LOCUS       NM_133215               5767 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus myotubularin related protein 4 (Mtmr4), transcript
            variant 1, mRNA.
ACCESSION   NM_133215
VERSION     NM_133215.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5767)
  AUTHORS   Sasner,M., Preuss,C., Pandey,R.S., Uyar,A., Garceau,D.,
            Kotredes,K.P., Williams,H., Oblak,A.L., Lin,P.B., Perkins,B.,
            Soni,D., Ingraham,C., Lee-Gosselin,A., Lamb,B.T., Howell,G.R. and
            Carter,G.W.
  TITLE     In vivo validation of late-onset Alzheimer's disease genetic risk
            factors
  JOURNAL   Alzheimers Dement 20 (7), 4970-4984 (2024)
   PUBMED   38687251
REFERENCE   2  (bases 1 to 5767)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5767)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5767)
  AUTHORS   Sheffield,D.A., Jepsen,M.R., Feeney,S.J., Bertucci,M.C.,
            Sriratana,A., Naughtin,M.J., Dyson,J.M., Coppel,R.L. and
            Mitchell,C.A.
  TITLE     The myotubularin MTMR4 regulates phagosomal phosphatidylinositol
            3-phosphate turnover and phagocytosis
  JOURNAL   J Biol Chem 294 (45), 16684-16697 (2019)
   PUBMED   31543504
  REMARK    GeneRIF: MTMR4 negatively regulated the phagocytosis of
            IgG-opsonized particles, indicating that MTMR4 inhibits
            FcgammaR-mediated phagocytosis, and was dynamically recruited to
            phagosomes of macrophages during phagocytosis.
REFERENCE   5  (bases 1 to 5767)
  AUTHORS   Dewi Pamungkas Putri,D., Kawasaki,T., Murase,M., Sueyoshi,T.,
            Deguchi,T., Ori,D., Suetsugu,S. and Kawai,T.
  TITLE     PtdIns3P phosphatases MTMR3 and MTMR4 negatively regulate innate
            immune responses to DNA through modulating STING trafficking
  JOURNAL   J Biol Chem 294 (21), 8412-8423 (2019)
   PUBMED   30944173
  REMARK    GeneRIF: these results suggest that MTMR3 and MTMR4 regulate the
            production of PtdIns3P, which plays a critical role in suppressing
            DNA-mediated innate immune responses via modulating STING
            trafficking.
REFERENCE   6  (bases 1 to 5767)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 5767)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 5767)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
REFERENCE   9  (bases 1 to 5767)
  AUTHORS   Eddleston,J., Murdoch,J.N., Copp,A.J. and Stanier,P.
  TITLE     Physical and transcriptional map of a 3-Mb region of mouse
            chromosome 1 containing the gene for the neural tube defect mutant
            loop-tail (Lp)
  JOURNAL   Genomics 56 (2), 149-159 (1999)
   PUBMED   10051400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY263784.1, AK146641.1, BC058091.1, BF470538.1, AK133861.1 and
            CO041663.1.
