LOCUS       NM_001373897            5753 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus myotubularin related protein 3 (Mtmr3), transcript
            variant 1, mRNA.
ACCESSION   NM_001373897 XM_006514847
VERSION     NM_001373897.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5753)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5753)
  AUTHORS   Wang,Y.N., Gan,T., Qu,S., Xu,L.L., Hu,Y., Liu,L.J., Shi,S.F.,
            Lv,J.C., Tsoi,L.C., Patrick,M.T., He,K., Berthier,C.C., Xu,H.J.,
            Zhou,X.J. and Zhang,H.
  TITLE     MTMR3 risk alleles enhance Toll Like Receptor 9-induced IgA
            immunity in IgA nephropathy
  JOURNAL   Kidney Int 104 (3), 562-576 (2023)
   PUBMED   37414396
  REMARK    GeneRIF: MTMR3 risk alleles enhance Toll Like Receptor 9-induced
            IgA immunity in IgA nephropathy.
REFERENCE   3  (bases 1 to 5753)
  AUTHORS   Dewi Pamungkas Putri,D., Kawasaki,T., Murase,M., Sueyoshi,T.,
            Deguchi,T., Ori,D., Suetsugu,S. and Kawai,T.
  TITLE     PtdIns3P phosphatases MTMR3 and MTMR4 negatively regulate innate
            immune responses to DNA through modulating STING trafficking
  JOURNAL   J Biol Chem 294 (21), 8412-8423 (2019)
   PUBMED   30944173
  REMARK    GeneRIF: these results suggest that MTMR3 and MTMR4 regulate the
            production of PtdIns3P, which plays a critical role in suppressing
            DNA-mediated innate immune responses via modulating STING
            trafficking.
REFERENCE   4  (bases 1 to 5753)
  AUTHORS   Wei,N., Cheng,Y., Wang,Z., Liu,Y., Luo,C., Liu,L., Chen,L., Xie,Z.,
            Lu,Y. and Feng,Y.
  TITLE     SRSF10 Plays a Role in Myoblast Differentiation and Glucose
            Production via Regulation of Alternative Splicing
  JOURNAL   Cell Rep 13 (8), 1647-1657 (2015)
   PUBMED   26586428
REFERENCE   5  (bases 1 to 5753)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 5753)
  AUTHORS   Kalsotra,A., Xiao,X., Ward,A.J., Castle,J.C., Johnson,J.M.,
            Burge,C.B. and Cooper,T.A.
  TITLE     A postnatal switch of CELF and MBNL proteins reprograms alternative
            splicing in the developing heart
  JOURNAL   Proc Natl Acad Sci U S A 105 (51), 20333-20338 (2008)
   PUBMED   19075228
REFERENCE   7  (bases 1 to 5753)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   8  (bases 1 to 5753)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606521.24 and AL645910.8.
            
            On Sep 4, 2019 this sequence version replaced XM_006514847.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.10250.1,
                                           SRR10223971.10676.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               AL606521.24        12367-12554         c
            189-272             AL645910.8         153393-153476       c
            273-362             AL645910.8         150488-150577       c
            363-479             AL645910.8         150007-150123       c
            480-562             AL645910.8         143003-143085       c
            563-729             AL645910.8         139912-140078       c
            730-826             AL645910.8         129761-129857       c
            827-940             AL645910.8         126203-126316       c
            941-1146            AL645910.8         121059-121264       c
            1147-1278           AL645910.8         120102-120233       c
            1279-1390           AL645910.8         119509-119620       c
            1391-1586           AL645910.8         114890-115085       c
            1587-1772           AL645910.8         113978-114163       c
            1773-1943           AL645910.8         113149-113319       c
