LOCUS       NM_008639               1606 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus melatonin receptor 1A (Mtnr1a), mRNA.
ACCESSION   NM_008639 XM_991330
VERSION     NM_008639.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1606)
  AUTHORS   Bisikirska,B., Labella,R., Cuesta-Dominguez,A., Luo,N., De
            Angelis,J., Mosialou,I., Lin,C.S., Beck,D., Lata,S., Shyu,P.T.,
            McMahon,D.J., Guo,E., Hagen,J., Chung,W.K., Shane,E., Cohen,A. and
            Kousteni,S.
  TITLE     Melatonin receptor 1A variants as genetic cause of idiopathic
            osteoporosis
  JOURNAL   Sci Transl Med 16 (769), eadj0085 (2024)
   PUBMED   39413162
  REMARK    GeneRIF: Melatonin receptor 1A variants as genetic cause of
            idiopathic osteoporosis.
REFERENCE   2  (bases 1 to 1606)
  AUTHORS   Pistono,C., Zimmermann,A., Morel,C., Herbeaux,K., Heraud,C.,
            Dumont-Kientzy,S., Pevet,P., Felder-Schmittbuhl,M.P. and Mathis,C.
  TITLE     Major role of MT2 receptors in the beneficial effect of melatonin
            on long-term recognition memory in C57BL/6J male mice
  JOURNAL   Horm Behav 136, 105076 (2021)
   PUBMED   34634697
REFERENCE   3  (bases 1 to 1606)
  AUTHORS   Zhao,H., Feng,L., Zhong,W., Zhen,H., Chi,Q. and Wang,X.
  TITLE     Hyperphosphorylation of Tau Due to the Interference of Protein
            Phosphatase Methylesterase-1 Overexpression by MiR-125b-5p in
            Melatonin Receptor Knockout Mice
  JOURNAL   Int J Mol Sci 22 (21), 11850 (2021)
   PUBMED   34769281
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1606)
  AUTHORS   Huang,Y.S., Lu,K.C., Chao,H.W., Chen,A., Chao,T.K., Guo,C.Y.,
            Hsieh,H.Y., Shih,H.M., Sytwu,H.K. and Wu,C.C.
  TITLE     The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal
            tubular cells
  JOURNAL   J Cell Physiol 236 (3), 2023-2035 (2021)
   PUBMED   32730662
  REMARK    GeneRIF: The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in
            renal tubular cells.
REFERENCE   5  (bases 1 to 1606)
  AUTHORS   Martinez-Aguila,A., Fonseca,B., Perez de Lara,M.J.,
            Miras-Portugal,M.T., Gomez-Villafuertes,R., Carracedo,G. and
            Pintor,J.
  TITLE     Changes in melatonin receptor expression in a murine model of
            glaucoma
  JOURNAL   Mol Vis 26, 530-539 (2020)
   PUBMED   32818016
  REMARK    GeneRIF: Changes in melatonin receptor expression in a murine model
            of glaucoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1606)
  AUTHORS   Liu,C., Weaver,D.R., Jin,X., Shearman,L.P., Pieschl,R.L.,
            Gribkoff,V.K. and Reppert,S.M.
  TITLE     Molecular dissection of two distinct actions of melatonin on the
            suprachiasmatic circadian clock
  JOURNAL   Neuron 19 (1), 91-102 (1997)
   PUBMED   9247266
REFERENCE   7  (bases 1 to 1606)
  AUTHORS   Weaver,D.R., Liu,C. and Reppert,S.M.
  TITLE     Nature's knockout: the Mel1b receptor is not necessary for
            reproductive and circadian responses to melatonin in Siberian
            hamsters
  JOURNAL   Mol Endocrinol 10 (11), 1478-1487 (1996)
   PUBMED   8923472
REFERENCE   8  (bases 1 to 1606)
  AUTHORS   Roca,A.L., Godson,C., Weaver,D.R. and Reppert,S.M.
  TITLE     Structure, characterization, and expression of the gene encoding
            the mouse Mel1a melatonin receptor
  JOURNAL   Endocrinology 137 (8), 3469-3477 (1996)
   PUBMED   8754776
  REMARK    Erratum:[Endocrinology 1997 Jun;138(6):2307]
REFERENCE   9  (bases 1 to 1606)
  AUTHORS   Bermingham,N.A., Martin,J.E. and Fisher,E.M.
  TITLE     The mouse lysosomal membrane protein 1 gene as a candidate for the
            motorneuron degeneration (mnd) locus
  JOURNAL   Genomics 32 (2), 266-271 (1996)
   PUBMED   8833154
REFERENCE   10 (bases 1 to 1606)
  AUTHORS   Slaugenhaupt,S.A., Roca,A.L., Liebert,C.B., Altherr,M.R.,
            Gusella,J.F. and Reppert,S.M.
  TITLE     Mapping of the gene for the Mel1a-melatonin receptor to human
            chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a)
  JOURNAL   Genomics 27 (2), 355-357 (1995)
   PUBMED   7558006
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158352.5.
