LOCUS       NM_001040699            3446 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus myotubularin related protein 7 (Mtmr7), mRNA.
ACCESSION   NM_001040699
VERSION     NM_001040699.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3446)
  AUTHORS   Zhao D, Shen C, Gao T, Li H, Guo Y, Li F, Liu C, Liu Y, Chen X,
            Zhang X, Wu Y, Yu Y, Lin M, Yuan Y, Chen X, Huang X, Yang S, Yu J,
            Zhang J and Zheng B.
  TITLE     Myotubularin related protein 7 is essential for the spermatogonial
            stem cell homeostasis via PI3K/AKT signaling
  JOURNAL   Cell Cycle 18 (20), 2800-2813 (2019)
   PUBMED   31478454
  REMARK    GeneRIF: Myotubularin related protein 7 is essential for the
            spermatogonial stem cell homeostasis via PI3K/AKT signaling.
REFERENCE   2  (bases 1 to 3446)
  AUTHORS   Yuan Z, Chen Y, Zhang X, Zhou X, Li M, Chen H, Wu M, Zhang Y and Mo
            D.
  TITLE     Silencing myotubularin related protein 7 enhances proliferation and
            early differentiation of C2C12 myoblast
  JOURNAL   Biochem Biophys Res Commun 484 (3), 592-597 (2017)
   PUBMED   28153733
  REMARK    GeneRIF: The improved proliferation capacity was related to the
            increased phosphorylation of AKT. Taken together, our research
            demonstrates that MTMR7 plays an important role in proliferation
            and early differentiation of C2C12 myoblast.
REFERENCE   3  (bases 1 to 3446)
  AUTHORS   Guo L, Martens C, Bruno D, Porcella SF, Yamane H, Caucheteux SM,
            Zhu J and Paul WE.
  TITLE     Lipid phosphatases identified by screening a mouse phosphatase
            shRNA library regulate T-cell differentiation and protein kinase B
            AKT signaling
  JOURNAL   Proc Natl Acad Sci U S A 110 (20), E1849-E1856 (2013)
   PUBMED   23630283
REFERENCE   4  (bases 1 to 3446)
  AUTHORS   Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB,
            Heard E, Lao K and Surani MA.
  TITLE     Deterministic and stochastic allele specific gene expression in
            single mouse blastomeres
  JOURNAL   PLoS One 6 (6), e21208 (2011)
   PUBMED   21731673
REFERENCE   5  (bases 1 to 3446)
  AUTHORS   Soehn AS, Pham TT, Schaeferhoff K, Floss T, Weisenhorn DM, Wurst W,
            Bonin M and Riess O.
  TITLE     Periphilin is strongly expressed in the murine nervous system and
            is indispensable for murine development
  JOURNAL   Genesis 47 (10), 697-707 (2009)
   PUBMED   19621438
REFERENCE   6  (bases 1 to 3446)
  AUTHORS   de Buhr MF, Mahler M, Geffers R, Hansen W, Westendorf AM, Lauber J,
            Buer J, Schlegelberger B, Hedrich HJ and Bleich A.
  TITLE     Cd14, Gbp1, and Pla2g2a: three major candidate genes for
            experimental IBD identified by combining QTL and microarray
            analyses
  JOURNAL   Physiol Genomics 25 (3), 426-434 (2006)
   PUBMED   16705022
REFERENCE   7  (bases 1 to 3446)
  AUTHORS   Mochizuki Y and Majerus PW.
  TITLE     Characterization of myotubularin-related protein 7 and its binding
            partner, myotubularin-related protein 9
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 9768-9773 (2003)
   PUBMED   12890864
  REMARK    GeneRIF: MTMR7 forms a complex with MTMR9 and dephosphorylates
            phosphatidylinositol 3-phosphate and Ins(1,3)P2 in neuronal cells.
REFERENCE   8  (bases 1 to 3446)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3446)
  AUTHORS   Laporte J, Blondeau F, Buj-Bello A, Tentler D, Kretz C, Dahl N and
            Mandel JL.
  TITLE     Characterization of the myotubularin dual specificity phosphatase
            gene family from yeast to human
  JOURNAL   Hum Mol Genet 7 (11), 1703-1712 (1998)
   PUBMED   9736772
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY741806.1, AK081973.1 and AC158915.4.