            
            On Nov 10, 2017 this sequence version replaced NM_133215.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                BY263784.1         1-85
            86-4619             AK146641.1         52-4585
            4620-4625           BC058091.1         4397-4402
            4626-4861           BF470538.1         77-312
            4862-5741           AK133861.1         1-880
            5742-5767           CO041663.1         1-26                c
FEATURES             Location/Qualifiers
     source          1..5767
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 52.15 cM"
     gene            1..5767
                     /gene="Mtmr4"
                     /gene_synonym="ESTM44; FYVE-DSP2; mKIAA0647; ZFYVE11"
                     /note="myotubularin related protein 4"
                     /db_xref="GeneID:170749"
                     /db_xref="MGI:MGI:2180699"
     exon            1..85
                     /gene="Mtmr4"
                     /gene_synonym="ESTM44; FYVE-DSP2; mKIAA0647; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            86..130
                     /gene="Mtmr4"
                     /gene_synonym="ESTM44; FYVE-DSP2; mKIAA0647; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..3700
                     /gene="Mtmr4"
                     /gene_synonym="ESTM44; FYVE-DSP2; mKIAA0647; ZFYVE11"
                     /EC_number="3.1.3.95"
                     /note="isoform 1 is encoded by transcript variant 1; FYVE
                     zinc finger phosphatase; phosphatidylinositol-3-phosphate
                     phosphatase; phosphatidylinositol-3,5-bisphosphate
                     3-phosphatase; phosphatidylinositol-3,5-bisphosphate
                     3-phosphatase MTMR4"
                     /codon_start=1
                     /product="phosphatidylinositol-3,5-bisphosphate
                     3-phosphatase MTMR4 isoform 1"
                     /protein_id="NP_573478.1"
                     /db_xref="CCDS:CCDS25214.1"
                     /db_xref="GeneID:170749"
                     /db_xref="MGI:MGI:2180699"
                     /translation="MGEEGPPSLEYIQAKDLFPPKELVKEEENLQVPFTVLQGEGVEF
                     LGRATDALIAISNYRLHIKFKDSVINVPLRMIDSVESRDMFQLHIACKDSKVVRCHFS
                     TFKQCQEWLSRLSRATARPAKPEDLFAFAYHAWCLGLTEEDQHTHLCQPGEHIRCRQE
                     AELARMGFDLQNVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPV
                     VVYRHLRNGAAIARCSQPEISWWGWRNADDEYLVTSIAKACALDPGTRASGGSLSTGT
                     NDASEACDTDFDSSLTACSGVESTAAPQKLLILDARSYTAAVANRAKGGGCECEEYYP
                     NCEVLFMGMANIHAIRNSFQYLRAVCSQMPDPSNWLSALESTKWLQHLSVMLKAAVLV
                     ANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKF
                     GDRCGHQENAEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYG
                     TFLANNPCEREKRNIYKRTCSVWALLRAGNKNFHNFLYTPGSDVVLHPVCHVRALHLW
                     TAVYLPASSPCTLGEENMDLYLSPVAQSQEFSGRSLDRLPKTRSMDDLLSACDTSSPL
                     TRTSSDPNLNNHSQEVRGSLEPWHSSPEGAETVIDSGVGSPQLTVGEMGLPPPLPSSQ
                     KEYLSNKPFKGHKSCSLSYKLLNTSVSWEMKSNTSDIKVLEETEALAPDPSAQEEQGR
                     TSDGLGKPPEQFLEKEAVSSLCSVSSKCGGACDFPEPPQDPLTGTPQQPHLDSMQISP
                     SRCTPDHSQGSLCNPPSVASQTPEPNTDLLSQDPPGSTASISHQEQPSSVPDLIYKKE
                     DAGKRGSKNGQLLENPRFGKMPLELARKPISQSQISEFSFLGSNWDSFQGMMTSFPSG
                     ETTPRRLLAYGCCSKRPSNKHIRAAGPCLGGQWAQREGMKSPVCSSHSNGHCTGPGGK
                     NNRMWFSSHPKQVSSTKPSLLSCPSPVPPLYLDDDGLPFPTDVIQHRLRQIEAGYRQE