            1944-2089           AL645910.8         111793-111938       c
            2090-3488           AL645910.8         109405-110803       c
            3489-3599           AL645910.8         108050-108160       c
            3600-3688           AL645910.8         107534-107622       c
            3689-5753           AL645910.8         103046-105110       c
FEATURES             Location/Qualifiers
     source          1..5753
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 2.94 cM"
     gene            1..5753
                     /gene="Mtmr3"
                     /gene_synonym="1700092A20Rik; FYVE-DSP1; mKIAA0371;
                     ZFYVE10"
                     /note="myotubularin related protein 3"
                     /db_xref="GeneID:74302"
                     /db_xref="MGI:MGI:1921552"
     exon            1..188
                     /gene="Mtmr3"
                     /gene_synonym="1700092A20Rik; FYVE-DSP1; mKIAA0371;
                     ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            189..272
                     /gene="Mtmr3"
                     /gene_synonym="1700092A20Rik; FYVE-DSP1; mKIAA0371;
                     ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..3860
                     /gene="Mtmr3"
                     /gene_synonym="1700092A20Rik; FYVE-DSP1; mKIAA0371;
                     ZFYVE10"
                     /EC_number="3.1.3.95"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphatidylinositol-3-phosphate phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3"
                     /codon_start=1
                     /product="phosphatidylinositol-3,5-bisphosphate
                     3-phosphatase MTMR3 isoform 1"
                     /protein_id="NP_001360826.1"
                     /db_xref="GeneID:74302"
                     /db_xref="MGI:MGI:1921552"
                     /translation="MDEEMRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEY
                     VGRAEEAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFP
                     TFEQCQDWLKRLNNAIRPPGKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSR
                     FKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVAGFRSWKRI
                     PAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVARACASDSQSSISKVSTRN
                     SCRDFPNAGDLSDVEFDSSLSNTSGAESLALQPQKLLILDARSYAAAVANRAKGGGCE
                     CPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLL
                     KSALLVVHAVDRDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWL
                     DFGHKFADRCGHGEDSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHT
                     YSCLFGTFLCNNAKERGEKQTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHV
                     RNLMLWSAVYLPCPSPSTPTDDSCAPYPVPGTSPDEPPLSRLPKTRSFDNLTTTCENM
                     VPLASRRSSDPSLNEKWQEHGRSLELSSFASAGEEVPAMDSLRKPSRLLGGAELSVAA
                     GVAEGQMENILQEATKEESGVEEPTHRGHTEVPEVKEEAPLAKESSMAAEGPVVLYQE
                     PQLDDATLRSHQGPSLSLFSQGIPEHQDGHNVLSSSLQAPLRGEDSQEVPVEQPQVEN
                     IAEDRENVAPAVPVDAKVGLGISQSSSLLPSQVPFETRGPHINNSVHMLLEDKVKSES
                     GPQLHHRPCPASSGRFSGKDMLPVAPEPRSAERPQWDSVLHRTSSPGNTLSLLQAPCA
                     LPLDKCRQGIVCNGALETENKASEQPAGFDTLQKYPTPNGHCANWEAGRSKDSLSHQL
                     SATSCSSAHLYSRNLHHKWLNSHSGRPSTTSSPDQPSRSHLDDDGMPVYTDTIQQRLR
                     QIESGHQQEVETLKKQVQELKSRLESQYLTSSLRFNGDFGDEVTSIPDSESNLDQNCV
                     SRCSTEIFSEASWEQVDKQDTEMTRWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVF
                     CSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN"
