENCE   4  (bases 1 to 1244)
  AUTHORS   Ma,X., Wang,J., Wang,L., Yan,L., Liu,Y., Ma,W., Ji,P., Zhang,L. and
            Liu,G.
  TITLE     The Uterine Melatonergic Systems of AANAT and Melatonin Membrane
            Receptor 2 (MT2) Are Essential for Endometrial Receptivity and
            Early Implantation in Mice
  JOURNAL   Int J Mol Sci 24 (8), 7127 (2023)
   PUBMED   37108290
  REMARK    GeneRIF: The Uterine Melatonergic Systems of AANAT and Melatonin
            Membrane Receptor 2 (MT2) Are Essential for Endometrial Receptivity
            and Early Implantation in Mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1244)
  AUTHORS   Jin,R., Li,Y., Jin,H., Yoon,H.S., Choi,J.S., Kim,J., Yoon,H.J. and
            Yoon,K.C.
  TITLE     Melatonin Type 2 Receptor Activation Regulates Blue Light
            Exposure-Induced Mouse Corneal Epithelial Damage by Modulating
            Impaired Autophagy and Apoptosis
  JOURNAL   Int J Mol Sci 23 (19), 11341 (2022)
   PUBMED   36232639
  REMARK    GeneRIF: Melatonin Type 2 Receptor Activation Regulates Blue Light
            Exposure-Induced Mouse Corneal Epithelial Damage by Modulating
            Impaired Autophagy and Apoptosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1244)
  AUTHORS   Larson,J., Jessen,R.E., Uz,T., Arslan,A.D., Kurtuncu,M., Imbesi,M.
            and Manev,H.
  TITLE     Impaired hippocampal long-term potentiation in melatonin MT2
            receptor-deficient mice
  JOURNAL   Neurosci Lett 393 (1), 23-26 (2006)
   PUBMED   16203090
  REMARK    GeneRIF: These results suggest that MT(2) receptors participate in
            hippocampal synaptic plasticity and in memory processes.
REFERENCE   7  (bases 1 to 1244)
  AUTHORS   Sumaya,I.C., Masana,M.I. and Dubocovich,M.L.
  TITLE     The antidepressant-like effect of the melatonin receptor ligand
            luzindole in mice during forced swimming requires expression of MT2
            but not MT1 melatonin receptors
  JOURNAL   J Pineal Res 39 (2), 170-177 (2005)
   PUBMED   16098095
REFERENCE   8  (bases 1 to 1244)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
REFERENCE   9  (bases 1 to 1244)
  AUTHORS   Jin,X., von Gall,C., Pieschl,R.L., Gribkoff,V.K., Stehle,J.H.,
            Reppert,S.M. and Weaver,D.R.
  TITLE     Targeted disruption of the mouse Mel(1b) melatonin receptor
  JOURNAL   Mol Cell Biol 23 (3), 1054-1060 (2003)
   PUBMED   12529409
  REMARK    GeneRIF: Mel(1b) melatonin receptor cDNA was isolated and
            characterized, and the gene has been disrupted.
REFERENCE   10 (bases 1 to 1244)
  AUTHORS   Weaver,D.R., Liu,C. and Reppert,S.M.
  TITLE     Nature's knockout: the Mel1b receptor is not necessary for
            reproductive and circadian responses to melatonin in Siberian
            hamsters
  JOURNAL   Mol Endocrinol 10 (11), 1478-1487 (1996)
   PUBMED   8923472
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB377276.1.