                     VEQLRRQVRELQMRLDIRHCCAPPAEPPMDYEDDFTCLKESDGSDTEDFGSDHSEDCL
                     SEASWEPVDKKETEVTRWVPDHMASHCFNCDCEFWLAKRRHHCRNCGNVFCAGCCHLK
                     LPIPDQQLYDPVLVCNSCYEHIQVSRARELMSQHLKKPIATASS"
     exon            131..220
                     /gene="Mtmr4"
                     /gene_synonym="ESTM44; FYVE-DSP2; mKIAA0647; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            221..337
                     /gene="Mtmr4"
                     /gene_synonym="ESTM44; FYVE-DSP2; mKIAA0647; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            338..420
                     /gene="Mtmr4"
                     /gene_synonym="ESTM44; FYVE-DSP2; mKIAA0647; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            421..581
                     /gene="Mtmr4"
                     /gene_synonym="ESTM44; FYVE-DSP2; mKIAA0647; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            582..678
                     /gene="Mtmr4"
                     /gene_synonym="ESTM44; FYVE-DSP2; mKIAA0647; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            679..792
                     /gene="Mtmr4"
                     /gene_synonym="ESTM44; FYVE-DSP2; mKIAA0647; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            793..989
                     /gene="Mtmr4"
                     /gene_synonym="ESTM44; FYVE-DSP2; mKIAA0647; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1118
                     /gene="Mtmr4"
                     /gene_synonym="ESTM44; FYVE-DSP2; mKIAA0647; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1230
                     /gene="Mtmr4"
                     /gene_synonym="ESTM44; FYVE-DSP2; mKIAA0647; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1426
                     /gene="Mtmr4"
                     /gene_synonym="ESTM44; FYVE-DSP2; mKIAA0647; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1612
                     /gene="Mtmr4"
                     /gene_synonym="ESTM44; FYVE-DSP2; mKIAA0647; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1783
                     /gene="Mtmr4"
                     /gene_synonym="ESTM44; FYVE-DSP2; mKIAA0647; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1938
                     /gene="Mtmr4"
                     /gene_synonym="ESTM44; FYVE-DSP2; mKIAA0647; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..3322
                     /gene="Mtmr4"
                     /gene_synonym="ESTM44; FYVE-DSP2; mKIAA0647; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            3323..3433
                     /gene="Mtmr4"
                     /gene_synonym="ESTM44; FYVE-DSP2; mKIAA0647; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            3434..3522
                     /gene="Mtmr4"
                     /gene_synonym="ESTM44; FYVE-DSP2; mKIAA0647; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            3523..5749
                     /gene="Mtmr4"
                     /gene_synonym="ESTM44; FYVE-DSP2; mKIAA0647; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5725..5730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtmr4"
                     /gene_synonym="ESTM44; FYVE-DSP2; mKIAA0647; ZFYVE11"
                     /note="hexamer: AATAAA"
     polyA_site      5744
                     /gene="Mtmr4"
                     /gene_synonym="ESTM44; FYVE-DSP2; mKIAA0647; ZFYVE11"
                     /note="major polyA site"
ORIGIN      
        1 gggttcgagc tgcgcggcct cagcagctgc gggagacgga agtggtgaga gcgcggcttt
       61 ggagggtcgg gcggacgccg cctggtgacg agcaggagca ggcagccagg accctcgcca
