LOCUS       NM_001401200            3902 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus myotubularin related protein 6 (Mtmr6), transcript
            variant 4, mRNA.
ACCESSION   NM_001401200 XM_017315971
VERSION     NM_001401200.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3902)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3902)
  AUTHORS   Maekawa,M., Terasaka,S., Mochizuki,Y., Kawai,K., Ikeda,Y.,
            Araki,N., Skolnik,E.Y., Taguchi,T. and Arai,H.
  TITLE     Sequential breakdown of 3-phosphorylated phosphoinositides is
            essential for the completion of macropinocytosis
  JOURNAL   Proc Natl Acad Sci U S A 111 (11), E978-E987 (2014)
   PUBMED   24591580
REFERENCE   3  (bases 1 to 3902)
  AUTHORS   Mochizuki,Y., Ohashi,R., Kawamura,T., Iwanari,H., Kodama,T.,
            Naito,M. and Hamakubo,T.
  TITLE     Phosphatidylinositol 3-phosphatase myotubularin-related protein 6
            (MTMR6) is regulated by small GTPase Rab1B in the early secretory
            and autophagic pathways
  JOURNAL   J Biol Chem 288 (2), 1009-1021 (2013)
   PUBMED   23188820
REFERENCE   4  (bases 1 to 3902)
  AUTHORS   Mochizuki,Y. and Majerus,P.W.
  TITLE     Characterization of myotubularin-related protein 7 and its binding
            partner, myotubularin-related protein 9
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 9768-9773 (2003)
   PUBMED   12890864
REFERENCE   5  (bases 1 to 3902)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166113.3.
            
            On Feb 4, 2022 this sequence version replaced XM_017315971.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB517623.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AC166113.3         57551-57658
            109-225             AC166113.3         69426-69542
            226-388             AC166113.3         72380-72542
            389-546             AC166113.3         74234-74391
            547-675             AC166113.3         77214-77342
            676-810             AC166113.3         81840-81974
            811-924             AC166113.3         83003-83116
            925-1057            AC166113.3         84291-84423
            1058-1167           AC166113.3         85215-85324
            1168-1293           AC166113.3         85681-85806
            1294-1343           AC166113.3         88417-88466
            1344-1544           AC166113.3         88871-89071
            1545-1676           AC166113.3         90360-90491
            1677-1803           AC166113.3         91212-91338
            1804-3902           AC166113.3         92570-94668
FEATURES             Location/Qualifiers
     source          1..3902
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14"
     gene            1..3902
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /note="myotubularin related protein 6"
                     /db_xref="GeneID:219135"
                     /db_xref="MGI:MGI:2145637"
     exon            1..108
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..2052
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /EC_number="3.1.3.95"
                     /note="isoform 3 is encoded by transcript variant 4;
                     phosphatidylinositol-3-phosphate phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6"
                     /codon_start=1
                     /product="phosphatidylinositol-3,5-bisphosphate
                     3-phosphatase MTMR6 isoform 3"
                     /protein_id="NP_001388129.1"
                     /db_xref="GeneID:219135"