            
            On Sep 3, 2009 this sequence version replaced NM_145712.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC104324.1, AY145850.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1244              AB377276.1         1-1244
FEATURES             Location/Qualifiers
     source          1..1244
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 5.15 cM"
     gene            1..1244
                     /gene="Mtnr1b"
                     /gene_synonym="Mel-1B-R; Mel1b; Mt2"
                     /note="melatonin receptor 1B"
                     /db_xref="GeneID:244701"
                     /db_xref="MGI:MGI:2181726"
     exon            1..319
                     /gene="Mtnr1b"
                     /gene_synonym="Mel-1B-R; Mel1b; Mt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1191
                     /gene="Mtnr1b"
                     /gene_synonym="Mel-1B-R; Mel1b; Mt2"
                     /note="Mel-1b melatonin receptor; mel1b receptor; MT2
                     melatonin receptor"
                     /codon_start=1
                     /product="melatonin receptor type 1B"
                     /protein_id="NP_663758.2"
                     /db_xref="CCDS:CCDS22841.1"
                     /db_xref="GeneID:244701"
                     /db_xref="MGI:MGI:2181726"
                     /translation="MPENSSIPNCCEASGLAARPSWSGSAGARPPVTARAPWVAPMLS
                     TVVVVTTAVDFVGNLLVILSVLRNRKLRNAGNLFVVSLALADLVIALYPYPLILVAII
                     RDGWVLGEAHCKASAFVMGLSVIGSVFNITAIAINRYCCICHSTTYHRVCSHWYTPIY
                     ISLVWLLTLVALVPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVAIHFLLPMAVVSF
                     CYLRIWVLVLQARRKAKAERKLRLRPSDLRSFLTMFAVFVVFAICWAPLNCIGLAVAI
                     NPEAMALQVPEGLFVTSYFLAYFNSCLNAIVYGLLNQNFRREYKRILLAIWNTRRCIQ
                     HASKHCLTEERQGPTPPAARATVPVKEGAL"
     exon            320..1244
                     /gene="Mtnr1b"
                     /gene_synonym="Mel-1B-R; Mel1b; Mt2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcagcctc ttcttaacac tcactgggcg gggaggggac agcgggagcg ccccaagcag
       61 tgcgcacctt gtgcatctat cccaggcagc gtcgagatgc ctgagaacag ctcaatccct
      121 aactgctgtg aggccagcgg gctggcagcg cgccctagtt ggtctgggtc agccggagcc
      181 aggccccctg tgactgcccg ggccccctgg gtggctccca tgctatctac agtagtcgtc
      241 gtcaccacag ccgtggactt cgtggggaac ctgcttgtca tcctctcagt gctcaggaac
      301 cgcaagctgc ggaacgcagg taatttgttt gtggtgagtc tggccttggc tgacttggtg
      361 atagccttgt acccttaccc actgatcctt gtggccatta tccgtgacgg ttgggtcctt
      421 ggggaggccc actgcaaggc cagtgccttt gtgatgggcc tgagtgtcat tggctctgtc
      481 ttcaacatca cagccattgc catcaaccgc tactgctgca tctgtcatag taccacctac
      541 caccgggtct gcagtcactg gtatactccc atctacatca gcctcgtctg gctcctcact
      601 ctggtggctt tggtgcccaa tttctttgtg gggtctttag agtatgatcc acgcatctat
      661 tcctgcacct tcatccagac agccagcaca cagtacacgg cagctgtggt ggccatccac
      721 ttcctccttc ccatggctgt ggtgtccttc tgctacctgc gaatctgggt actggtgctc
      781 caggcccgaa ggaaggccaa ggctgagagg aagctgcgtc tgagaccgag tgatttgcgc
      841 agtttcctaa ccatgtttgc agtgtttgtg gtttttgcca tatgctgggc ccccctcaac
      901 tgtatcggcc ttgcagtggc catcaaccca gaggcaatgg ctctccaggt cccagaaggg
      961 ctctttgtca ccagttactt cttagcttac tttaacagct gccttaatgc cattgtttat
     1021 gggctcctga accagaactt ccgcagggag tacaagagga tccttttggc catatggaac
     1081 actaggcgct gcatacagca tgcttccaaa cactgtctta ctgaggagcg acagggcccg
     1141 acgccacctg ctgccagggc taccgtgcct gtcaaggaag gtgctctcta gcctgcatca
     1201 gctcagtggg cctagcagca aacctgtgaa gtgagcagag tgga
//