      121 aggtagaatg ggtgaggagg gcccccccag cctggagtac atccaagcca aggatctgtt
      181 cccccccaag gaactggtga aggaggagga gaatcttcag gtacccttca cagtgctgca
      241 gggtgaggga gtggaattcc tgggccgggc aaccgatgcc ctcattgcca tctctaacta
      301 ccggctgcac atcaagttca aagactctgt catcaacgtg cccctccgga tgattgacag
      361 tgtggaaagc cgtgatatgt ttcagttgca cattgcctgc aaggactcca aagtggtgag
      421 gtgccacttc tctactttca agcagtgcca agagtggctc tcaaggctaa gccgggccac
      481 agcgagacct gccaagcccg aggatctctt tgcctttgcc taccatgcgt ggtgcctggg
      541 gctgaccgag gaggaccagc atacccacct gtgccagcca ggagagcaca tccgatgtcg
      601 acaggaggca gagctcgcaa ggatgggttt tgacctgcag aatgtctgga gagtctcgca
      661 tatcaacagc aattacaagc tgtgccctag ttacccccag aagctgctgg ttcctgtgtg
      721 gatcacagat aaagagctgg agaacgtggc ttctttccgc tcttggaaac gcatccctgt
      781 tgtggtatac agacacctgc gcaacggggc tgccattgct cgctgcagcc agcctgagat
      841 cagctggtgg ggctggcgca atgctgatga tgaatacctc gtcacgtcca ttgccaaagc
      901 ctgcgcctta gacccaggga caagggccag tgggggctcc ctcagcactg ggactaatga
      961 tgccagtgag gcatgtgaca cagatttcga ttcttctctg actgcatgct ctggggtgga
     1021 gagcacagca gccccacaga aactgctgat cctggatgca cggtcctaca cagcagccgt
     1081 ggctaaccgg gccaagggtg gaggctgtga atgtgaagaa tactatccga actgtgaggt
     1141 cttgtttatg ggaatggcca acatccacgc catccggaat agcttccagt acctccgggc
     1201 tgtgtgtagc cagatgccag atcccagcaa ctggttgtcg gcactggaga gtaccaaatg
     1261 gctgcagcac ttgtcagtga tgctaaaagc agctgtgttg gtagccaata cggtagatcg
     1321 ggaaggccgg cctgtgctgg tacactgctc tgacggctgg gaccgtacac cacagattgt
     1381 agccctggcc aaaatactac tggatccata ttacaggact ctggagggct tccaagtgtt
     1441 agtggagtct gattggctgg atttcggaca caagtttgga gaccgctgtg gccatcagga
     1501 aaatgcagag gaccaaaatg aacagtgtcc tgtgttcctc cagtggcttg attccgtgca
     1561 tcagctgctt aagcagttcc cctgcctgtt tgagttcaat gaagcatttc tggtaaagct
     1621 ggtgcagcac acatactcgt gtctctacgg cacattcctg gccaacaacc cctgcgagcg
     1681 agagaagcgc aacatctata aacggacgtg ctctgtgtgg gcactcctgc gagctggcaa
     1741 caagaacttt cataacttcc tctatacacc tggttcagac gtggtcctgc atcctgtgtg
     1801 tcatgtccgg gccctgcacc tctggacagc tgtttatctg cctgcgtcat ctccatgcac
     1861 ccttggagag gaaaatatgg atctttacct ttccccagtg gctcagagcc aggaattttc
     1921 tggtcgttct ctggacaggt tacctaaaac cagatccatg gatgatctgc tctctgcctg
     1981 tgatacaagc agccccctca ctcgtacttc cagcgaccct aacctgaata accactctca
     2041 ggaggtcaga ggcagcctgg agccctggca cagcagtcct gaaggagcag agacagtcat
     2101 agactctgga gttggaagcc cacagctgac tgtgggagaa atgggccttc ctcctcctct
     2161 gcccagtagc cagaaagagt acttgagcaa taaacctttc aagggtcata aaagttgttc
     2221 tcttagttat aagttgctta atacttctgt gtcctgggaa atgaagagca acacctctga
     2281 catcaaggtc ctggaagaaa ctgaagcact ggccccggac ccttcagccc aagaggagca
     2341 gggtaggact tctgatggct tagggaagcc acctgaacag tttctagaga aggaagctgt
     2401 cagctcactc tgcagtgtct ctagcaagtg tggtggagcc tgtgattttc ctgagcctcc
     2461 ccaggacccc ctaacaggta ctccccaaca gccccaccta gactccatgc agatctcgcc
     2521 ctcaaggtgc actccagatc acagtcaggg cagcctttgc aacccaccaa gtgtggccag
     2581 ccaaactcca gagccaaata ctgacctcct cagccaagat ccccctggtt ctacggcaag
     2641 tatctcccac caggaacagc ctagctctgt gccggatctg atctacaaga aggaggatgc
     2701 tggcaagaga ggaagtaaga atgggcagct gttggaaaat cctcgctttg gaaaaatgcc
     2761 attggagttg gcccgaaagc caatttctca gagccagatc agtgagttct catttttagg
     2821 gtcaaactgg gacagcttcc aagggatgat gacttcattc ccaagcggag agaccactcc
     2881 tcggcgcctg cttgcttatg gctgttgtag caagaggccg agcaataagc atattcgagc