                     /db_xref="MGI:MGI:2145637"
                     /translation="MEHIRTTKVEQVKLLDRFSTNNKSLTGTLYLTATHLLFIDAQQK
                     ETWILHHHIASVEKLALTTSGCPLVIQCKNFRIVHFIVPRERDCHDIYNSLLQLSKQA
                     KYEDLYAFSYNPKQNDTERRNGWQLIDLAAEYERMGVPNANWQLSDANREYKVCETYP
                     RELYVPRTASRPVIVGSSNFRSKGRLPVLSYCRQGTEAAICRCSQPLSGFSARCLEDE
                     HLLQAISKANPGNRYMYVVDTRPKHRMQSWWDTQKDIGRIIVRISSKIWNDEKIRESD
                     ERKRLNAIANRAAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEVNGSKGLSVN
                     DFYSGLESSGWLRHIKAVLDAAIFLAKAIVVENASVLVHCSDGWDRTSQVCSLGSLLL
                     DSYYRTMKGFMVLIEKDWISFGHKFSERCGHLDGDPREVSPVFTQFLECVWHLTQQFP
                     QAFEFNEAFLLQIHEHIHSCQFGNFLGNCQKEREELRLKEKTYSLWPFLLDDKKKYLN
                     PLYSSKSQRLTVLEPNTASFNFKFWRNMYHQFDRTLHPRQSVLSIIMNMNEQSKQLEE
                     DIKDLEAKIKQCKNGILTKELLHAVHPESPALKTSLCLKEPSLLPVKDTLRAIEGSSP
                     ADNRYCDYAEEFSKSEPTVVSLEYGVARMTC"
     exon            109..225
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            226..388
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            389..546
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            547..675
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            676..810
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            811..924
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1057
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1167
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1293
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1343
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1544
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1676
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1803
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..3902
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3884..3889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /note="hexamer: ATTAAA"
     polyA_site      3902
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /note="major polyA site"
ORIGIN      
        1 agttcctgcg ggtggctgtc accgccccgt ttctctcccg atggtgctct cctgaggcca
       61 gctgcctgcg ggcgtcgccc cgggatggag cacatccgga caaccaaggt tgaacaagta
      121 aagttacttg accggtttag taccaacaac aagtcactga caggaacact gtatcttacg
      181 gccacacacc tattatttat tgacgctcag caaaaagaaa cctggatact acaccaccat
      241 attgcctctg tggagaaact tgctctgacc acttctggat gcccacttgt gattcagtgc
      301 aagaacttca ggattgtgca tttcattgtt cccagggaaa gagattgcca cgatatttat
      361 aactctctcc tgcagctatc aaaacaagca aaatatgaag atctctatgc cttctcttat
      421 aatcccaagc aaaatgatac tgaacgacgg aatggttggc agcttattga ccttgctgcg
      481 gagtatgaga ggatgggagt gcccaatgca aactggcaac tgtcggatgc caaccgagag
      541 tacaaggtct gtgagactta tcccagagag ctgtatgttc ctcggacagc tagccggccg
      601 gtgatcgtgg gcagttccaa cttccggagc aagggcagac ttccggtcct atcctactgc
      661 cggcagggca ctgaggctgc catttgtcga tgtagtcagc cattgtcagg cttcagtgcc
      721 aggtgcctag aggatgagca tttgcttcaa gccattagta aagccaaccc aggaaaccgc
      781 tacatgtatg ttgtggatac caggcccaag catcgcatgc agagctggtg ggatacacaa
      841 aaggacattg gcagaattat agtgaggatt tcttcaaaaa tctggaatga tgagaaaata
      901 agagaaagcg atgagagaaa gcgactcaat gcaatagcta acagagcagc tggaaaaggt
      961 tatgaaaatg aagacaacta ttctaatatt agatttcagt tcgttggaat agaaaatatt
     1021 catgtcatga gatccagcct tcagaaatta ctggaagtga atggtagcaa ggggctttct
     1081 gtcaatgatt tctactctgg tttggaaagt tcaggatggc ttcgccatat caaggctgtt