     exon            273..362
                     /gene="Mtmr3"
                     /gene_synonym="1700092A20Rik; FYVE-DSP1; mKIAA0371;
                     ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            363..479
                     /gene="Mtmr3"
                     /gene_synonym="1700092A20Rik; FYVE-DSP1; mKIAA0371;
                     ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            480..562
                     /gene="Mtmr3"
                     /gene_synonym="1700092A20Rik; FYVE-DSP1; mKIAA0371;
                     ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            563..729
                     /gene="Mtmr3"
                     /gene_synonym="1700092A20Rik; FYVE-DSP1; mKIAA0371;
                     ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            730..826
                     /gene="Mtmr3"
                     /gene_synonym="1700092A20Rik; FYVE-DSP1; mKIAA0371;
                     ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            827..940
                     /gene="Mtmr3"
                     /gene_synonym="1700092A20Rik; FYVE-DSP1; mKIAA0371;
                     ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1146
                     /gene="Mtmr3"
                     /gene_synonym="1700092A20Rik; FYVE-DSP1; mKIAA0371;
                     ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1278
                     /gene="Mtmr3"
                     /gene_synonym="1700092A20Rik; FYVE-DSP1; mKIAA0371;
                     ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1390
                     /gene="Mtmr3"
                     /gene_synonym="1700092A20Rik; FYVE-DSP1; mKIAA0371;
                     ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1586
                     /gene="Mtmr3"
                     /gene_synonym="1700092A20Rik; FYVE-DSP1; mKIAA0371;
                     ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1772
                     /gene="Mtmr3"
                     /gene_synonym="1700092A20Rik; FYVE-DSP1; mKIAA0371;
                     ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1943
                     /gene="Mtmr3"
                     /gene_synonym="1700092A20Rik; FYVE-DSP1; mKIAA0371;
                     ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2089
                     /gene="Mtmr3"
                     /gene_synonym="1700092A20Rik; FYVE-DSP1; mKIAA0371;
                     ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..3488
                     /gene="Mtmr3"
                     /gene_synonym="1700092A20Rik; FYVE-DSP1; mKIAA0371;
                     ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            3489..3599
                     /gene="Mtmr3"
                     /gene_synonym="1700092A20Rik; FYVE-DSP1; mKIAA0371;
                     ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            3600..3688
                     /gene="Mtmr3"
                     /gene_synonym="1700092A20Rik; FYVE-DSP1; mKIAA0371;
                     ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            3689..5753
                     /gene="Mtmr3"
                     /gene_synonym="1700092A20Rik; FYVE-DSP1; mKIAA0371;
                     ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5729..5734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtmr3"
                     /gene_synonym="1700092A20Rik; FYVE-DSP1; mKIAA0371;
                     ZFYVE10"
                     /note="hexamer: AATAAA"
     polyA_site      5753
                     /gene="Mtmr3"
                     /gene_synonym="1700092A20Rik; FYVE-DSP1; mKIAA0371;