            
            [WARNING] On Nov 22, 2023 this sequence was replaced by
            NM_001040699.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028160.1, AK081973.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BY741806.1         2-17
            17-2174             AK081973.1         3-2160
            2175-3446           AC158915.4         54903-56174         c
FEATURES             Location/Qualifiers
     source          1..3446
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 23.89 cM"
     gene            1..3446
                     /gene="Mtmr7"
                     /note="myotubularin related protein 7"
                     /db_xref="GeneID:54384"
                     /db_xref="MGI:MGI:1891693"
     exon            1..95
                     /gene="Mtmr7"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..2054
                     /gene="Mtmr7"
                     /EC_number="3.1.3.64"
                     /note="inositol 1,3-bisphosphate phosphatase;
                     phosphatidylinositol-3-phosphate phosphatase"
                     /codon_start=1
                     /product="myotubularin-related protein 7"
                     /protein_id="NP_001035789.1"
                     /db_xref="CCDS:CCDS40324.1"
                     /db_xref="GeneID:54384"
                     /db_xref="MGI:MGI:1891693"
                     /translation="MEHIRTPKVENVRLVDRVSCKKAALGTLYLTATHVIFVENAPDT
                     RKETWILHSQISTIEKQATTATGCPLLIRCKNFQIVQLVIPQERDCHDVYISLIRLAR
                     PVKYEELYCFSFNPKLDKEEREQGWLLVDLSEEYKRMGLPDNYWQLSDVNRDYRVCDS
                     YPTELYVPRSATAHIIVGSSKFRSRRRFPALSYYCKDSHASICRSSQPLSGFSARCLE
                     DEQMLQAIRKANPGSDFIYVVDTRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIENI
                     HVMRNSLQKMLEVCELKSPSMSDFLWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASV
                     LVHCSDGWDRTAQVCSVASLLLDPYYRTLKGFMVLIEKDWISFGHKFNHRYGNLDGDP
                     KEISPVIDQFIECVWQLTEQFPCAFEFNERFLTHIQHHVYSCQFGNFLCNSQKERREL
                     KIQERTYSLWSNLWKNRADYLNPLFRADHSQTQGSLHLPTAPCNFTYKFWNGMYNRFE
                     KGLQPRQSVTDYLMAVKEESQQLEEELESLEERLEKIQKVHLHGTKVKSKQSEPSKHS
                     GFSTSDHSTANTPQDYSGNSKSFPSRSPSQGDEDSALILTQDNLKSSDPDLSVNSDQE
                     SGVEDLSCRSPSGGEHAPSEDSGKDRDSDEAVFLTA"
     exon            96..218
                     /gene="Mtmr7"
                     /inference="alignment:Splign:2.1.0"
     exon            219..381
                     /gene="Mtmr7"
                     /inference="alignment:Splign:2.1.0"
     exon            382..539
                     /gene="Mtmr7"
                     /inference="alignment:Splign:2.1.0"
     exon            540..668
                     /gene="Mtmr7"
                     /inference="alignment:Splign:2.1.0"
     exon            669..803
                     /gene="Mtmr7"
                     /inference="alignment:Splign:2.1.0"
     exon            804..936
                     /gene="Mtmr7"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1046
                     /gene="Mtmr7"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1172
                     /gene="Mtmr7"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1222
                     /gene="Mtmr7"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1423
                     /gene="Mtmr7"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1564
                     /gene="Mtmr7"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1691
                     /gene="Mtmr7"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..3446
                     /gene="Mtmr7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgcgccgc acgcgcgcgc gcaggtgcgt gaggccgcgc ccgccgggga ccctgcagac
       61 gcgggcccgc catggagcac atccgcacgc ccaaggttga aaacgtgcgc ttggtagaca
      121 gagtgtcttg taaaaaggca gcgctgggaa ctttgtatct gacggccact cacgtcatat
      181 tcgtggaaaa tgcacctgac acaagaaaag aaacctggat tctgcacagt cagatctcca