            
            On Feb 5, 2019 this sequence version replaced NM_008639.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U52222.1, BC119313.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849378, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-296               AC158352.5         54315-54610         c
            297-1606            AC158352.5         35211-36520         c
FEATURES             Location/Qualifiers
     source          1..1606
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 24.95 cM"
     gene            1..1606
                     /gene="Mtnr1a"
                     /gene_synonym="MelR; MR"
                     /note="melatonin receptor 1A"
                     /db_xref="GeneID:17773"
                     /db_xref="MGI:MGI:102967"
     exon            1..296
                     /gene="Mtnr1a"
                     /gene_synonym="MelR; MR"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1165
                     /gene="Mtnr1a"
                     /gene_synonym="MelR; MR"
                     /note="mel-1A-R; Mel1a receptor"
                     /codon_start=1
                     /product="melatonin receptor type 1A"
                     /protein_id="NP_032665.1"
                     /db_xref="CCDS:CCDS22273.1"
                     /db_xref="GeneID:17773"
                     /db_xref="MGI:MGI:102967"
                     /translation="MKGNVSELLNATQQAPGGGEGGRPRPSWLASTLAFILIFTIVVD
                     ILGNLLVILSVYRNKKLRNSGNIFVVSLAVADLVVAVYPYPLVLTSILNNGWNLGYLH
                     CQVSAFLMGLSVIGSIFNITGIAMNRYCYICHSLKYDKIYSNKNSLCYVFLIWMLTLI
                     AIMPNLQTGTLQYDPRIYSCTFTQSVSSAYTIAVVVFHFIVPMIIVIFCYLRIWVLVL
                     QVRRRVKPDNKPKLKPQDFRNFVTMFVVFVLFAICWAPLNLIGLIVASDPATMVPRIP
                     EWLFVASYYLAYFNSCLNAIIYGLLNQNFRKEYKKIIVSLCTAKMFFVESSNEEADKI
                     KCKPSPLIPNNNLIKVDSV"
     exon            297..1606
                     /gene="Mtnr1a"
                     /gene_synonym="MelR; MR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1144..1149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtnr1a"
                     /gene_synonym="MelR; MR"
                     /note="hexamer: AATAAA"
     polyA_site      1172
                     /gene="Mtnr1a"
                     /gene_synonym="MelR; MR"
                     /note="major polyA site"
     regulatory      1584..1589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtnr1a"
                     /gene_synonym="MelR; MR"
                     /note="hexamer: ATTAAA"
     polyA_site      1606
                     /gene="Mtnr1a"
                     /gene_synonym="MelR; MR"
                     /note="major polyA site"
ORIGIN      
        1 ataaaaagtg gcggagaggg ctcgagcaga gctgagcagt tgagggctcc ggggcgacag
       61 gacaatggcc ctggctgtgc tgcggtgagg cacccagggg accatgaagg gcaatgtcag
      121 cgagctgctc aatgccactc agcaggctcc aggcggcggg gagggaggga gaccacgacc
      181 gtcctggctg gcctctacac tggccttcat cctcatcttt accatcgtgg tggacattct
      241 gggcaacctg ctggtcatcc tgtctgtgta ccgcaacaag aagctcagga actcagggaa
      301 tatatttgtg gtgagtttag ctgtggcaga cctcgtggtg gctgtttacc cttatccctt
      361 ggtgctgaca tctatcctta acaacggatg gaatctggga tatctacact gtcaagtcag
      421 cgcatttcta atgggcttga gtgtcatcgg ctcgatattc aacatcacgg ggatcgctat
      481 gaaccgttac tgctacattt gccacagcct caagtacgac aaaatataca gtaacaagaa
      541 ctcgctctgc tacgtgttcc tgatatggat gctgacactc atcgccatca tgcccaacct
      601 gcaaaccgga acactccagt acgatccccg gatctactcc tgtaccttca cccagtctgt
      661 cagctcagcg tacacgatag cagtggtggt tttccatttc atcgtgccta tgattattgt
      721 catcttctgc tacttaagga tatgggtcct ggtccttcag gtcagacgga gggtgaaacc
      781 cgacaacaag cccaaactga agccccagga cttcaggaac tttgtcacca tgttcgtagt
      841 ttttgtactt tttgccattt gttgggcccc actcaacctc ataggtctta ttgtggcctc
      901 agaccctgcc accatggtcc ccaggatccc agagtggctg ttcgtggcta gttactacct
      961 ggcgtacttc aacagctgcc tcaacgcaat tatatacgga ctactgaatc agaatttcag
     1021 aaaggaatac aaaaagatta ttgtctcgtt gtgcacagcc aagatgttct ttgtggagag
     1081 ttcaaatgaa gaagcagata agattaaatg taagccctct ccactaatac ccaataataa
     1141 cttaataaag gtggactctg tttaaaaagc cagtggtgct agcagattat ccacactggt
     1201 tggggtctta ctgctctcct tgtttgcttt cttttgtcta gaaatcagtc tatccaactt
     1261 gaagctcttc agggttgcct ccatagtgtt ggaaaggatc tcctgtctgc cccataatca
     1321 gattgctagt atcaagggga atgctgaaca ggcacaccat atgttaaatg gacaacttgt
     1381 atcagcagag gaggtctgtg tgcagactct ctcgtctctg gggcaaccag gtcttggggg
     1441 ttgcccacat ttaggattac aatatacagc aacagaccaa acctgaacaa aatgtggaag
     1501 gaactcaaga caagagggac catggggacc ttccttttat tgtaagcgag tgatacagag
     1561 tgtttattct tacctatggc tgaattaaaa tagtcaaaaa acttaa
//
