LOCUS       NM_001401198            3979 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus myotubularin related protein 6 (Mtmr6), transcript
            variant 2, mRNA.
ACCESSION   NM_001401198 XM_006518865
VERSION     NM_001401198.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3979)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3979)
  AUTHORS   Maekawa,M., Terasaka,S., Mochizuki,Y., Kawai,K., Ikeda,Y.,
            Araki,N., Skolnik,E.Y., Taguchi,T. and Arai,H.
  TITLE     Sequential breakdown of 3-phosphorylated phosphoinositides is
            essential for the completion of macropinocytosis
  JOURNAL   Proc Natl Acad Sci U S A 111 (11), E978-E987 (2014)
   PUBMED   24591580
REFERENCE   3  (bases 1 to 3979)
  AUTHORS   Mochizuki,Y., Ohashi,R., Kawamura,T., Iwanari,H., Kodama,T.,
            Naito,M. and Hamakubo,T.
  TITLE     Phosphatidylinositol 3-phosphatase myotubularin-related protein 6
            (MTMR6) is regulated by small GTPase Rab1B in the early secretory
            and autophagic pathways
  JOURNAL   J Biol Chem 288 (2), 1009-1021 (2013)
   PUBMED   23188820
REFERENCE   4  (bases 1 to 3979)
  AUTHORS   Mochizuki,Y. and Majerus,P.W.
  TITLE     Characterization of myotubularin-related protein 7 and its binding
            partner, myotubularin-related protein 9
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 9768-9773 (2003)
   PUBMED   12890864
REFERENCE   5  (bases 1 to 3979)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166113.3.
            
            On Feb 4, 2022 this sequence version replaced XM_006518865.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.31491.1,
                                           SRR1660815.20208.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AC166113.3         57551-57658
            109-299             AC166113.3         62656-62846
            300-416             AC166113.3         69426-69542
            417-579             AC166113.3         72380-72542
            580-737             AC166113.3         74234-74391
            738-866             AC166113.3         77214-77342
            867-1001            AC166113.3         81840-81974
            1002-1134           AC166113.3         84291-84423
            1135-1244           AC166113.3         85215-85324
            1245-1370           AC166113.3         85681-85806
            1371-1420           AC166113.3         88417-88466
            1421-1621           AC166113.3         88871-89071
            1622-1753           AC166113.3         90360-90491
            1754-1880           AC166113.3         91212-91338
            1881-3979           AC166113.3         92570-94668
FEATURES             Location/Qualifiers
     source          1..3979
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14"
     gene            1..3979
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /note="myotubularin related protein 6"
                     /db_xref="GeneID:219135"
                     /db_xref="MGI:MGI:2145637"
     exon            1..108
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            109..299
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..2129
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /EC_number="3.1.3.95"
                     /note="isoform 2 is encoded by transcript variant 2;
                     phosphatidylinositol-3-phosphate phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6"
                     /codon_start=1
                     /product="phosphatidylinositol-3,5-bisphosphate
                     3-phosphatase MTMR6 isoform 2"