      241 ccattgaaaa gcaggcgaca acagctacgg gctgccctct gcttattcgc tgcaagaact
      301 tccagatcgt acaacttgtc attccacagg agagagactg ccacgacgtg tacatctctc
      361 tgatacgcct tgcacggcca gtgaagtacg aggagctata ctgcttttcc ttcaacccca
      421 agctggataa ggaagaacgg gagcagggct ggttgctggt tgaccttagt gaagaataca
      481 agcgaatggg cctccctgat aattattggc agctcagcga tgtgaataga gactacagag
      541 tttgtgactc ttaccccacg gaactgtacg tccccagatc ggccacggca cacatcatcg
      601 tgggcagctc caagttccgg agcagacggc gatttcctgc cctttcctac tactgtaaag
      661 acagccatgc ctccatctgc aggagcagcc agcccctttc cggcttcagc gctcggtgcc
      721 tggaggatga gcagatgctc caagccatca ggaaagccaa tcctggaagt gacttcattt
      781 atgtcgtgga cacaaggcct aaacttaatg cgatggcaaa tcgtgctgca gggaaaggct
      841 atgagaatga agacaattat tccaatatca agtttcagtt tatcggcata gagaacatcc
      901 acgtcatgag gaacagtctt cagaaaatgc tggaagtgtg tgaacttaaa tctccctcta
      961 tgagtgattt cctgtgggga ctggagaact caggctggct gaggcacatc aaagccatca
     1021 tggatgcagg gatcttcatt gcaaaggcag tttcagagga aggggcaagt gtgcttgttc
     1081 actgttctga cggctgggac agaacggccc aggtgtgctc ggtggctagc ctgctgctgg
     1141 acccttacta ccggactctg aaaggattca tggtattaat tgaaaaggac tggatttcct
     1201 tcggacataa atttaatcat agatatggca acttagatgg tgacccaaaa gaaatctctc
     1261 cagtaatcga ccagttcatt gagtgtgtct ggcagctaac ggaacagttc ccttgcgcct
     1321 ttgagttcaa cgagaggttt ctgactcaca ttcagcatca tgtttattcc tgccagtttg
     1381 ggaacttcct gtgtaatagc cagaaggaga ggcgagaact caagattcaa gaaagaacct
     1441 actctttgtg gtccaacctg tggaagaatc gagctgacta cctcaatcct ctgtttagag
     1501 ctgaccacag tcagacccag gggagccttc atctgcctac agctccatgc aacttcacct
     1561 ataagttttg gaatgggatg tataaccgct ttgaaaaggg gttgcagcct cgacagtctg
     1621 ttacagatta cctcatggct gtgaaggagg agtcccagca gctggaggaa gaactggagt
     1681 ccctagaaga aaggctggaa aaaattcaga aagtccactt acatggtacc aaagtgaaga
     1741 gtaagcaaag tgagcccagc aaacactcgg ggttctctac ctcagaccac agcacagcca
     1801 acacccctca ggattacagt gggaacagca agtccttccc atccaggagc ccgtcccagg
     1861 gtgatgaaga ttctgctctg attctaaccc aagacaattt aaaaagctca gaccccgacc
     1921 tctcagtgaa tagtgatcaa gagtctgggg tggaggattt gagctgtcga tctcccagtg
     1981 gtggtgagca tgcacccagc gaagacagtg gcaaggaccg ggactcggac gaagctgtgt
     2041 ttctcactgc ctaagttccc ctttggagtt ccaaagtaaa agacacagaa acactttcaa
     2101 attaagggga aagtgcaatt cgtagtaaaa atgttgagaa atggcaagtt ctatccagaa
     2161 ccataaaatt acagctgtga aaatggggaa aaaaaagctc tttatcaata accagttgtt
     2221 ttatcaaatc atactgaaga ctgatcatca ttcctgaggc tcatgctaga ctatgaaaat
     2281 tatatcacta caaggagaga gagtatcttc acccaaggtt gtccagacag tctttcctgg
     2341 catagcatgt gtctgcttaa aagccctcct ggtttctccc atacctgata atgttgggac
     2401 tttgatttca cttccagttg caggttgcat tcaggaactt tgacatttcc ttctgccttt
     2461 accaatattt aaaagaaata aatatggaga gtaccctttt ctgttataaa tgtaatcatt
     2521 ttatttttcc cctgtggagc atcttctgct tctcaaaaaa atgtctgtct ttctttacca
     2581 tgaatgtaga acctattaag ctgaagctgg attcattttc tccatctcga atctgagtcc
     2641 agacattagc tcttagtagc cttttactac tctttcagag attacacata acaaaactgt
     2701 gagccagcca acctgattgc aaactacaac actctaaatg cagtaggtag tgatacatca
     2761 acaagggaaa aggtcaagaa cgagggaatt tgcttatcat gtagttatcg catgctttct
     2821 gtgataagac accacaacca aggcaactag aataaaggat ttattaggac ttacagtttc
     2881 agagggttag aatctacaac catcatggtg gaaggcatgg tatcagccaa gcaggtatgg
     2941 cattggagca gcagctgaca gctcacattt caagacataa ccaagaggca gtgagagcta
     3001 actagaaaag gcatgggctt tttgaaaatt taaaggcagc tcccaggaac aaaccccctc
     3061 ccacaaggcc acatctccta atccctccta aacagttcca ccaaccagga acagagcatt
     3121 caaatagatg agcctttggg agccattctt caaaccccca acccatctgc taaacacagg
     3181 gaataaaggt tacagcactt ttcattttac aaattctata gaaagctaat gttttctgta
     3241 acattagcaa tatctcatga ccatggacta ctggatggca attctgaagt ttctgttaaa
     3301 atgcatttaa aacaggattt gaattgagct tttgatctga aaactcttaa tggagaaatg
     3361 ttgctgtgtt tgaacatact gaaatgttct tattatatga ttttacagtg taagtacatt
     3421 ctaataaaga gatacattta atctta
//