     1141 ttggatgctg caatcttctt agccaaagca atagtggttg aaaatgcaag tgtgttggtc
     1201 cactgttccg atgggtggga caggacctcc caagtgtgct ccctcggctc actgttgttg
     1261 gattcctact acaggacaat gaaaggattc atggttttaa tagaaaaaga ttggatatca
     1321 tttgggcata aattttcaga gaggtgtggc catttggatg gagacccgag ggaggtctca
     1381 ccagtgttca ctcagttctt ggagtgtgtc tggcacctga ctcagcagtt cccacaagcc
     1441 ttcgagttca acgaagcgtt tcttcttcag atccatgagc acattcattc atgccaattt
     1501 gggaacttcc ttggcaactg tcagaaggag agagaggaac tcaggttaaa ggagaaaact
     1561 tactccctgt ggccttttct tttggatgac aaaaagaagt acttaaatcc tctctacagt
     1621 tccaaatctc agagactgac agtcttggag ccaaatacag cctctttcaa ttttaagttt
     1681 tggagaaaca tgtaccacca gtttgatcgg acgctccatc ctcggcagtc tgtgctgagc
     1741 ataattatga atatgaatga gcaaagcaag cagttagagg aagacattaa agacctcgag
     1801 gctaaaatta agcaatgcaa aaatggcatc ctaacgaagg agttgctgca tgctgtccac
     1861 cctgaatcac ctgccctgaa aacctcgctg tgtctcaaag agccgagtct gcttcccgtg
     1921 aaggacacac tccgagctat agagggcagc agcccagcag ataatcgcta ctgtgactat
     1981 gccgaggaat tttctaagtc ggagcctacc gtggtcagct tggagtacgg ggtggccaga
     2041 atgacttgtt agcctccttc cgtgatccct ggatgactgt agtgtaagaa atgtatagtt
     2101 gtgaggatgg tctgtacaca tgggcaggag gggttgttga gtgactttgg ggcttagcag
     2161 taagtgagaa agtaggtagc tgagaaaagg atcatagcaa ctcttgagag gagtgagtca
     2221 gctaagtgcc atttgtaaca agaacatact catttctgta ggaagtgagt gctagtgtgt
     2281 gtatgtactg gaaaggggtt acacaggact ggtgagctga cagtctgttg attcagatgt
     2341 taattccagc cacgctcagt agctttcctc taactctgag aaaacagacc tgacaacctg
     2401 aaccctcagt gactgatgtg gcatgtgctt tcagttctgg agctgtgtga ctgtggattt
     2461 tgcagtcaca aaaatccaaa tatatagtca aaaatatagt gacgttttaa cattaaagtg
     2521 ccatgaaaag tacttatggg acagccttaa agtagactct cagtttattc tgtgggtttt
     2581 atagccgagg acaggatgtt tgatctctcc tttaatcagc cttatttcat atgaagaact
     2641 aactgcactc tgattacttg ggggccgcac actgcagtgc tccaccatgg aaagttgtag
     2701 acatactctg ctagtttgta attagccagc tccacccgta tttaaaatca gtgttaccga
     2761 aggctttgtt ctcgttgtca tttgttccaa gctgcagctg acagttcatt attcacagct
     2821 tagaggactc atttcttagg ctagtataag cacatttggc atttactttc ggcttactgc
     2881 agtctattaa ttcttactct gtggttggct ttaatccttt gataactgta catttaaagt
     2941 ggcaaagctc taaagcgttc tgagtactaa atacattttt aacttgactg tagctgccta
     3001 taaactttca ggtaaaggaa aaagggaagt gcgggtagtg gagattttgc ttggttacga
     3061 attctaaagc aatcattttt gtgtggagca tatttcctta ctcttaatat aggaggggca
     3121 gagaagggag cactggggga gccagctaat gtccaacaga agcagctttg acgcaggaaa
     3181 aggtttattt tgctttatag gctcattgtt attctgtgca ctggggcata catatctttt
     3241 ctaaaaaatc acttacaact gtcagtatta ccagctggct ctcaaagttt aatatcattg
     3301 atggtgtgtg aggtacagtt caggggcact acaaaatctg tgtacattgt cttatatacc
     3361 tcctgaccac acctatatct gtagtatttc ttgtgttagt tttgaacata tgtatctttt
     3421 tttttttttt gggaaaaaaa aggaaagctt tatcgtatat gattttatct agtccttatt
     3481 tttccaattc acttctgtaa gaccttatgt aataaaaaca ctgcatttta aaaagtaaca
     3541 gaaatatact aaaaattaca atgtataatg aacagtgttt agacattgag aaaggaaact
     3601 taatctctgt gtccacaaca ggagggtttt gtgccttggt tccagtcaag ttgtggtttt
     3661 agacttctgt ggcagacttc ctagtcatct tctgggttcc ttatgctaat tttcaacttc
     3721 acatgtatat atgtgtttac atgctcacac agaaaacatc ctgagtgacg tacaggacat
     3781 acgttggcaa aagtctgtgt aaatgtctca taaaattaga tttatgttca ttgtgttttg
     3841 ggatgtatag catgtaaatt atttcatgta ttatttaaag gcaattaaat gttcatgctt
     3901 ta
//