                     ZFYVE10"
                     /note="major polyA site"
ORIGIN      
        1 gtggccgctg ccgccatgtt gttgtggttg tgagaaggcg gcggcggcag cggcggcggc
       61 ggcggcggag cagccggcgg agacgctcca gcggcccagg cgctggcccc cgccgaccct
      121 ggctggcagc ctcctggggt ggcggaggag gccctgcggt ggcgggcctc gccatgtcct
      181 gccgcctgta aaaggtctca agcagaagag aaagagtagc cttgtcagag actggagaag
      241 gacgcagccg ctcctgacct ggcctggtca tggatgaaga gatgcggcat agccttgagt
      301 gcatccaggc caatcagatc tttcccagga agcagctgat tcgggaggat gagaatcttc
      361 aggttccttt ccttgaactt catggagaga gcacagagta tgtgggccgt gctgaggagg
      421 ccatcattgc tctttctaat tacaggcttc acatcaagtt caaggagtct cttgtcaatg
      481 ttccattaca gcttattgaa agcgttgaat gccgtgatat atttcagctt catttgacat
      541 gcaaagactg caaagttatc aggtgtcagt tcccaacctt tgagcaatgt caagattggc
      601 ttaagagatt gaacaatgca atccgaccac ctggtaaaat agaagatctc ttctcatttg
      661 cataccatgc ttggtgcatg gaggtctacg ccagtgaaaa ggagcagcat ggagacctgt
      721 gcagaccagg ggaacatgtg acgtcaaggt ttaagaatga agtggagcgg atgggttttg
      781 atatgaacaa tgcctggagg atttccaaca tcaatgagaa atacaaatta tgtggtagtt
      841 atccacaaga gctcatagtg cctgcttgga tcactgacaa agagctggaa agcgtggcag
      901 gcttcagatc ctggaagcgc atccctgctg tcatctacag gcaccagagc aatggagctg
      961 tcattgcccg ctgcggacaa ccggaggtta gctggtgggg ctggcgaaat gctgatgatg
     1021 aacatctggt gcagtcagtg gccagagcct gtgcttctga ctctcagtca agtatcagca
     1081 aggtttccac tcggaacagt tgtcgggact ttcccaacgc aggggatctt tcagatgtgg
     1141 agttcgattc ctctctgtca aatacttcag gagcagaaag tttagctctc cagccccaga
     1201 agcttttgat cttggatgca cgctcctatg cagcagctgt ggcaaatcga gccaaaggag
     1261 gaggctgtga gtgcccagag tattatccta actgtgaagt tgtgtttatg ggaatggcaa
     1321 acatacattc tatccggagg agtttccagt ctctgcggct gctgtgcaca cagatgccag
     1381 atcctggaaa ttggctttct gcccttgaaa gtacaaagtg gctccatcac ctatctgtgc
     1441 ttctgaagtc ggcacttctc gtggtgcatg ctgtggaccg tgatcagcga ccagtgctag
     1501 tgcactgctc cgatggctgg gatcggactc cccagattgt ggccctagct aagctcctac
     1561 ttgaccctta ttaccgaacc atagagggtt tccaagtcct ggtggagatg gaatggctcg
     1621 attttggcca taagtttgct gaccggtgtg gtcatgggga ggactcagat gatctgaatg
     1681 agcgctgccc agtgtttcta caatggcttg actgtgttca tcaacttcag aggcagtttc
     1741 cttgctcttt tgagttcaac gaagcattcc ttgtgaaact ggtacagcat acctattcct
     1801 gtctctttgg aacattcctg tgcaacaacg ccaaagagag aggggaaaag cagactcagg
     1861 aacggacatg ctctgtgtgg tcacttcttc gagcaggcaa caaggctttc aaaaacctac
     1921 tgtattcatc tcagtcagaa gccgtgctct accccgtgtg ccatgtgcgg aatctgatgc
     1981 tgtggagcgc agtgtacctt ccctgcccat ccccatctac ccccacagat gacagctgtg
     2041 caccataccc agtcccaggc actagccctg atgagccccc actgagccgg ctacccaaga
     2101 ctagatcatt tgacaatctg accacaacct gcgaaaacat ggtgccgctg gccagccggc
     2161 gcagcagtga ccccagcctg aatgagaagt ggcaggagca cgggcgctcg ctggagctga
     2221 gcagctttgc cagcgctggg gaagaggtgc ctgctatgga cagcctgcgc aagcccagca
     2281 ggctgctcgg aggtgctgag ctttctgtgg cagccggagt ggctgaaggg cagatggaga
     2341 acattttgca agaggccacc aaagaggaga gtggggtaga agagcctacc cacagggggc
     2401 acactgaggt gccagaggtc aaagaggagg cacccctagc aaaagaaagt agcatggcgg
     2461 ccgagggccc cgttgtactt taccaagaac cacagctgga tgacgctact ttaagaagcc
     2521 atcaaggccc cagcctctct ttgttctccc agggtattcc tgaacatcag gatgggcaca
     2581 atgtcctctc tagttcactc caagctcctc tcaggggaga ggactcccag gaggtccctg
     2641 tagaacagcc tcaagtagag aatattgcag aggacaggga gaatgtagct cctgctgtcc
     2701 cagtagatgc aaaagttggc cttggtatct cacagtctag ttctctgctg ccttcccaag
     2761 tcccattcga gacaagagga ccacacatca acaactccgt gcacatgtta ctcgaagata