                     /protein_id="NP_001388127.1"
                     /db_xref="GeneID:219135"
                     /db_xref="MGI:MGI:2145637"
                     /translation="MQVEQVKLLDRFSTNNKSLTGTLYLTATHLLFIDAQQKETWILH
                     HHIASVEKLALTTSGCPLVIQCKNFRIVHFIVPRERDCHDIYNSLLQLSKQAKYEDLY
                     AFSYNPKQNDTERRNGWQLIDLAAEYERMGVPNANWQLSDANREYKVCETYPRELYVP
                     RTASRPVIVGSSNFRSKGRLPVLSYCRQGTEAAICRCSQPLSGFSARCLEDEHLLQAI
                     SKANPGNRYMYVVDTRPKLNAIANRAAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQ
                     KLLEVNGSKGLSVNDFYSGLESSGWLRHIKAVLDAAIFLAKAIVVENASVLVHCSDGW
                     DRTSQVCSLGSLLLDSYYRTMKGFMVLIEKDWISFGHKFSERCGHLDGDPREVSPVFT
                     QFLECVWHLTQQFPQAFEFNEAFLLQIHEHIHSCQFGNFLGNCQKEREELRLKEKTYS
                     LWPFLLDDKKKYLNPLYSSKSQRLTVLEPNTASFNFKFWRNMYHQFDRTLHPRQSVLS
                     IIMNMNEQSKQLEEDIKDLEAKIKQCKNGILTKELLHAVHPESPALKTSLCLKEPSLL
                     PVKDTLRAIEGSSPADNRYCDYAEEFSKSEPTVVSLEYGVARMTC"
     exon            300..416
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            417..579
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            580..737
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            738..866
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1001
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1134
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1244
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1370
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1420
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1621
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1753
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1880
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..3979
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3961..3966
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /note="hexamer: ATTAAA"
     polyA_site      3979
                     /gene="Mtmr6"
                     /gene_synonym="4022440C11Rik; Gm38641"
                     /note="major polyA site"
ORIGIN      
        1 agttcctgcg ggtggctgtc accgccccgt ttctctcccg atggtgctct cctgaggcca
       61 gctgcctgcg ggcgtcgccc cgggatggag cacatccgga caaccaagct ttactattag
      121 acaacatggg cttcctctct gcgtgcttcc tccaggctcc atcatctccc aaccacgcct
      181 ccactgtttc cttactcctc ggtggttcca cctgcccagc cgaattttct ctgggttgat
      241 actgtcagta ctactgcact taaaggcctg tttgtgttcc ttcatcagat aaaatgcagg
      301 ttgaacaagt aaagttactt gaccggttta gtaccaacaa caagtcactg acaggaacac
      361 tgtatcttac ggccacacac ctattattta ttgacgctca gcaaaaagaa acctggatac
      421 tacaccacca tattgcctct gtggagaaac ttgctctgac cacttctgga tgcccacttg
      481 tgattcagtg caagaacttc aggattgtgc atttcattgt tcccagggaa agagattgcc
      541 acgatattta taactctctc ctgcagctat caaaacaagc aaaatatgaa gatctctatg
      601 ccttctctta taatcccaag caaaatgata ctgaacgacg gaatggttgg cagcttattg
      661 accttgctgc ggagtatgag aggatgggag tgcccaatgc aaactggcaa ctgtcggatg
      721 ccaaccgaga gtacaaggtc tgtgagactt atcccagaga gctgtatgtt cctcggacag
      781 ctagccggcc ggtgatcgtg ggcagttcca acttccggag caagggcaga cttccggtcc
      841 tatcctactg ccggcagggc actgaggctg ccatttgtcg atgtagtcag ccattgtcag
      901 gcttcagtgc caggtgccta gaggatgagc atttgcttca agccattagt aaagccaacc
      961 caggaaaccg ctacatgtat gttgtggata ccaggcccaa gctcaatgca atagctaaca
     1021 gagcagctgg aaaaggttat gaaaatgaag acaactattc taatattaga tttcagttcg
     1081 ttggaataga aaatattcat gtcatgagat ccagccttca gaaattactg gaagtgaatg