     2941 tgcagggccc tgccttgggg gccagtgggc tcagagagaa gggatgaaat ctcctgtctg
     3001 ttctagtcat tccaatggac actgcacagg cccaggaggg aagaacaacc ggatgtggtt
     3061 ttccagtcat ccgaagcaag tctccagcac aaagccttct cttctgagct gcccttcccc
     3121 agtgcctcct ctctacctgg atgatgatgg actccccttt cccacggatg tgatccaaca
     3181 caggttacgg cagatcgaag cagggtacag gcaagaggtg gaacagctac ggcgacaggt
     3241 tcgagagctt cagatgaggc tagacattcg tcattgctgt gcccctccag cagaaccccc
     3301 catggactat gaggatgact ttacgtgttt aaaggagtca gatggcagtg acactgaaga
     3361 ctttggctct gatcacagtg aagactgcct ttcagaagca agctgggaac ccgttgataa
     3421 gaaggagact gaggtgactc gctgggttcc agaccatatg gcatcccact gctttaactg
     3481 tgactgtgaa ttctggttgg ccaaacgaag acatcattgc agaaattgtg ggaacgtatt
     3541 ttgtgctgga tgctgccacc ttaagctgcc cattcctgat cagcaactct atgacccagt
     3601 tctcgtctgt aactcatgtt atgaacacat tcaagtatct cgtgccaggg aactcatgag
     3661 ccaacatctg aagaaaccca ttgctacggc ttccagttga atgccagagg aaatgatctg
     3721 tccattttta gcagatttga agggaggatc tgcttcaggt gtagtctgga aggttccttg
     3781 gtatggctca tgaacacaga gctcaaagat accgtcttga gaaatcctcc ttggtaccat
     3841 gtgaccggag cagaggaatt tgaatttggc aggagctttt tctactggag agaccctcac
     3901 tttggggtga tggtcctgac ctagacccag agtctggaag cttcacactg agttggtgac
     3961 tccagcttct atctcctgga ggtcccaaga tgattcataa atactgcctg gtgcacagtg
     4021 cccaaacagc aatagaaagg cttacttata accaaactcc aagtgatagt gagacccatc
     4081 tctcctctac cttgaagaga gcagatcata gtatatgaga taggaattcc catcctattt
     4141 gagttgaact ctcttctgta cctctgtgct ctgtgtctgt gcatgaaggc tcagtcttta
     4201 gaggcactcc ctctagttga ttagcactgt cttctgtgga gtttggttca aagactggta
     4261 tggcagatag aggcttggat gcatttttca tcaggctcag tggctagcat cagtgaacat
     4321 tcagtttcag agggacagtt ttgaggatta agacacttgg aaacagaaga actctggtaa
     4381 tgcttagtct tgtgagaacc agttattctg ggctgtgaag gcagttgcca ctgttatgca
     4441 gtggctgctt ttgagggacg cactgtgaag aatgagaagg gaaaagcaag attatccttg
     4501 tgaaattctg ctgattgtgc cctacccttt gcacctgact tttcctagtt gtcctggtgc
     4561 taaaatggaa gctacacctt gatctctcct ggcatgaaaa taaaggattt tgttgttcca
     4621 ctgcccactt cccccatgtt gtctttccct tggccgctgc ctcctctggg tcacactgct
     4681 tcttatcctg aacacttgac accttgaggg tagaatatag catttggttt ttacctccta
     4741 gcatatgcta cttggtatgt gagggtttca gtacaaatgc tgctgtctat ttctgtgcac
     4801 ttaacaatgg aacccaaaca gaaggaagaa agccttgata ccaaaattgg gagtgaggat
     4861 gtgtccattt ggaccaaaca ctttgttttg ttttatttag attttgtttt tcatcttact
     4921 atgtaccagt ggcacttaac caaaagatac agtaacatag ccatgtactg tggttgggac
     4981 agatacagtc tccttggctt ataggacttc ctagctacac tttccttagc gcattaatgt
     5041 gatgctcact ctgtgttaaa actgcagccg ttgtctttct caactgctac tgtcacgttg
     5101 ctttcaagaa aacatttttt ttcattccag actaaccaga acctgcattt agaataggag
     5161 tcctttctcc gaccttttct tcagttccac agcgaagcct ctgtgctcct tttatacttg
     5221 ccatggatgt aacctaaaaa gttttggcat atttaggtca gcctagcaca tttttttttt
     5281 tttcatttta atggagctga agaatggaga tttttttttt gtgtgtgtgt gtctgagaaa
     5341 ttcctaagat caatgaaaga gtgataaact atttgtctct gatacataaa attattttaa
     5401 gcattttctc aatcattaaa tgttactgcc agtcataagt ggctttttaa ttaccagttt
     5461 tcattgcact tcactctgtt ttcaggggga ttggggacat tcggggagac tgtatctgtc
     5521 tactttgtgt gactgttttg agggactgtc ccatcagtga acagattgca tggccttgga
     5581 gagagactct gggcttctgg ctcagatgtg tgcatccttt tagagctgtt gtgggtgtaa
     5641 gtgacatgat gtggccaaaa atccaaactg tgcagttgcg ttgtgacaaa catgcaatgt
     5701 gctgtaaaaa ctcaatacag ttcaaataaa atctctatat tagtgctgca aaaaaaaaaa
     5761 aaaaaaa
//