     2821 aggtaaagtc agaaagtggg ccccagctcc atcacagacc ttgcccagca agcagtggta
     2881 gattcagtgg caaggacatg cttcctgtag caccagagcc caggtctgct gagaggcccc
     2941 agtgggactc tgtgctacac aggacttcat cccctggcaa cacccttagc ctgctgcagg
     3001 ctccttgtgc cttgccgtta gataaatgta gacagggaat tgtgtgcaac ggtgccctag
     3061 agactgaaaa caaggcctca gaacagcctg cagggtttga cacccttcag aagtacccca
     3121 cacccaatgg gcattgtgcc aattgggagg ctgggaggag caaggactca ctgagccacc
     3181 agctgtctgc cacaagctgt agctctgctc acttgtactc gaggaacttg caccacaagt
     3241 ggctgaatag ccactcaggg aggccatcca ctaccagcag ccctgaccag ccttcccgca
     3301 gccacctgga tgacgatggc atgcctgtgt acacggacac aatccaacag cgcctgcgac
     3361 agatagagtc tggtcaccag caggaagtgg agaccttgaa gaaacaagtc caggagttga
     3421 agagtcgcct ggagagccag tacctgacca gctctctgcg cttcaatgga gactttggag
     3481 atgaagtgac ttcaatcccc gactcggaaa gcaatctgga tcagaactgt gtgtctcgct
     3541 gcagcacaga gattttctct gaagccagct gggagcaggt ggataaacag gacacagaga
     3601 tgactcgttg gctacctgac cacctggctg cccactgcta tgcctgtgac agtgccttct
     3661 ggctcgccag taggaagcac cactgcagga attgtgggaa tgtattctgc tccagttgtt
     3721 gtaaccagaa ggttccggtt cctagccagc agctctttga acccagtcga gtgtgcaagt
     3781 cttgctatag cagcctccat cctacaagct ccagcattga ccttgaactg gataagccta
     3841 ttgctgccac ttcaaactga agctcagtga cccggggtgg cagaggccat gctgctgttc
     3901 ctttaacagg ctcacacaca gcctgggcag tccaagaggc ccatacattt tggaatgggg
     3961 gcatggaata acctgtacag agattgggat gtaccactgg attgtaaatt gatttttgtt
     4021 tcatctcccc ttcccttcca tcctcttctt tgccttctaa aaagaaaaat atcccagttg
     4081 tcttaatttt ttttttaatg gaagcccaga ggttgccagg ctcttataac tgctgagccg
     4141 cttgctgtca gtcattctgt gagatcactc agtgcttccc tgtgggagga gccagaatga
     4201 aggcctgaga cagcaggaca gaaagtcagc ctcccattgg taaccattct tcacatcaca
     4261 gctatgtcag agttgactgg taaaccttgc tgctggggag gctggaagcc cttttgagag
     4321 tacgttcctg agagggatag ggccatccca cctcacagac aaaaagcagg gtggcgttgg
     4381 gaggaaagca cacagtgagc tactccccag gcctcacttt gaaacgagag gtatgtgctg
     4441 cttttgagtt aactgagggg ctagatgttg gcccatgtgg atcccaactt taacatgacc
     4501 aagattgggt agggctctct ctgcctcctt gggcttctag acagaaaggt acagactggc
     4561 cagaaagcag tatcctcctg cagtggtcaa ggcctgcact gagcgaggca cctgggagcc
     4621 ccctctgggt tccacaagca atctcttcct cagccaacac agggaaatcc agactcaggg
     4681 ttccacaagt ctcctattcc aaagcaaacc aatcatgcat ctccccttga gggacagagt
     4741 ccccacagtt ccaaagctct gcacacaatc agccttcctc ttctacttct ggggcagcag
     4801 gaaggaccca ggagcccctt gtcctgcttc tggctgcctg agtgggcaca tgtctgactc
     4861 ctgttatcta tcagtgaaga gcccttgatg attgtagggc tctaagaaaa tgacatggcc
     4921 tggaggagat tcggggtacc tttcctcagt gagctttgat gtggtccaaa aagagccttc
     4981 aaccagtagt tatctgtggt ggaggtgggt atgggaaggg tggagagcag ttttggtttg
     5041 tgctttgaat tgttggcatc tatgtttgtg accaccccac cccccaaggg tgatgcttag
     5101 ctctgctaag agctgcaaac tggtaagaga gcagattata gtgtgggggc tgggagaagt
     5161 tgggagacag ctcagttcta gcctggccta tatccttgcc ccgcccctct ggacgctgtt
     5221 acctggccat gggccttctg tgtctcagga aggtggcttc tgcatgctcc tcagtatgaa
     5281 tgcaagaaag cagaagcctt ccctagtctg ctgaagggaa ggctgcagta tcagagtatt
     5341 gctcatccct ccagaagcaa gtcaggcagg gccaagcttg gtgaaacagg gtgacgtgct
     5401 ccatgctctc tgtggtctgg agttagggtg gggaaaggtt ggtataattg aagattgtgc
     5461 agttcctagt gacaggtgcc aagaggttat gatacgggtt tcttgggtct gttgtacagt
     5521 gtgaataaat gcttgcagct cttagccctt tttgatcaat gaagcacttt tttattaata
     5581 ttttctttgt atgtaaagga ggaagcgtaa ctccatagct gtacatagaa ccttttctcc
     5641 taaagaggag tcagcgctcc tatagttttc attttttgtc aaagcaagaa gtaaatactt
     5701 tagaattgtt aaatatatag ataaagtgaa taaagttgag tgtccgcacg gtg
//