     1141 gtagcaaggg gctttctgtc aatgatttct actctggttt ggaaagttca ggatggcttc
     1201 gccatatcaa ggctgttttg gatgctgcaa tcttcttagc caaagcaata gtggttgaaa
     1261 atgcaagtgt gttggtccac tgttccgatg ggtgggacag gacctcccaa gtgtgctccc
     1321 tcggctcact gttgttggat tcctactaca ggacaatgaa aggattcatg gttttaatag
     1381 aaaaagattg gatatcattt gggcataaat tttcagagag gtgtggccat ttggatggag
     1441 acccgaggga ggtctcacca gtgttcactc agttcttgga gtgtgtctgg cacctgactc
     1501 agcagttccc acaagccttc gagttcaacg aagcgtttct tcttcagatc catgagcaca
     1561 ttcattcatg ccaatttggg aacttccttg gcaactgtca gaaggagaga gaggaactca
     1621 ggttaaagga gaaaacttac tccctgtggc cttttctttt ggatgacaaa aagaagtact
     1681 taaatcctct ctacagttcc aaatctcaga gactgacagt cttggagcca aatacagcct
     1741 ctttcaattt taagttttgg agaaacatgt accaccagtt tgatcggacg ctccatcctc
     1801 ggcagtctgt gctgagcata attatgaata tgaatgagca aagcaagcag ttagaggaag
     1861 acattaaaga cctcgaggct aaaattaagc aatgcaaaaa tggcatccta acgaaggagt
     1921 tgctgcatgc tgtccaccct gaatcacctg ccctgaaaac ctcgctgtgt ctcaaagagc
     1981 cgagtctgct tcccgtgaag gacacactcc gagctataga gggcagcagc ccagcagata
     2041 atcgctactg tgactatgcc gaggaatttt ctaagtcgga gcctaccgtg gtcagcttgg
     2101 agtacggggt ggccagaatg acttgttagc ctccttccgt gatccctgga tgactgtagt
     2161 gtaagaaatg tatagttgtg aggatggtct gtacacatgg gcaggagggg ttgttgagtg
     2221 actttggggc ttagcagtaa gtgagaaagt aggtagctga gaaaaggatc atagcaactc
     2281 ttgagaggag tgagtcagct aagtgccatt tgtaacaaga acatactcat ttctgtagga
     2341 agtgagtgct agtgtgtgta tgtactggaa aggggttaca caggactggt gagctgacag
     2401 tctgttgatt cagatgttaa ttccagccac gctcagtagc tttcctctaa ctctgagaaa
     2461 acagacctga caacctgaac cctcagtgac tgatgtggca tgtgctttca gttctggagc
     2521 tgtgtgactg tggattttgc agtcacaaaa atccaaatat atagtcaaaa atatagtgac
     2581 gttttaacat taaagtgcca tgaaaagtac ttatgggaca gccttaaagt agactctcag
     2641 tttattctgt gggttttata gccgaggaca ggatgtttga tctctccttt aatcagcctt
     2701 atttcatatg aagaactaac tgcactctga ttacttgggg gccgcacact gcagtgctcc
     2761 accatggaaa gttgtagaca tactctgcta gtttgtaatt agccagctcc acccgtattt
     2821 aaaatcagtg ttaccgaagg ctttgttctc gttgtcattt gttccaagct gcagctgaca
     2881 gttcattatt cacagcttag aggactcatt tcttaggcta gtataagcac atttggcatt
     2941 tactttcggc ttactgcagt ctattaattc ttactctgtg gttggcttta atcctttgat
     3001 aactgtacat ttaaagtggc aaagctctaa agcgttctga gtactaaata catttttaac
     3061 ttgactgtag ctgcctataa actttcaggt aaaggaaaaa gggaagtgcg ggtagtggag
     3121 attttgcttg gttacgaatt ctaaagcaat catttttgtg tggagcatat ttccttactc
     3181 ttaatatagg aggggcagag aagggagcac tgggggagcc agctaatgtc caacagaagc
     3241 agctttgacg caggaaaagg tttattttgc tttataggct cattgttatt ctgtgcactg
     3301 gggcatacat atcttttcta aaaaatcact tacaactgtc agtattacca gctggctctc
     3361 aaagtttaat atcattgatg gtgtgtgagg tacagttcag gggcactaca aaatctgtgt
     3421 acattgtctt atatacctcc tgaccacacc tatatctgta gtatttcttg tgttagtttt
     3481 gaacatatgt atcttttttt tttttttggg aaaaaaaagg aaagctttat cgtatatgat
     3541 tttatctagt ccttattttt ccaattcact tctgtaagac cttatgtaat aaaaacactg
     3601 cattttaaaa agtaacagaa atatactaaa aattacaatg tataatgaac agtgtttaga
     3661 cattgagaaa ggaaacttaa tctctgtgtc cacaacagga gggttttgtg ccttggttcc
     3721 agtcaagttg tggttttaga cttctgtggc agacttccta gtcatcttct gggttcctta
     3781 tgctaatttt caacttcaca tgtatatatg tgtttacatg ctcacacaga aaacatcctg
     3841 agtgacgtac aggacatacg ttggcaaaag tctgtgtaaa tgtctcataa aattagattt
     3901 atgttcattg tgttttggga tgtatagcat gtaaattatt tcatgtatta tttaaaggca
     3961 attaaatgtt catgcttta
//
